β-Agonists and asthma: Too much of a good thing?

Journal of Clinical Investigation

Volumn 112, Issue 4, 2003, Pages 495-497

  Shore, Stephanie A ^a   Drazen, Jeffrey M ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; BETA 2 ADRENERGIC RECEPTOR; LIGAND;

ASTHMA; DISEASE EXACERBATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HUMAN; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE RELAXATION; ANIMAL; BIOLOGICAL MODEL; BRONCHUS; DRUG EFFECT; METABOLISM; NOTE; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ASTHMA; BRONCHI; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 85047694895     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI19642     Document Type: Review

References (20)

1. Vathenen, A.S., Knox, A.J., Higgins, B.G., Britton, J.R., and Tattersfield, A.E. 1988. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet. 1:554-558.
2. Israel, E., et al. 2000. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 162:75-80.
3. Taylor, D.R., et al. 2000. Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax. 55:762-767.
4. Taylor, D.R., et al. 1998. Asthma control during long-term treatment with regular inhaled salbutamol and salmeterol. Thorax. 53:744-752.
5. Hancox, R.J., Sears, M.R., and Taylor, D.R. 1998. Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma. Eur. Respir. J. 11:589-593.
6. Sears, M.R., et al. 1990. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet. 336:1391-1396.
7. Hanania, N.A., Sharafkhaneh, A., Barber, R., and Dickey, B.F. 2002. Beta-agonist intrinsic efficacy: measurement and clinical significance. Am. J. Respir. Crit. Care Med. 165:1353-1358.
8. q receptor signaling via phospholipase C underlies the airway β-agonist paradox. J. Clin. Invest. 112:619-626. doi:10.1172/JCI200318193.
9. Tohgo, A., et al. 2003. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J. Biol. Chem. 278:6258-6267.
10. Crespo, P., Cachero, T.G., Xu, N., and Gutkind, J.S. 1995. Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition. J. Biol. Chem. 270:25259-25265.
11. Zhu, W.Z., et al. 2001. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci U. S. A. 98:1607-1612.
12. Zou, Y., et al. 1999. Both Gs and Gi proteins are critically involved in isoprorerenol-induced cardiomyocyte hypertrophy. J. Biol. Chem. 274:9760-9770.
13. Daaka, Y., Luttrell, L.M., and Lefkowitz, R.J. 1997. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390:88-91.
14. Hall, R.A., and Lefkowitz, R.J. 2002. Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ. Res. 91:672-680.
15. Cook, S.J., and McCormick, F. 1993. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 262:1069-1072.
16. Orsini, M.J., et al. 1999. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am. J. Physiol. 277:L479-L488.
17. Hallsworth, M.P., Moir, L.M., Lai, D., and Hirst,S.J. 2001. Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle. Am. J. Respir. Crit. Care Med. 164:688-697.
18. Roth, M., et al. 2002. Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet. 360:1293-1299.
19. Pang, L., and Knox, A.J. 2001. Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosreroids. FASEB J. 15:261-269.
20. Mak, J.C., Hisada, T., Salmon, M., Barnes, P.J., and Chung, K.F. 2002. Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. Br. J. Pharmacol. 135:987-996.