β2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12785-12795

  Xiao, Kunhong ^a   Shenoy, Sudha K ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; G PROTEIN; HEK293 CELLS; INTRACELLULAR DOMAIN; LC-MS/MS; LYSOSOMAL DEGRADATION; PROTEOMIC ANALYSIS; RECEPTOR DOMAINS; RECEPTOR MUTANTS; REGULATORY MECHANISM; SPECIFIC SITES; THIRD INTRACELLULAR LOOPS; TRANSMEMBRANE RECEPTORS; UBIQUITINATION;

AMINO ACIDS; DEGRADATION; ENZYME INHIBITION; HYDROLASES;

ENZYME ACTIVITY;

BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSINE; PROTEASOME; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE;

ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; UBIQUITINATION; CELL STRAIN HEK293; CHEMISTRY; CONFOCAL MICROSCOPY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MASS SPECTROMETRY; METABOLISM; PROTEIN TRANSPORT; PROTEOMICS; TANDEM MASS SPECTROMETRY;

ADRENERGIC BETA-AGONISTS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; ISOPROTERENOL; LYSOSOMES; MASS SPECTROMETRY; MICROSCOPY, CONFOCAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEOMICS; RECEPTORS, ADRENERGIC, BETA-2; TANDEM MASS SPECTROMETRY; UBIQUITINATION;

EID: 79953296222     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.203091     Document Type: Article

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