Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

Preventive Medicine

Volumn 54, Issue SUPPL., 2012, Pages

  Prasad, Sahdeo ^a   Sung, Bokyung ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Aging; Chronic disease; Diet; Inflammation; Lifestyle

Indexed keywords

BETA CATENIN; C REACTIVE PROTEIN; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTATE SPECIFIC ANTIGEN; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR TWIST; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; WNT PROTEIN;

AGE; AGING; ALZHEIMER DISEASE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CEREAL; CEREBROVASCULAR DISEASE; CHRONIC DISEASE; CHRONIC FATIGUE SYNDROME; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CROHN DISEASE; DEMENTIA; DIABETES MELLITUS; DIET; DIETARY INTAKE; DISEASE ASSOCIATION; EPILEPSY; FRUIT; HEART DISEASE; HEART FAILURE; HUMAN; LEGUME; LIFESTYLE MODIFICATION; LUNG DISEASE; METABOLIC SYNDROME X; MUSCLE ATROPHY; MUSCULAR DYSTROPHY; NEOPLASM; NEUROLOGIC DISEASE; NONHUMAN; OSTEOARTHRITIS; PARKINSON DISEASE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROSTATITIS; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SPICE; STROKE; VEGETABLE; WRINKLE;

AGING; CHRONIC DISEASE; DIET; FEMALE; HUMANS; INFLAMMATION; MALE; RISK REDUCTION BEHAVIOR;

EID: 84860880318     PISSN: 00917435     EISSN: 10960260     Source Type: Journal    
DOI: 10.1016/j.ypmed.2011.11.011     Document Type: Review

References (119)

1. Abate C., Curran T. Encounters with Fos and Jun on the road to AP-1. Semin. Cancer Biol. 1990, 1:19-26.
2. Adler A.S., Kawahara T.L., Segal E., Chang H.Y. Reversal of aging by NFkappaB blockade. Cell Cycle 2008, 7:556-559.
3. Adzersen K.H., Jess P., Freivogel K.W., Gerhard I., Bastert G. Raw and cooked vegetables, fruits, selected micronutrients, and breast cancer risk: a case-control study in Germany. Nutr. Cancer 2003, 46:131-137.
4. Aggarwal B.B. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004, 6:203-208.
5. Aggarwal B.B. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 2010, 30:173-199.
6. Aggarwal B.B., Ichikawa H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 2005, 4:1201-1215.
7. Aggarwal B.B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71:1397-1421.
8. Aggarwal B.B., Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol. Sci. 2009, 30:85-94.
9. Akiyama T. Wnt/beta-catenin signaling. Cytokine Growth Factor Rev. 2000, 11:273-282.
10. Ames B.N., Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk?. Nat. Rev. Cancer 2002, 2:694-704.
11. Andersson D., Liu J.J., Nilsson A., Duan R.D. Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Anticancer. Res. 2003, 23:3317-3322.
12. Anthony M.S., Clarkson T.B., Hughes C.L., Morgan T.M., Burke G.L. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J. Nutr. 1996, 126:43-50.
13. Arya M., Ahmed H., Silhi N., Williamson M., Patel H.R. Clinical importance and therapeutic implications of the pivotal CXCL12-CXCR4 (chemokine ligand-receptor) interaction in cancer cell migration. Tumour Biol. 2007, 28:123-131.
14. Belfiore A., Genua M., Malaguarnera R. PPAR-gamma agonists and their effects on IGF-I receptor signaling: implications for cancer. PPAR Res. 2009, 2009:830501.
15. Berg A.H., Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ. Res. 2005, 96:939-949.
16. Block G., Patterson B., Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer 1992, 18:1-29.
17. Bouraoui Y., Ricote M., García-Tuñón I., et al. Pro-inflammatory cytokines and prostate-specific antigen in hyperplasia and human prostate cancer. Cancer Detect. Prev. 2008, 32:23-32.
18. Braunstein J., Brutsaert S., Olson R., Schindler C. STATs dimerize in the absence of phosphorylation. J. Biol. Chem. 2003, 278:34133-34140.
19. Bremmer M.A., Beekman A.T., Deeg D.J., et al. Inflammatory markers in late-life depression: results from a population-based study. J. Affect. Disord. 2008, 106:249-255.
20. Brenner D.A., O'Hara M., Angel P., Chojkier M., Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 1989, 337:661-663.
21. Capristo E., Mingrone G., Addolorato G., Greco A.V., Gasbarrini G. Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohn's disease. Eur. J. Gastroenterol. Hepatol. 2000, 12:5-11.
22. Chadalapaka G., Jutooru I., McAlees A., Stefanac T., Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorg. Med. Chem. Lett. 2008, 18:2633-2639.
23. Chainy G.B., Manna S.K., Chaturvedi M.M., Aggarwal B.B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene 2000, 19:2943-2950.
24. Chatenoud L., Tavani A., La Vecchia C., et al. Whole grain food intake and cancer risk. Int. J. Cancer 1998, 77:24-28.
25. Chen C., Nan B., Lin P., Yao Q. C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells. Thromb. Res. 2008, 122:125-133.
26. Curran T., Franza B.R. Fos and Jun: the AP-1 connection. Cell 1988, 55:395-397.
27. de Gonzalo-Calvo D., Neitzert K., Fernandez M., Vega-Naredo I., Caballero B., Garcia-Macia M., Suarez F.M., Rodriguez-Colunga M.J., Solano J.J., Coto-Montes A. Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers. Free Radic Biol Med 2010, 49:733-737.
28. Deon D., Ahmed S., Tai K., et al. Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts. J. Immunol. 2001, 167:5395-5403.
29. Desreumaux P., Brandt E., Gambiez L., et al. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 1997, 113:118-126.
30. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:11908-11913.
31. Erkkila A.T., Herrington D.M., Mozaffarian D., Lichtenstein A.H. Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease. Am. Heart J. 2005, 150:94-101.
32. Es-saady D., Simon A., Ollier M., Maurizis J.C., Chulia A.J., Delage C. Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. Cancer Lett. 1996, 106:193-197.
33. Esposito K., Kastorini C.M., Panagiotakos D.B., Giugliano D. Prevention of type 2 diabetes by dietary patterns: a systematic review of prospective studies and meta-analysis. Metab. Syndr. Relat. Disord. 2010, 8:471-476.
34. Ferrucci L., Ble A., Bandinelli S., Lauretani F., Suthers K., Guralnik J.M. A flame burning within. Aging Clin. Exp. Res. 2004, 16:240-243.
35. Ford E.S., Bergmann M.M., Kroger J., Schienkiewitz A., Weikert C., Boeing H. Healthy living is the best revenge: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. Arch. Intern. Med. 2009, 169:1355-1362.
36. Franzini, L.,Ardigo, D.,Valtuena, S., et al., in press. Food selection based on high total antioxidant capacity improves endothelial function in a low cardiovascular risk population. Nutr. Metab. Cardiovasc. Dis.
37. Gaziano J.M., Manson J.E., Branch L.G., Colditz G.A., Willett W.C., Buring J.E. A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. Ann. Epidemiol. 1995, 5:255-260.
38. Ghadirian P., Jain M., Ducic S., Shatenstein B., Morisset R. Nutritional factors in the aetiology of multiple sclerosis: a case-control study in Montreal, Canada. Int. J. Epidemiol. 1998, 27:845-852.
39. Giancarlo S., Rosa L.M., Nadjafi F., Francesco M. Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Nat. Prod. Res. 2006, 20:882-886.
40. Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899.
41. Groner B., Lucks P., Borghouts C. The function of Stat3 in tumor cells and their microenvironment. Semin. Cell Dev. Biol. 2008, 19:341-350.
42. Gveric D., Kaltschmidt C., Cuzner M.L., Newcombe J. Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 1998, 57:168-178.
43. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
44. Harikumar K.B., Aggarwal B.B. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 2008, 7:1020-1035.
45. Harmand P.O., Duval R., Delage C., Simon A. Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. Int. J. Cancer 2005, 114:1-11.
46. Hartl M., Vogt P.K. Oncogenic transformation by Jun: role of transactivation and homodimerization. Cell Growth Differ. 1992, 3:899-908.
47. Hermsdorff H.H., Zulet M.A., Puchau B., Martinez J.A. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr. Metab. (Lond.) 2010, 7:42.
48. Horinaga M., Okita H., Nakashima J., Kanao K., Sakamoto M., Murai M. Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer. Urology 2005, 66:671-675.
49. Hou J.K., Abraham B., El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am. J. Gastroenterol. 2011, 106:563-573.
50. Hsu Y.L., Kuo P.L., Lin C.C. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci. 2004, 75:2303-2316.
51. Itoh K., Wakabayashi N., Katoh Y., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999, 13:76-86.
52. Jacobs D.R., Marquart L., Slavin J., Kushi L.H. Whole-grain intake and cancer: an expanded review and meta-analysis. Nutr. Cancer 1998, 30:85-96.
53. Jeffcoate W.J. Abnormalities of vasomotor regulation in the pathogenesis of the acute charcot foot of diabetes mellitus. Int. J. Low. Extrem. Wounds 2005, 4:133-137.
54. Jensen G.L. Inflammation: an expanding universe. Nutr. Clin. Pract. 2008, 23:1-2.
55. Jiang C., Ting A.T., Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998, 391:82-86.
56. Kannappan R., Gupta S.C., Kim J.H., Reuter S., Aggarwal B.B. Neuroprotection by spice-derived nutraceuticals: you are what you eat!. Mol. Neurobiol. 2011, 44:142-159.
57. Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb. Perspect. Biol. 2009, 1:a000141.
58. Kim D.H., Kim C.H., Kim M.S., et al. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 2007, 8:545-554.
59. Kim S.S., Oh O.J., Min H.Y., et al. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci. 2003, 73:337-348.
60. Klein B., Zhang X.G., Jourdan M., Portier M., Bataille R. Interleukin-6 is a major myeloma cell growth factor in vitro and in vivo especially in patients with terminal disease. Curr. Top. Microbiol. Immunol. 1990, 166:23-31.
61. Kochar J., Djousse L., Gaziano J.M. Breakfast cereals and risk of type 2 diabetes in the Physicians' Health Study I. Obesity (Silver Spring) 2007, 15:3039-3044.
62. Kolappaswamy K., Williams K.A., Benazzi C., et al. Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice. Comp. Med. 2009, 59:147-152.
63. Kolonel L.N., Hankin J.H., Whittemore A.S., et al. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol. Biomarkers Prev. 2000, 9:795-804.
64. Kriete A., Mayo K.L. Atypical pathways of NF-kappaB activation and aging. Exp. Gerontol. 2009, 44:250-255.
65. Kuhl M., Sheldahl L.C., Malbon C.C., Moon R.T. Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 2000, 275:12701-12711.
66. Kwak J.H., Lee J.H., Ahn C.W., et al. Black soy peptide supplementation improves glucose control in subjects with prediabetes and newly diagnosed type 2 diabetes mellitus. J. Med. Food 2010, 13:1307-1312.
67. Lavrovsky Y., Chatterjee B., Clark R.A., Roy A.K. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp. Gerontol. 2000, 35:521-532.
68. Lee H., Herrmann A., Deng J.H., et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009, 15:283-293.
69. Liu J. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 1995, 49:57-68.
70. Marx N., Schonbeck U., Lazar M.A., Libby P., Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ. Res. 1998, 83:1097-1103.
71. Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275.
72. McGeer P.L., McGeer E.G. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 2004, 1035:104-116.
73. Mendoza-Nunez V.M., Rosado-Perez J., Santiago-Osorio E., Ortiz R., Sanchez-Rodriguez M.A., Galvan-Duarte R.E. Aging linked to type 2 diabetes increases oxidative stress and chronic inflammation. Rejuvenation Res. 2011, 14:25-31.
74. Michalik L., Auwerx J., Berger J.P., et al. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. 2006, 58:726-741.
75. Mora L.B., Buettner R., Seigne J., et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002, 62:6659-6666.
76. Mueller M., Beck V., Jungbauer A. PPARalpha activation by culinary herbs and spices. Planta Med. 2011, 77:497-504.
77. Nishino H., Murakosh M., Ii T., et al. Carotenoids in cancer chemoprevention. Cancer Metastasis Rev. 2002, 21:257-264.
78. Palumbo, S., Toscano, C.D., Parente, L.,Weigert, R., Bosetti, F., in press. The cyclooxygenase-2 pathway via the PGE(2) EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. J. Neurochem.
79. Pathak A.K., Bhutani M., Nair A.S., et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol. Cancer Res. 2007, 5:943-955.
80. Pattison D.J., Symmons D.P., Young A. Does diet have a role in the aetiology of rheumatoid arthritis?. Proc. Nutr. Soc. 2004, 63:137-143.
81. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001, 286:327-334.
82. Prasad S., Ravindran J., Aggarwal B.B. NF-kappaB and cancer: how intimate is this relationship. Mol. Cell. Biochem. 2010, 336:25-37.
83. Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J. Biochem. Mol. Biol. 2003, 36:95-109.
84. Ramadan G., Al-Kahtani M.A., El-Sayed W.M. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation 2011, 34:291-301.
85. Rao A.R., Hashim S. Chemopreventive action of oriental food-seasoning spices mixture Garam masala on DMBA-induced transplacental and translactational carcinogenesis in mice. Nutr. Cancer 1995, 23:91-101.
86. Rein D., Schijlen E., Kooistra T., et al. Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato. J. Nutr. 2006, 136:2331-2337.
87. Ricote M., Glass C.K. PPARs and molecular mechanisms of transrepression. Biochim. Biophys. Acta 2007, 1771:926-935.
88. Ricote M., Li A.C., Willson T.M., Kelly C.J., Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998, 391:79-82.
89. Ridker P.M., Rifai N., Cook N.R., Bradwin G., Buring J.E. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA 2005, 294:326-333.
90. Roschek B., Fink R.C., Li D., et al. Pro-inflammatory enzymes, cyclooxygenase 1, cyclooxygenase 2, and 5-lipooxygenase, inhibited by stabilized rice bran extracts. J. Med. Food 2009, 12:615-623.
91. Rutgeerts P., Geboes K. Understanding inflammatory bowel disease-the clinician's perspective. Eur. J. Surg. Suppl. 2001, 66-72.
92. Saltzman E., Das S.K., Lichtenstein A.H., et al. An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J. Nutr. 2001, 131:1465-1470.
93. Scartozzi M., Bearzi I., Pierantoni C., et al. Nuclear factor-κB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy. J. Clin. Oncol. 2007, 25:3930-3935.
94. Schmidt A., Bengtsson A., Tylman M., Blomqvist L. Pro-inflammatory cytokines in elective flap surgery. J. Surg. Res. 2007, 137:117-121.
95. Semenza G.L. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 2004, 19:176-182.
96. Sen R., Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986, 46:705-716.
97. Senftleben U., Cao Y., Xiao G., et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001, 293:1495-1499.
98. Shapira E., Brodsky B., Proscura E., Nyska A., Erlanger-Rosengarten A., Wormser U. Amelioration of experimental autoimmune encephalitis by novel peptides: involvement of T regulatory cells. J. Autoimmun. 2010, 35:98-106.
99. Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 2006, 116:3015-3025.
100. Shishodia S., Potdar P., Gairola C.G., Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 2003, 24:1269-1279.
101. Siddique H.R., Saleem M. Beneficial health effects of lupeol triterpene: a review of preclinical studies. Life Sci. 2011, 88:285-293.
102. Spiotto M.T., Chung T.D. STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP. Prostate 2000, 42:88-98.
103. Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int. J. Food Sci. Nutr. 2005, 56:399-414.
104. Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 1999, 428:305-327.
105. Tam L., McGlynn L.M., Traynor P., Mukherjee R., Bartlett J.M., Edwards J. Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer. Br. J. Cancer 2007, 97:378-383.
106. Thomas T.H., Advani A. Inflammation in cardiovascular disease and regulation of the actin cytoskeleton in inflammatory cells: the actin cytoskeleton as a target. Cardiovasc. Hematol. Agents Med. Chem. 2006, 4:165-182.
107. Tomiyama H., Okazaki R., Koji Y., et al. Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population. Atherosclerosis 2005, 178:187-192.
108. Tripathi S., Maier K.G., Bruch D., Kittur D.S. Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages. J. Surg. Res. 2007, 138:209-213.
109. Unnikrishnan M.C., Kuttan R. Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett. 1990, 51:85-89.
110. van't Veer P., Jansen M.C., Klerk M., Kok F.J. Fruits and vegetables in the prevention of cancer and cardiovascular disease. Public Health Nutr. 2000, 3:103-107.
111. Wei H., Saladi R., Lu Y., et al. Isoflavone genistein: photoprotection and clinical implications in dermatology. J. Nutr. 2003, 133:3811S-3819S.
112. Wen Z., Zhong Z., Darnell J.E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250.
113. Westwick J.K., Weitzel C., Minden A., Karin M., Brenner D.A. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J. Biol. Chem. 1994, 269:26396-26401.
114. Woodroofe M.N., Cuzner M.L. Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization. Cytokine 1993, 5:583-588.
115. Yang J., Liao X., Agarwal M.K., Barnes L., Auron P.E., Stark G.R. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 2007, 21:1396-1408.
116. Yim E.K., Lee K.H., Namkoong S.E., Um S.J., Park J.S. Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells. Cancer Lett. 2006, 235:209-220.
117. Yoshimura T., Takeda A., Hamano S., et al. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J. Immunol. 2006, 177:5377-5385.
118. Zhang Y., Turkson J., Carter-Su C., et al. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J. Biol. Chem. 2000, 275:24935-24944.
119. Zhang Y.X., Kong C.Z., Wang L.H., et al. Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. J. Cell. Biochem. 2010, 109:764-773.