Biophysics of mitosis

Quarterly Reviews of Biophysics

Volumn 45, Issue 2, 2012, Pages 147-207

  McIntosh, J Richard ^a   Molodtsov, Maxim I ^b   Ataullakhanov, Fazly I ^b,c,d  

^a UNIVERSITY OF COLORADO   (United States)

^b CENTER FOR THEORETICAL PROBLEMS OF PHYSICOCHEMICAL PHARMACOLOGY   (Russian Federation)

^c NATIONAL RESEARCH CENTER FOR HEMATOLOGY   (Russian Federation)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; BIOPHYSICS; HUMAN; MITOSIS; PHYSIOLOGY; REVIEW;

BIOPHYSICAL PHENOMENA; HUMANS; MITOSIS; MODELS, BIOLOGICAL;

EUKARYOTA;

EID: 84860724358     PISSN: 00335835     EISSN: 14698994     Source Type: Journal    
DOI: 10.1017/S0033583512000017     Document Type: Review

References (311)

1. AIST, J. R., BAYLES, C. J., TAO, W. & BERNS, M. W. (1991). Direct experimental evidence for the existence, structural basis and function of astral forces during anaphase B in vivo. Journal of Cell Science 100, 279-288. (Pubitemid 21925060)
2. AKIYOSHI, B., SARANGAPANI, K. K., POWERS, A. F., NELSON, C. R., REICHOW, S. L., ARELLANO-SANTOYO, H., GONEN, T., RANISH, J. A., ASBURY, C. L. & BIGGINS, S. (2010). Tension directly stabilizes reconstituted kinetochoremicrotubule attachments. Nature 468, 576-579.
3. ALEXANDER, S. P. & RIEDER, C. L. (1991). Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibers. Journal of Cell Biology 113, 805-815. (Pubitemid 21909716)
4. ALTAN-BONNET, N., SOUGRAT, R. & LIPPINCOTT-SCHWARTZ, J. (2004). Molecular basis for Golgi maintenance and biogenesis. Current Opinion in Cell Biology 16, 364-372. (Pubitemid 38903142)
5. ANTONIO, C., FERBY, I., WILHELM, H., JONES, M., KARSENTI, E., NEBREDA, A. R. & VERNOS, I. (2000). Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. Cell 102, 425-435.
6. ASBURY, C. L., GESTAUT, D. R., POWERS, A. F., FRANCK, A. D. & DAVIS, T. N. (2006). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement. Proceedings of the National Academy of Sciences of the United States of America 103, 9873-9878. (Pubitemid 43993590)
7. ATHALE, C. A., DINARINA, A., MORA-CORAL, M., PUGIEUX, C., NEDELEC, F. & KARSENTI, E. (2008). Regulation of microtubule dynamics by reaction cascades around chromosomes. Science 322, 1243-1247.
8. AULT, J. G.,DEMARCO, A. J., SALMON, E. D. &RIEDER, C. L. (1991). Studies on the ejection properties of asters: astral microtubule turnover influences the oscillatory behavior and positioning of mono-oriented chromosomes. Journal of Cell Science 99, 701-710.
9. BAJER, A. S., CYPHER, C., MOLE-BAJER, J. & HOWARD, H. M. (1982). Taxol-induced anaphase reversal: evidence that elongating microtubules can exert a pushing force in living cells. Proceedings of the National Academy of Sciences of the United States of America 79, 6569-6573. (Pubitemid 13207536)
10. BAJER, A. S. & MOLE-BAJER, J. (1986). Reorganization of microtubules in endosperm cells and cell fragments of the higher plant Haemanthus in vivo. Journal of Cell Biology 102, 263-281.
11. BANNIGAN, A., LIZOTTE-WANIEWSKI, M., RILEY, M. & BASKIN, T. I. (2008). Emerging molecular mechanisms that power and regulate the anastral mitotic spindle of flowering plants. Cell Motility and the Cytoskeleton 65, 1-11.
12. BARAK, L. S., NOTHNAGEL, E. A., DEMARCO, E. F. &WEBB, W. W. (1981). Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3- diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? Proceedings of the National Academy of Sciences of the United States of America 78, 3034-3038.
13. BARR, F. A., SILLJE, H.H. & NIGG, E. A. (2004). Polo-like kinases and the orchestration of cell division. Nature Reviews. Molecular Cell Biology 5, 429-440. (Pubitemid 38745493)
14. BASTO, R., LAU, J., VINOGRADOVA, T., GARDIOL, A.,WOODS, C. G., KHODJAKOV, A. & RAFF, J. W. (2006). Flies without centrioles. Cell 125, 1375-1386. (Pubitemid 43929089)
15. BEGG, D.A. & ELLIS, G. W. (1979). Micromanipulation studies of chromosome movement. I. Chromosomespindle attachment and the mechanical properties of chromosomal spindle fibers. Journal of Cell Biology 82, 528-541. (Pubitemid 9241115)
16. BELMONT, A. S. (2006). Mitotic chromosome structure and condensation. Current Opinion in Cell Biology 18, 632-638. (Pubitemid 44711888)
17. BIRD, A.W. & HYMAN, A. A. (2008). Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. Journal of Cell Biology 182, 289-300.
18. BOLLEN, M., GERLICH, D.W. & LESAGE, B. (2009). Mitotic phosphatases: from entry guards to exit guides. Trends in Cell Biology 19, 531-541.
19. BORMUTH, V., VARGA, V., HOWARD, J. & SCHAFFER, E. (2009). Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science 325, 870-873.
20. BROUHARD, G.J. & HUNT, A. J. (2005). Microtubule movements on the arms of mitotic chromosomes: polar ejection forces quantified in vitro. Proceedings of the National Academy of Sciences of the United States of America 102, 13903-13908. (Pubitemid 41377676)
21. BROUHARD, G. J., STEAR, J. H., NOETZEL, T. L., AL-BASSAM, J., KINOSHITA, K., HARRISON, S. C., HOWARD, J. & HYMAN, A. A. (2008). XMAP215 is a processive microtubule polymerase. Cell 132, 79-88.
22. BROWN, K. S., BLOWER, M. D., MARESCA, T. J., GRAMMER, T. C., HARLAND, R.M. & HEALD, R. (2007). Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. The Journal of Cell Biology 176, 765-770. (Pubitemid 46425536)
23. BRUST-MASCHER, I., CIVELEKOGLU-SCHOLEY, G., KWON, M., MOGILNER, A. & SCHOLEY, J. M. (2004). Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongation. Proceedings of the National Academy of Sciences of the United States of America 101, 15938-15943. (Pubitemid 39517024)
24. BRUST-MASCHER, I. & SCHOLEY, J. M. (2007). Mitotic spindle dynamics in Drosophila. International Review of Cytology 259, 139-172. (Pubitemid 46529409)
25. BURBANK, K. S., MITCHISON, T. J. & FISHER, D. S. (2007). Slide-and-cluster models for spindle assembly. Current Biology: CB 17, 1373-1383. (Pubitemid 47259391)
26. CAI, S., O'CONNELL, C. B., KHODJAKOV, A. & WALCZAK, C. E. (2009a). Chromosome congression in the absence of kinetochore fibres. Nature Cell Biology 11, 832-838.
27. CAI, S., WEAVER, L. N., EMS-MCCLUNG, S. C. & WALCZAK, C. E. (2009b). Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Molecular Biology of the Cell 20, 1348-1359.
28. CARAZO-SALAS, R. E., GUARGUAGLINI, G., GRUSS, O. J., SEGREF, A., KARSENTI, E. & MATTAJ, I. W. (1999). Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400, 178-181. (Pubitemid 29327548)
29. CASSIMERIS, L., RIEDER, C.L. & SALMON, E. D. (1994). Microtubule assembly and kinetochore directional instability in vertebrate monopolar spindles: implications for the mechanism of chromosome congression. Journal of Cell Science 107, 285-297. (Pubitemid 24039054)
30. CHAKRAVARTY, A., HOWARD, L. & COMPTON, D. A. (2004). A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract. Molecular Biology of the Cell 15, 2116-2132. (Pubitemid 38580632)
31. CHANG, P., COUGHLIN, M. & MITCHISON, T. J. (2005). Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nature Cell Biology 7, 1133-1139.
32. CHANNELS, W. E., NEDELEC, F. J., ZHENG, Y. & IGLESIAS, P. A. (2008). Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly. Biophysical Journal 94, 2598-2609.
33. CHARLEBOIS, B. D., KOLLU, S., SCHEK, H. T., COMPTON, D. A. & HUNT, A. J. (2011). Spindle pole mechanics studied in mitotic asters: dynamic distribution of spindle forces through compliant linkages. Biophysical Journal 100, 1756-1764.
34. CHEESEMAN, I.M. & DESAI, A. (2008). Molecular architecture of the kinetochore-microtubule interface. Journal of Cell Biology 9, 33-46.
35. CHEESEMAN, I. M., HORI, T., FUKAGAWA, T. & DESAI, A. (2008). KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Molecular Biology of the Cell 19, 587-594. (Pubitemid 351272147)
36. CHENG, L., ZHANG, J., AHMAD, S., ROZIER, L., YU, H., DENG, H. &MAO, Y. (2011). Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment. Developmental Cell 20, 342-352.
37. CILIBERTO, A. & SHAH, J. V. (2009). A quantitative systems view of the spindle assembly checkpoint. EMBO Journal 28, 2162-2173.
38. CIMINI, D., WAN, X., HIREL, C. B. & SALMON, E. D. (2006). Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Current Biology 16, 1711-1718. (Pubitemid 44691779)
39. CIOSK, R., DEPALMA, M. & PRIESS, J. R. (2006). Translational regulators maintain totipotency in the Caenorhabditis elegans germline. Science 311, 851-853. (Pubitemid 43228849)
40. CIVELEKOGLU-SCHOLEY, G. & SCHOLEY, J. M. (2010a). Mitotic force generators and chromosome segregation. Cellular and Molecular Life Sciences: CMLS 67, 2231-2250.
41. CIVELEKOGLU-SCHOLEY, G., SHARP, D. J., MOGILNER, A. & SCHOLEY, J. M. (2006). Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis. Biophysical Journal 90, 3966-3982. (Pubitemid 43846114)
42. CIVELEKOGLU-SCHOLEY, G., TAO, L., BRUST-MASCHER, I., WOLLMAN, R. & SCHOLEY, J. M. (2010b). Prometaphase spindle maintenance by an antagonistic motordependent force balance made robust by a disassembling lamin-B envelope. Journal of Cell Biology 188, 49-68.
43. CLEVELAND, D. W., MAO, Y. & SULLIVAN, K. F. (2003). Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112, 407-421. (Pubitemid 36263076)
44. COMPTON, D.A. & CLEVELAND, D. W. (1994). NuMA, a nuclear protein involved in mitosis and nuclear reformation. Current Opinion in Cell Biology 6, 343-346. (Pubitemid 24170003)
45. COTTINGHAM, F. R., GHEBER, L., MILLER, D. L. & HOYT, M. A. (1999). Novel roles for saccharomyces cerevisiae mitotic spindle motors. Journal of Cell Biology 147, 335-350.
46. COUE, M., LOMBILLO, V.A. & MCINTOSH, J. R. (1991). Microtubule depolymerization promotes particle and chromosome movement in vitro. Journal of Cell Biology 112, 1165-1175. (Pubitemid 21909659)
47. COWLEY, D. O., RIVERA-PEREZ, J. A., SCHLIEKELMAN, M., HE, Y. J., OLIVER, T. G., LU, L., O'QUINN, R., SALMON, E. D., MAGNUSON, T.&VAN DYKE, T. (2009). Aurora-A kinase is essential for bipolar spindle formation and early development. Molecular and Cellular Biology 29, 1059-1071.
48. DE BRABANDER, M., GEUENS, G., NUYDENS, R., WILLEBRORDS, R., AERTS, F., DEMEY, J. & MCINTOSH, J. R. (1986). Microtubule dynamics during the cell cycle: The effects of taxol and nocodazole on the microtubule separation of PtK2 cells at different stages of the mitotic cycle. International Review of Cytology 101, 215-274. (Pubitemid 16118443)
49. DE MEY, J., LAMBERT, A. M., BAJER, A. S., MOEREMANS, M. & DE BRABANDER, M. (1982). Visualization of microtubules in interphase and mitotic plant cells of Haemanthus endosperm with the immuno-gold staining method. Proceedings of the National Academy of Sciences of the United States of America 79, 1898-1902. (Pubitemid 12088535)
50. DELUCA, J. G., GALL, W. E., CIFERRI, C., CIMINI, D., MUSACCHIO, A. & SALMON, E. D. (2006). Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127, 969-982. (Pubitemid 44792254)
51. DESAI, A., VERMA, S., MITCHISON, T. J. & WALCZAK, C. E. (1999). Kin I kinesins are microtubule-destabilizing enzymes. Cell 96(1), 69-78. (Pubitemid 29044154)
52. DESAI, A., MADDOX, P. S., MITCHISON, T. J. & SALMON, E. D. (1998). Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles. The Journal of Cell Biology 141, 703-713. (Pubitemid 28217915)
53. DESAI, A. & MITCHISON, T. J. (1997). Microtubule polymerization dynamics. Annual Review of Cell and Developmental Biology 13, 83-117. (Pubitemid 28034521)
54. DICTENBERG, J. B., ZIMMERMAN, W., SPARKS, C. A., YOUNG, A., VIDAIR, C., ZHENG, Y., CARRINGTON, W., FAY, F. S. & DOXSEY, S. J. (1998). Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. Journal of Cell Biology 141, 163-174. (Pubitemid 28182649)
55. DINARINA, A., PUGIEUX, C., CORRAL, M. M., LOOSE, M., SPATZ, J., KARSENTI, E. & NEDELEC, F. (2009). Chromatin shapes the mitotic spindle. Cell 138, 502-513.
56. DUJARDIN, D. L. & VALLEE, R. B. (2002). Dynein at the cortex. Current Opinion in Cell Biology 14, 44-49. (Pubitemid 34131655)
57. DUMONT, S. &MITCHISON, T. (2012). Mechanical forces in mitosis. In Comprehensive Biophysics, vol. 4, Chapter 4.16. (Ed. E. Egelman). Amsterdam: Elsevier. doi:10.1016/B978-0-12-374920-8.00419-7.
58. DUMONT, S. &MITCHISON, T. (2011). Mechanical forces in mitosis. In Comprehensive Biophysics, vol. 7 (Eds. Y. E. Goldman and M. E. Ostap). Elsevier (online, in press).
59. DUMONT, S. & MITCHISON, T. J. (2009a). Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Current Biology 19, 1086-1095.
60. DUMONT, S. & MITCHISON, T. J. (2009b). Force and length in the mitotic spindle. Current Biology 19, R749-R761.
61. DUNCAN, T. &WAKEFIELD, J. G. (2011). 50 ways to build a spindle: the complexity of microtubule generation during mitosis. Chromosome Research: An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology 19, 321-333.
62. EFREMOV, A., GRISHCHUK, E. L., MCINTOSH, J.R. & ATAULLAKHANOV, F. I. (2007). In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proceedings of the National Academy of Sciences of the United States of America 104, 19017-19022.
63. EUTENEUER, U. & MCINTOSH, J. R. (1981). Structural polarity of kinetochore microtubules in PtK1 cells. Journal of Cell Biology 89, 338-345. (Pubitemid 11081457)
64. FABIAN, L., XIA, X., VENKITARAMANI, D. V., JOHANSEN, K. M., JOHANSEN, J., ANDREW, D. J. & FORER, A. (2007). Titin in insect spermatocyte spindle fibers associates with microtubules, actin, myosin and the matrix proteins skeletor, megator and chromator. Journal of Cell Science 120, 2190-2204. (Pubitemid 47074124)
65. FENG, J., HUANG, H. & YEN, T. J. (2006). CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay. Chromosoma 115, 320-329. (Pubitemid 43923358)
66. FINK, G., SCHUCHARDT, I., COLOMBELLI, J., STELZER, E. & STEINBERG, G. (2006). Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis. The EMBO Journal 25, 4897-4908. (Pubitemid 44607034)
67. FORER, A. (1965). Local reduction of spindle fiber birefringence in living Nephrotoma suturalis (Loew) spermatocytes induced by ultraviolet microbeam irradiation. Journal of Cell Biology 25 (Suppl.), 95-117.
68. FRANCISCO, L., WANG, W. & CHAN, C. S. (1994). Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Molecular and Cellular Biology 14, 4731-4740. (Pubitemid 24196823)
69. FULLER, B. G., LAMPSON, M. A., FOLEY, E. A., ROSASCONITCHER, S., LE, K. V., TOBELMANN, P., BRAUTIGAN, D. L., STUKENBERG, P.T. & KAPOOR, T. M. (2008). Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature 453, 1132-1136. (Pubitemid 351871729)
70. FUNABIKI, H. & MURRAY, A. W. (2000). The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102, 411-424.
71. GAGLIO, T., DIONNE, M.A. & COMPTON, D. A. (1997). Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. Journal of Cell Biology 138, 1055-1066. (Pubitemid 27386455)
72. GAGLIO, T., SAREDI, A., BINGHAM, J. B., HASBANI, M. J., GILL, S. R., SCHROER, T.A. & COMPTON, D. A. (1996). Opposing motor activities are required for the organization of the mammalian mitotic spindle pole. Journal of Cell Biology 135, 399-414. (Pubitemid 26359334)
73. GARDNER, M. K., BOUCK, D. C., PALIULIS, L. V., MEEHL, J. B., O'TOOLE, E. T., HAASE, J., SOUBRY, A., JOGLEKAR, A. P., WINEY, M., SALMON, E. D., BLOOM, K. & ODDE, D. J. (2008). Chromosome congression by kinesin-5 motor-mediated disassembly of longer kinetochore microtubules. Cell 135, 894-906.
74. GARDNER, M. K., PEARSON, C. G., SPRAGUE, B. L., ZARZAR, T. R., BLOOM, K., SALMON, E.D. & ODDE, D. J. (2005). Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast. Molecular Biology of the Cell 16, 3764-3775. (Pubitemid 41077085)
75. GARRETT, S., AUER, K., COMPTON, D. A. & KAPOOR, T.M. (2002). hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Current Biology 12, 2055-2059. (Pubitemid 35450930)
76. GATLIN, J. C. & BLOOM, K. (2010). Microtubule motors in eukaryotic spindle assembly and maintenance. Seminars in Cell and Developmental Biology 21, 248-254.
77. GEUENS, G., HILL, A. M., LEVILLIERS, N., ADOUTTE, A. & DEBRABANDER, M. (1989). Microtubule dynamics investigated by microinjection of Paramecium axonemal tubulin: lack of nucleation but proximal assembly of microtubules at the kinetochore during prometaphase. Journal of Cell Biology 108, 939-953.
78. GLOVER, D. M., LEIBOWITZ, M. H., MCLEAN, D.A. & PARRY, H. (1995). Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81, 95-105.
79. GOODWIN, S. S. & VALE, R. D. (2010). Patronin regulates the microtubule network by protecting microtubule minus ends. Cell 143, 263-274.
80. GORBSKY, G. J. & BORISY, G. G. (1989). Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase. Journal of Cell Biology 109, 653-662. (Pubitemid 19197027)
81. GORBSKY, G. J., SAMMAK, P. J. & BORISY, G. G. (1987). Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. Journal of Cell Biology 104, 9-18. (Pubitemid 17018652)
82. GORBSKY, G. J., SAMMAK, P. J. & BORISY, G. G. (1988). Microtubule dynamics and chromosome motion visualized in living anaphase cells. Journal of Cell Biology 106, 1185-1192.
83. GOSHIMA, G., MAYER, M., ZHANG, N., STUURMAN, N. & VALE, R. D. (2008). Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle. Journal of Cell Biology 181, 421-429. (Pubitemid 351645032)
84. GOSHIMA, G. & SCHOLEY, J. M. (2010). Control of mitotic spindle length. Annual Review of Cell and Developmental Biology 26, 21-57.
85. GOSHIMA, G. & VALE, R. D. (2003). The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. Journal of Cell Biology 162, 1003-1016. (Pubitemid 37174184)
86. GOSHIMA, G. &YANAGIDA, M. (2001). Time course analysis of precocious separation of sister centromeres in budding yeast: continuously separated or frequently reassociated? Genes to Cells 6, 765-773. (Pubitemid 32894070)
87. GREENAN, G., BRANGWYNNE, C. P., JAENSCH, S., GHARAKHANI, J., JULICHER, F. & HYMAN, A. A. (2010). Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos. Current Biology 20, 353-358.
88. GREGAN, J., POLAKOVA, S., ZHANG, L., TOLIC-NORRELYKKE, I. M. & CIMINI, D. (2011). Merotelic kinetochore attachment: causes and effects. Trends in Cell Biology 21, 374-381.
89. GRISHCHUK, E. L., MCINTOSH, J. R., MOLODTSOV, M. I. & ATAULLAKHANOV, F. I. (2012). Force generation by dynamic microtubule polymers. In Comprehensive Biophysics, vol. 4, Chapter 4.7. (Ed. E. Egelman). Amsterdam: Elsevier. doi:10.1016/B978-0-12-374920-8.00409-4.
90. GRISHCHUK, E. L. (2009). Toward a comprehensive and quantitative understanding of intracellular microtubule organization. Molecular Systems Biology 5, 251.
91. GRISHCHUK, E. L., EFREMOV, A. K., VOLKOV, V. A., SPIRIDONOV, I. S., GUDIMCHUK, N., WESTERMANN, S., DRUBIN, D., BARNES, G., MCINTOSH, J.R. & ATAULLAKHANOV, F. I. (2008a). The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proceedings of the National Academy of Sciences of the United States of America 105, 15423-15428.
92. GRISHCHUK, E. L. & MCINTOSH, J. R. (2006). Microtubule depolymerization can drive poleward chromosome motion in fission yeast. EMBO Journal 25, 4888-4896. (Pubitemid 44607033)
93. GRISHCHUK, E. L., MOLODTSOV, M. I., ATAULLAKHANOV, F. I. & MCINTOSH, J. R. (2005). Force production by disassembling microtubules. Nature 438(7066), 384-388. (Pubitemid 41643957)
94. GRISHCHUK, E. L., SPIRIDONOV, I. S., VOLKOV, V. A., EFREMOV, A., WESTERMANN, S., DRUBIN, D., BARNES, G., ATAULLAKHANOV, F.I. & MCINTOSH, J. R. (2008b). Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America 105(19), 6918-6923. (Pubitemid 351754505)
95. GRISSOM, P. M., FIEDLER, T., GRISHCHUK, E. L., NICASTRO, D., WEST, R.R. & MCINTOSH, J. R. (2009). Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement. Molecular Biology of the Cell 20, 963-972.
96. GRUSS, O. J. & VERNOS, I. (2004). The mechanism of spindle assembly: functions of Ran and its target TPX2. Journal of Cell Biology 166, 949-955. (Pubitemid 39304757)
97. GUPTA, JR., M. L., CARVALHO, P., ROOF, D.M. & PELLMAN, D. (2006). Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nature Cell Biology 8, 913-923. (Pubitemid 44314722)
98. HARA, Y. & KIMURA, A. (2009). Cell-size-dependent spindle elongation in the Caenorhabditis elegans early embryo. Current Biology 19, 1549-1554.
99. HARTWELL, L.H. & SMITH, D. (1985). Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110, 381-395. (Pubitemid 15065175)
100. HAYS, T. (1985). The Force-Balance Mechanism of Chromosome Congression, Ph.D. thesis, University of North Carolina.
101. HAYS, T. S. & SALMON, E. D. (1990). Poleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules. Journal of Cell Biology 110, 391-404.
102. HAYS, T. S., WISE, D. & SALMON, E. D. (1982). Traction force on a kinetochore at metaphase acts as a linear function of kinetochore fiber length. Journal of Cell Biology 93, 374-389.
103. HEALD, R., TOURNEBIZE, R., BLANK, T., SANDALTZOPOULOS, R., BECKER, P., HYMAN, A. & KARSENTI, E. (1996). Selforganization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382, 420-425. (Pubitemid 26264851)
104. HEPLER, P. K., MCINTOSH, J.R. & CLELAND, S. (1970). Intermicrotubule bridges in mitotic spindle apparatus. Journal of Cell Biology 45, 438-444.
105. HILL, T. L. (1985). Theoretical problems related to the attachment of microtubules to kinetochores. Proceedings of the National Academy of Sciences of the United States of America 82, 4404-4408.
106. HOGAN, C. J., WEIN, H., WORDEMAN, L., SCHOLEY, J. M., SAWIN, K.E. & CANDE, W. Z. (1993). Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain. Proceedings of the National Academy of Sciences of the United States of America 90, 6611-6615. (Pubitemid 23207263)
107. HOLY, T.E. & LEIBLER, S. (1994). Dynamic instability of microtubules as an efficient way to search in space. Proceedings of the National Academy of Sciences of the United States of America 91, 5682-5685. (Pubitemid 24174392)
108. HOWELL, B. J., HOFFMAN, D. B., FANG, G., MURRAY, A.W. & SALMON, E. D. (2000). Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. Journal of Cell Biology 150, 1233-1250.
109. HOYT, M. A., HE, L., TOTIS, L. & SAUNDERS, W.S. (1993). Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations. Genetics 135, 35-44. (Pubitemid 23254055)
110. HOYT, M. A., TOTIS, L. & ROBERTS, B. T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517. (Pubitemid 121001387)
111. HUITOREL, P. & KIRSCHNER, M. W. (1988). The polarity and stability of microtubule capture by the kinetochore. Journal of Cell Biology 106, 151-159. (Pubitemid 18051402)
112. HYMAN, A.A. & KARSENTI, E. (1996). Morphogenetic properties of microtubules and mitotic spindle assembly. Cell 84, 401-410. (Pubitemid 26058565)
113. INOUE, S. & BAJER, A. (1961). Birefringence in endosperm mitosis. Chromosoma 12, 48-63.
114. INOUE, S., FUSELER, J., SALMON, E.D. & ELLIS, G.W. (1975). Functional organization of mitotic microtubules. Physical chemistry of the in vivo equilibrium system. Biophysical Journal 15, 725-744.
115. INOUE, S. & SALMON, E. D. (1995). Force generation by microtubule assembly/disassembly in mitosis and related movements. Molecular Biology of the Cell 6, 1619-1640.
116. ITABASHI, T., TAKAGI, J., SHIMAMOTO, Y., INOE, H., KUWANA, K., SHIMOYAMA, I., GAETZ, J., KAPOOR, T. M., and ISHIWATA, S. (2009). Probing the mechanical architecture of the vertebrate meiotic spindle. Nature Methods 6, 167-72.
117. JANSON, M. E., LOUGHLIN, R., LOIODICE, I., FU, C., BRUNNER, D., NEDELEC, F. J. & TRAN, P. T. (2007). Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Cell 128, 357-368. (Pubitemid 46123515)
118. JAQAMAN, K., KING, E. M., AMARO, A. C., WINTER, J. R., DORN, J. F., ELLIOTT, H. L., MCHEDLISHVILI, N., MCCLELLAND, S. E., PORTER, I. M., POSCH, M., TOSO, A., DANUSER, G., MCAINSH, A. D., MERALDI, P. & SWEDLOW, J. R. (2010). Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. Journal of Cell Biology 188, 665-679.
119. JENSEN, C. & BAJER, A. (1973). Spindle dynamics and arrangement of microtubules. Chromosoma 44, 73-89.
120. JOGLEKAR, A. P. & HUNT, A. J. (2002). A simple, mechanistic model for directional instability during mitotic chromosome movements. Biophysical Journal 83, 42-58. (Pubitemid 34694719)
121. KALAB, P. & HEALD, R. (2008). The RanGTP gradient-a GPS for the mitotic spindle. Journal of Cell Science 121, 1577-1586. (Pubitemid 351911814)
122. KAPOOR, T. M., LAMPSON, M. A., HERGERT, P., CAMERON, L., CIMINI, D., SALMON, E. D., MCEWEN, B.F. & KHODJAKOV, A. (2006). Chromosomes can congress to the metaphase plate before biorientation. Science 311, 388-391. (Pubitemid 43132665)
123. KAPOOR, T.M. & MITCHISON, T. J. (2001). Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix. Journal of Cell Biology 154, 1125-1133. (Pubitemid 34286191)
124. KE, K., CHENG, J. & HUNT, A. J. (2009). The distribution of polar ejection forces determines the amplitude of chromosome directional instability. Current Biology 19, 807-815.
125. KEMPHUES, K. J., PRIESS, J. R., MORTON, D.G. & CHENG, N. S. (1988). Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311-320.
126. KHODJAKOV, A., COLE, R. W., OAKLEY, B.R. & RIEDER, C. L. (2000). Centrosome-independent mitotic spindle formation in vertebrates. Current Biology 10, 59-67. (Pubitemid 30079190)
127. KHODJAKOV, A. & PINES, J. (2010). Centromere tension: a divisive issue. Nature Cell Biology 12, 919-923.
128. KHODJAKOV, A. & RIEDER, C. L. (1996). Kinetochores moving away from their associated pole do not exert a significant pushing force on the chromosome. The Journal of Cell Biology 135, 315-327. (Pubitemid 26359328)
129. KHODJAKOV, A. & RIEDER, C. L. (1999). The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. Journal of Cell Biology 146, 585-596. (Pubitemid 29388133)
130. KILMARTIN, J. V. & GOH, P. Y. (1996). Spc110p: assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body. EMBO Journal 15, 4592-4602. (Pubitemid 26294578)
131. KING, J. M., HAYS, T. S. & NICKLAS, R. B. (2000). Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension. Journal of Cell Biology 151, 739-748.
132. KIRSCHNER, M. & MITCHISON, T. (1986). Beyond selfassembly: from microtubules to morphogenesis. Cell 45, 329-342.
133. KITAMURA, E., TANAKA, K., KITAMURA, Y.&TANAKA, T. U. (2007). Kinetochore microtubule interaction during S phase in Saccharomyces cerevisiae. Genes and Development 21, 3319-3330. (Pubitemid 350277758)
134. KITAMURA, E., TANAKA, K., KOMOTO, S., KITAMURA, Y., ANTONY, C. & TANAKA, T. U. (2010). Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Developmental Cell 18, 248-259.
135. KOPS, G. J., SAURIN, A. T. & MERALDI, P. (2010). Finding the middle ground: how kinetochores power chromosome congression. Cellular and Molecular Life Sciences 67, 2145-2161.
136. KURIYAMA, R. (1986). Isolation of sea urchin spindles and cytasters. Methods in Enzymology 134, 190-199.
137. LAAN, L. & DOGTEROM, M. (2010). In vitro assays to study force generation at dynamic microtubule ends. Methods in Cell Biology 95, 617-639.
138. LABBE, J. C., MCCARTHY, E.K. & GOLDSTEIN, B. (2004). The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. Journal of Cell Biology 167, 245-256. (Pubitemid 39435068)
139. LAFOUNTAIN, JR., J. R., COHAN, C. S., SIEGEL, A. J. & LAFOUNTAIN, D. J. (2004). Direct visualization of microtubule flux during metaphase and anaphase in crane-fly spermatocytes. Molecular Biology of the Cell 15, 5724-5732. (Pubitemid 39564762)
140. LAMPSON, M.A. & CHEESEMAN, I. M. (2011). Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends in Cell Biology 21, 133-140.
141. LESLIE, R. J. & PICKETT-HEAPS, J. D. (1983). Ultraviolet microbeam irradiations of mitotic diatoms: investigation of spindle elongation. Journal of Cell Biology 96, 548-561. (Pubitemid 13115861)
142. LEVESQUE, A. A. & COMPTON, D. A. (2001). The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. Journal of Cell Biology 154, 1135-1146. (Pubitemid 34286192)
143. LI, R. & MURRAY, A. W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531. (Pubitemid 121001388)
144. LI, X. & NICKLAS, R. B. (1995). Mitotic forces control a cell-cycle checkpoint. Nature 373, 630-632.
145. LIU, B., MARC, J., JOSHI, H.C. & PALEVITZ, B. A. (1993). A gamma-tubulin-related protein associated with the microtubule arrays of higher plants in a cell cycledependent manner. Journal of Cell Science 104, 1217-1228. (Pubitemid 23154329)
146. LOMBILLO, V. A., NISLOW, C., YEN, T. J., GELFAND, V. I. & MCINTOSH, J. R. (1995a). Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. Journal of Cell Biology 128, 107-115.
147. LOMBILLO, V. A., STEWART, R.J. & MCINTOSH, J.R. (1995b). Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Nature 373, 161-164.
148. LOUGHLIN, R., HEALD, R. & NEDELEC, F. (2010). A computational model predicts Xenopus meiotic spindle organization. Journal of Cell Biology 191, 1239-1249.
149. MAGIDSON, V., O'CONNELL, C. B., LONČAREK, J., PAUL, R., MOGILNER, A. & KHODJAKOV, A. (2011). The spatial arrangement of chromosomes during prometaphase facilitates spindle formation. Cell 146, 555-567.
150. MAHONEY, N. M., GOSHIMA, G., DOUGLASS, A.D. & VALE, R. D. (2006). Making microtubules and mitotic spindles in cells without functional centrosomes. Current Biology 16, 564-569.
151. MAIATO, H., RIEDER, C.L. & KHODJAKOV, A. (2004). Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. Journal of Cell Biology 167, 831-840. (Pubitemid 39628106)
152. MANDELKOW, E. M., MANDELKOW, E. & MILLIGAN, R.A. (1991). Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study. Journal of Cell Biology 114, 977-991. (Pubitemid 21909861)
153. MANDELKOW, E. M., SCHULTHEISS, R., RAPP, R., MULLER, M. & MANDELKOW, E. (1986). On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness. Journal of Cell Biology 102, 1067-1073. (Pubitemid 16013163)
154. MANEY, T., HUNTER, A. W., WAGENBACH, M. & WORDEMAN, L. (1998). Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. Journal of Cell Biology 142, 787-801. (Pubitemid 28381495)
155. MARESCA, T. J. & SALMON, E. D. (2010). Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal. Journal of Cell Science 123, 825-835.
156. MARGOLIS, R. L. & WILSON, L. (1981). Microtubule treadmills-possible molecular machinery. Nature 293, 705-711.
157. MASTRONARDE, D. N., MCDONALD, K. L., DING, R. & MCINTOSH, J. R. (1993). Interpolar spindle microtubules in PTK cells. Journal of Cell Biology 123, 1475-1489. (Pubitemid 24012026)
158. MASUDA, H., HIRANO, T., YANAGIDA, M. & CANDE, W. Z. (1990). In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. Journal of Cell Biology 110, 417-425.
159. MATOS, I.&MAIATO, H. (2011). Prevention and correction mechanisms behind anaphase synchrony: implications for the genesis of aneuploidy. Cytogenetic and Genome Research 133, 243-253.
160. MAYR, M. I., HUMMER, S., BORMANN, J., GRUNER, T., ADIO, S., WOEHLKE, G. & MAYER, T. U. (2007). The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Current Biology 17, 488-498. (Pubitemid 46401386)
161. MCAINSH, A. D., TYTELL, J.D. & SORGER, P. K. (2003). Structure, function, and regulation of budding yeast kinetochores. Annual Review of Cell and Developmental Biology 19, 519-539. (Pubitemid 37487359)
162. MCDONALD, K., PICKETT-HEAPS, J. D., MCINTOSH, J. R. & TIPPIT, D. H. (1977). On the mechanism of anaphase spindle elongation in Diatoma vulgare. Journal of Cell Biology 74, 377-388. (Pubitemid 8153976)
163. MCDONALD, K. L., PFISTER, K., MASUDA, H., WORDEMAN, L., STAIGER, C. & CANDE, W. Z. (1986). Comparison of spindle elongation in vivo and in vitro in Stephanopyxis turris. Journal of Cell Science Supplement 5, 205-227.
164. MCEWEN, B. F., HSIEH, C. E., MATTHEYSES, A.L. & RIEDER, C. L. (1998). A new look at kinetochore structure in vertebrate somatic cells using high-pressure freezing and freeze substitution. Chromosoma 107, 366-375. (Pubitemid 29057529)
165. MCINTOSH, J. R., VOLKOV, V., ATAULLAKHANOV, F. I. & GRISHCHUK, E. L. (2010). Tubulin depolymerization may be an ancient biological motor. Journal of Cell Science 123(Pt 20), 3425-3434.
166. MCINTOSH, J. R. (1991). Structural and mechanical control of mitotic progression. Cold Spring Harbour Symposis on Quantitative Biology 56, 613-619.
167. MCINTOSH, J. R., GRISHCHUK, E. L., MORPHEW, M. K., EFREMOV, A. K., ZHUDENKOV, K., VOLKOV, V. A., CHEESEMAN, I. M., DESAI, A., MASTRONARDE, D.N. & ATAULLAKHANOV, F. I. (2008). Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell 135, 322-333.
168. MCINTOSH, J. R., GRISHCHUK, E. L. & WEST, R. R. (2002). Chromosome-microtubule interactions during mitosis. Annual Review of Cell and Developmental Biology 18, 193-219. (Pubitemid 35387350)
169. MCINTOSH, J. R., HEPLER, P.K. & VAN WIE, D. G. (1969). Model for Mitosis. Nature 224, 659-663.
170. MCINTOSH, J.R. & HERING, G. E. (1991). Spindle fiber action and chromosome movement. Annual Review of Cell Biology 7, 403-426.
171. MCINTOSH, J.R. & LANDIS, S. C. (1971). The distribution of spindle microtubules during mitosis in cultured human cells. Journal of Cell Biology 49, 468-497.
172. MCINTOSH, J. R., MORPHEW, M. K., GRISSOM, P. M., GILBERT, S. P. & HOENGER, A. (2009). Lattice structure of cytoplasmic microtubules in a cultured mammalian cell. Journal of Molecular Biology 394, 177-182.
173. MCNEILL, P.A. & BERNS, M. W. (1981). Chromosome behavior after laser microirradiation of a single kinetochore in mitotic PtK2 cells. Journal of Cell Biology 88, 543-553. (Pubitemid 11097946)
174. MERDES, A., HEALD, R., SAMEJIMA, K., EARNSHAW, W. C. & CLEVELAND, D. W. (2000). Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. Journal of Cell Biology 149, 851-862.
175. MIRANDA, J. J., DE WULF, P., SORGER, P.K. & HARRISON, S. C. (2005). The yeast DASH complex forms closed rings on microtubules. Nature Structural and Molecular Biology 12, 138-143.
176. MITCHISON, T., EVANS, L., SCHULZE, E. & KIRSCHNER, M. (1986). Sites of microtubule assembly and disassembly in the mitotic spindle. Cell 45, 515-527. (Pubitemid 16014974)
177. MITCHISON, T. & KIRSCHNER, M. (1984). Dynamic instability of microtubule growth. Nature 312, 237-242. (Pubitemid 15201998)
178. MITCHISON, T. J. (1989a). Mitosis: basic concepts. Current Opinion in Cell Biology 1, 67-74. (Pubitemid 19174518)
179. MITCHISON, T. J. (1989b). Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. Journal of Cell Biology 109, 637-652. (Pubitemid 19197026)
180. MITCHISON, T. J. & KIRSCHNER, M. W. (1985). Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. Journal of Cell Biology 101, 755-765. (Pubitemid 16256829)
181. MITCHISON, T.J. & SALMON, E. D. (1992). Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. Journal of Cell Biology 119, 569-582.
182. MOGILNER, A. & CRAIG, E. (2010). Towards a quantitative understanding of mitotic spindle assembly and mechanics. Journal of Cell Science 123, 3435-3445.
183. MOLODTSOV, M. I., GRISHCHUK, E. L., EFREMOV, A. K., MCINTOSH, J. R. & ATAULLAKHANOV, F. I. (2005). Force production by depolymerizing microtubules: a theoretical study. Proceedings of the National Academy of Sciences of the United States of America 102, 4353-4358. (Pubitemid 40397115)
184. MUNRO, E., NANCE, J. & PRIESS, J. R. (2004). Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. Developmental Cell 7, 413-424. (Pubitemid 39232976)
185. MURATA, T., SONOBE, S., BASKIN, T. I., HYODO, S., HASEZAWA, S., NAGATA, T., HORIO, T. & HASEBE, M. (2005). Microtubule-dependent microtubule nucleation based on recruitment of gamma-tubulin in higher plants. Nature Cell Biology 7, 961-968. (Pubitemid 41486269)
186. MURPHY, D. B. (1980). Identification of microtubuleassociated proteins in the meiotic spindle of surf clam oocytes. The Journal of Cell Biology 84, 235-245. (Pubitemid 10147862)
187. MURRAY, A. W., DESAI, A. B. & SALMON, E. D. (1996). Real time observation of anaphase in vitro. Proceedings of the National Academy of Sciences of the United States of America 93, 12327-12332. (Pubitemid 26367142)
188. NEDELEC, F. (2002). Computer simulations reveal motor properties generating stable antiparallel microtubule interactions. Journal of Cell Biology 158, 1005-1015.
189. NEDELEC, F. J., SURREY, T., MAGGS, A.C. & LEIBLER, S. (1997). Self-organization of microtubules and motors. Nature 389, 305-308. (Pubitemid 27406647)
190. NEZI, L.&MUSACCHIO, A. (2009). Sister chromatid tension and the spindle assembly checkpoint. Current Opinion in Cell Biology 21, 785-795.
191. NICKLAS, R. B. (1965). Chromosome velocity during mitosis as a function of chromosome size and position. Journal of Cell Biology 25 (Suppl.), 119-135.
192. NICKLAS, R. B. (1979). Chromosome movement and spindle birefringence in locally heated cells: interaction versus local control. Chromosoma 74, 1-37. (Pubitemid 9249552)
193. NICKLAS, R. B. (1983). Measurements of the force produced by the mitotic spindle in anaphase. Journal of Cell Biology 97, 542-548. (Pubitemid 13041017)
194. NICKLAS, R. B. (1988). The forces that move chromosomes in mitosis. Annual Review of Biophysics and Biophysical Chemistry 17, 431-449.
195. NICKLAS, R. B. (1989). The motor for poleward chromosome movement in anaphase is in or near the kinetochore. Journal of Cell Biology 109, 2245-2255. (Pubitemid 19282613)
196. NICKLAS, R. B. (1997). How cells get the right chromosomes. Science 275, 632-637.
197. NICKLAS, R.B. & ARANA, P. (1992). Evolution and the meaning of metaphase. Journal of Cell Science 102, 681-690.
198. NICKLAS, R. B. & GORDON, G. W. (1985). The total length of spindle microtubules depends on the number of chromosomes present. Journal of Cell Biology 100, 1-7. (Pubitemid 15151875)
199. NICKLAS, R. B., KUBAI, D. F. & HAYS, T. S. (1982). Spindle microtubules and their mechanical associations after micromanipulation in anaphase. Journal of Cell Biology 95, 91-104. (Pubitemid 13197079)
200. NICKLAS, R. B. & WARD, S. C. (1994). Elements of error correction in mitosis: microtubule capture, release, and tension. Journal of Cell Biology 126, 1241-1253. (Pubitemid 24266556)
201. NURSE, P. M. (2002). Nobel Lecture. Cyclin dependent kinases and cell cycle control. Bioscience Reports 22, 487-499. (Pubitemid 36250188)
202. O'CONNELL, C.B. & KHODJAKOV, A. L. (2007). Cooperative mechanisms of mitotic spindle formation. Journal of Cell Science 120, 1717-1722. (Pubitemid 46930409)
203. O'TOOLE, E. T., MCDONALD, K. L., MANTLER, J., MCINTOSH, J. R., HYMAN, A. A. &MULLER-REICHERT, T. (2003). Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans. Journal of Cell Biology 163, 451-456. (Pubitemid 37429858)
204. O'TOOLE, E. T., WINEY, M. & MCINTOSH, J. R. (1999). High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae. Molecular Biology of the Cell 10, 2017-2031. (Pubitemid 29272647)
205. OSTERGREN, G. (1945). Equilibrium of trivalents and the mechanism of chromosome movement. Hereditas 31, 498-511.
206. OSTERGREN, G. (1951). The mechanism of co-ordination of bivalents and multivalents. Hereditas 37, 85-156.
207. OSTERGREN, G. (1961). Mitosis with undivided chromosomes. II. Some theoretical aspects of the problem. Chromosoma 12, 80-96.
208. OSTERGREN, G.&BAJER, A. (1961). Mitosis with undivided chromosomes. I. A study of living material. Chromosoma 12, 72-79.
209. PAUL, R., WOLLMAN, R., SILKWORTH, W. T., NARDI, I. K., CIMINI, D. & MOGILNER, A. (2009). Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy. Proceedings of the National Academy of Sciences of the United States of America 106, 15708-15713.
210. PEASE, D. C. (1946). Hydrostatic pressure effects upon the spindle figure and chromosome movement. II. Experiments on the meiotic divisions of tradescantia pollen mother cells. Biological Bulletin 91, 146-169.
211. PELLMAN, D., BAGGET, M., TU, Y. H., FINK, G. R.&TU, H. (1995). Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae. Journal of Cell Biology 130, 1373-1385.
212. PETERMAN, E. J. & SCHOLEY, J. M. (2009). Mitotic microtubule crosslinkers: insights from mechanistic studies. Current Biology 19, R1089-R1094.
213. PICKETT-HEAPS, J. D. (1969). Preprophase microtubules and stomatal differentiation; some effects of centrifugation on symmetrical and asymmetrical cell division. Journal of Ultrastructure Research 27, 24-44.
214. PICKETT-HEAPS, J. D., TIPPIT, D.H. & LESLIE, R. (1980). Light and electron microscopic observations on cell division in two large pennate diatoms, Hantzschia and Nitzschia. I. Mitosis in vivo. European Journal of Cell Biology 21, 1-11.
215. POIRIER, M., EROGLU, S., CHATENAY, D. & MARKO, J. F. (2000). Reversible and irreversible unfolding of mitotic newt chromosomes by applied force. Molecular Biology of the Cell 11, 269-276. (Pubitemid 30075522)
216. POLLARD, T. D. (2010). Mechanics of cytokinesis in eukaryotes. Current Opinion in Cell Biology 22, 50-56.
217. POWERS, A. F., FRANCK, A. D., GESTAUT, D. R., COOPER, J., GRACYZK, B.,WEI, R. R.,WORDEMAN, L., DAVIS, T. N. & ASBURY, C. L. (2009). The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion. Cell 136, 865-875.
218. PUTKEY, F. R., CRAMER, T., MORPHEW, M. K., SILK, A. D., JOHNSON, R. S., MCINTOSH, J.R. & CLEVELAND, D.W. (2002). Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Developmental Cell 3, 351-365.
219. QI, H., RATH, U., WANG, D., XU, Y. Z., DING, Y., ZHANG, W., BLACKETER, M. J., PADDY, M. R., GIRTON, J., JOHANSEN, J. & JOHANSEN, K. M. (2004). Megator, an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila. Molecular Biology of the Cell 15, 4854-4865. (Pubitemid 39392202)
220. RASALA, B. A., ORJALO, A. V., SHEN, Z., BRIGGS, S. & FORBES, D. J. (2006). ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proceedings of the National Academy of Sciences of the United States of America 103, 17801-17806. (Pubitemid 44852240)
221. RASMUSSEN, C. G., HUMPHRIES, J. A. & SMITH, L. G. (2011). Determination of symmetric and asymmetric division planes in plant cellsAnnual Review of Plant Biology 62, 387-409.
222. REBHUN, L. I., JEMIOLO, D., IVY, N., MELLON, M. & NATH, J. (1975). Regulation of the in vivo mitotic apparatus by glycols and metabolic inhibitors. Annals of the New York Academy of Sciences 253, 362-377.
223. RIEDER, C. L., DAVISON, E. A., JENSEN, L. C., CASSIMERIS, L. & SALMON, E. D. (1986). Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle. Journal of Cell Biology 103, 581-591. (Pubitemid 16055053)
224. RIEDER, C. L., KHODJAKOV, A., PALIULIS, L. V., FORTIER, T. M., COLE, R.W. & SLUDER, G. (1997). Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage. Proceedings of the National Academy of Sciences of the United States of America 94, 5107-5112. (Pubitemid 27214744)
225. RIEDER, C.L. & SALMON, E. D. (1994). Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle. Journal of Cell Biology 124, 223-233. (Pubitemid 24050342)
226. RIEDER, C. L. & SALMON, E. D. (1998). The vertebrate cell kinetochore and its roles during mitosis. Trends in Cell Biology 8, 310-318. (Pubitemid 28362588)
227. RIEDER, C. L., SCHULTZ, A., COLE, R. & SLUDER, G. (1994). Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. Journal of Cell Biology 127, 1301-1310. (Pubitemid 24362564)
228. ROGERS, G. C., ROGERS, S. L., SCHWIMMER, T. A., EMSMCCLUNG, S. C., WALCZAK, C. E., VALE, R. D., SCHOLEY, J. M. & SHARP, D. J. (2004). Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature 427, 364-370. (Pubitemid 38133665)
229. ROOS, U. P. (1973). Light and electron microscopy of rat kangaroo cells in mitosis. I. Formation and breakdown of the mitotic apparatus. Chromosoma 40, 43-82.
230. ROOSTALU, J., HENTRICH, C., BIELING, P., TELLEY, I. A., SCHIEBEL, E. & SURREY, T. (2011). Directional switching of the kinesin Cin8 through motor coupling. Science 332, 94-99.
231. SALMON, E. D. (1975). Spindle microtubules: thermodynamics of in vivo assembly and role in chromosome movement. Annals of the New York Academy of Sciences 253, 383-406.
232. SALMON, E. D., GOODE, D., MAUGEL, T.K. & BONAR, D. B. (1976). Pressure-induced depolymerization of spindle microtubules. III. Differential stability in HeLa cells. The Journal of Cell Biology 69, 443-454.
233. SALMON, E. D., MCKEEL, M. & HAYS, T. (1984). Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine. The Journal of Cell Biology 99, 1066-1075. (Pubitemid 14043364)
234. SAUNDERS, A. M., POWERS, J., STROME, S. & SAXTON, W. M. (2007). Kinesin-5 acts as a brake in anaphase spindle elongation. Current Biology 17, R453-R454. (Pubitemid 46899529)
235. SAXTON, W.M. & MCINTOSH, J. R. (1987). Interzone microtubule behavior in late anaphase and telophase spindles. The Journal of Cell Biology 105, 875-886. (Pubitemid 18043847)
236. SAXTON, W. M., STEMPLE, D. L., LESLIE, R. J., SALMON, E. D., ZAVORTINK, M. & MCINTOSH, J.R. (1984). Tubulin dynamics in cultured mammalian cells. Journal of Cell Biology 99, 2175-2186. (Pubitemid 15181881)
237. SCHAAP, C. J. & FORER, A. (1979). Temperature effects on anaphase chromosome movement in the spermatocytes of two species of crane flies (Nephrotoma suturalis Loew and Nephrotoma ferruginea Fabricius). Journal of Cell Science 39, 29-52. (Pubitemid 10239642)
238. SCHAAR, B. T., CHAN, G. K., MADDOX, P., SALMON, E. D. & YEN, T. J. (1997). CENP-E function at kinetochores is essential for chromosome alignment. Journal of Cell Biology 139, 1373-1382. (Pubitemid 28013659)
239. SCHAFFNER, S. C. & JOSE, J. V. (2006). Biophysical model of self-organized spindle formation patterns without centrosomes and kinetochores. Proceedings of the National Academy of Sciences of the United States of America 103, 11166-11171. (Pubitemid 44156490)
240. SCHMIDT, D. J., ROSE, D. J., SAXTON, W.M. & STROME, S. (2005). Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Molecular Biology of the Cell 16, 1200-1212. (Pubitemid 40349557)
241. SEGUI-SIMARRO, J. M., AUSTIN, II, J. R., WHITE, E. A. & STAEHELIN, L. A. (2004). Electron tomographic analysis of somatic cell plate formation in meristematic cells of Arabidopsis preserved by high-pressure freezing. Plant Cell 16, 836-856. (Pubitemid 38459206)
242. SHARP, D. J., ROGERS, G.C. & SCHOLEY, J. M. (2000). Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos. Nature Cell Biology 2, 922-930.
243. SHARP, D. J., YU, K. R., SISSON, J. C., SULLIVAN, W. & SCHOLEY, J. M. (1999). Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos. Nature Cell Biology 1, 51-54. (Pubitemid 129495010)
244. SHIMAMOTO, Y., MAEDA, Y. T., ISHIWATA, S., LIBCHABER, A. J. & KAPOOR, T. M. (2011). Insights into the micromechanical properties of the metaphase spindle. Cell 145, 1062-1074.
245. SILLER, K.H. & DOE, C. Q. (2009). Spindle orientation during asymmetric cell division. Nature Cell Biology 11, 365-374.
246. SKIBBENS, R. V., RIEDER, C.L. & SALMON, E. D. (1995). Kinetochore motility after severing between sister centromeres using laser microsurgery: evidence that kinetochore directional instability and position is regulated by tension. Journal of Cell Science 108, 2537-2548.
247. SKIBBENS, R. V., SKEEN, V.P. & SALMON, E. D. (1993). Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: a push-pull mechanism. Journal of Cell Biology 122, 859-875. (Pubitemid 23241095)
248. SKOUFIAS, D. A., ANDREASSEN, P. R., LACROIX, F. B., WILSON, L.&MARGOLIS, R. L. (2001). Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proceedings of the National Academy of Sciences of the United States of America 98, 4492-4497. (Pubitemid 32295004)
249. SMIRNOVA, E.A. & BAJER, A. S. (1994). Microtubule converging centers and reorganization of the interphase cytoskeleton and the mitotic spindle in higher plant Haemanthus. Cell Motility and the Cytoskeleton 27, 219-233. (Pubitemid 24108021)
250. SNYDER, J.A. & COHEN, L. (1995). Cytochalasin J affects chromosome congression and spindle microtubule organization in PtK1 cells. Cell Motility and the Cytoskeleton 32, 245-257.
251. SNYDER, J.A. & MCINTOSH, J. R. (1975). Initiation and growth of microtubules from mitotic centers in lysed mammalian cells. Journal of Cell Biology 67, 744-760.
252. SPRAGUE, B. L., PEARSON, C. G., MADDOX, P. S., BLOOM, K. S., SALMON, E.D. & ODDE, D. J. (2003). Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophysical Journal 84, 3529-3546. (Pubitemid 36637855)
253. SPURCK, T., FORER, A. & PICKETT-HEAPS, J. (1997). Ultraviolet microbeam irradiations of epithelial and spermatocyte spindles suggest that forces act on the kinetochore fibre and are not generated by its disassembly. Cell Motility and the Cytoskeleton 36, 136-148. (Pubitemid 27063206)
254. SPURCK, T.P. & PICKETT-HEAPS, J. D. (1987). On the mechanism of anaphase A: evidence that ATP is needed for microtubule disassembly and not generation of polewards force. Journal of Cell Biology 105, 1691-1705.
255. STOUT, J. R., RIZK, R. S., KLINE, S. L. & WALCZAK, C.E. (2006). Deciphering protein function during mitosis in PtK cells using RNAi. BMC Cell Biology [electronic resource] 7, 26.
256. STRAIGHT, A. F., MARSHALL,W. F., SEDAT, J.W. & MURRAY, A. W. (1997). Mitosis in living budding yeast: anaphase A but no metaphase plate. Science 277, 574-578. (Pubitemid 27369007)
257. SURREY, T., NEDELEC, F., LEIBLER, S. & KARSENTI, E. (2001). Physical properties determining selforganization of motors and microtubules. Science 292(5519), 1167-1171. (Pubitemid 32440939)
258. TANAKA, K., KITAMURA, E., KITAMURA, Y.&TANAKA, T. U. (2007). Molecular mechanisms of microtubuledependent kinetochore transport toward spindle poles. Journal of Cell Biology 178, 269-281. (Pubitemid 47076463)
259. TANAKA, K., MUKAE, N., DEWAR, H., VAN BREUGEL, M., JAMES, E. K., PRESCOTT, A. R., ANTONY, C. & TANAKA, T. U. (2005). Molecular mechanisms of kinetochore capture by spindle microtubules. Nature 434, 987-994. (Pubitemid 40586041)
260. TANAKA, T. U., RACHIDI, N., JANKE, C., PEREIRA, G., GALOVA, M., SCHIEBEL, E., STARK, M. J. & NASMYTH, K. (2002). Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome biorientation by altering kinetochore-spindle pole connections. Cell 108, 317-329. (Pubitemid 34178397)
261. TANG, D., MAR, K., WARREN, G. & WANG, Y. (2008). Molecular mechanism of mitotic Golgi disassembly and reassembly revealed by a defined reconstitution assay. Journal of Biological Chemistry 283, 6085-6094.
262. TAYLOR, E. W. (1959). Dynamics of spindle formation and its inhibition by chemicals. Journal of Cell Biology 6, 193-196.
263. TISCHER, C., BRUNNER, D.&DOGTEROM, M. (2009). Forceand kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics. Molecular Systems Biology 5, 250.
264. TOKAI-NISHIZUMI, N., OHSUGI, M., SUZUKI, E. & YAMAMOTO, T. (2005). The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Molecular Biology of the Cell 16, 5455-5463. (Pubitemid 41566853)
265. TOSO, A., WINTER, J. R., GARROD, A. J., AMARO, A. C., MERALDI, P. & MCAINSH, A. D. (2009). Kinetochoregenerated pushing forces separate centrosomes during bipolar spindle assembly. Journal of Cell Biology 184, 365-372.
266. TSAI, M. Y.,WANG, S., HEIDINGER, J. M., SHUMAKER, D. K., ADAM, S. A., GOLDMAN, R.D. & ZHENG, Y. (2006). A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science 311, 1887-1893.
267. UEHARA, R. & GOSHIMA, G. (2010). Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase. Journal of Cell Biology 191, 259-267.
268. URRUTIA, R., MCNIVEN, M. A., ALBANESI, J. P., MURPHY, D. B. & KACHAR, B. (1991). Purified kinesin promotes vesicle motility and induces active sliding between microtubules in vitro. Proceedings of the National Academy of Sciences of the United States of America 88, 6701-6705. (Pubitemid 21915017)
269. VAISBERG, E. A., KOONCE, M. P. &MCINTOSH, J. R. (1993). Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. Journal of Cell Biology 123, 849-858. (Pubitemid 23333574)
270. VALE, R. D. (2003). The molecular motor toolbox for intracellular transport. Cell 112, 467-480. (Pubitemid 36263080)
271. VALLOTTON, P., PONTI, A., WATERMAN-STORER, C. M., SALMON, E.D. & DANUSER, G. (2003). Recovery, visualization, and analysis of actin and tubulin polymer flow in live cells: a fluorescent speckle microscopy study. Biophysical Journal 85, 1289-1306. (Pubitemid 36909689)
272. VARETTI, G. & MUSACCHIO, A. (2008). The spindle assembly checkpoint. Current Biology 18, R591-R595. (Pubitemid 351982010)
273. VARGA, V., HELENIUS, J., TANAKA, K., HYMAN, A. A., TANAKA, T.U. & HOWARD, J. (2006). Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nature Cell Biology 8, 957-962. (Pubitemid 44314726)
274. VIGERS, G. P., COUE, M. & MCINTOSH, J. R. (1988). Fluorescent microtubules break up under illumination. Journal of Cell Biology 107, 1011-1024.
275. VLADIMIROU, E., HARRY, E., BURROUGHS, N. & MCAINSH, A. D. (2011). Springs, clutches and motors: driving forward kinetochore mechanism by modelling. Chromosome Research: An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology 19, 409-421.
276. VOROZHKO, V. V., EMANUELE, M. J., KALLIO, M. J., STUKENBERG, P.T. & GORBSKY, G. J. (2008). Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma 117, 169-179.
277. VOS, J. W., PIEUCHOT, L., EVRARD, J. L., JANSKI, N., BERGDOLL, M., DE RONDE, D., PEREZ, L. H., SARDON, T., VERNOS, I. & SCHMIT, A. C. (2008). The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown. Plant Cell 20, 2783-2797. (Pubitemid 352844590)
278. WALCZAK, C.E. & HEALD, R. (2008). Mechanisms of mitotic spindle assembly and function. International Review of Cytology 265, 111-158. (Pubitemid 351215987)
279. WALCZAK, C. E., MITCHISON, T. J. & DESAI, A. (1996). XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 84, 37-47. (Pubitemid 26031459)
280. WALCZAK, C. E., VERNOS, I., MITCHISON, T. J., KARSENTI, E. & HEALD, R. (1998). A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Current Biology 8, 903-913. (Pubitemid 28371755)
281. WAN, X., O'QUINN, R. P., PIERCE, H. L., JOGLEKAR, A. P., GALL, W. E., DELUCA, J. G., CARROLL, C. W., LIU, S. T., YEN, T. J., MCEWEN, B. F., STUKENBERG, P. T., DESAI, A. & SALMON, E. D. (2009). Protein architecture of the human kinetochore microtubule attachment site. Cell 137, 672-684.
282. WANG, H.W. & NOGALES, E. (2005). Nucleotidedependent bending flexibility of tubulin regulates microtubule assembly. Nature 435, 911-915. (Pubitemid 40896310)
283. WANG, S.Z. & ADLER, R. (1995). Chromokinesin: a DNA-binding, kinesin-like nuclear protein. Journal of Cell Biology 128, 761-768.
284. WATERMAN-STORER, C. M., DESAI, A., BULINSKI, J.C. & SALMON, E. D. (1998). Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells. Current Biology 8, 1227-1230. (Pubitemid 29006663)
285. WATERS, J. C., COLE, R.W. & RIEDER, C. L. (1993). The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster. Journal of Cell Biology 122, 361-372. (Pubitemid 23210463)
286. WATERS, J. C., SKIBBENS, R.V. & SALMON, E. D. (1996). Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push. Journal of Cell Science 109, 2823-2831. (Pubitemid 27029253)
287. WEISENBERG, R. & ROSENFELD, A. (1975). Role of intermediates in microtubule assembly in vivo and in vitro. Annals of the New York Academy of Sciences 253, 78-89.
288. WELBURN, J.P. & CHEESEMAN, I. M. (2008). Toward a molecular structure of the eukaryotic kinetochore. Developmental Cell 15, 645-655.
289. WELBURN, J. P., GRISHCHUK, E. L., BACKER, C. B., WILSONKUBALEK, E. M., YATES, 3RD, J. R. & CHEESEMAN, I.M. (2009). The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Developmental Cell 16, 374-385.
290. WELBURN, J. P., VLEUGEL, M., LIU, D., YATES, 3RD, J. R., LAMPSON, M. A., FUKAGAWA, T. & CHEESEMAN, I.M. (2010). Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Molecular Cell 38, 383-392.
291. WEST, R. R., MALMSTROM, T. & MCINTOSH, J. R. (2002). Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis. Journal of Cell Science 115(Pt 5), 931-940. (Pubitemid 34257378)
292. WESTERMANN, S., WANG, H. W., AVILA-SAKAR, A., DRUBIN, D. G., NOGALES, E. & BARNES, G. (2006). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440, 565-569.
293. WIDLUND, P. O., STEAR, J. H., POZNIAKOVSKY, A., ZANIC, M., REBER, S., BROUHARD, G. J., HYMAN, A.A. & HOWARD, J. (2011). XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region. Proceedings of the National Academy of Sciences of the United States of America 108, 2741-2746.
294. WIESE, C. & ZHENG, Y. (2006). Microtubule nucleation: gamma-tubulin and beyond. Journal of Cell Science 119(Pt 20), 4143-4153.
295. WIRTH, K. G., WUTZ, G., KUDO, N. R., DESDOUETS, C., ZETTERBERG, A., TAGHYBEEGLU, S., SEZNEC, J., DUCOS, G. M., RICCI, R., FIRNBERG, N., PETERS, J.M. & NASMYTH, K. (2006). Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. Journal of Cell Biology 172, 847-860.
296. WITT, P. L., RIS, H. & BORISY, G. G. (1980). Origin of kinetochore microtubules in Chinese hamster ovary cells. Chromosoma 81, 483-505. (Pubitemid 11171177)
297. WOLLMAN, R., CIVELEKOGLU-SCHOLEY, G., SCHOLEY, J.M. & MOGILNER, A. (2008). Reverse engineering of force integration during mitosis in the Drosophila embryo. Molecular Systems Biology 4, 195.
298. WOLLMAN, R., CYTRYNBAUM, E. N., JONES, J. T., MEYER, T., SCHOLEY, J.M. & MOGILNER, A. (2005). Efficient chromosome capture requires a bias in the 'search-andcapture' process during mitotic-spindle assembly. Current Biology 15, 828-832. (Pubitemid 40689401)
299. WOOD, K. W., SAKOWICZ, R., GOLDSTEIN, L.S. & CLEVELAND, D. W. (1997). CENP-E is a plus enddirected kinetochore motor required for metaphase chromosome alignment. Cell 91, 357-366. (Pubitemid 27467966)
300. WORDEMAN, L. (2005). Microtubule-depolymerizing kinesins. Current Opinion in Cell Biology 17, 82-88. (Pubitemid 40138092)
301. WORDEMAN, L. & STUMPFF, J. (2009). Microtubule length control, a team sport? Developmental Cell 17, 437-438.
302. YAJIMA, J., EDAMATSU, M., WATAI-NISHII, J., TOKAI-NISHIZUMI, N., YAMAMOTO, T. & TOYOSHIMA, Y. Y. (2003). The human chromokinesin Kid is a plus end-directed microtubule-based motor. The EMBO Journal 22, 1067-1074. (Pubitemid 36313591)
303. YANG, G., CAMERON, L. A., MADDOX, P. S., SALMON, E.D. & DANUSER, G. (2008). Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle. Journal of Cell Biology 182, 631-639.
304. YANG, G., HOUGHTALING, B. R., GAETZ, J., LIU, J. Z., DANUSER, G. & KAPOOR, T. M. (2007a). Architectural dynamics of the meiotic spindle revealed by singlefluorophore imaging. Nature Cell Biology 9, 1233-1242. (Pubitemid 350042355)
305. YANG, Z., GUO, J., CHEN, Q., DING, C., DU, J. & ZHU, X. (2005). Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Molecular and Cellular Biology 25, 4062-4074. (Pubitemid 40617654)
306. YANG, Z., KENNY, A. E., BRITO, D.A. & RIEDER, C.L. (2009). Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. Journal of Cell Biology 186, 675-684.
307. YANG, Z., TULU, U. S., WADSWORTH, P. & RIEDER, C. L. (2007b). Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Current Biology 17, 973-980. (Pubitemid 46829839)
308. YOKOYAMA, H., GRUSS, O. J., RYBINA, S., CAUDRON, M., SCHELDER, M., WILM, M., MATTAJ, I.W. & KARSENTI, E. (2008). Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. Journal of Cell Biology 180, 867-875. (Pubitemid 351398414)
309. ZHAI, Y., KRONEBUSCH, P. J. & BORISY, G. G. (1995). Kinetochore microtubule dynamics and the metaphaseanaphase transition. Journal of Cell Biology 131, 721-734.
310. ZHANG, D., ROGERS, G. C., BUSTER, D.W. & SHARP, D. J. (2007). Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. Journal of Cell Biology 177, 231-242. (Pubitemid 46658635)
311. ZHU, C. & JIANG, W. (2005). Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proceedings of the National Academy of Sciences of the United States of America 102, 343-348. (Pubitemid 40116769)