Chromosome congression in the absence of kinetochore fibres

Nature Cell Biology

Volumn 11, Issue 7, 2009, Pages 832-838

  Cai, Shang ^a   O'Connell, Christopher B ^b   Khodjakov, Alexey ^b   Walczak, Claire E ^a  

^a INDIANA UNIVERSITY   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN E; KINESIN; KINESIN 14; KINESIN 7; NDC80 COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME ANALYSIS; CHROMOSOME POSITIONING; CHROMOSOME SEGREGATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; METAPHASE CHROMOSOME; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; SPINDLE POLE BODY;

CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; CHROMOSOMES; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; KINESIN; KINETOCHORES; METAPHASE; MITOTIC SPINDLE APPARATUS; PROMETAPHASE;

EID: 67650087879     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1890     Document Type: Article

References (30)

1. Maiato, H., DeLuca, J., Salmon, E. D. & Earnshaw, W. C. The dynamic kinetochoremicrotubule interface. J. Cell Sci.117, 5461-5477 (2004).
2. Walczak, C. E. & Heald, R. Mechanisms of mitotic spindle assembly and function. Int. Rev Cytol. 265, 111-158 (2008).
3. Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E. Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol. Biol. Cell 20, 1348-1359 (2009).
4. Manning, A. L. & Compton, D. A. Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells. Curr. Biol. 17, 260-265 (2007).
5. DeLuca, J. G., Moree, B., Hickey, J. M., Kilmartin, J. V. & Salmon, E. D. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 159, 549-555 (2002).
6. Wood, K. W., Sakowicz, R., Goldstein, L. S. & Cleveland, D. W. CENP-E is a plus enddirected kinetochore motor required for metaphase chromosome alignment. Cell 91, 357-366 (1997).
7. Kapoor, T. M. et al. Chromosomes can congress to the metaphase plate before biorientation. Science 311, 388-391 (2006).
8. Nicklas, R. B. & Arana, P. Evolution and the meaning of metaphase. J Cell Sci 102 (Pt 4), 681-690 (1992).
9. Rieder, C. L. & Salmon, E. D. The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 8, 310-318 (1998).
10. Maiato, H. & Sunkel, C. E. Kinetochore-microtubule interactions during cell division. Chromosome Res. 12, 585-597 (2004).
11. DeLuca, J. G. et al. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol. Biol. Cell 16, 519-531 (2005).
12. Heald, R. & Walczak, C. E. in The Kinetochore: From Molecular Discoveries to Cancer Therapy (eds. De Wulf, P. & Earnshaw, W. C.) 231-268 (Springer Science and Business Media, 2009).
13. Scholey, J. M., Brust-Mascher, I. & Mogilner, A. Cell division. Nature 422, 746-752 (2003).
14. Starr, D. A., Williams, B. C., Hays, T. S. & Goldberg, M. L. ZW10 helps recruit dynactin and dynein to the kinetochore. J. Cell Biol. 142, 763-774 (1998).
15. Sillje, H. H., Nagel, S., Korner, R. & Nigg, E. A. HURP is a Ran-importin β-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr. Biol. 16, 731-742 (2006).
16. Wong, J. & Fang, G. HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J. Cell Biol. 173, 879-891 (2006).
17. Skibbens, R. V., Skeen, V. P. & Salmon, E. D. Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: A push-pull mechanism. J. Cell Biol. 122, 859-875 (1993).
18. Bomont, P., Maddox, P., Shah, J. V., Desai, A. B. & Cleveland, D. W. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP.-F. EMBO J. 24, 3927-3939 (2005).
19. Rieder, C. L. & Alexander, S. P. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 110, 81-95 (1990).
20. Vorozhko, V. V., Emanuele, M. J., Kallio, M. J., Stukenberg, P. T. & Gorbsky, G. J. Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma 117, 169-179 (2008).
21. Kirschner, M. W. & Mitchison, T. Microtubule dynamics. Nature 324, 621 (1986).
22. Wollman, R. et al. Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly. Curr. Biol. 15, 828-832 (2005).
23. McEwen, B. F. et al. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol. Biol. Cell 12, 2776-2789 (2001).
24. Putkey, F. R. et al. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP.-E. Dev. Cell 3, 351-365 (2002).
25. Weaver, B. A. et al. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol.162, 551-563 (2003).
26. Ems-McClung, S. C., Zheng, Y. & Walczak, C. E. Importin α/β and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal. Mol. Biol. Cell 15, 46-57 (2004).
27. Walczak, C. E., Verma, S. & Mitchison, T. J. XCTK2: A kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. J. Cell Biol. 136, 859-870 (1997).
28. Rodriguez, A. & Flemington, E. K. Transfection-mediated cell-cycle signaling: Considerations for transient transfection-based cell-cycle studies. Anal. Biochem. 272, 171-181 (1999).
29. Yang, Z., Tulu, U. S., Wadsworth, P. & Rieder, C. L. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr. Biol. 17, 973-980 (2007).
30. Rieder, C. L. & Cassels, G. Correlative light and electron microscopy of mitotic cells in monolayer cultures. Methods Cell Biol. 61, 297-315 (1999).