Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

Nature

Volumn 427, Issue 6972, 2004, Pages 364-370

  Rogers, Gregory C ^a   Rogers, Stephen L ^b   Schwimmer, Tamara A ^a   Ems McClung, Stephanie C ^c   Walczak, Claire E ^c   Vale, Ronald D ^b   Scholey, Jonathan M ^d   Sharp, David J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INDIANA UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; DEPOLYMERIZATION; ENZYMES; POLYPEPTIDES;

MICROTUBULES;

CYTOLOGY;

ADENOSINE TRIPHOSPHATASE; DYNEIN ADENOSINE TRIPHOSPHATASE; GREEN FLUORESCENT PROTEIN; HISTONE; KINESIN; TUBULIN;

MICROBIOLOGY;

ANAPHASE; ARTICLE; BLASTODERM; CENTROMERE; CHROMOSOME SEGREGATION; DEPOLYMERIZATION; DROSOPHILA MELANOGASTER; FLUORESCENCE; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID; TRANSGENE;

ANAPHASE; ANIMALS; CHROMATIDS; CHROMOSOME PAIRING; CHROMOSOME SEGREGATION; CHROMOSOMES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; KINESIN; MITOSIS; MITOTIC SPINDLE APPARATUS;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 1642540211     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02256     Document Type: Article

References (30)

1. Mitchison, T. J. & Salmon, E. D. Mitosis: a history of division. Nature Cell Biol. 3, E17-E21 (2001).
2. Wittmann, T., Hyman, A. & Desai, A. The spindle: a dynamic assembly of microtubules and motors. Nature Cell Biol. 3, E28-E34 (2001).
3. Rieder, C. L. & Salmon, E. D. The venebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 8, 310-318 (1998).
4. Mitchison, T. J., Evans, L., Schulze, E. & Kirschner, M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell 45, 515-527 (1986).
5. Gorbsky, G. I., Sammak, P. I. & Borisy, G. G. Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. J. Cell Biol. 104, 9-18 (1987).
6. Mitchison, T. J. Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. J. Cell Biol. 109, 637-652 (1989).
7. Hunter, A. W. & Wordeman, L. How motor proteins influence microtubule polymerization dynamics. J. Cell Sci. 24, 4379-4389 (2000).
8. Wordeman, L. & Mitchison, T. J. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J. Cell Biol. 128, 95-104 (1995).
9. Walczak, C. E., Mitchison, T. J. & Desai, A. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell 84, 37-47 (1996).
10. Desai, A., Verma, S., Mitchison, T. J. & Walczak, C. E. KinI kinesins are microtubule-destabilizing enzymes. Cell 96, 69-78 (1999).
11. Maney, T., Hunter, A. W., Wagenbach, M. & Wordeman, L. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J. Cell Biol. 142, 787-801 (1998).
12. Kline-Smith, S. L. & Walczak, C. E. The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol. Biol. Cell 13, 2718-2731 (2002).
13. Walczak, C. E., Gan, E. C., Desai, A., Mitchison, T. J. & Kline-Smith, S. L. The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr. Biol. 12, 1885-1889 (2002).
14. Goldstein, L. S. B. & Gunawardena, S. Flying through the Drosophila cytoskeletal genome. J. Cell Biol. 150, F63-F68 (2000).
15. Sullivan, W. & Theurkauf, W. E. The cytoskeleton and morphogenesis of the early Drosophila embryo. Curr. Opin. Cell Biol. 7, 18-22 (1995).
16. Sullivan, W., Fogarty, P. & Theurkauf, W. E. Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos. Development 118, 1245-1254 (1993).
17. Waterman-Storer, C. M., Desai, A., Bulinski, J. C. & Salmon, E. D. Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells. Curr. Biol. 8, 1227-1230 (1998).
18. Brust-Mascher, I. & Scholey, J. M. Microtubule flux and sliding in mitotic spindles of Drosophila embryos. Mol. Biol. Cell 13, 3967-3975 (2002).
19. Maddox, P., Desai, A., Oegema, K., Mitchison, T. J. & Salmon, E. D. Poleward microtubule flux is a major component of spindle dynamics and anaphase A in mitotic Drosophila embryos. Curr. Biol. 12, 1670-1674 (2002).
20. Waters, J. C., Mitchison, T. J., Rieder, C. L. & Salmon, E. D. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol. Biol. Cell 7, 1547-1558 (1996).
21. Sharp, D. J., Rogers, G. C. & Scholey, J. M. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos. Nature Cell Biol. 2, 922-930 (2000).
22. 2: Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis. Mol. Biol. Cell 12, 3476-3488 (2001).
23. +, foster microtubule disassembly and are required for meiosis in fission yeast. Mol. Biol. Cell 12, 3919-3932 (2001).
24. + are required for normal chromosome movement in mitosis. J. Cell Sci. 115, 931-940 (2002).
25. Garcia, M. A., Koonrugsa, N. & Toda, T. Two kinesin-like KinI family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase. Curr. Biol. 12, 610-621 (2002).
26. Rogers, S. L., Rogers, G. C., Sharp, D. J. & Vale, R. D. Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle. J. Cell Biol. 158, 873-884 (2002).
27. Bousbaa, H., Correia, L., Gorbsky, G. J. & Sunkel, C. E. Mitotic phosphoepitopes are expressed in Kc cells, neuroblasts and isolated chromosomes of Drosophila melanogaster. J. Cell Sci. 110, 1979-1988 (1997).
28. Sharp, D. J., Yu, K. R., Sisson, J. C., Sullivan, W. & Scholey, J. M. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos. Nature Cell Biol. 1, 51-54 (1999).
29. Valdes-Perez, R. E. & Minden, L. S. Drosophila melanogaster syncytial nuclear divisions are patterned: time-lapse images, hypothesis and computational evidence. J. Theor. Biol. 175, 525-532 (1995).
30. McIntosh, J. R., Grishchuk, E. L. & West, R. R. Chromosome-microtubule interactions during mitosis. Annu. Rev. Cell Dev. Biol. 18, 193-219 (2002).