Peroxiredoxins in parasites

Antioxidants and Redox Signaling

Volumn 17, Issue 4, 2012, Pages 608-633

  Gretes, Michael C ^a   Poole, Leslie B ^b   Karplus, P Andrew ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY; ANTIPARASITIC AGENT; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; CONOIDIN A; METRONIDAZOLE; PEROXIREDOXIN; PEROXIREDOXIN 1; PEROXIREDOXIN 1A; PEROXIREDOXIN 5; PEROXIREDOXIN 6; PEROXIREDOXIN AHPE; PEROXIREDOXIN Q; PMX 464; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VACCINE;

ANTIBIOTIC RESISTANCE; APICOMPLEXA; BIOCHEMISTRY; CATALYSIS; CESTODE; CROSS FERTILIZATION; CRYPTOSPORIDIUM; CYTOLOGY; DEVELOPMENTAL STAGE; DRUG TARGETING; ENTAMOEBA; FUNGUS; GENOME; GIARDIA LAMBLIA; HELMINTH; HOST PARASITE INTERACTION; HUMAN; IMMUNE RESPONSE; KINETOPLASTIDA; LEISHMANIA; MOLECULAR EVOLUTION; NAEGLERIA FOWLERI; NEMATODE; NOMENCLATURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PLASMODIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN QUATERNARY STRUCTURE; PROTOZOON; REGULATORY MECHANISM; REVIEW; STRUCTURAL GENOMICS; TOXOPLASMA; TREMATODE; TRICHOMONAS VAGINALIS; TRYPANOSOMA; UNINDEXED SEQUENCE;

ANIMALS; HUMANS; MODELS, MOLECULAR; PARASITES; PEROXIREDOXINS; PROTEIN FOLDING;

EID: 84860294541     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2011.4404     Document Type: Review

References (278)

1. Acestor N, Masina S, Ives A, Walker J, Saravia N, and Fasel N. Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. J Infect Dis 194: 1160-1167, 2006. (Pubitemid 44547657)
2. Adimora N, Jones D, and Kemp M. A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses. Antioxid Redox Signal 13: 731-743, 2010.
3. Akbar MA, Chatterjee NS, Sen P, Debnath A, Pal A, Bera T, and Das P. Genes induced by a high-oxygen environment in Entamoeba histolytica. Mol Biochem Parasitol 133: 187-196, 2004. (Pubitemid 38032867)
4. Akerman S and Muller S. 2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum. Mol Biochem Parasitol 130: 75-81, 2003. (Pubitemid 37289125)
5. Akerman S and Muller S. Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. J Biol Chem 280: 564-570, 2005. (Pubitemid 40165022)
6. Alger H, Sayed A, Stadecker M, and Williams D. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol 32: 1285-1292, 2002. (Pubitemid 35232180)
7. Ali IKM, Hossain MB, Roy S, Ayeh-Kumi PF, Petri WA, Haque R, and Clark CG. Entamoeba moshkovskii infections in children, Bangladesh. Emerging Infect Dis 9: 580-584, 2003. (Pubitemid 36529517)
8. Alphey MS, König J, and Fairlamb AH. Structural and mechanistic insights into type II trypanosomatid tryparedoxin- dependent peroxidases. Biochem J 414: 375, 2008.
9. Alvarez M, Peluffo G, Piacenza L, and Radi R. Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem 286: 6627-6640, 2011.
10. Anand S, Murugan V, Prabhu P, Anandharaman V, Reddy M, and Kaliraj P. Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice. Acta Trop 107: 106-112, 2008.
11. Andrade H, Murta S, Chapeaurouge A, Perales J, Nirde P, and Romanha A. Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole. J Proteome Res 7: 2357-2367, 2008.
12. 2+ promote the reversible oligomerization and aggregation of chloroplast 2-Cys peroxiredoxin. J Biol Chem 286: 23441-23451, 2011.
13. Arias D, Carranza P, Lujan H, Iglesias A, and Guerrero S. Immunolocalization and enzymatic functional characterization of the thioredoxin system in Entamoeba histolytica. Free Radic Biol Med 45: 32-39, 2008.
14. Aslett M, Aurrecoechea C, Berriman M, Brestelli J, Brunk BP, Carrington M, Depledge DP, Fischer S, Gajria B, Gao X, Gardner MJ, Gingle A, Grant G, Harb OS, Heiges M, Hertz- Fowler C, Houston R, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Logan FJ, Miller JA, Mitra S, Myler PJ, Nayak V, Pennington C, Phan I, Pinney DF, Ramasamy G, Rogers MB, Roos DS, Ross C, Sivam D, Smith DF, Srinivasamoorthy G, Stoeckert CJ, Subramanian S, Thibodeau R, Tivey A, Treatman C, Velarde G, and Wang H. TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res 38: D457-D462, 2010.
15. Aurrecoechea C, Brestelli J, Brunk BP, Carlton JM, Dommer J, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Miller JA, Morrison HG, Nayak V, Pennington C, Pinney DF, Roos DS, Ross C, Stoeckert CJ, Sullivan S, Treatman C, and Wang H. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res 37: D526-D530, 2009.
16. Aurrecoechea C, Brestelli J, Brunk BP, Dommer J, Fischer S, Gajria B, Gao X, Gingle A, Grant G, Harb OS, Heiges M, Innamorato F, Iodice J, Kissinger JC, Kraemer E, Li W, Miller JA, Nayak V, Pennington C, Pinney DF, Roos DS, Ross C, Stoeckert CJ, Treatman C, and Wang H. PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res 37: D539-D543, 2009.
17. Avila A, Yamada-Ogatta S, da Silva Monteiro V, Krieger M, Nakamura C, de Souza W, and Goldenberg S. Cloning and characterization of the metacyclogenin gene, which is specifically expressed during Trypanosoma cruzi metacyclogenesis. Mol Biochem Parasitol 117: 169-177, 2001. (Pubitemid 32972278)
18. Azzam EI, de Toledo SM, and Little JB. Stress signaling from irradiated to non-irradiated cells. Curr Cancer Drug Targets 4: 53-64, 2004. (Pubitemid 38332564)
19. Bae Y, Kim S, Lee E, Sohn W, and Kong Y. Identification and biochemical characterization of two novel peroxir- edoxins in a liver fluke, Clonorchis sinensis. Parasitology 138: 1143-1153, 2011.
20. Baker LM and Poole LB. Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. J Biol Chem 278: 9203-9211, 2003. (Pubitemid 36800402)
21. Barr S and Gedamu L. Cloning and characterization of three differentially expressed peroxidoxin genes from Leishmania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals. J Biol Chem 276: 34279-34287, 2001.
22. Barr SD and Gedamu L. Role of peroxidoxins in Leishmania chagasi survival. Evidence of an enzymatic defense against nitrosative stress. J Biochem 278: 10816-10823, 2003. (Pubitemid 36800355)
23. Barranco-Medina S, Lázaro J-J, and Dietz K-J. The oligomeric conformation of peroxiredoxins links redox state to function. FEBS Lett 583: 1809-1816, 2009.
24. Becker K, Kanzok S, Iozef R, Fischer M, Schirmer R, and Rahlfs S. Plasmoredoxin, a novel redox-active protein unique for malarial parasites. Eur J Biochem 270: 1057-1064, 2003. (Pubitemid 36384440)
25. Bendtsen JD, Jensen LJ, Blom N, von Heijne G, and Brunak S. Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel 17: 349-356, 2004. (Pubitemid 39093515)
26. Bendtsen JD, Nielsen H, von Heijne G, and Brunak S. Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340: 783-795, 2004. (Pubitemid 38829638)
27. Boucher IW, Mcmillan PJ, Gabrielsen M, Akerman SE, Brannigan JA, Schnick C, Brzozowski AM, Wilkinson AJ, and Müller S. Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Mol Microbiol 61: 948-959, 2006. (Pubitemid 44134172)
28. Bradley P and Sibley L. Rhoptries: an arsenal of secreted virulence factors. Curr Opin Microbiol 10: 582-587, 2007. (Pubitemid 350180592)
29. Brosson D, Kuhn L, Delbac F, Garin J, Vivares CP, and Texier C. Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages. Proteomics 6: 3625-3635, 2006. (Pubitemid 44000190)
30. Bruchhaus I, Richter S, and Tannich E. Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica. Biochem J 326: 785-789, 1997. (Pubitemid 27438052)
31. Buchholz K, Putrianti ED, Rahlfs S, Schirmer RH, Becker K, and Matuschewski K. Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite. J Biol Chem 285: 37388-37395, 2010.
32. Budde H, Flohé L, Hecht H-J, Hofmann B, Stehr M, Wissing J, and Lünsdorf H. Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei brucei. Biol Chem 384: 619-633, 2003. (Pubitemid 36609177)
33. Budde H, Flohe L, Hofmann B, and Nimtz M. Verification of the interaction of a tryparedoxin peroxidase with tryparedoxin by ESI-MS/MS. Biol Chem 384: 1305-1309, 2003. (Pubitemid 37168699)
34. Campos-Neto A, Porrozzi R, Greeson K, Coler R, Webb J, Seiky Y, Reed S, and Grimaldi G. Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease. Infect Immun 69: 4103-4108, 2001. (Pubitemid 32493335)
35. Castro H, Budde H, Flohé L, Hofmann B, Lünsdorf H, Wissing J, and Tomás A. Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantum. Free Radic Biol Med 33: 1563-1574, 2002. (Pubitemid 35351600)
36. Castro H, Romao S, Gadelha F, and Tomás A. Leishmania infantum: provision of reducing equivalents to the mitochondrial tryparedoxin/tryparedoxin peroxidase system. Exp Parasitol 120: 421-423, 2008.
37. Castro H, Sousa C, Novais M, Santos M, Budde H, Cordeiro-da-Silva A, Flohé L, and Tomás A. Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion. Mol Biochem Parasitol 136: 137-147, 2004. (Pubitemid 38757982)
38. Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohé L, and Tomás A. Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. Free Radic Biol Med 33: 1552-1562, 2002. (Pubitemid 35351599)
39. Castro H and Tomás A. Peroxidases of Trypanosomatids. Antioxid Redox Signal 10: 1593-1606, 2008. (Pubitemid 351934269)
40. Cha M-K, Kim W-C, Lim C-J, Kim K, and Kim I-H. Escherichia coli periplasmic thiol peroxidase acts as lipid hydroperoxide peroxidase and the principal antioxidative function during anaerobic growth. J Biol Chem 279: 8769- 8778, 2004.
41. Chae H, Chung S, and Rhee S. Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269: 27670- 27678, 1994.
42. Chae H, Robison K, Poole L, Church G, Storz G, and Rhee S. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiolspecific antioxidant define a large family of antioxidant enzymes. Proc Natl Acad Sci U S A 91: 7017-7021, 1994. (Pubitemid 24226793)
43. Chaithirayanon K and Sobhon P. Molecular cloning and characterization of two genes encoding 2-Cys peroxiredoxins from Fasciola gigantica. Exp Parasitol 125: 106-113, 2010.
44. Chandrashekar R, Curtis K, Lu W, and Weil G. Molecular cloning of an enzymatically active thioredoxin peroxidase from Onchocerca volvulus. Mol Biochem Parasitol 93: 309-312, 1998. (Pubitemid 28277067)
45. Chandrashekar R, Tsuji N, Morales TH, Carmody AB, Ozols VO, Welton J, and Tang L. Removal of hydrogen peroxide by a 1-cysteine peroxiredoxin enzyme of the filarial parasite Dirofilaria immitis. Parasitol Res 86: 200-206, 2000.
46. Chang T-S, Jeong W, Woo HA, Lee SM, Park S, and Rhee SG. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J Biol Chem 279: 50994-51001, 2004. (Pubitemid 40017840)
47. Cheng X and Tachibana H. Molecular cloning and characterization of peroxiredoxin from Entamoeba moshkovskii. Arch Med Res 31: S65-S66, 2000.
48. Cheng X-J, Yoshihara E, Takeuchi T, and Tachibana H. Molecular characterization of peroxiredoxin from Entamoeba moshkovskii and a comparison with Entamoeba histolytica. Mol Biochem Parasitol 138: 195-203, 2004. (Pubitemid 39536229)
49. Choi HJ, Kang SW, Yang CH, Rhee SG, and Ryu SE. Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat Struct Biol 5: 400-406, 1998. (Pubitemid 28211179)
50. Choi M-H, Sajed D, Poole L, Hirata K, Herdman S, Torian BE, and Reed SL. An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack. Mol Biochem Parasitol 143: 80-89, 2005. (Pubitemid 41039034)
51. Coler RN, Goto Y, Bogatzki L, Raman V, and Reed SG. Leish-111f, a recombinant polyprotein vaccine that protects against visceral Leishmaniasis by elicitation of CD4 + T cells. Infect Immun 75: 4648-4654, 2007. (Pubitemid 47378126)
52. Cooley RB, Arp DJ, and Karplus PA. Evolutionary origin of a secondary structure: pi-helices as cryptic but widespread insertional variations of alpha-helices that enhance protein functionality. J Mol Biol 404: 232-246, 2010.
53. Coombs GH, Westrop GD, Suchan P, Puzova G, Hirt RP, Embley TM, Mottram JC, and Müller S. The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. J Biol Chem 279: 5249-5256, 2004. (Pubitemid 38220544)
54. Cordeiro-da-Silva A, Cardoso L, Araujo N, Castro H, Tomas A, Rodrigues M, Cabral M, Vergnes B, Sereno D, and Ouaissi A. Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications. Immunol Lett 86: 155-162, 2003. (Pubitemid 36324276)
55. Cuervo P, De Jesus J, Saboia-Vahia L, Mendonça-Lima L, Domont G, and Cupolillo E. Proteomic characterization of the released/secreted proteins of Leishmania (Viannia) braziliensis promastigotes. J Proteomics 73: 79-92, 2009.
56. Cunningham ML, Zvelebil MJ, and Fairlamb AH. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. Eur J Biochem 221: 285-295, 1994. (Pubitemid 24120573)
57. Davis P, Zhang X, Guo J, Townsend R, and Stanley S. Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. Mol Microbiol 61: 1523-1532, 2006. (Pubitemid 44359380)
58. de Oliveira A, Ruiz J, Cruz A, Greene L, Rosa J, and Ward R. Subproteomic analysis of soluble proteins of the microsomal fraction from two Leishmania species. Comp Biochem Physiol Part D Genomics Proteomics 1: 300-308, 2006. (Pubitemid 44437815)
59. Dea-Ayuela M, Ordonez-Gutierrez L, and Bolas-Fernandez F. Changes in the proteome and infectivity of Leishmania infantum induced by in vitro exposure to a nitric oxide donor. Int J Med Microbiol 299: 221-232, 2009.
60. Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A, and Knoops B. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 Å resolution. J Mol Biol 311: 751-759, 2001. (Pubitemid 32803733)
61. Deponte M and Becker K. Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx. Mol Biochem Parasitol 140: 87-96, 2005. (Pubitemid 40203418)
62. DeponteM, Rahlfs S, and Becker K. Peroxiredoxin systems of protozoal parasites. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 219-229.
63. Diamond LS and Clark CG. A redescription of Entamoeba histolytica Schaudinn, 1903 (Emended Walker, 1911) separating it from Entamoeba dispar Brumpt, 1925. J Eukaryot Microbiol 40: 340-344, 1993.
64. Diaz M, Solari A, and Gonzalez C. Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. J Proteomics 74: 1673-1682, 2011.
65. Diechtierow M and Krauth-Siegel R. A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage. Free Radic Biol Med 51: 856-868, 2011.
66. Ding M, Kwok LY, Schluter D, Clayton C, and Soldati D. The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Mol Microbiol 51: 47-61, 2004. (Pubitemid 38031070)
67. Donnelly S, O'Neill S, Sekiya M, Mulcahy G, and Dalton J. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun 73: 166-173, 2005. (Pubitemid 40041106)
68. Donnelly S, Stack C, O'Neill S, Sayed A, Williams D, and Dalton J. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J 22: 4022-4032, 2008.
69. El Ridi R and Tallima H. Schistosoma mansoni ex vivo lungstage larvae excretory-secretory antigens as vaccine candidates against schistosomiasis. Vaccine 27: 666-673, 2009.
70. Ellis JE, Yarlett N, Cole D, Humphreys MJ, and Lloyd D. Antioxidant defences in the microaerophilic protozoan Trichomonas vaginalis: comparison of metronidazole-resistant and sensitive strains. Microbiology 140: 2489-2494, 1994. (Pubitemid 24297057)
71. Emanuelsson O, Brunak S, von Heijne G, and Nielsen H. Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc 2: 953-971, 2007. (Pubitemid 46745592)
72. Eslami G, Frikha F, Salehi R, Khamesipour A, Hejazi H, and Nilforoushzadeh M. Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/ 75/ER). Mol Biol Rep 38: 3765-3776, 2011.
73. Fahey R, Newton G, Arrick B, and Overdank-Bogart T. Entamoeba histolytica: a eukaryote without glutathione metabolism. Science 224: 70-72, 1984. (Pubitemid 14171643)
74. Fairlamb AH, Henderson GB, and Cerami A. Trypanothione is the primary target for arsenical drugs against African trypanosomes. Proc Natl Acad Sci U S A 86: 2607-2611, 1989. (Pubitemid 19112596)
75. Fast NM, Law JS, Williams BAP, and Keeling PJ. Bacterial catalase in the microsporidian Nosema locustae: implications for microsporidian metabolism and genome evolution. Eukaryot cell 2: 1069-1075, 2003. (Pubitemid 37298721)
76. Felsenstein J. PHYLIP - Phylogeny Inference Package (Version 3.2). Cladistics 5: 164-166, 1989.
77. Ferrer-Sueta G, Manta B, Botti H, Radi R, Trujillo M, and Denicola A. Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem Res Toxicol 24: 434-450, 2011.
78. Finzi J, Chiavegatto C, Corat K, Lopez J, Cabrera O, Mielniczki-Pereira A, Colli W, Alves M, and Gadelha F. Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide. Mol Biochem Parasitol 133: 37-43, 2004. (Pubitemid 37510306)
79. Flohé L. Changing paradigms in thiology from antioxidant defense toward redox regulation. Methods Enzymol 473: 1-39, 2010.
80. Flohé L, Budde H, Bruns K, Castro H, Clos J, Hofmann B, Kansal-Kalavar S, Krumme D, Menge U, Plank-Schumacher K, Sztajer H, Wissing J, Wylegalla C, and Hecht H. Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism. Arch Biochem Biophys 397: 324-335, 2002. (Pubitemid 34852299)
81. Flohé L, Budde H, and Hofmann B. Peroxiredoxins in antioxidant defense and redox regulation. Biofactors 19: 3-10, 2003. (Pubitemid 38073139)
82. Flores BM, Batzer MA, Stein MA, Petersen C, Diedrich DL, and Torian BE. Structural analysis and demonstration of the 29 kDa antigen of pathogenic Entamoeba histolytica as the major accessible free thiol-containing surface protein. Mol Microbiol 7: 755-763, 1993. (Pubitemid 23090357)
83. Foster J, Ganatra M, Kamal I, Ware J, Makarova K, Ivanova N, Bhattacharyya A, Kapatral V, Kumar S, Posfai J, Vincze T, Ingram J, Moran L, Lapidus A, Omelchenko M, Kyrpides N, Ghedin E, Wang S, Goltsman E, Joukov V, Ostrovskaya O, Tsukerman K, Mazur M, Comb D, Koonin E, and Slatko B. The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol 3: e121, 2005.
84. Fritz-Laylin LK, Prochnik SE, Ginger ML, Dacks JB, Carpenter ML, Field MC, Kuo A, Paredez A, Chapman J, Pham J, Shu S, Neupane R, Cipriano M, Mancuso J, Tu H, Salamov A, Lindquist E, Shapiro H, Lucas S, Grigoriev IV, Cande WZ, Fulton C, Rokhsar DS, and Dawson SC. The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell 140: 631-642, 2010.
85. Gajria B, Bahl A, Brestelli J, Dommer J, Fischer S, Gao X, Heiges M, Iodice J, Kissinger JC, Mackey AJ, Pinney DF, Roos DS, Stoeckert CJ, Wang H, and Brunk BP. ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res 36: D553-D556, 2008. (Pubitemid 351149784)
86. Ghosh I, Eisinger S, Raghavan N, and Scott A. Thioredoxin peroxidases from Brugia malayi. Mol Biochem Parasitol 91: 207-220, 1998.
87. Guerrero S, Lopez J, Steinert P, Montemartini M, Kalisz H, Colli W, Singh M, Alves M, and Flohe L. His-tagged tryparedoxin peroxidase of Trypanosoma cruzi as a tool for drug screening. Appl Microbiol Biotechnol 53: 410-414, 2000. (Pubitemid 30236113)
88. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, and Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 59: 307-321, 2010.
89. Hall A, Karplus PA, and Poole LB. Typical 2-Cys peroxiredoxins- structures, mechanisms and functions. FEBS J 276: 2469-2477, 2009.
90. Hall A, Nelson KJ, Poole LB, and Karplus PA. Structurebased insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal 15: 795- 815, 2011.
91. Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, and Barbar E. Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry 48: 5984-5993, 2009.
92. Hall A, Parsonage D, Poole LB, and Karplus PA. Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol 402: 194-209, 2010.
93. Hall A, Sankaran B, Poole LB, and Karplus PA. structural changes common to catalysis in the Tpx peroxiredoxin subfamily. J Mol Biol 393: 867-881, 2009.
94. Hamza A. Homology modeling and docking mechanism of the mercaptosuccinate and methotrexate to P. falciparum 1- Cys peroxiredoxin: a preliminary molecular study. J Biomol Struct Dyn 20: 7-20, 2002.
95. Haraldsen J, Liu G, Botting C, Walton J, Storm J, Phalen T, Kwok L, Soldati-Favre D, Heintz N, Müller S, Westwood N, and Ward G. Identification of conoidin A as a covalent inhibitor of peroxiredoxin II. Org Biomol Chem 7: 3040, 2009.
96. Harder S, Bente M, Isermann K, and Bruchhaus I. Expression of a mitochondrial peroxiredoxin prevents programmed cell death in Leishmania donovani. Eukaryot Cell 5: 861-870, 2006. (Pubitemid 43794484)
97. Hattori F and Oikawa S. Peroxiredoxins in the central nervous system. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 357-374.
98. Heiges M, Wang H, Robinson E, Aurrecoechea C, Gao X, Kaluskar N, Rhodes P, Wang S, He C-Z, Su Y, Miller J, Kraemer E, and Kissinger JC. CryptoDB: a Cryptosporidium bioinformatics resource update. Nucleic Acids Res 34: D419- D422, 2006.
99. Hotez P and Pecoul B. "Manifesto" for advancing the control and elimination of neglected tropical diseases. PLoS Negl Trop Dis 4: e718, 2010.
100. Hou Q, Wang H, Zhang Z, Cao W, Zhang F, and Zhang W. [Immunolocalization of the antioxidant protein TPx of Echinococcus granulosus] (abstract of Chinese-language article). Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 998-1000, 2007.
101. Hsu J-Y, Lin Y-C, Chiang S-C, and Lee S. Divergence of trypanothione-dependent tryparedoxin cascade into cytosolic and mitochondrial pathways in arsenite-resistant variants of Leishmania amazonensis. Mol Biochem Parasitol 157: 193-204, 2008.
102. Hughes M, Lee C, Holm C, Ghosh S, Mills A, Lockhart L, Reed S, and Mann B. Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein. Mol Biochem Parasitol 127: 113-120, 2003. (Pubitemid 36369686)
103. Hugo M, Turell L, Manta B, Botti H, Monteiro G, Netto L, Alvarez B, Radi R, and Trujillo M. Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry 48: 9416-9426, 2009.
104. Isakov E, Siman-Tov R, Weber C, Guillen N, and Ankri S. Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. Mol Biochem Parasitol 158: 82-94, 2008. (Pubitemid 351172466)
105. Ishii T and Yanagawa T. Stress-induced peroxiredoxins. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 375-384.
106. Iyer J, Kaprakkaden A, Choudhary M, and Shaha C. Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence. Mol Microbiol 68: 372-391, 2008. (Pubitemid 351422957)
107. Jaeger T and Flohe L. The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs. Biofactors 27: 109-120, 2006. (Pubitemid 44444593)
108. Jefferies J, Campbell A, van Rossum A, Barrett J, and Brophy P. Proteomic analysis of Fasciola hepatica excretorysecretory products. Proteomics 1: 1128-1132, 2001. (Pubitemid 33696478)
109. Jeong W, Cha MK, and Kim IH. Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiolspecific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family. J Biol Chem 275: 2924-2930, 2000. (Pubitemid 30082068)
110. Jiménez-Delgadillo B, Chaudhuri PP, Baylón-Pacheco L, López-Monteon A, Talamás-Rohana P, and Rosales-Encina JL. Entamoeba histolytica: cDNAs cloned as 30 kDa collagenbinding proteins (CBP) belong to an antioxidant molecule family. Protection of hamsters from amoebic liver abscess by immunization with recombinant CBP. Exp Parasitol 108: 7-17, 2004. (Pubitemid 39445850)
111. Jing B, Deng S, Zhang R, and Zhang J. [Comparative proteomic analysis of the promastigotes and amastigotes of Leishmania donovani] (abstract of Chinese-language article). Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 27: 102-106, 2009.
112. Jirata D, Kuru T, Genetu A, Barr S, Hailu A, Aseffa A, and Gedamu L. Identification, sequencing and expression of peroxidoxin genes from Leishmania aethiopica. Acta Trop 99: 88-96, 2006. (Pubitemid 44402246)
113. Jönsson T and Lowther W. The peroxiredoxin repair proteins. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 115-141.
114. Ju J, Joo H, Lee M, Cho S, Cheun H, Kim J, Lee Y, Lee K, Sohn W, Kim D, Kim I, Park B, and Kim T. Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms. Proteomics 9: 3066-3078, 2009.
115. Kang S, Baines I, and Rhee S. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. J Biol Chem 273: 6303-6311, 1998. (Pubitemid 28144720)
116. Kang S, Rhee S, Chang T-S, Jeong W, and Choi M. 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends Mol Med 11: 571-578, 2005. (Pubitemid 41713999)
117. Kawazu S, Ikenoue N, Takemae H, Komaki-Yasuda K, and Kano S. Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum. FEBS J 272: 1784-1791, 2005. (Pubitemid 40516227)
118. Kawazu S, Komaki K, Tsuji N, Kawai S, Ikenoue N, Hatabu T, Ishikawa H, Matsumoto Y, Himeno K, and Kano S. Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 116: 73-79, 2001. (Pubitemid 32706428)
119. Kawazu S, Nozaki T, Tsuboi T, Nakano Y, Komaki-Yasuda K, Ikenoue N, Torii M, and Kano S. Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii. Int J Parasitol 33: 1455-1461, 2003. (Pubitemid 37324183)
120. Kawazu S, Tsuji N, Hatabu T, Kawai S, Matsumoto Y, and Kano S. Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 109: 165-169, 2000. (Pubitemid 30665413)
121. Kehr S, Sturm N, Rahlfs S, Przyborski JM, and Becker K. Compartmentation of redox metabolism in malaria parasites. PLoS Pathog 6: e1001242, 2010.
122. Kim J, Yang A, Sohn H, Kim D, Song K, and Shin H. Immunodominant antigens in Naegleria fowleri excretory- secretory proteins were potential pathogenic factors. Parasitol Res 105: 1675-1681, 2009.
123. Kim K, Kim IH, Lee KY, Rhee SG, and Stadtman ER. The isolation and purification of a specific ''protector'' protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biochem 263: 4704-4711, 1988.
124. Kim SJ, Woo JR, Hwang YS, Jeong DG, Shin DH, Kim K, and Ryu SE. The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins. J Biochem 278: 10790-10798, 2003. (Pubitemid 36800352)
125. Kima P, Bonilla J, Cho E, Ndjamen B, Canton J, Leal N, and Handfield M. Identification of Leishmania proteins preferentially released in infected cells using change mediated antigen technology (CMAT). PLoS Negl Trop Dis 4: pii e842, 2010.
126. Klomsiri C, Karplus PA, and Poole LB. Cysteine-based redox switches in enzymes. Antioxid Redox Signal 14: 1065- 1077, 2011.
127. Klotz FW, Hadley TJ, Aikawa M, Leech J, Howard RJ, and Miller LH. A 60-kDa Plasmodium falciparum protein at the moving junction formed between merozoite and erythrocyte during invasion. Mol Biochem Parasitol 36: 177-185, 1989.
128. Knoops B, Loumaye E, and Van Der Eecken V. Evolution of the peroxiredoxins. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 27-40.
129. Komaki-Yasuda K, Kawazu S, and Kano S. Disruption of the Plasmodium falciparum 2-Cys peroxiredoxin gene renders parasites hypersensitive to reactive oxygen and nitrogen species. FEBS Lett 547: 140-144, 2003. (Pubitemid 36829394)
130. Komaki-Yasuda K, Okuwaki M, Kano S, Nagata K, and Kawazu S. 5¢ sequence- and chromatin modificationdependent gene expression in Plasmodium falciparum erythrocytic stage. Mol Biochem Parasitol 162: 40-51, 2008.
131. Koncarevic S, Rohrbach P, Deponte M, Krohne G, Prieto JH, Yates J, Rahlfs S, and Becker K. The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification. Proc Natl Acad Sci U S A 106: 13323-13328, 2009.
132. Kong W, Shiota S, Shi Y, Nakayama H, and Nakayama K. A novel peroxiredoxin of the plant Sedum lineare is a homologue of Escherichia coli bacterioferritin co-migratory protein (Bcp). Biochem J 351: 107-114, 2000.
133. Konig J and Fairlamb A. A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major. FEBS J 274: 5643-5658, 2007. (Pubitemid 47622078)
134. Konig J, Wyllie S, Wells G, Stevens M, Wyatt P, and Fairlamb A. Antitumor quinol PMX464 is a cytocidal antitrypanosomal inhibitor targeting trypanothione metabolism. J Biol Chem 286: 8523-8533, 2011.
135. Krauth-Siegel L, Comini M, and Schlecker T. The trypanothione system. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 231-251.
136. Krauth-Siegel R, Bauer H, and Schirmer R. Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malariacausing plasmodia. Angew Chem Int Ed Engl 44: 690-715, 2005. (Pubitemid 40203977)
137. Krnajski Z, Walter R, and Müller S. Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum. Mol Biochem Parasitol 113: 303- 308, 2001.
138. Kumagai T, Osada Y, and Kanazawa T. 2-Cys peroxiredoxins from Schistosoma japonicum: the expression profile and localization in the life cycle. Mol Biochem Parasitol 149: 135-143, 2006. (Pubitemid 44403931)
139. Kumagai T, Osada Y, Ohta N, and Kanazawa T. Peroxiredoxin- 1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide. Mol Biochem Parasitol 164: 26-31, 2009.
140. Kwatia M, Botkin D, and Williams D. Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase. J Parasitol 86: 908-915, 2000.
141. Kwok L, Schlüter D, Clayton C, and Soldati D. The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Mol Microbiol 51: 47-61, 2003. (Pubitemid 38031070)
142. Lee SU, Joung M, Nam T, Park WY, Ji YH, and Yu JR. Cryptosporidium parvum: radiation-induced alteration of the oocyst proteome. Exp Parasitol 127: 25-30, 2011.
143. Leitsch D, Kolarich D, Binder M, Stadlmann J, Altmann F, and Duchene M. Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance. Mol Microbiol 72: 518-536, 2009.
144. Levick M, Tetaud E, Fairlamb A, and Blackwell J. Identification and characterisation of a functional peroxidoxin from Leishmania major. Mol Biochem Parasitol 96: 125-137, 1998. (Pubitemid 28511029)
145. Li J, Zhang W, Loukas A, Lin R, Ito A, Zhang L, Jones M, and McManus D. Functional expression and characteriza- tion of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. Gene 326: 157-165, 2004. (Pubitemid 38068497)
146. Li S, Peterson N, Kim M, Kim C, Hung L, Yu M, Lekin T, Segelke B, Lott J, and Baker E. Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. J Mol Biol 346: 1035-1046, 2005. (Pubitemid 40215528)
147. Liao S-J, Yang C-Y, Chin K-H, Wang AHJ, and Chou S-H. Insights into the alkyl peroxide reduction pathway of Xanthomonas campestris bacterioferritin comigratory protein from the trapped intermediate-ligand complex structures. J Mol Biol 390: 951-966, 2009.
148. Lim YS, Cha MK, Kim HK, Uhm TB, Park JW, Kim K, and Kim IH. Removals of hydrogen peroxide and hydroxyl radical by thiol-specific antioxidant protein as a possible role in vivo. Biochem Biophys Res Commun 192: 273-280, 1993. (Pubitemid 23205297)
149. Lin Y-C, Hsu J-Y, Chiang S-C, and Lee S. Distinct overexpression of cytosolic and mitochondrial tryparedoxin peroxidases results in preferential detoxification of different oxidants in arsenite-resistant Leishmania amazonensis with and without DNA amplification. Mol Biochem Parasitol 142: 66-75, 2005. (Pubitemid 40720129)
150. Liu G, Botting C, Evans K, Walton J, Xu G, Slawin A, and Westwood N. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem 5: 41-45, 2010.
151. Lopez J, Carvalho T, de Souza W, Flohe L, Guerrero S, Montemartini M, Kalisz H, Nogoceke E, Singh M, Alves M, and Colli W. Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi. Free Radic Biol Med 28: 767-772, 2000. (Pubitemid 30171290)
152. Lu W, Egerton G, Bianco A, and Williams S. Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites. Mol Biochem Parasitol 91: 221-235, 1998. (Pubitemid 28161455)
153. MacFarlane R and Singh U. Identification of differentially expressed genes in virulent and nonvirulent Entamoeba species: potential implications for amebic pathogenesis. Infect Immun 74: 340-351, 2006. (Pubitemid 43023090)
154. Madhumathi J, Anugraha G, Prince P, Pradiba D, and Kaliraj P. Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis. Microbes Infect 13: 602-606, 2011.
155. Madhumathi J, Prince P, Gayatri S, Aparnaa R, and Kaliraj P. Identification of a highly immunoreactive epitope of Brugia malayi TPx recognized by the endemic sera. J Parasitol 96: 1228-1229, 2010.
156. Maiorino M, Roche C, Kiess M, Koenig K, Gawlik D, Matthes M, Naldini E, Pierce R, and Flohe L. A seleniumcontaining phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni. Eur J Biochem 238: 838-844, 1996. (Pubitemid 26235128)
157. Manevich Y and Fisher AB. Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Radic Biol Med 38: 1422- 1432, 2005.
158. Margutti P, Ortona E, Delunardo F, Tagliani A, Profumo E, Rigano R, Buttari B, Teggi A, and Siracusano A. Thioredoxin peroxidase from Echinococcus granulosus: a candidate to extend the antigenic panel for the immunodiagnosis of human cystic echinococcosis. Diagn Microbiol Infect Dis 60: 279-285, 2008. (Pubitemid 351253606)
159. Marshall E, Elshekiha H, Hakimi M-A, and Flynn R. Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1b secretion enhances parasite replication. Vet Res 42: 80, 2011.
160. McGonigle S, Curley G, and Dalton J. Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica. Parasitology 115: 101-104, 1997. (Pubitemid 27337233)
161. Mendes R, Perez-Ecija R, Zafra R, Buffoni L, Martinez- Moreno A, Dalton J, Mulcahy G, and Perez J. Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica. Vaccine 28: 2832-2840, 2010.
162. Mentel M, Zimorski V, Haferkamp P, Martin W, and Henze K. Protein import into hydrogenosomes of Trichomonas vaginalis involves both N-terminal and internal targeting signals: a case study of thioredoxin reductases. Eukaryot Cell 7: 1750-1757, 2008.
163. Mielniczki-Pereira A, Chiavegatto C, Lopez J, Colli W, Alves M, and Gadelha F. Trypanosoma cruzi strains, Tulahuen 2 and Y, besides the difference in resistance to oxidative stress, display differential glucose-6-phosphate and 6-phosphogluconate dehydrogenases activities. Acta Trop 101: 54-60, 2007. (Pubitemid 46198791)
164. Missall T, Lodge J, and Mcewen J. Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts. Eukaryot Cell 3: 835- 846, 2004.
165. Missall T, Moran J, Corbett J, and Lodge J. Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. Eukaryot Cell 4: 202-208, 2005. (Pubitemid 40234437)
166. Missall TA, Pusateri ME, Donlin MJ, Chambers KT, Corbett JA, and Lodge JK. Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot Cell 5: 518-529, 2006.
167. Missall TA, Pusateri ME, and Lodge JK. Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. Mol Microbiol 51: 1447-1458, 2004. (Pubitemid 38338905)
168. Mkoji GM, Smith JM, and Prichard RK. Antioxidant systems in Schistosoma mansoni: correlation between susceptibility to oxidant killing and the levels of scavengers of hydrogen peroxide and oxygen free radicals. Int J Parasitol 18: 661-666, 1988.
169. Mogi T and Kita K. Diversity in mitochondrial metabolic pathways in parasitic protists Plasmodium and Cryptosporidium. Parasitol Int 59: 305-312, 2010.
170. Molina-López J, Jiménez L, Ochoa-Sánchez A, and Landa A. Molecular cloning and characterization of a 2-Cys peroxiredoxin from Taenia solium. J Parasitol 92: 796-802, 2006. (Pubitemid 44435598)
171. Monteiro G, Horta B, Pimenta D, Augusto O, and Netto L. Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proc Natl Acad Sci U S A 104: 4886- 4891, 2007.
172. Moran M. Funding for research and development and the financial crisis. Lancet Infect Dis 10: 214-215, 2010.
173. Moran M, Guzman J, Ropars A-L, McDonald A, Jameson N, Omune B, Ryan S, and Wu L. Neglected disease research and development: how much are we really spending? PLoS Med 6: e30, 2009.
174. Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, Huse SM, Kim UU, Lasek-Nesselquist E, Manning G, Nigam A, Nixon JE, Palm D, Passamaneck NE, Prabhu A, Reich CI, Reiner DS, Samuelson J, Svard SG, and Sogin ML. Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science 317: 1921-1926, 2007. (Pubitemid 47509437)
175. Motyka S, Drew M, Yildirir G, and Englund P. Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. J Biol Chem 281: 18499-18506, 2006. (Pubitemid 44035509)
176. Mourao M, Dinguirard N, Franco G, and Yoshino T. Phenotypic screen of early-developing larvae of the blood fluke, Schistosoma mansoni, using RNA interference. PLoS Negl Trop Dis 3: e502, 2009.
177. Mourao Mde M, Dinguirard N, Franco G, and Yoshino T. Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stress. PLoS Negl Trop Dis 3: e550, 2009.
178. Mukhopadhyay R, Dey S, Xu N, Gage D, Lightbody J, Ouellette M, and Rosen BP. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Proc Natl Acad Sci U S A 93: 10383-10387, 1996. (Pubitemid 26314631)
179. Müller M. The hydrogenosome. J Gen Microbiol 139: 2879- 2889, 1993.
180. Müller S. Redox and antioxidant systems of the malaria parasite Plasmodium falciparum. Mol Microbiol 53: 1291-1305, 2004. (Pubitemid 39209105)
181. Murphy S, Samuel B, Harrison T, Speicher K, Speicher D, Reid M, Prohaska R, Low P, Tanner M, Mohandas N, and Haldar K. Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection. Blood 103: 1920-1928, 2004. (Pubitemid 38268992)
182. Murray H and Nathan C. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med 189: 741-746, 1999. (Pubitemid 29193376)
183. Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, and Fetrow JS. Analysis of the peroxiredoxin family: using active- site structure and sequence information for global classification and residue analysis. Proteins 79: 947-964, 2010.
184. Netto L, Chae H, Kang S, Rhee S, and Stadtman E. Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. TSA possesses thiol peroxidase activity. J Biol Chem 271: 15315- 15321, 1996.
185. Nickel C, Rahlfs S, Deponte M, Koncarevic S, and Becker K. Thioredoxin networks in the malarial parasite Plasmodium falciparum. Antioxid Redox Signal 8: 1227-1239, 2006. (Pubitemid 44182421)
186. Nickel C, Trujillo M, Rahlfs S, Deponte M, Radi R, and Becker K. Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite. Biol Chem 386: 1129-1136, 2005. (Pubitemid 41705367)
187. Nogoceke E, Gommel D, Kiess M, Kalisz H, and Flohe L. A unique cascade of oxidoreductases catalyses trypanothione- mediated peroxide metabolism in Crithidia fasciculata. Biol Chem 378: 827-836, 1997. (Pubitemid 27388943)
188. Nogueira F, Ruiz J, Robello C, Romanha A, and Murta S. Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Parasitol Res 104: 835-844, 2009.
189. Paget TA and Lloyd D. Trichomonas vaginalis requires traces of oxygen and high concentrations of carbon dioxide for optimal growth. Mol Biochem Parasitol 41: 65-72, 1990. (Pubitemid 20176669)
190. Parsonage D, Karplus PA, and Poole LB. Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Proc Natl Acad Sci U S A 105: 8209-8214, 2008. (Pubitemid 351904736)
191. Parsonage D, Youngblood DS, Sarma GN, Wood ZA, Karplus PA, and Poole LB. Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin. Biochemistry 44: 10583-10592, 2005. (Pubitemid 41098235)
192. Pedone E, Limauro D, D'Ambrosio K, De Simone G, and Bartolucci S. Multiple catalytically active thioredoxin folds: a winning strategy for many functions. Cell Mol Life Sci 67: 3797-3814, 2010.
193. Pedrajas J, Miranda-Vizuete A, Javanmardy N, Gustafsson J, and Spyrou G. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem 275: 16296- 16301, 2000.
194. Pescher P, Blisnick T, Bastin P, and Spath G. Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation. Cell Microbiol 13: 978-991, 2011.
195. Peskin A, Low F, Paton L, and Maghzal G. The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. J Biol Chem 282: 11885-11892, 2007. (Pubitemid 47100684)
196. Peskin AV, Cox AG, Nagy P, Morgan PE, Hampton MB, Davies MJ, and Winterbourn CC. Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochem J 432: 313-321, 2010.
197. Phalen T, Weirather K, Deming P, Anathy V, Howe A, Van Der Vliet A, Jonsson T, Poole L, and Heintz N. Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol 175: 779-789, 2006. (Pubitemid 44878510)
198. Piacenza L, Alvarez M, Peluffo G, and Radi R. Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol 12: 415-421, 2009.
199. Piacenza L, Peluffo G, Alvarez M, Kelly J, Wilkinson S, and Radi R. Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenouslyderived peroxynitrite. Biochem J 410: 359-368, 2008. (Pubitemid 351346194)
200. Piacenza L, Zago M, Peluffo G, Alvarez M, Basombrio M, and Radi R. Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence. Int J Parasitol 39: 1455-1464, 2009.
201. Piñeyro M, Arcari T, Robello C, Radi R, and Trujillo M. Tryparedoxin peroxidases from Trypanosoma cruzi: High efficiency in the catalytic elimination of hydrogen peroxide and peroxynitrite. Arch Biochem Biophys 507: 287-295, 2011.
202. Piñeyro M, Pizarro J, Lema F, Pritsch O, Cayota A, Bentley G, and Robello C. Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi. J Struct Biol 150: 11-22, 2005. (Pubitemid 40395298)
203. Piñeyro MD, Parodi-Talice A, Portela M, Arias DG, Guerrero SA, and Robello C. Molecular characterization and interactome analysis of Trypanosoma cruzi Tryparedoxin 1. J Proteomics 74: 1683-1692, 2011.
204. Pino P, Foth BJ, Kwok LY, Sheiner, L, Schepers R, Soldati T, and Soldati-Favre D. Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii. PLoS Pathog 3: e115, 2007.
205. Poole LB. Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases. Arch Biochem Biophys 433: 240-254, 2005. (Pubitemid 39586595)
206. Poole L and Nelson K. Discovering mechanisms of signalingmediated cysteine oxidation. Curr Opin Chem Biol 12: 18, 2008.
207. Poole LB, Chae HZ, Flores BM, Reed SL, Rhee SG, and Torian BE. Peroxidase activity of a TSA-like antioxidant protein from a pathogenic amoeba. Free Radic Biol Med 23: 955-959, 1997. (Pubitemid 27402621)
208. Poole LB and Ellis HR. Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase. In: Methods in Enzymology, edited by Sies H and Packer L. Maryland Heights, MO: Academic Press, 2002, pp. 122-136. (Pubitemid 41103104)
209. Putz S, Gelius-Dietrich G, Piotrowski M, and Henze K. Rubrerythrin and peroxiredoxin: two novel putative peroxidases in the hydrogenosomes of the microaerophilic protozoon Trichomonas vaginalis. Mol Biochem Parasitol 142: 212-223, 2005. (Pubitemid 40835913)
210. Rahlfs S and Becker K. Thioredoxin peroxidases of the malarial parasite Plasmodium falciparum. Eur J Biochem 268: 1404-1409, 2001. (Pubitemid 32231894)
211. Raina O, Nagar G, Varghese A, Prajitha G, Alex A, Maharana B, and Joshi P. Lack of protective efficacy in buffaloes vaccinated with Fasciola gigantica leucine aminopeptidase and peroxiredoxin recombinant proteins. Acta Trop 118: 217-222, 2011.
212. Ramos-Martinez E, Olivos-Garcia A, Saavedra E, Nequiz M, Sanchez E, Tello E, El-Hafidi M, Saralegui A, Pineda E, Delgado J, Montfort I, and Perez-Tamayo R. Entamoeba histolytica: oxygen resistance and virulence. Int J Parasitol 39: 693-702, 2009.
213. Rhee SG and Woo HA. Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones. Antioxid Redox Signal 15: 781-794, 2011.
214. Richard D, Bartfai R, Volz J, Ralph SA, Müller S, Stunnenberg HG, and Cowman AF. A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum. J Biol Chem 286: 11746-11755, 2011.
215. Romao S, Castro H, Sousa C, Carvalho S, and Tomas AM. The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival. Int J Parasitol 39: 703-711, 2009.
216. Roos D, Crawford MJ, Donald RG, Fraunholz M, Harb OS, He CY, Kissinger JC, Shaw MK, and Striepen B. Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? Philos Trans R Soc Lond B Biol Sci 357: 35-46, 2002. (Pubitemid 34147262)
217. Salazar-Calderon M, Martin-Alonso J, Ruiz de Eguino A, Casais R, Marin M, and Parra F. Fasciola hepatica: heterologous expression and functional characterization of a thioredoxin peroxidase. Exp Parasitol 95: 63-70, 2000. (Pubitemid 30415954)
218. Salinas G, Fernandez V, Fernandez C, and Selkirk M. Echinococcus granulosus: cloning of a thioredoxin peroxidase. Exp Parasitol 90: 298-301, 1998. (Pubitemid 28525106)
219. Santarem N, Silvestre R, Cardoso L, Schallig H, Reed S, and Cordeiro-da-Silva A. Application of an improved enzymelinked immunosorbent assay method for serological diagnosis of canine leishmaniasis. J Clin Microbiol 48: 1866-1874, 2010.
220. Santarem N, Tomas A, Ouaissi A, Tavares J, Ferreira N, Manso A, Campino L, Correia J, and Cordeiro-da-Silva A. Antibodies against a Leishmania infantum peroxiredoxin as a possible marker for diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment. Immunol Lett 101: 18-23, 2005. (Pubitemid 41297494)
221. Santi-Rocca J, Weber C, Guigon G, Sismeiro O, Coppee J, and Guillen N. The lysine- and glutamic acid-rich protein KERP1 plays a role in Entamoeba histolytica liver abscess pathogenesis. Cell Microbiol 10: 202-217, 2008. (Pubitemid 350252854)
222. Sarma GN, Nickel C, Rahlfs S, Fischer M, Becker K, and Karplus PA. Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin. J Mol Biol 346: 1021-1034, 2005. (Pubitemid 40215527)
223. Sautel C, Ortet P, Saksouk N, Kieffer S, Garin J, Bastien O, and Hakimi M. The histone methylase KMTox interacts with the redox-sensor peroxiredoxin-1 and targets genes involved in Toxoplasma gondii antioxidant defences. Mol Microbiol 71: 212-226, 2009.
224. Sayed AA, Cook SK, and Williams DL. Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. J Biol Chem 281: 17001-17010, 2006.
225. Sayed AA and Williams DL. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. J Biol Chem 279: 26159-26166, 2004. (Pubitemid 38798761)
226. Sayers EW, Barrett T, Benson DA, Bolton E, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Federhen S, Feolo M, Fingerman IM, Geer LY, Helmberg W, Kapustin Y, Landsman D, Lipman DJ, Lu Z, Madden TL, Madej T, Maglott DR, Marchler-Bauer A, Miller V, Mizrachi I, Ostell J, Panchenko A, Phan L, Pruitt KD, Schuler GD, Sequeira E, Sherry ST, Shumway M, Sirotkin K, Slotta D, Souvorov A, Starchenko G, Tatusova TA, Wagner L, Wang Y, Wilbur WJ, Yaschenko E, and Ye J. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 39: D38-D51, 2011.
227. Schrum S, Bialonski A, Marti T, and Zipfel P. Identification of a peroxidoxin protein (OvPXN-2) of the human parasitic nematode Onchocerca volvulus by sequential protein fractionation. Mol Biochem Parasitol 94: 131-135, 1998. (Pubitemid 28345155)
228. Seeber F and Soldati-Favre D. Metabolic pathways in the apicoplast of apicomplexa. Int Rev Cell Mol Biol 281: 161- 228, 2010.
229. Sekiya M, Mulcahy G, Irwin J, Stack C, Donnelly S, Xu W, Collins P, and Dalton J. Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica. FEBS Lett 580: 5016-5022, 2006. (Pubitemid 44404083)
230. Sela D, Yaffe N, and Shlomai J. Enzymatic mechanism controls redox-mediated protein-DNA interactions at the replication origin of kinetoplast DNA minicircles. J Biol Chem 283: 32034-32044, 2008.
231. Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, Söding J, Thompson JD, and Higgins DG. Fast, scalable generation of highquality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol 7: 539, 2011.
232. Silverman J, Chan S, Robinson D, Dwyer D, Nandan D, Foster L, and Reiner N. Proteomic analysis of the secretome of Leishmania donovani. Genome Biol 9: R35, 2008.
233. Silvestre R, Santarem N, Cunha J, Cardoso L, Nieto J, Carrillo E, Moreno J, and Cordeiro-da-Silva A. Serological evaluation of experimentally infected dogs by LicTXNPx- ELISA and amastigote-flow cytometry. Vet Parasitol 158: 23-30, 2008.
234. Siracusano A, Rigano R, Ortona E, Profumo E, Margutti P, Buttari B, Delunardo F, and Teggi A. Immunomodulatory mechanisms during Echinococcus granulosus infection. Exp Parasitol 119: 483-489, 2008.
235. Soito L, Williamson C, Knutson ST, Fetrow JS, Poole LB, and Nelson KJ. PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family. Nucleic Acids Res 39: D332-D337, 2011.
236. Soong CJ, Torian BE, Abd-Alla MD, Jackson TF, Gatharim V, and Ravdin JI. Protection of gerbils from amebic liver abscess by immunization with recombinant Entamoeba histolytica 29-kilodalton antigen. Infect Immun 63: 472-477, 1995.
237. Stober C, Lange U, Roberts M, Alcami A, and Blackwell J. Heterologous priming-boosting with DNA and modified vaccinia virus Ankara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania major in susceptible BALB/c Mice. Infect Immun 75: 852-860, 2007. (Pubitemid 46203449)
238. Stockwell BR. Chemical genetics: ligand-based discovery of gene function. Nat Rev Genet 1: 116-125, 2000.
239. Suttiprapa S, Loukas A, Laha T, Wongkham S, Kaewkes S, Gaze S, Brindley P, and Sripa B. Characterization of the antioxidant enzyme, thioredoxin peroxidase, from the carcinogenic human liver fluke, Opisthorchis viverrini. Mol Biochem Parasitol 160: 116-122, 2008.
240. Szabó C, Ischiropoulos H, and Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 6: 662-680, 2007. (Pubitemid 47207751)
241. This reference has been deleted.
242. Tachibana H and Cheng XJ. Entamoeba dispar: cloning and characterization of peroxiredoxin genes. Exp Parasitol 94: 51-55, 2000. (Pubitemid 30062522)
243. Tachibana H, Yanagi T, Akatsuka A, Kobayashi S, Kanbara H, and Tsutsumi V. Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques. Parasitology 136: 1169-1177, 2009.
244. Tachibana H, Yanagi T, Pandey K, Cheng X, Kobayashi S, Sherchand J, and Kanbara H. An Entamoeba sp. strain isolated from rhesus monkey is virulent but genetically different from Entamoeba histolytica. Mol Biochem Parasitol 153: 107-114, 2007. (Pubitemid 46654245)
245. Tamayo EM, Iturbe A, Hernandez E, Hurtado G, de Lourdes Gutierrez XM, Rosales JL, Woolery M, and Ondarza RN. Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target. Biotechnol Appl Biochem 41: 105-115, 2005. (Pubitemid 40523406)
246. Tazreiter M, Leitsch D, Hatzenbichler E, Mair-Scorpio G, Steinborn R, Schreiber M, and Duchene M. Entamoeba histolytica: response of the parasite to metronidazole challenge on the levels of mRNA and protein expression. Exp Parasitol 120: 403-410, 2008.
247. Tetaud E, Giroud C, Prescott A, Parkin D, Baltz D, Biteau N, Baltz T, and Fairlamb A. Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei. Mol Biochem Parasitol 116: 171-183, 2001. (Pubitemid 32777826)
248. Thamsen M, Kumsta C, Li F, and Jakob U. Is overoxidation of peroxiredoxin physiologically significant? Antioxid Redox Signal 14: 725-730, 2011.
249. Trujillo M, Budde H, Piñeyro MD, Stehr M, Robello C, Flohé L, and Radi R. Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem 279: 34175-34182, 2004. (Pubitemid 39318040)
250. Trujillo M, Ferrer-Sueta G, Thomson L, Flohé L, and Radi R. Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. In: Peroxiredoxin Systems, edited by Flohé L and Harris JR. New York: Springer, 2007, pp. 83-113.
251. Tsuji N, Kasuga-Aoki H, Isobe T, and Yoshihara S. Cloning and characterisation of a peroxiredoxin from the swine roundworm Ascaris suum. Int J Parasitol 30: 125-128, 2000. (Pubitemid 30127875)
252. Vaca-Paniagua F, Parra-Unda R, and Landa A. Characterization of one typical 2-Cys peroxiredoxin gene of Taenia solium and Taenia crassiceps. Parasitol Res 105: 781- 787, 2009.
253. Vaca-Paniagua F, Torres-Rivera A, Parra-Unda R, and Landa A. Taenia solium: antioxidant metabolism enzymes as targets for cestocidal drugs and vaccines. Curr Top Med Chem 8: 393-399, 2008. (Pubitemid 351791017)
254. Veal E, Day A, and Morgan B. Hydrogen peroxide sensing and signaling. Mol Cell 26: 1-14, 2007. (Pubitemid 46578115)
255. Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney G, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, and Hui R. Genome-scale protein expression and structural biology of Plasmodium falciparum and related apicomplexan organisms. Mol Biochem Parasitol 151: 100-110, 2007. (Pubitemid 44911074)
256. Vermeire J and Yoshino T. Antioxidant gene expression and function in in vitro-developing Schistosoma mansoni mother sporocysts: possible role in self-protection. Parasitology 134: 1369-1378, 2007. (Pubitemid 47236798)
257. Wakita M, Masuda S, Motohashi K, Hisabori T, Ohta H, and Takamiya K. The significance of type II and PrxQ peroxiredoxins for antioxidative stress response in the purple bacterium Rhodobacter sphaeroides. J Biol Chem 282: 27792-27801, 2007. (Pubitemid 47529504)
258. Walker J, Acestor N, Gongora R, Quadroni M, Segura I, Fasel N, and Saravia N. Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Mol Biochem Parasitol 145: 254-264, 2006. (Pubitemid 43083367)
259. Wassmann C, Hellberg A, Tannich E, and Bruchhaus I. Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase. J Biol Chem 274: 26051-26056, 1999.
260. Wilkinson S, Horn D, Prathalingam S, and Kelly J. RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the African trypanosome. J Biol Chem 278: 31640-31646, 2003. (Pubitemid 37048342)
261. Wilkinson S, Temperton N, Mondragon A, and Kelly J. Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi. J Biol Chem 275: 8220-8225, 2000. (Pubitemid 30159739)
262. Williams D, Asahi H, Botkin D, and Stadecker M. Schistosome infection stimulates host CD4 (+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infect Immun 69: 1134-1141, 2001. (Pubitemid 32109582)
263. Winterbourn C and Hampton M. Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 45: 549- 561, 2008.
264. Woo HA, Yim SH, Shin DH, Kang D, Yu DY, and Rhee SG. Inactivation of peroxiredoxin I by phosphorylation allows localized H2O2 accumulation for cell signaling. Cell 140: 517-528, 2010.
265. Wood ZA, Poole LB, and Karplus PA. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 300: 650-653, 2003. (Pubitemid 36520591)
266. Wood ZA, Poole LB, Hantgan RR, and Karplus PA. Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry 41: 5493-5504, 2002. (Pubitemid 34429383)
267. World Health Organization Department of Control of Neglected Tropical Diseases. Working to Overcome the Global Impact of Neglected Tropical Diseases: 1st WHO Report on NTDs. Geneva, Switzerland: WHO Press, 2010, p. 171.
268. Wood ZA, Schröder E, Harris JR, and Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 28: 32-40, 2003. (Pubitemid 36051004)
269. Wyllie S, Cunningham ML, and Fairlamb AH. Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani. J Biol Chem 279: 39925- 39932, 2004.
270. Wyllie S, Mandal G, Singh N, Sundar S, Fairlamb A, and Chatterjee M. Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates. Mol Biochem Parasitol 173: 162-164, 2010.
271. Yano K, Komaki-Yasuda K, Kobayashi T, Takemae H, Kita K, Kano S, and Kawazu S-I. Expression of mRNAs and proteins for peroxiredoxins in Plasmodium falciparum erythrocytic stage. Parasitol Int 54: 35-41, 2005. (Pubitemid 40248723)
272. Yano K, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, and Kawazu S. 2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei. Mol Biochem Parasitol 148: 44-51, 2006. (Pubitemid 43810229)
273. Yano K, Otsuki H, Arai M, Komaki-Yasuda K, Tsuboi T, Torii M, Kano S, and Kawazu S. Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito. Mol Biochem Parasitol 159: 142-145, 2008. (Pubitemid 351621905)
274. Yoo W, Kim D-W, Ju J-W, Cho P, Kim T, Cho S-H, Choi SH, Park H-S, Kim T-S, and Hong S-J. Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis. PLoS Negl Trop Dis 5: e1208, 2011.
275. Yuan Y, Knaggs MH, Poole LB, Fetrow JS, and Salsbury FA. Conformational and oligomeric effects on the cysteine pKa of tryparedoxin peroxidase. J Biomol Struct Dyn 28: 51-70, 2010.
276. Zhang J, Fu Y, Xu X, Wu T, and Cao F. [RNA interference to the expression of peroxiredoxin-related genes in Trichomonas vaginalis]. (Abstract of Chinese-language article). Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 23: 437-440, 2005.
277. Zhang W, Rogniaux H, Huang W, Chauvin A, and Moreau E. Analysis of thioredoxin peroxidase as a promising antigen for diagnosis of Fasciola gigantica infection: a preliminary study. Parasitol Int 60: 206-208, 2011.
278. Zipfel P, Schrum S, Bialonski A, and Buttner D. The peroxidoxin 2 protein of the human parasite Onchocerca volvulus: recombinant expression, immunolocalization, and demonstration of homologous molecules in other species. Parasitol Res 84: 623-631, 1998. (Pubitemid 28370751)