"Manifesto" for advancing the control and elimination of neglected tropical diseases

PLoS Neglected Tropical Diseases

Volumn 4, Issue 5, 2010, Pages

  Hotez, Peter J ^a   Pecoul, Bernard ^b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZNIDAZOLE; EFLORNITHINE; MEBENDAZOLE; NIFURTIMOX; PENTAMIDINE; PRAZIQUANTEL;

AFRICAN TRYPANOSOMIASIS; CHAGAS DISEASE; CONFLICT; CONTROL STRATEGY; DOSE RESPONSE; DRUG COST; DRUG EFFICACY; DRUG INDUSTRY; DRUG SAFETY; EDITORIAL; ERADICATION THERAPY; FUNDING; HEALTH CARE DISPARITY; HEALTH CARE SYSTEM; HEALTH EDUCATION; HEALTH PROGRAM; HOOKWORM INFECTION; HUMAN; HUMAN RIGHTS; INFECTION CONTROL; INFECTION PREVENTION; LEADERSHIP; MEDICAL SOCIETY; PRODUCT DEVELOPMENT; RESOURCE ALLOCATION; SCHISTOSOMIASIS; SINGLE DRUG DOSE; SOCIAL STATUS; TROPICAL DISEASE; VECTOR CONTROL; BACTERIAL INFECTION; MEDICAL RESEARCH; PARASITOSIS; PUBLIC HEALTH; TROPICAL MEDICINE; VIRUS INFECTION;

BACTERIAL INFECTIONS; BIOMEDICAL RESEARCH; HUMANS; PARASITIC DISEASES; PUBLIC HEALTH; TROPICAL MEDICINE; VIRUS DISEASES;

EID: 77955283075     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000718     Document Type: Editorial

References (75)

1. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Ehrlich Sachs S, et al. (2007) Control of neglected tropical diseases. N Engl J Med 357: 1018-1027.
2. Hotez PJ (2008) Forgotten People, Forgotten Diseases: the Neglected Tropical Diseases and their Impact on Global Health and Development. ASM Press 218.
3. Hotez PJ, Fenwick A, Savioli L, Molyneux DH (2009) Rescuing the bottombillion through control of neglected tropical diseases. Lancet 373: 1570-1575.
4. Hotez PJ (2009) Empowering women and improving female reproductive health through control of neglected tropical diseases. PLoS Negl Trop Dis 3: e559. doi:10.1371/journal.pntd. 0000559.
5. Moran M, Guzman J, Henderson K, Ropars A-L, McDonald A, et al. (2009) G-Finder: Neglected Disease Research & Development: New Times, New Trends; Health Policy Division, The George Institute for International Health. 101 p.
6. United Nations (2009) The Millennium Development Goals Report. Available. http://www.un.org/millenniumgoals/pdf/MDG_Report_2009_ENG.pdf. Accessed 27 Apr 2010.
7. Hotez PJ, Ferris MT (2006) The antipoverty vaccines. Vaccine 24: 5787-5799.
8. Hotez PJ, Brown AS (2009) Neglected tropical disease vaccines. Biologicals 37: 160-164.
9. Ad Hoc Committee on Health Research Relating to Future Intervention Options (1996) Investing in health research and development. Document 10. TDR/Gen/96.1. Geneva: World Health Organization.
10. Chirac P, Torreele E (2006) Global framework on essential health R&D. Lancet 367: 1560-1561.
11. Webster's New World College Dictionary Fourth Edition 2000.
12. Hotez PJ (2009) Mass drug administration and integrated control for the world's high-prevalence neglected tropical diseases. Clin Pharmacol Therap 85: 659-664.
13. [No authors listed] (2008) Global programme to eliminate lymphatic filariasis. Wkly Epidemiol Rec 83: 333-341.
14. Diawara L, Traoré MO, Badji A, Bissan Y, Doumbia K, et al. (2009) Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: First evidence from studies in Mali and Senegal. PLoS Negl Trop Dis 3: e497. doi:10.1371/journal.pntd.0000497.
15. Biebesheimer JB, House J, Hong KC, Lakew T, Alemayehu W, et al. (2009) Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions. Ophthalmology 116: 2047-2050.
16. Molyneux DH, Hotez PJ, Fenwick A (2005) "Rapid impact" interventions: How a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Med 2: e336. doi:10.1371/journal.pmed.0020336.
17. Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs J (2006) Incorporating a rapid impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis and malaria, a comprehensive pro-poor health policy and strategy for the developing world. PLoS Med 3: e102. doi:10.1371/journal.pmed.0030102.
18. Rinaldi A (2005) The global campaign to eliminate leprosy. PLoS Med 2: e341. doi:10.1371/journal.pmed.0020341.
19. Hopkins DR, Ruiz-Tiben E, Downs P, Withers PC, Jr., Roy S (2008) Dracunculiasis eradication: neglected no longer. Am J Trop Med Hyg 79: 474-479.
20. Vu SN, Nguyen TY, Tran VP, Truong UN, Le QM, et al. (2005) Elimination of dengue by community programs using Mesocycyclops (Copepoda) against Aedes aegypti in central Vietham. Am J Trop Med Hyg 72: 67-73.
21. Wright HR, Turner A, Taylor HR (2008) Trachoma. Lancet 37: 1945-1954.
22. Jannin J, Louis FJ, Lucas P, Simarro PP (2001) Control of human African trypanosomiasis: back to square one (French). Med Trop (Mars) 61: 437-440.
23. Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, et al. (2009) Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet 374: 56-64.
24. Dias JC (2009) Elimination of Chagas disease transmission: perspectives. Mem Inst Oswaldo Cruz 104 (Suppl 1): 41-45.
25. Yun O, Lima MA, Ellman T, Chambi W, Castillo S, et al. (2009) Feasibility, drug safety, and effectiveness of etiological treatment programs for chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins Sans Frontieres. PLoS Negl Trop Dis 3: e488. doi:10.1371/journal.pntd.0000488.
26. Narain JA, Prasittisuk C, Bhatia R, Hashim G, Banjara JA, et al. (2008) Can visceral leishmaniasis be eliminated from Asia? J Vector Borne Dis 45: 105-111.
27. Sharma U, Singh S (2008) Insect vectors of Leishmania: distribution, physiology and their control. J Vector Borne Dis 45: 255-272.
28. Croft SL, Sundar S, Fairlamb AH (2006) Drug Resistance in Leishmaniasis. Clin Microbiol Rev 19: 111-126.
29. Hailu A, Musa AM, Royce C, Wasunna M (2005) Visceral Leishmaniasis: new health tools are needed. PLoS Med 2: e211. doi:10.1371/journal. pmed.0020211.
30. Kaewpitoon N, Kaewpitoon SJ, Pengsaa P, Sripa B (2008) Opisthorchias viverrini: the carcinogenic human liver fluke. World J Gastroenterol 14: 666-674.
31. Portaels F, Silva MT, Meyers WM (2009) Buruli ulcer. Clin Dermatol 27: 291-305.
32. World Health Organization Maximizing Positive Synergies Collaborative Group (2009) An assessment of interactions between global health initiatives and country health systems. Lancet 373: 2137-2169.
33. Wilkinson SR, Kelly M (2009) Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev Mol Med 11: e31.
34. El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, et al. (2005) Comparative genomics of trypanosomatid parasitic protozoa. Science 309: 404-409.
35. The TDR Targets Database. Available: http://tdrtargets.org/. Accessed 8 Feb 2010.
36. Jennings FW, Atouguia JM, Murray M (1996) Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436. Trop Med Int Health 1: 590-598.
37. Urbina JA (2009) Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Trop, Epub ahead of print. doi:10.1016/j.actatropica.2009.10.023.
38. McKerrow JH, Doyle PS, Engel JC, Podhust LM, Robertson SA, et al. (2009) Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz 104 (Suppl 1): 263-269.
39. Den Boer ML, Alvar J, Davidson RN, Ritmeijer K, Balasegaram M (2009) Developments in the treatment of visceral leishmaniasis. Expert Opin Emerg Drugs 14: 395-410.
40. Camargo EP (2009) Perspectives of vaccination in Chagas disease revisited. Mem Inst Oswaldo Cruz 104 (Suppl 1): 275-280.
41. Coler RN, Reed SG (2005) Second-generation vaccines against leishmaniasis. Trends Parasitol 21: 244-249.
42. Chaudhry OA, Petri WA, Jr. (2005) Vaccine prospects for amebiasis. Expert Rev Vaccines 4: 657-668.
43. Huygen K, Adjei O, Affolabi D, Bretzel G, Demangel C, et al. (2009) Buruli ulcer disease: prospects for a vaccine. Med Microbiol Immunol 198: 69-77.
44. Schuring RP, Richardus JH, Pahan D, Oskam L (2009) Protective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention. Vaccine 27: 7125-7128.
45. Webster DP, Farrar J, Rowland-Jones S (2009) Progress towards a dengue vaccine. Lancet Infect Dis 9: 678-687.
46. Durbin AP, Whitehaead SS (2010) Dengue vaccine candidates in development. Curr Top Microbiol Immunol 338: 129-143.
47. Keiser J, Utzinger J (2008) Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 1937-1948.
48. Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, et al. (2008) A new class of anthelmintics effective against drug-resistant nematodes. Nature 452: 176-180.
49. Hu Y, Xiao SH, Aroian RV (2009) The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis 3: e499. doi:10.1371/journal.pntd.0000499.
50. Hu Y, Georghious SB, Kelleher AJ, Aroian RV (2010) Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice. PLoS Negl Trop Dis 4: e614. doi:10.1371/journal. pntd.0000614.
51. Loukas A, Bethony J, Brooker S, Hotez P (2006) Hookworm vaccines: past, present, and future. Lancet Infect Dis 6: 733-741.
52. Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, et al. (2008) Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med 14: 407-412.
53. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, et al. (2009) Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by mediumthroughput phenotypic screening. PLoS Negl Trop Dis 3: e478. doi:10.1371/journal.pntd. 0000478.
54. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, et al. (2009) The genome of the blood fluke Schistosoma mansoni. Nature 460: 352-358.
55. McManus DP, Loukas A (2008) Current status of vaccines for schistosomiasis. Clin Microbiol Rev 21: 225-242.
56. Utzinger J, Raso G, Brooker S, De Savigny D, Tanner M, et al. (2009) Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology 136: 1859-1872.
57. Hopkins AD (2005) Ivermectin and onchocerciasis: is it all solved? Eye (Lond) 19: 1057-1066.
58. Hoerauf A (2008) Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis 21: 673-681.
59. Perkins MD, Small PM (2006) Partnering for better microbial diagnostics. Nat Biotechnol 24: 919-921.
60. Frew SE, Liu VY, Singer PA (2009) A business plan to help the 'global South' in its fight against neglected diseases. Health Aff (Millwood) 28: 1760-1773.
61. The George Institute for International Health. Registering New Drugs: The African Context, Available: http://www.dndi.org/images/stories/advocacy/regulatory-report_george-ins titutedndi_jan2010.pdf. Accessed 29 March 2010.
62. Beyrer C, Villar JC, Suwanvanichkij V, Singh S, Baral SD, et al. (2007) Neglected diseases, civil conflicts, and the right to health. Lancet 370: 619-627.
63. Hotez PJ (2010) Neglected Infections of Poverty among the Indigenous Peoples of the Arctic. PLoS Negl Trop Dis 4: e606. doi:10.1371/ journal.pntd.0000606.
64. Hotez P (2009) Neglected diseases amid wealth in the United States and Europe. Health Aff (Millwood) 28: 1720-1725.
65. Lammie PJ, Lindo JF, Secor WE, Vasquez J, Ault SK, et al. (2007) Eliminating lymphatic filariasis, onchocerciasis, and schistosomiasis from the Americas: breaking a historical legacy of slavery. PLoS Negl Trop Dis 1: e71. doi:10.1371/ journal.pntd.0000071.
66. Hotez PJ (2008) Neglected infections of poverty in the United States of America. PLoS Negl Trop Dis 2: e256. doi:10.1371/journal.pntd.0000256.
67. Hotez PJ (21 January 2010) Gandhi's hookworms. Foreign Policy, Available: http://www.foreignpolicy.com/articles/2010/01/21/gandhis_hookworms. Accessed 8 February 2010.
68. Fischer L (1997) The Life of Mahatma Gandhi. HarperCollins. Part II; 43: 424.
69. Collier P (2007) The bottom billion: Why the poorest countries are failing and what can be done about it. Oxford, UK: Oxford University Press.
70. Hotez PJ, Thompson TG (2009) Waging peace through neglected tropical disease control: a U.S. foreign policy for the bottom billion. PLoS Negl Trop Dis 3: e346.
71. Médicins Sans Frontières (2005) Sleeping Sickness. A practical manual for the treatment and control of human African trypanosomiasis.
72. Remme JHF (2004) Research for control: the onchocerciasis experience. Trop Med Int Health 9: 243-254.
73. Amazigo UV, Obono OM, Dadzie KY, Remme J, Jiya J, et al. (2002) Monitoring communitydirected treatment programmes for sustainability: lessons from the African Programme for Onchocerciasis Control (APOC). Ann Trop Med Parasitol 96 (Suppl 1): 75-92.
74. CDI study group (2009) Community directed interventions for priority health problems in Africa: results of a multi-country study Bull World Health Organization. doi:10.2471/ BLT.09.069203.
75. Pecoul B (2005) Government action needed to step up research and development for the world's most neglected diseases. Expert Rev Anti Infect Ther 3: 841-843.