Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites

Molecular and Biochemical Parasitology

Volumn 91, Issue 2, 1998, Pages 221-235

  Lu, Wenhong ^a,b   Egerton, Gillian L ^c   Bianco, Albert E ^c   Williams, Steven A ^a,b  

^a SMITH COLLEGE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antioxidant enzyme; Bp, base pair; EST, expressed sequence tag; Expressed sequence tag; Infective larva; L3, third stage larva; Nematode; Onchocerca volvulus; Ov tpx 2, O. volvulus thioredoxin peroxidase 2 gene; Ov TPX 2, O. volvulus thioredoxin peroxidase 2 protein; PBS, phosphate buffered saline; PCR, polymerase chain reaction; Peroxidoxin; Thiol specific antioxidant; Thioredoxin peroxidase; Third stage larva; TPx, thioredoxin peroxidase

Indexed keywords

ANTIOXIDANT; COMPLEMENTARY DNA; HYDROGEN PEROXIDE; OXYGEN RADICAL; PEROXIDASE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN;

AMINO ACID SEQUENCE; ARTICLE; DETOXIFICATION; ESCHERICHIA COLI; GENE EXPRESSION; HOST RESISTANCE; NONHUMAN; ONCHOCERCA VOLVULUS; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; ONCHOCERCA VOLVULUS; OXIDATION-REDUCTION; PEROXIDASES; PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA;

EID: 0032521486     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00230-2     Document Type: Article

References (33)

1. [1] Chae HZ, Rhee SG. A thiol-specific antioxidant and sequence homology to various proteins of unknown function. BioFactors 1994;4:177-80.
2. [2] Chae HZ, Robison K, Poole LB, Church G, Storz G, Rhee SG. Cloning and sequencing of thiol-specific antioxidant from mammaliam brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc Natl Acad Sci USA 1994;91:7017-21.
3. [3] Chae HZ, Chung SJ, Rhee SG. Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 1994;269:27670-8.
4. [4] McGonigle S, Dalton JP, James, ER. Peroxidoxins: a new antioxidant family. Parasitol Today (in press).
5. [5] Docampo R. Antioxidant mechanisms. In: Marr JJ, Muller M, editors. Biochemistry and Molecular Biology of Parasites. San Diego: Academic Press, 1995:147-60.
6. [6] Leibau E, Walter RD, Henkle-Duhrsen K. Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA. Mol Biochem Parasitol 1994;63:305-9.
7. [7] Leibau E, Walter RD, Henkle-Duhrsen K. Isolation and sequence of a second glutathione S-transferase cDNA. Exp Parasitol 1994;79:68-71.
8. [8] James ER, Mclean DCJ, Perler F. Molecular cloning of an Onchocerca volvulus extracellular Cu-Zn superoxide dismutase. Infect Immun 1994;62:713-6.
9. [9] Henkle KJ, Liebau E, Muller S, Bergmann B, Walter RD. Characterization and molecular cloning of a Cu/Zn superoxide dismutase from the human parasite Onchocerca volvulus. Infect Immun 1991;59:2063-9.
10. [10] Henkle-Duhrsen K, Tawe W, Warnecke C, Walter RD. Characterization of the manganese superoxide dismutase cDNA and gene from the human parasite Onchocerca volvulus. Biochem J 1995;308:441-6.
11. [11] Leibau E, Wildenburg G, Walter RD, Henkle-Duhrsen K. A novel type of glutathione S-transferase in Onchocerca volvulus. Infect Immun 1994;62:4762-7.
12. [12] Ou X, Thomas GR, Chacon MR, Tang L, SeIlkirk ME. Brugia malayi: differential susceptibility to and metabolism of hydrogen peroxide in adults and microfilariae. Exp Parasitol 1995;80:530-40.
13. [13] McGonigle S, Curley GP, Dalton JP. Cloning of peroxiredoxin, a novel antioxidant enzyme from the helminth parasite Fasciola hepatica. Parasitology 1997;115:101-4.
14. [14] Lok JB, Pollack RJ, Cupp EW, Bernardo MJ, Donnelly JJ, Albiez EJ. Development of Onchocerca lienalis and O. volvulus from the third to fourth larval stage in vitro. Tropenmedizin und Parasitologie 1984;35:209-11.
15. [15] Altshul SF, Gish W, Miller W, Myers EW, Lipman D. Basic local alignment search tool. J Mol Biol 1990;215:403-10.
16. [16] Smith PK, Krohn RI, Hermason GT, Malla AK, Gartner FH, Provenzano EK, Fujimoto NM, Goake BF, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
17. [17] Lim YS, Cha MK, Kim HK, Uhm TB, Park JW, Kim JW, Kim IH. Removal of hydrogen peroxide and hydroxyl radicals by thiol-specific antioxidant protein as a possible role in vivo. Biochem Biophys Res Commun 1993;192:273-80.
18. [18] Tuan RS, Shepley KJ, Mulligan MM, Abraham D, Perler FB. Histochemical localization of gene expression in Onchocerca volvulus: in situ DNA histohybridization and immunocytochemistry. Mol Biochem Parasitol 1991;49:191-204.
19. [19] Jenkins RE, Taylor MJ, Gilvary N, Bianco AE. Characterization of a secreted antigen of Onchocerca volvulus with host-protective potential. Parasite Immunol 1996;18:29-42.
20. [20] Nilsen TW. Trans-splicing of nematode premessenger RNA. Annu Rev Microbiol 1993;47:413-40.
21. [21] Bain O. Morphologie des stades larvaires d'Onchocerca volvulus chezSimulium damnosum et redescription de la microfilaire. Annu Parasitol Hum Comp (Paris) 1969;44:69-82.
22. [22] Karam M, Schulz-Key H, Remme J. Population dynamics of Onchocerca volvulus. Acta Trop 1987;44:445-57.
23. [23] Strote G, Bokhof A, Comley JCW. Viability of Onchocerca volvulus in vitro. Parasitology 1993;107:175-82.
24. [24] Ham PJ. Immunity in haematophagus insect vectors of parasitic infection. Adv Dis Vector Res 1992;9:101-49.
25. [25] Greene BM, Fanning MM, Ellner JJ. Non-specific suppression of antigen-induced lymphocyte blastogenesis in Onchocerca volvulus infection in man. Clin Exp Immunol 1983;52:259-65.
26. [26] Mackenzie CD. Eosinophil leukocytes in filarial infections. Trans R Soc Trop Med Hyg 1980;74:51-8.
27. [27] Duke BOL. The population dynamics of Onchocerca volvulus in the human host. Trop Med Parasitol 1993;44:61-8.
28. [28] Taylor MJ, Cross HF, Mohammed AA, Trees AJ, Bianco AE. Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell free culture and from IFNγ activated macrophages. Parasitology 1996;112:315-22.
29. [29] Ogbogu VC, Storey DM. Ultrastructure and the alimentary tract of third-stage larvae of Litomosoides carinii. J Helminthol 1996;70:223-9.
30. [30] Strote G, Bonow I. Morphological demonstration of essential function changes after in vitro and in vivo transition of infective Onchocerca volvulus to the post-infective stage. Parasit Res 1991;77:526-35.
31. [31] Kuchler K, Thorner J. Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators. Endocr Rev 1992;13:499-514.
32. [32] Abdel-Wahab N, Kuo Y-M, Wu Y, Tuan RS, Bianco AE. OvB20, an Onchocerca volvulus cDNA selected by differential immunoscreening with vaccination serum in a cattle model of onchocerciasis. Mol Biochem Parasitol 1996;76:187-99.
33. [33] Shau H, Butterfield LH, Chiu R, Kim A. Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. Immunogenetics 1994;40:129-34.