Trichomonas vaginalis: Metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance

Molecular Microbiology

Volumn 72, Issue 2, 2009, Pages 518-536

  Leitsch, David ^a   Kolarich, Daniel ^b,c   Binder, Marina ^a   Stadlmann, Johannes ^b   Altmann, Friedrich ^b   Duchêne, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVOPROTEIN; FURAZOLIDONE; MALATE DEHYDROGENASE; METRONIDAZOLE; NITROFURAN; NITROIMIDAZOLE; NITROREDUCTASE; QUERCETIN; RIBONUCLEOTIDE REDUCTASE; THIOREDOXIN PEROXIDASE; THIOREDOXIN REDUCTASE;

ARTICLE; DISULFIDE BOND; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVITY; GIARDIA LAMBLIA; NONHUMAN; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS;

ANIMALS; ANTIPROTOZOAL AGENTS; CELLS, CULTURED; DRUG RESISTANCE; FLAVINS; FURAZOLIDONE; METRONIDAZOLE; OXIDATION-REDUCTION; PROTEOMICS; PROTOZOAN PROTEINS; SULFHYDRYL COMPOUNDS; THIOREDOXIN-DISULFIDE REDUCTASE; TRICHOMONAS VAGINALIS;

ENTAMOEBA HISTOLYTICA; GIARDIA INTESTINALIS; TRICHOMONAS VAGINALIS;

EID: 64149123281     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06675.x     Document Type: Article

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