Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of trypanosoma brucei brucei

Biological Chemistry

Volumn 384, Issue 4, 2003, Pages 619-633

  Budde, Heike ^a   Flohé, Leopold ^a   Hecht, Hans Jürgen ^b   Hofmann, Birgit ^a   Stehr, Matthias ^a   Wissing, Josef ^a   Lünsdorf, Heinrich ^b  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b German Research Centre   (Germany)

Author keywords

Cooperatively; Electron microscopy; Molecular models; Molecular mutants; Peroxiredoxin; Steady state kinetics

Indexed keywords

GLUTATHIONE; HYDROPEROXIDE; OLIGOMER; PEROXIDASE; PEROXIREDOXIN; THIOREDOXIN; TRYPANOTHIONE; TRYPAREDOXIN PEROXIDASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DEPOLYMERIZATION; DETOXIFICATION; ELECTRON MICROSCOPY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME RECONSTITUTION; ENZYME SUBUNIT; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR MODEL; MOLECULAR SIZE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REDUCTION; STOICHIOMETRY; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

ANIMALS; CLONING, MOLECULAR; DNA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN PEROXIDE; KINETICS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PEROXIDASES; PROTOZOAN PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; THROMBIN; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMATIDAE;

EID: 0037959650     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.069     Document Type: Article

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