Divergence of trypanothione-dependent tryparedoxin cascade into cytosolic and mitochondrial pathways in arsenite-resistant variants of Leishmania amazonensis

Molecular and Biochemical Parasitology

Volumn 157, Issue 2, 2008, Pages 193-204

  Hsu, Ju Yu ^a   Lin, Yi Chun ^a   Chiang, Su Chi ^a   Lee, Sho Tone ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Antioxidant; Antisense; Arsenite resistance; Leishmania; Tryparedoxin cascades

Indexed keywords

ARSENIC TRIOXIDE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; TRYPANOTHIONE; TRYPAREDOXIN PEROXIDASES; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CYTOSOL; DETOXIFICATION; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; LEISHMANIA; MITOCHONDRION; NUCLEIC ACID PROBE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMASTIGOTE; RECEPTOR UPREGULATION;

ANIMALS; ANTIPROTOZOAL AGENTS; ARSENITES; DNA, PROTOZOAN; DRUG RESISTANCE, MICROBIAL; GLUTATHIONE; HYDROGEN PEROXIDE; LEISHMANIA; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; REACTIVE OXYGEN SPECIES; SEQUENCE ANALYSIS, DNA; SPERMIDINE; TERT-BUTYLHYDROPEROXIDE; THIOREDOXINS;

LEISHMANIA AMAZONENSIS;

EID: 38049132516     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2007.11.002     Document Type: Article

References (33)

1. Nogoceke E., Gommel D.U., Kiess M., Kalisz H.M., and Flohe L. A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculate. Biol Chem 378 (1997) 827-836
2. McGonigle S., Dalton J.P., and James E.R. Peroxidosins: a new antioxidant family. Parasitol Today 14 (1998) 139-145
3. Dormeyer M., Reckenfelderbaumer N., Ludemann H., and Krauth-Siegel R.L. Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. J Biol Chem 276 14 (2001) 10602-10606
4. Onn I., Milman-Shtepel N., and Shlomai J. Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin. Eukaryot Cell 3 2 (2004) 277-287
5. Motyka S.A., Drew M.E., Yildirir G., and Englund P.T. Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei. J Biol Chem 281 27 (2006) 18499-18506
6. Guerrero S.A., Flohe L., Kalisz H.M., et al. Sequence, heterologous expression and functional characterization of tryparedoxin 1 from Crithidia fasciculate. Eur J Biochem 259 (1999) 789-794
7. Tetaud E., Giroud C., Prescott A.R., et al. Molecular characterization of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei. Mol Biochem Parasitol 116 (2001) 171-183
8. Castro H., Sousa C., Santos M., Cordeiro-da-Silva A., Flohe L., and Tomas A.M. Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. Free Radic Biol Med 33 (2002) 1552-1562
9. Castro H., Sousa C., Novais M., et al. Two linked genes of Leishmania infantum encode tryparedoxins localized to cytosol and mitochondrion. Mol Biochem Parasitol 136 (2004) 137-147
10. Lee S.T., Liu H.Y., Lee S.P., and Tarn C. Selection of arsenite resistance causes reversible changes in minicircle composition and kinetoplast organization in Leishmania mexicana. Mol Cell Biol 14 (1994) 587-596
11. Lee S.T., Liu H.Y., Chu T.Y., and Liu S.Y. Specific A + T-rich repetitive DNA sequences in maxicircles from wildtype Leishmania mexicana amazonensis and variants with DNA amplification. Exp Parasitol 79 (1994) 29-40
12. Lee S.T., Tarn C., and Chang K.P. Characterization of the switch of kinetoplast DNA minicircle dominance during development and reversion of drug resistance in Leishmania. Mol Biochem Parasitol 48 (1993) 187-204
13. Lee S.T., Tarn C., and Wang C.Y. Characterization of sequence changes in kinetoplast DNA maxicircles of drug-resistant Leishmania. Mol Biochem Parasitol 15 (1992) 197-208
14. Singh A.K., Liu H.Y., and Lee S.T. Determination of the uptake and release of sodium arsenite in arsenite-resistant variants of Leishmania by atomic absorption spectrophotometry. Mol Biochem Parasitol 66 (1994) 161-164
15. Lin Y.C., Hsu J.Y., Chiang S.C., and Lee S.T. Distinct overexpression of cytosolic and mitochondrial tryparedoxin peroxidases results in preferential detoxification of different oxidants in arsenite-resistant Leishmania amazonensis with and without DNA amplification. Mol Biochem Parasitol 142 (2005) 66-75
16. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
17. Kapler G.M., Coburn C.M., and Beverley S.M. Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression. Mol Cell Biol 10 (1990) 1084-1094
18. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature 227 (1970) 680-685
19. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Biotechnology 24 (1992) 145-149
20. Vassella E., Straesser K., and Boshart M. A mitochondrion-specific dye for multicolour fluorescent imaging of Trypanosoma brucei. Mol Biochem Parasitol 90 (1997) 381-385
21. Mittal M.K., Misra S., Owais M., and Goyal N. Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli. Protein Exp Purif 40 2 (2005) 279-286
22. Oza S.L., Tetaud E., Ariyanayagam M.R., Warnon S.S., and Fairlamb A.H. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. J Biol Chem 277 39 (2002) 35853-35861
23. Oza S.L., Shaw M.P., Wyllie S., and Fairlamb A.H. Trypanothione biosynthesis in Leishmania major. Mol Biochem Parasitol 139 1 (2005) 107-116
24. Tetaud E., Manai F., Barrett M.P., Nadeau K., Walsh C.T., and Fairlamb A.H. Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. J Biol Chem 273 31 (1998) 19383-19390
25. Oza S.L., Wyllie S., and Fairlamb A.H. Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major. Mol Biochem Parasitol 149 1 (2006) 117-120
26. Liu S.X., Athar M., Lippai I., Waldren C., and Hei T.K. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA 98 4 (2001) 1643-1648
27. Finzi J.K., Chiavegatto C.W., Corat K.F., et al. Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide. Mol Biochem Parasitol 133 1 (2004) 37-43
28. Davies J.M., Lowry C.V., and Davies K.J. Transient adaptation to oxidative stress in yeast. Arch Biochem Biophys 317 1 (1995) 1-6
29. Wiese A.G., Pacifici R.E., and Davies K.J. Transient adaptation of oxidative stress in mammalian cells. Arch Biochem Biophys 318 1 (1995) 231-240
30. Robinson K.A., and Beverley S.M. Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania. Mol Biochem Parasitol 128 2 (2003) 217-228
31. Zhang W.W., and Matlashewski G. Analysis of antisense and double stranded RNA downregulation of A2 protein expression in Leishmania donovani. Mol Biochem Parasitol 107 2 (2000) 315-319
32. Somanna A., Mundodi V., and Gedamu L. Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta. J Biol Chem 277 28 (2002) 25305-25312
33. Chen D.Q., Kolli B.K., Yadava N., et al. Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro. Infect Immun 68 1 (2000) 80-86