Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: Consequences for oxidative killing and role of microbial peroxiredoxins in infectivity

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6627-6640

  Alvarez, María Noel ^a   Peluffo, Gonzalo ^a   Piacenza, Lucía ^a   Radi, Rafael ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; CAUSATIVE AGENTS; CHAGAS DISEASE; CYTOSOLIC; CYTOTOXIC MECHANISMS; CYTOTOXINS; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INFECTION CONTROL; MICROBIAL KILLING; NADPH OXIDASE; OVER-EXPRESSION; OXIDATIVE DAMAGE; PEROXIREDOXINS; PEROXYNITRITES; REACTIVE SPECIES; STRONG OXIDANTS; SUPEROXIDE RADICAL; TRYPANOSOMA CRUZI; ULTRASTRUCTURAL ANALYSIS;

CYTOTOXICITY; DISEASE CONTROL; FREE RADICAL REACTIONS; NITRIC OXIDE; OXYGEN; PATHOGENS;

MACROPHAGES;

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEROXIDASE; PEROXIREDOXIN; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVITY; INFECTION CONTROL; INTERNALIZATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARASITE VIRULENCE; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CELL LINE; CHAGAS DISEASE; CYTOTOXINS; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; PEROXYNITROUS ACID; PROTOZOAN PROTEINS; SUPEROXIDES; THIOREDOXINS; TRYPANOSOMA CRUZI;

ANIMALIA; TRYPANOSOMA CRUZI;

EID: 79953183972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.167247     Document Type: Article

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