Neurogenic potential of stem/progenitor-like cells in the adult mammalian eye

Progress in Retinal and Eye Research

Volumn 31, Issue 3, 2012, Pages 213-242

  Wohl, Stefanie G ^a,b   Schmeer, Christian W ^a   Isenmann, Stefan ^b,c  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c HELIOS KLINIKUM WUPPERTAL   (Germany)

Author keywords

Ciliary body; Growth factors; Injury; Microglia; M ller glia; NG2 glia

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; NERVE GROWTH FACTOR; NESTIN; NEUROTROPHIN 3; NEUROTROPHIN 4;

AMPHIBIA; ASTROCYTE; BIRD; CELL DIFFERENTIATION; CELL MIGRATION; CELL TRANSPLANTATION; CELL TYPE; CILIARY BODY; ENDOTHELIUM CELL; EPITHELIUM CELL; EYE; FISH; GLAUCOMA; GLIA CELL; HUMAN; MAMMAL; MICROGLIA; MUELLER CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; OPTIC NERVE DISEASE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA INJURY; RETINA ISCHEMIA; RETINA STEM CELL; REVIEW; RODENT; STEM CELL; VERTEBRATE;

ANIMALS; CELL DIFFERENTIATION; CILIARY BODY; EYE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURAL STEM CELLS; NEUROGLIA; ORGANOGENESIS; RETINAL DISEASES; RETINAL NEURONS;

EID: 84860000454     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2012.02.001     Document Type: Review

References (405)

1. Abdouh M., Bernier G. In vivo reactivation of a quiescent cell population located in the ocular ciliary body of adult mammals. In: Exp. Eye Res. 2006, 83:153-164.
2. Abrous D.N., Koehl M., Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol. Rev. 2005, 85:523-569.
3. Agudo M., Perez-Marin M.C., Lonngren U., Sobrado P., Conesa A., Canovas I., Salinas-Navarro M., Miralles-Imperial J., Hallbook F., Vidal-Sanz M. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Mol. Vis. 2008, 14:1050-1063.
4. Ahmad I., Tang L., Pham H. Identification of neural progenitors in the adult mammalian eye. Biochem. Biophy. Res. Commun. 2000, 270:517-521.
5. Ahmad I., Das A.V., James J., Bhattacharya S., Zhao X. Neural stem cells in the mammalian eye: types and regulation. Semin. Cell Dev. Biol. 2004, 15:53-62.
6. Akagi T., Mandai M., Ooto S., Hirami Y., Osakada F., Kageyama R., Yoshimura N., Takahashi M. Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. Invest. Ophthalmol. Vis. Sci. 2004, 45:4570-4575.
7. Akagi T. Photoreceptors derived from adult iris tissue: prospects for retinal transplantation. Semin. Ophthalmol. 2005, 20:11-15.
8. Akagi T., Akita J., Haruta M., Suzuki T., Honda Y., Inoue T., Yoshiura S., Kageyama R., Yatsu T., Yamada M., Takahashi M. Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes. Invest. Ophthalmol. Vis. Sci. 2005, 46:3411-3419.
9. Al-Hussaini H., Kam J.H., Vugler A., Semo M., Jeffery G. Mature retinal pigment epithelium cells are retained in the cell cycle and proliferate in vivo. Mol. Vis. 2008, 14:1784-1791.
10. Alliot F., Rutin J., Leenen P.J., Pessac B. Pericytes and periendothelial cells of brain parenchyma vessels co-express aminopeptidase N, aminopeptidase A, and nestin. J. Neurosci. Res. 1999, 58:367-378.
11. Almazan G., Vela J.M., Molina-Holgado E., Guaza C. Re-evaluation of nestin as a marker of oligodendrocyte lineage cells. Microsc. Res. Tech. 2001, 52:753-765.
12. Alonso G. Proliferation of progenitor cells in the adult rat brain correlates with the presence of vimentin-expressing astrocytes. Glia 2001, 34:253-266.
13. Alonso G. NG2 proteoglycan-expressing cells of the adult rat brain: possible involvement in the formation of glial scar astrocytes following stab wound. Glia 2005, 49:318-338.
14. Alvarez-Buylla A., Temple S. Stem cells in the developing and adult nervous system. J. Neurobiol. 1998, 36:105-110.
15. Alvarez-Buylla A., Garcia-Verdugo J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 2002, 22:629-634.
16. Amato M.A., Arnault E., Perron M. Retinal stem cells in vertebrates: parallels and divergences. Int. J. Dev. Biol. 2004, 48:993-1001.
17. Amemiya K., Haruta M., Takahashi M., Kosaka M., Eguchi G. Adult human retinal pigment epithelial cells capable of differentiating into neurons. Biochem. Biophys. Res. Commun. 2004, 316:1-5.
18. Anchan R.M., Reh T.A., Angello J., Balliet A., Walker M. EGF and TGF-alpha stimulate retinal neuroepithelial cell proliferation in vitro. Neuron 1991, 6:923-936.
19. Angenieux B., Schorderet D.F., Arsenijevic Y. Epidermal growth factor is a neuronal differentiation factor for retinal stem cells in vitro. Stem Cells 2006, 24:696-706.
20. Arsenijevic Y., Weiss S., Schneider B., Aebischer P. Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2. J. Neurosci. 2001, 21:7194-7202.
21. Arsenijevic Y. Mammalian neural stem-cell renewal: nature versus nurture. Mol. Neurobiol. 2003, 27:73-98.
22. Aruta C., Giordano F., De Marzo A., Comitato A., Raposo G., Nandrot E.F., Marigo V. In vitro differentiation of retinal pigment epithelium from adult retinal stem cells. Pigment Cell Melanoma Res. 2011, 24:233-240.
23. Asami M., Sun G., Yamaguchi M., Kosaka M. Multipotent cells from mammalian iris pigment epithelium. Dev. Biol. 2007, 304:433-446.
24. Bähr M., Bonhoeffer F. Perspectives on axonal regeneration in the mammalian CNS. Trends Neurosci. 1994, 17:473-479.
25. Balu D.T., Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci. Biobehav Rev. 2009, 33:232-252.
26. Barde Y.A., Lindsay R.M., Monard D., Thoenen H. New factor released by cultured glioma cells supporting survival and growth of sensory neurones. Nature 1978, 274:818.
27. Barde Y.A., Edgar D., Thoenen H. Sensory neurons in culture: changing requirements for survival factors during embryonic development. Proc. Natl. Acad. Sci. U S A 1980, 77:1199-1203.
28. Barde Y.A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1982, 1:549-553.
29. Barde Y.A., Edgar D., Thoenen H. New neurotrophic factors. Annu. Rev. Physiol. 1983, 45:601-612.
30. Barde Y.A., Davies A.M., Johnson J.E., Lindsay R.M., Thoenen H. Brain derived neurotrophic factor. Prog. Brain Res. 1987, 71:185-189.
31. Barron K.D. The microglial cell. A historical review. J. Neurol. Sci. 1995, 134(Suppl.):57-68.
32. Baye L.M., Link B.A. Nuclear migration during retinal development. Brain Res. 2008, 1192:29-36.
33. Belecky-Adams T., Tomarev S., Li H.S., Ploder L., McInnes R.R., Sundin O., Adler R. Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest. Ophthalmol. Vis. Sci. 1997, 38:1293-1303.
34. Berkelaar, M., 1992. Retinal ganglion cell loss after different types of axotomy in the potic nerve. Thesis, McGill University.
35. Berkelaar M., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 1994, 14:4368-4374.
36. Bernardos R.L., Barthel L.K., Meyers J.R., Raymond P.A. Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells. J. Neurosci. 2007, 27:7028-7040.
37. Berninger B. Making neurons from mature glia: a far-fetched dream?. Neuropharmacology 2010, 58:894-902.
38. Bhatia B., Singhal S., Lawrence J.M., Khaw P.T., Limb G.A. Distribution of Muller stem cells within the neural retina: evidence for the existence of a ciliary margin-like zone in the adult human eye. Exp. Eye Res. 2009, 89:373-382.
39. Bhatia B., Singhal S., Jayaram H., Khaw P.T., Limb G.A. Adult retinal stem cells revisited. Open Ophthalmol. J. 2010, 4:30-38.
40. Bi Y.Y., Feng D.F., Pan D.C. Stem/progenitor cells: a potential source of retina-specific cells for retinal repair. Neurosci. Res. 2009, 65:215-221.
41. Boucher S.E., Hitchcock P.F. Insulin-related growth factors stimulate proliferation of retinal progenitors in the goldfish. J. Comp. Neurol. 1998, 394:386-394.
42. Braisted J.E., Essman T.F., Raymond P.A. Selective regeneration of photoreceptors in goldfish retina. Development 1994, 120:2409-2419.
43. Brazelton T.R., Rossi F.M., Keshet G.I., Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000, 290:1775-1779.
44. Bringmann A., Reichenbach A. Role of Muller cells in retinal degenerations. Front. Biosci. 2001, 6:E72-E92.
45. Bringmann A., Pannicke T., Grosche J., Francke M., Wiedemann P., Skatchkov S.N., Osborne N.N., Reichenbach A. Muller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 2006, 25:397-424.
46. Bringmann A., Iandiev I., Pannicke T., Wurm A., Hollborn M., Wiedemann P., Osborne N.N., Reichenbach A. Cellular signaling and factors involved in Muller cell gliosis: neuroprotective and detrimental effects. Prog. Retin. Eye Res. 2009, 28:423-451.
47. Bu J., Akhtar N., Nishiyama A. Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion. Glia 2001, 34:296-310.
48. Büchi E.R., Suivaizdis I., Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica 1991, 203:138-147.
49. Büchi E.R. Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study. I. Ganglion cell layer and inner nuclear layer. Exp. Eye Res. 1992, 55:605-613.
50. Buffo A., Rite I., Tripathi P., Lepier A., Colak D., Horn A.P., Mori T., Gotz M. Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain. Proc. Natl. Acad. Sci. U S A 2008, 105:3581-3586.
51. Bull N.D., Limb G.A., Martin K.R. Human Muller stem cell (MIO-M1) transplantation in a rat model of glaucoma: survival, differentiation, and integration. Invest. Ophthalmol. Vis. Sci. 2008, 49:3449-3456.
52. Butovsky O., Ziv Y., Schwartz A., Landa G., Talpalar A.E., Pluchino S., Martino G., Schwartz M.L. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell Neurosci. 2006, 31:149-160.
53. Butt A.M., Duncan A., Hornby M.F., Kirvell S.L., Hunter A., Levine J.M., Berry M. Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter. Glia 1999, 26:84-91.
54. Butt A.M., Kiff J., Hubbard P., Berry M. Synantocytes: new functions for novel NG2 expressing glia. J. Neurocytol. 2002, 31:551-565.
55. Butt A.M., Pugh M., Hubbard P., James G. Functions of optic nerve glia: axoglial signalling in physiology and pathology. Eye (Lond) 2004, 18:1110-1121.
56. Butt A.M., Hamilton N., Hubbard P., Pugh M., Ibrahim M. Synantocytes: the fifth element. J. Anat. 2005, 207:695-706.
57. Cameron H.A., Hazel T.G., McKay R.D. Regulation of neurogenesis by growth factors and neurotransmitters. J. Neurobiol. 1998, 36:287-306.
58. Cao W., Li F., Steinberg R.H., Lavail M.M.L. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp. Eye Res. 2001, 72:591-604.
59. Carson M.J., Reilly C.R., Sutcliffe J.G., Lo D. Mature microglia resemble immature antigen-presenting cells. Glia 1998, 22:72-85.
60. Caudle W.M., Zhang J. Glutamate, excitotoxicity, and programmed cell death in Parkinson disease. Exp. Neurology 2009, 220:230-233.
61. Chacko D.M., Das A.V., Zhao X., James J., Bhattacharya S., Ahmad I. Transplantation of ocular stem cells: the role of injury in incorporation and differentiation of grafted cells in the retina. Vis. Res. 2003, 43:937-946.
62. Chang M.L., Wu C.H., Jiang-Shieh Y.F., Shieh J.Y., Wen C.Y. Reactive changes of retinal astrocytes and Muller glial cells in kainate-induced neuroexcitotoxicity. J. Anat. 2007, 210:54-65.
63. Chen H.L., Yuh C.H., Wu K.K. Nestin is essential for zebrafish brain and eye development through control of progenitor cell apoptosis. PLoS One 2010, 5:e9318.
64. Chen L., Yang P., Kijlstra A. Distribution, markers, and functions of retinal microglia. Ocul. Immunol. Inflamm. 2002, 10:27-39.
65. Chen Z.J., Negra M., Levine A., Ughrin Y., Levine J.M. Oligodendrocyte precursor cells: reactive cells that inhibit axon growth and regeneration. J. Neurocytol. 2002, 31:481-495.
66. Chiba C., Hoshino A., Nakamura K., Susaki K., Yamano Y., Kaneko Y., Kuwata O., Maruo F., Saito T. Visual cycle protein RPE65 persists in new retinal cells during retinal regeneration of adult newt. J. Comp. Neurol. 2006, 495:391-407.
67. Cicero S.A., Johnson D., Reyntjens S., Frase S., Connell S., Chow L.M., Baker S.J., Sorrentino B.P., Dyer M.A. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc. Natl. Acad. Sci. U S A 2009, 106:6685-6690.
68. Close J.L., Liu J., Gumuscu B., Reh T.A. Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina. Glia 2006, 54:94-104.
69. Coles B.L., Angenieux B., Inoue T., Del Rio-Tsonis K., Spence J.R., McInnes R.R., Arsenijevic Y., van der Kooy D. Facile isolation and the characterization of human retinal stem cells. Proc. Natl. Acad. Sci. U S A 2004, 101:15772-15777.
70. Costa M.R., Gotz M., Berninger B. What determines neurogenic competence in glia?. Brain Res. Rev. 2010, 63:47-59.
71. Dahlmann-Noor A., Vijay S., Jayaram H., Limb A., Khaw P.T. Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve. Can. J. Ophthalmol. 2010, 45:333-341.
72. Dahlstrand J., Lardelli M., Lendahl U.L. Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Brain Res. Dev. Brain Res. 1995, 84:109-129.
73. Daniel C., Albrecht H., Ludke A., Hugo C. Nestin expression in repopulating mesangial cells promotes their proliferation. Lab. Invest. 2008, 88:387-397.
74. Das A.V., James J., Zhao X., Rahnenfuhrer J., Ahmad I. Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling. Dev. Biol. 2004, 273:87-105.
75. Das A.V., James J., Rahnenfuhrer J., Thoreson W.B., Bhattacharya S., Zhao X., Ahmad I. Retinal properties and potential of the adult mammalian ciliary epithelium stem cells. Vis. Res. 2005, 45:1653-1666.
76. Das A.V., Mallya K.B., Zhao X., Ahmad F., Bhattacharya S., Thoreson W.B., Hegde G.V., Ahmad I. Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling. Dev. Biol. 2006, 299:283-302.
77. Das A.V., Zhao X., James J., Kim M., Cowan K.H., Ahmad I. Neural stem cells in the adult ciliary epithelium express GFAP and are regulated by Wnt signaling. Biochem. Biophys. Res. Commun. 2006, 339:708-716.
78. Davies A.M., Thoenen H., Barde Y.A. Different factors from the central nervous system and periphery regulate the survival of sensory neurones. Nature 1986, 319:497-499.
79. Denham M., Conley B., Olsson F., Cole T.J., Mollard R. Stem cells: an overview. Curr. Protoc. Cell Biol. 2005, Chapter 23, Unit 23 21.
80. Dennis C.L. Developmental reprogramming: take a cell, any cell. Nature 2003, 426:490-491.
81. Di Polo A., Aigner L.J., Dunn R.J., Bray G.M., Aguayo A.J.L. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. U S A 1998, 95:3978-3983.
82. Doetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999, 97:703-716.
83. Dore-Duffy P., Katychev A., Wang X., Van Buren E. CNS microvascular pericytes exhibit multipotential stem cell activity. J. Cereb. Blood Flow Metab. 2006, 26:613-624.
84. Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 1995, 82:359-370.
85. Dreyer E.B., Zurakowski D., Schumer R.A., Podos S.M., Lipton S.A. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch. Ophthalmol. 1996, 114:299-305.
86. Dyer M.A., Cepko C.L. Control of Muller glial cell proliferation and activation following retinal injury. Nat. Neurosci. 2000, 3:873-880.
87. Eddleston M., Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 1993, 54:15-36.
88. Eguchi G. Instability in cell commitment of vertebrate pigmented epithelial cells and their transdifferentiation into lens cells. Curr. Top. Dev. Biol. 1986, 20:21-37.
89. el-Asrar A.M., Morse P.H., Maimone D., Torczynski E., Reder A.T. MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate. Invest. Ophthalmol. Vis. Sci. 1992, 33:3463-3468.
90. Ellis P., Fagan B.M., Magness S.T., Hutton S., Taranova O., Hayashi S., McMahon A., Rao M., Pevny L.L. SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev. Neurosci. 2004, 26:148-165.
91. Engelhardt M., Wachs F.P., Couillard-Despres S., Aigner L. The neurogenic competence of progenitors from the postnatal rat retina in vitro. Exp. Eye Res. 2004, 78:1025-1036.
92. Engelhardt M., Bogdahn U., Aigner L. Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res. 2005, 1040:98-111.
93. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., Gage F.H. Neurogenesis in the adult human hippocampus. Nat. Med. 1998, 4:1313-1317.
94. Faberowski N., Stefansson E., Davidson R.C. Local hypothermia protects the retina from ischemia. A quantitative study in the rat. Invest. Ophthalmology Visual Science 1989, 30:2309-2313.
95. Fausett B.V., Goldman D. A role for alpha1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina. J. Neurosci. 2006, 26:6303-6313.
96. Fawcett J.W., Asher R.A. The glial scar and central nervous system repair. Brain Res. Bull. 1999, 49:377-391.
97. Ffrench-Constant C., Raff M.C. Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature 1986, 319:499-502.
98. Fiedorowicz A., Figiel I., Zaremba M., Dzwonek K., Oderfeld-Nowak B. The ameboid phenotype of NG2 (+) cells in the region of apoptotic dentate granule neurons in trimethyltin intoxicated mice shares antigen properties with microglia/macrophages. Glia 2008, 56:209-222.
99. Filippov V., Kronenberg G., Pivneva T., Reuter K., Steiner B., Wang L.P., Yamaguchi M., Kettenmann H., Kempermann G.L. Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes. Mol. Cell Neurosci. 2003, 23:373-382.
100. Fimbel S.M., Montgomery J.E., Burket C.T., Hyde D.R. Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. J. Neurosci. 2007, 27:1712-1724.
101. Fischer A.J., Reh T.A. Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens. Dev. Biol. 2000, 220:197-210.
102. Fischer A.J., Hendrickson A., Reh T.A. Immunocytochemical characterization of cysts in the peripheral retina and pars plana of the adult primate. Invest. Ophthalmol. Vis. Sci. 2001, 42:3256-3263.
103. Fischer A.J., Reh T.A. Transdifferentiation of pigmented epithelial cells: a source of retinal stem cells?. Dev. Neurosci. 2001, 23:268-276.
104. Fischer A.J., Reh T.A. Muller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat. Neurosci. 2001, 4:247-252.
105. Fischer A.J., McGuire C.R., Dierks B.D., Reh T.A. Insulin and fibroblast growth factor 2 activate a neurogenic program in Muller glia of the chicken retina. J. Neurosci. 2002, 22:9387-9398.
106. Fischer A.J., Reh T.A. Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina. Dev. Biol. 2002, 251:367-379.
107. Fischer A.J., Reh T.A. Growth factors induce neurogenesis in the ciliary body. Dev. Biol. 2003, 259:225-240.
108. Fischer A.J., Reh T.A. Potential of Muller glia to become neurogenic retinal progenitor cells. Glia 2003, 43:70-76.
109. Fischer A.J. Neural regeneration in the chick retina. Prog. Retin. Eye Res. 2005, 24:161-182.
110. Fischer A.J., Omar G. Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Muller glia in the chicken retina. J. Comp. Neurol. 2005, 484:1-14.
111. Fischer A.J., Bongini R. Turning Muller glia into neural progenitors in the retina. Mol. Neurobiol. 2010, 42:199-209.
112. Fischer A.J., Zelinka C., Scott M.A. Heterogeneity of glia in the retina and optic nerve of birds and mammals. PLoS One 2010, 5:e10774.
113. Franze K., Grosche J., Skatchkov S.N., Schinkinger S., Foja C., Schild D., Uckermann O., Travis K., Reichenbach A., Guck J. Muller cells are living optical fibers in the vertebrate retina. Proc. Natl. Acad. Sci. U S A 2007, 104:8287-8292.
114. Froen R.C., Johnsen E.O., Petrovski G., Berenyi E., Facsko A., Berta A., Nicolaissen B., Moe M.C. Pigment epithelial cells isolated from human peripheral iridectomies have limited properties of retinal stem cells. Acta Ophthalmol. (Copenh) 2011.
115. Galli-Resta L. Putting neurons in the right places: local interactions in the genesis of retinal architecture. Trends Neurosci. 2002, 25:638-643.
116. Galli R., Gritti A., Bonfanti L., Vescovi A.L.L. Neural stem cells: an overview. Circ. Res. 2003, 92:598-608.
117. Gallo V., Pende M., Scherer S., Molne M., Wright P. Expression and regulation of kainate and AMPA receptors in uncommitted and committed neural progenitors. Neurochem. Res. 1995, 20:549-560.
118. Gallo V., Russell J.T. Excitatory amino acid receptors in glia: different subtypes for distinct functions?. J. Neurosci. Res. 1995, 42:1-8.
119. Gallo V., Ghiani C.A. Glutamate receptors in glia: new cells, new inputs and new functions. Trends Pharmacol. Sci. 2000, 21:252-258.
120. Garcia-Valenzuela E., Gorczyca W., Darzynkiewicz Z., Sharma S.C. Apoptosis in adult retinal ganglion cells after axotomy. J. Neurobiol. 1994, 25:431-438.
121. Garcia-Valenzuela E., Shareef S., Walsh J., Sharma S.C. Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp. Eye Res. 1995, 61:33-44.
122. Garcia-Valenzuela E., Sharma S.C. Laminar restriction of retinal macrophagic response to optic nerve axotomy in the rat. J. Neurobiol. 1999, 40:55-66.
123. Garcia M., Vecino E. Role of Muller glia in neuroprotection and regeneration in the retina. Histol. Histopathol. 2003, 18:1205-1218.
124. Garcia Valenzuela E., Sharma S.C. Rescue of retinal ganglion cells from axotomy-induced apoptosis through TRK oncogene transfer. Neuroreport 1998, 9:3165-3170.
125. Gariano R.F., Gardner T.W. Retinal angiogenesis in development and disease. Nature 2005, 438:960-966.
126. Geisert E.E., Williams R.C., Bidanset D.J. A CNS specific proteoglycan associated with astrocytes in rat optic nerve. Brain Res. 1992, 571:165-168.
127. Gilyarov A.V. Nestin in central nervous system cells. Neurosci. Behav. Physiol. 2008, 38:165-169.
128. Ginhoux F., Greter M., Leboeuf M., Nandi S., See P., Gokhan S., Mehler M.F., Conway S.J., Ng L.G., Stanley E.R., Samokhvalov I.M., Merad M. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330:841-845.
129. Giordano F., De Marzo A., Vetrini F., Marigo V. Fibroblast growth factor and epidermal growth factor differently affect differentiation of murine retinal stem cells in vitro. Mol. Vis. 2007, 13:1842-1850.
130. Glanzer J.G., Enose Y., Wang T., Kadiu I., Gong N., Rozek W., Liu J., Schlautman J.D., Ciborowski P.S., Thomas M.P., Gendelman H.E. Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation. J. Neurochemistry 2007, 102:627-645.
131. Goolsby J., Marty M.C., Heletz D., Chiappelli J., Tashko G., Yarnell D., Fishman P.S., Dhib-Jalbut S., Bever C.T., Pessac B., Trisler D. Hematopoietic progenitors express neural genes. Proc. Natl. Acad. Sci. U S A 2003, 100:14926-14931.
132. Gould E., Reeves A.J., Graziano M.S., Gross C.G. Neurogenesis in the neocortex of adult primates. Science 1999, 286:548-552.
133. Grafstein B., Ingoglia N.A. Intracranial transection of the optic nerve in adult mice: preliminary observations. Exp. Neurol. 1982, 76:318-330.
134. Grigoryan E.N. Differentiation markers of retinal cell types in studies on vertebrate eye development and regeneration. Russ. J. Develpomental Biol. 2001, 32:63-80.
135. Gross C.G.L. Neurogenesis in the adult brain: death of a dogma. Nat. Rev. Neurosci. 2000, 1:67-73.
136. Gu P., Harwood L.J., Zhang X., Wylie M., Curry W.J., Cogliati T. Isolation of retinal progenitor and stem cells from the porcine eye. Mol. Vis. 2007, 13:1045-1057.
137. Gualdoni S., Baron M., Lakowski J., Decembrini S., Smith A.J., Pearson R.A., Ali R.R., Sowden J.C. Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells 2010, 28:1048-1059.
138. Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J. Leukoc. Biol. 2004, 75:388-397.
139. Guo F., Maeda Y., Ma J., Xu J., Horiuchi M., Miers L., Vaccarino F., Pleasure D. Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J. Neurosci.: Official J. Soc. Neurosci. 2010, 30:12036-12049.
140. Hailer N.P., Grampp A., Nitsch R. Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: a quantitative bromodeoxyuridine-labelling study. Eur. J. Neurosci. 1999, 11:3359-3364.
141. Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neuroscience 2007, 10:1387-1394.
142. Harris J.R., Brown G.A., Jorgensen M., Kaushal S., Ellis E.A., Grant M.B., Scott E.W. Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Invest. Ophthalmol. Vis. Sci. 2006, 47:2108-2113.
143. Harris W.A., Perron M.L. Molecular recapitulation: the growth of the vertebrate retina. Int. J. Dev. Biol. 1998, 42:299-304.
144. Hartfuss E., Galli R., Heins N., Gotz M. Characterization of CNS precursor subtypes and radial glia. Dev. Biol. 2001, 229:15-30.
145. Haruta M., Kosaka M., Kanegae Y., Saito I., Inoue T., Kageyama R., Nishida A., Honda Y., Takahashi M. Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue. Nat. Neurosci. 2001, 4:1163-1164.
146. Harvey A.R., Hu Y., Leaver S.G., Mellough C.B., Park K., Verhaagen J., Plant G.W., Cui Q. Gene therapy and transplantation in CNS repair: the visual system. Prog. Retin. Eye Res. 2006, 25:449-489.
147. Hatten M.E. Riding the glial monorail: a common mechanism for glial-guided neuronal migration in different regions of the developing mammalian brain. Trends Neurosci. 1990, 13:179-184.
148. Hatten M.E. Central nervous system neuronal migration. Annu. Rev. Neurosci. 1999, 22:511-539.
149. Haynes T., Del Rio-Tsonis K. Retina repair, stem cells and beyond. Curr. Neurovasc Res. 2004, 1:231-239.
150. Hitchcock P., Ochocinska M., Sieh A., Otteson D. Persistent and injury-induced neurogenesis in the vertebrate retina. Prog. Retin. Eye Res. 2004, 23:183-194.
151. Hitchcock P.F., Macdonald R.E., VanDeRyt J.T., Wilson S.W. Antibodies against Pax6 immunostain amacrine and ganglion cells and neuronal progenitors, but not rod precursors, in the normal and regenerating retina of the goldfish. J. Neurobiol. 1996, 29:399-413.
152. Hockfield S., McKay R.D. Identification of major cell classes in the developing mammalian nervous system. J. Neurosci.: Official J. Soc. Neurosci. 1985, 5:3310-3328.
153. Hou B., You S.W., Wu M.M., Kuang F., Liu H.L., Jiao X.Y., Ju G. Neuroprotective effect of inosine on axotomized retinal ganglion cells in adult rats. Invest. Ophthalmol. Vis. Sci. 2004, 45:662-667.
154. Hyer J. Looking at an oft-overlooked part of the eye: a new perspective on ciliary body development in chick. Dev. Neuroscience 2004, 26:456-465.
155. Hynd M.R., Scott H.L., Dodd P.R. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem. Int. 2004, 45:583-595.
156. Ikegami Y., Mitsuda S., Araki M. Neural cell differentiation from retinal pigment epithelial cells of the newt: an organ culture model for the urodele retinal regeneration. J. Neurobiol. 2002, 50:209-220.
157. Inman D.M., Horner P.J. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia 2007, 55:942-953.
158. Inoue T., Kagawa T., Fukushima M., Shimizu T., Yoshinaga Y., Takada S., Tanihara H., Taga T. Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin. Stem Cells 2006, 24:95-104.
159. Inoue T., Coles B.L., Dorval K., Bremner R., Bessho Y., Kageyama R., Hino S., Matsuoka M., Craft C.M., McInnes R.R., Tremblay F., Prusky G.T., van der Kooy D. Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells 2010, 28:489-500.
160. Inoue Y., Yanagi Y., Tamaki Y., Uchida S., Kawase Y., Araie M., Okochi H. Clonogenic analysis of ciliary epithelial derived retinal progenitor cells in rabbits. Exp. Eye Res. 2005, 81:437-445.
161. Isenmann S., Bähr M. Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat. Exp. Neurol. 1997, 147:28-36.
162. Isenmann S., Wahl C., Krajewski S., Reed J.C., Bähr M. Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat. Eur. J. Neurosci. 1997, 9:1763-1772.
163. Isenmann S., Klöcker N., Gravel C., Bähr M. Short communication: protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo. Eur. Journal Neuroscience 1998, 10:2751-2756.
164. Isenmann S., Cellerino A., Gravel C., Bähr M. Excess target-derived brain-derived neurotrophic factor preserves the transient uncrossed retinal projection to the superior colliculus. Mol. Cellular Neurosciences 1999, 14:52-65.
165. Isenmann S., Kretz A., Cellerino A. Molecular determinants of retinal ganglion cell development, survival, and regeneration. Prog. Retin. Eye Res. 2003, 22:483-543.
166. Isenmann S., Schmeer C., Kretz A. How to keep injured CNS neurons viable-strategies for neuroprotection and gene transfer to retinal ganglion cells. Mol. Cell Neurosci. 2004, 26:1-16.
167. Ishiwata T., Matsuda Y., Naito Z. Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J. Gastroenterol. 2011, 17:409-418.
168. Jadhav A.P., Roesch K., Cepko C.L. Development and neurogenic potential of Muller glial cells in the vertebrate retina. Prog. Retin. Eye Res. 2009, 28:249-262.
169. James J., Das A.V., Bhattacharya S., Chacko D.M., Zhao X., Ahmad I. In vitro generation of early-born neurons from late retinal progenitors. J. Neurosci. 2003, 23:8193-8203.
170. James J., Das A.V., Rahnenfuhrer J., Ahmad I. Cellular and molecular characterization of early and late retinal stem cells/progenitors: differential regulation of proliferation and context dependent role of Notch signaling. J. Neurobiol. 2004, 61:359-376.
171. Jian Q., Xu H., Xie H., Tian C., Zhao T., Yin Z. Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa. Neurosci. Lett. 2009, 465:41-44.
172. Johansson C.B., Lothian C., Molin M., Okano H., Lendahl U. Nestin enhancer requirements for expression in normal and injured adult CNS. J. Neurosci. Res. 2002, 69:784-794.
173. Johnson J.E., Barde Y.A., Schwab M., Thoenen H. Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J. Neurosci.: Official J. Soc. Neurosci. 1986, 6:3031-3038.
174. Joo C.K., Choi J.S., Ko H.W., Park K.Y., Sohn S., Chun M.H., Oh Y.J., Gwag B.J. Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. Invest. Ophthalmol. Vis. Sci. 1999, 40:713-720.
175. Kagiwada K., Chida D., Sakatani T., Asano M., Nambu A., Kakuta S., Iwakura Y. Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha. Endocrinology 2004, 145:5044-5048.
176. Karl M.O., Hayes S., Nelson B.R., Tan K., Buckingham B., Reh T.A. Stimulation of neural regeneration in the mouse retina. Proc. Natl. Acad. Sci. U S A 2008, 105:19508-19513.
177. Karl M.O., Reh T.A. Regenerative medicine for retinal diseases: activating endogenous repair mechanisms. Trends Mol. Med. 2010, 16:193-202.
178. Kaur C., Foulds W.S., Ling E.A. Hypoxia-ischemia and retinal ganglion cell damage. Clin. Ophthalmol. 2008, 2:879-889.
179. Kawaguchi A., Miyata T., Sawamoto K., Takashita N., Murayama A., Akamatsu W., Ogawa M., Okabe M., Tano Y., Goldman S.A., Okano H. Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Mol. Cellular Neurosciences 2001, 17:259-273.
180. Kawai S.I., Vora S., Das S., Gachie E., Becker B., Neufeld A.H. Modeling of risk factors for the degeneration of retinal ganglion cells after ischemia/reperfusion in rats: effects of age, caloric restriction, diabetes, pigmentation, and glaucoma. Faseb J. 2001, 15:1285-1287.
181. Keiner S., Walter J., Oberland J., Redecker C. Contribution of constitutively proliferating precursor cell subtypes to dentate neurogenesis after cortical infarcts. BMC Neurosci. 2010, 11:146.
182. Kempermann G., Jessberger S., Steiner B., Kronenberg G. Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 2004, 27:447-452.
183. Kermer P., Klocker N., Labes M., Bahr M. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J. Neurosci.: Official J. Soc. Neurosci. 1998, 18:4656-4662.
184. Kernie S.G., Erwin T.M., Parada L.F.L. Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice. J. Neurosci. Res. 2001, 66:317-326.
185. Kezic J., McMenamin P.G. Differential turnover rates of monocyte-derived cells in varied ocular tissue microenvironments. J. Leukoc. Biol. 2008, 84:721-729.
186. Kicic A., Shen W.Y., Wilson A.S., Constable I.J., Robertson T., Rakoczy P.E. Differentiation of marrow stromal cells into photoreceptors in the rat eye. J. Neurosci.: Official J. Soc. Neurosci. 2003, 23:7742-7749.
187. Kim I.B., Kim K.Y., Joo C.K., Lee M.Y., Oh S.J., Chung J.W., Chun M.H. Reaction of Muller cells after increased intraocular pressure in the rat retina. Exp. Brain Res. 1998, 121:419-424.
188. Kim S.U., de Vellis J. Microglia in health and disease. J. Neurosci. Res. 2005, 81:302-313.
189. Kinouchi R., Takeda M., Yang L., Wilhelmsson U., Lundkvist A., Pekny M., Chen D.F.L. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat. Neurosci. 2003, 6:863-868.
190. Klassen H., Sakaguchi D.S., Young M.J. Stem cells and retinal repair. Prog. Retin. Eye Res. 2004, 23:149-181.
191. Klassen H.J., Ng T.F., Kurimoto Y., Kirov I., Shatos M., Coffey P., Young M.J. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest. Ophthalmol. Vis. Sci. 2004, 45:4167-4173.
192. Klöcker N., Braunling F., Isenmann S., Bähr M. In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells. Neuroreport 1997, 8:3439-3442.
193. Klöcker N., Zerfowski M., Gellrich N.C., Bähr M. Morphological and functional analysis of an incomplete CNS fiber tract lesion: graded crush of the rat optic nerve. J. Neurosci. Methods 2001, 110:147-153.
194. Kohno H., Sakai T., Kitahara K. Induction of nestin, Ki-67, and cyclin D1 expression in Muller cells after laser injury in adult rat retina. Graefes Arch. Clin. Exp. Ophthalmol. 2006, 244:90-95.
195. Kohno R., Ikeda Y., Yonemitsu Y., Hisatomi T., Yamaguchi M., Miyazaki M., Takeshita H., Ishibashi T., Sueishi K. Sphere formation of ocular epithelial cells in the ciliary body is a reprogramming system for neural differentiation. Brain Res. 2006, 1093:54-70.
196. Kondo T., Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 2000, 289:1754-1757.
197. Kostyk S.K., D'Amore P.A., Herman I.M., Wagner J.A. Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract. J. Neurosci. 1994, 14:1441-1449.
198. Krebs C., Fernandes H.B., Sheldon C., Raymond L.A., Baimbridge K.G. Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. J. Neurosci.: Official J. Soc. Neurosci. 2003, 23:3364-3372.
199. Krempler K., Schmeer C.W., Isenmann S., Witte O.W., Lowel S. Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice. Invest. Ophthalmol. Vis. Sci. 2011, 52:2606-2618.
200. Kretz A., Happold C.J., Marticke J.K., Isenmann S. Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation. Mol. Cellular Neurosciences 2005, 29:569-579.
201. Kretz A., Jacob A.M., Tausch S., Straten G., Isenmann S. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Brain Res. 2006, 1090:1-14.
202. Kretz A., Schmeer C., Tausch S., Isenmann S. Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivo. Neurobiol. Dis. 2006, 21:421-430.
203. Kreutzberg G.W. Microglia, the first line of defence in brain pathologies. Arzneimittelforschung 1995, 45:357-360.
204. Krupkova O., Loja T., Zambo I., Veselska R. Nestin expression in human tumors and tumor cell lines. Neoplasma 2010, 57:291-298.
205. Kubota R., Hokoc J.N., Moshiri A., McGuire C., Reh T.A. A comparative study of neurogenesis in the retinal ciliary marginal zone of homeothermic vertebrates. Brain Res. Dev. Brain Res. 2002, 134:31-41.
206. Ladeby R., Wirenfeldt M., Dalmau I., Gregersen R., Garcia-Ovejero D., Babcock A., Owens T., Finsen B. Proliferating resident microglia express the stem cell antigen CD34 in response to acute neural injury. Glia 2005, 50:121-131.
207. Lafuente M.P., Villegas-Perez M.P., Selles-Navarro I., Mayor-Torroglosa S., Miralles de Imperial J., Vidal-Sanz M. Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. Neuroscience 2002, 109:157-168.
208. Lam T.T., Siew E., Chu R., Tso M.O. Ameliorative effect of MK-801 on retinal ischemia. J. Ocul. Pharmacol. Ther. 1997, 13:129-137.
209. Lamas M., Lee-Rivera I., Lopez-Colome A.M. Cell-specific expression of N-methyl-D-aspartate receptor subunits in Muller glia and neurons from the chick retina. Invest. Ophthalmol. Vis. Sci. 2005, 46:3570-3577.
210. Lamba D., Karl M., Reh T. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008, 2:538-549.
211. Laquis S., Chaudhary P., Sharma S.C. The patterns of retinal ganglion cell death in hypertensive eyes. Brain Res. 1998, 784:100-104.
212. Lawrence J.M., Singhal S., Bhatia B., Keegan D.J., Reh T.A., Luthert P.J., Khaw P.T., Limb G.A. MIO-M1 cells and similar Muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells 2007, 25:2033-2043.
213. Lendahl U., Zimmerman L.B., McKay R.D. CNS stem cells express a new class of intermediate filament protein. Cell 1990, 60:585-595.
214. Levkovitch-Verbin H. Animal models of optic nerve diseases. Eye (Lond) 2004, 18:1066-1074.
215. Lewis G.P., Erickson P.A., Guerin C.J., Anderson D.H., Fisher S.K.L. Basic fibroblast growth factor: a potential regulator of proliferation and intermediate filament expression in the retina. J. Neurosci. 1992, 12:3968-3978.
216. Lewis G.P., Fisher S.K. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int. Rev. Cytol. 2003, 230:263-290.
217. Liesegang T.J. Glaucoma: changing concepts and future directions. Mayo Clin. Proc. 1996, 71:689-694.
218. Limb G.A., Lawrence J.M., Keegan D.J., Reh T.A., Coffey P.J., Luthert P.J., Khaw P.T. Muller glial cells from adult human retina exhibit neural stem cell characteristics and prevent loss of visual function and retinal degeneration in the RCS rat. Invest. Ophthalmol. Vis. Sci. 2004, 45:5387.
219. Limb G.A., Lawrence J.M., Reh T.A., Khaw P.T. Localization of Muller glia with neural stem cell characteristics in the adult human retina. Invest. Ophthalmol. Vis. Sci. 2005, 46:3231.
220. Ling T.L., Mitrofanis J., Stone J. Origin of retinal astrocytes in the rat: evidence of migration from the optic nerve. J. Comp. Neurol. 1989, 286:345-352.
221. Liu I.H., Chen S.J., Ku H.H., Kao C.L., Tsai F.T., Hsu W.M., Lo C.W., Kuo Y.H., Kuo C.D., Lee C.H., Chiou S.H. Comparison of the proliferation and differentiation ability between adult rat retinal stem cells and cerebral cortex-derived neural stem cells. Ophthalmologica 2005, 219:171-176.
222. Liu I.S., Chen J.D., Ploder L., Vidgen D., van der Kooy D., Kalnins V.I., McInnes R.R. Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron 1994, 13:377-393.
223. Livesey F.J., Cepko C.L.L. Vertebrate neural cell-fate determination: lessons from the retina. Nat. Rev. Neurosci. 2001, 2:109-118.
224. Livesey F.J., Young T.L., Cepko C.L.L. An analysis of the gene expression program of mammalian neural progenitor cells. Proc. Natl. Acad. Sci. U S A 2004, 101:1374-1379.
225. Lobo M.V., Arenas M.I., Alonso F.J., Gomez G., Bazan E., Paino C.L., Fernandez E., Fraile B., Paniagua R., Moyano A., Caso E. Nestin, a neuroectodermal stem cell marker molecule, is expressed in Leydig cells of the human testis and in some specific cell types from human testicular tumours. Cell Tissue Res. 2004, 316:369-376.
226. Locker M., El Yakoubi W., Mazurier N., Dullin J.P., Perron M. A decade of mammalian retinal stem cell research. Arch. Ital Biol. 2010, 148:59-72.
227. Lois C., Alvarez-Buylla A.L. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Natl. Acad. Sci. U S A 1993, 90:2074-2077.
228. Lord-Grignon J., Abdouh M., Bernier G. Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice. Gene Expr. Patterns 2006.
229. Loughlin S., Fallon J.H. Neurotrophic Factors Pages 1993, Academic Press, Inc, London.
230. Louzada-Junior P., Dias J.J., Santos W.F., Lachat J.J., Bradford H.F., Coutinho-Netto J. Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J. Neurochemistry 1992, 59:358-363.
231. Lund R.D., Kwan A.S., Keegan D.J., Sauve Y., Coffey P.J., Lawrence J.M.L. Cell transplantation as a treatment for retinal disease. Prog. Retin. Eye Res. 2001, 20:415-449.
232. MacLaren R.E., Pearson R.A., MacNeil A., Douglas R.H., Salt T.E., Akimoto M., Swaroop A., Sowden J.C., Ali R.R. Retinal repair by transplantation of photoreceptor precursors. Nature 2006, 444:203-207.
233. MacLaren R.E., Pearson R.A. Stem cell therapy and the retina. Eye (Lond) 2007, 21:1352-1359.
234. MacNeil A., Pearson R.A., MacLaren R.E., Smith A.J., Sowden J.C., Ali R.R. Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye. Stem Cells 2007, 25:2430-2438.
235. Magavi S.S., Leavitt B.R., Macklis J.D. Induction of neurogenesis in the neocortex of adult mice. Nature 2000, 405:951-955.
236. Marquardt T., Ashery-Padan R., Andrejewski N., Scardigli R., Guillemot F., Gruss P.L. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 2001, 105:43-55.
237. Marquardt T., Gruss P.L. Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci. 2002, 25:32-38.
238. Marquardt T.L. Transcriptional control of neuronal diversification in the retina. Prog. Retin. Eye Res. 2003, 22:567-577.
239. Martinez-Navarrete G.C., Angulo A., Martin-Nieto J., Cuenca N. Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans. J. Comp. Neurol. 2008, 511:557-580.
240. Matsuda S., Niidome T., Nonaka H., Goto Y., Fujimura K., Kato M., Nakanishi M., Akaike A., Kihara T., Sugimoto H. Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons. Biochem. Biophys. Res. Commun. 2008, 368:971-976.
241. Matsumoto H., Kumon Y., Watanabe H., Ohnishi T., Shudou M., Chuai M., Imai Y., Takahashi H., Tanaka J. Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 2008, 28:149-163.
242. Matsumura S., Takagi K., Okuda-Ashitaka E., Lu J., Naritsuka H., Yamaguchi M., Ito S. Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury. Neuroscience 2010, 170:942-953.
243. Matsushima D., Heavner W., Pevny L.H. Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development 2011, 138:443-454.
244. Mayer E.J., Carter D.A., Ren Y., Hughes E.H., Rice C.M., Halfpenny C.A., Scolding N.J., Dick A.D.L. Neural progenitor cells from postmortem adult human retina. Br. J. Ophthalmol. 2005, 89:102-106.
245. McMenamin P.G., Holthouse I., Holt P.G. Class II major histocompatibility complex (Ia) antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia. Immunology 1992, 77:385-393.
246. McMenamin P.G. Dendritic cells and macrophages in the uveal tract of the normal mouse eye. Br. J. Ophthalmol. 1999, 83:598-604.
247. Mellough C.B., Cui Q., Spalding K.L., Symons N.A., Pollett M.A., Snyder E.Y., Macklis J.D., Harvey A.R. Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells. Exp. Neurol. 2004, 186:6-19.
248. Merhi-Soussi F., Angenieux B., Canola K., Kostic C., Tekaya M., Hornfeld D., Arsenijevic Y. High yield of cells committed to the photoreceptor fate from expanded mouse retinal stem cells. Stem Cells 2006, 24:2060-2070.
249. Mey J., Thanos S. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 1993, 602:304-317.
250. Mezey E., Chandross K.J. Bone marrow: a possible alternative source of cells in the adult nervous system. Eur. J. Pharmacol. 2000, 405:297-302.
251. Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000, 290:1779-1782.
252. Mezey E., Key S., Vogelsang G., Szalayova I., Lange G.D., Crain B. Transplanted bone marrow generates new neurons in human brains. Proc. Natl. Acad. Sci. U S A 2003, 100:1364-1369.
253. Michalczyk K., Ziman M. Nestin structure and predicted function in cellular cytoskeletal organisation. Histol. Histopathol 2005, 20:665-671.
254. Miller R.H., Ffrench-Constant C., Raff M.C. The macroglial cells of the rat optic nerve. Annu. Rev. Neurosci. 1989, 12:517-534.
255. Ming G.L., Song H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 2005, 28:223-250.
256. Misantone L.J., Gershenbaum M., Murray M. Viability of retinal ganglion cells after optic nerve crush in adult rats. J. Neurocytol. 1984, 13:449-465.
257. Mitashov V.I. Multipotent and stem cells in the developing, definitive, and regerationg vertebrate eye. Biol. Bull. 2001, 28:606-615. SYMPOSIUM.
258. Moe M.C., Kolberg R.S., Sandberg C., Vik-Mo E., Olstorn H., Varghese M., Langmoen I.A., Nicolaissen B. A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain. Exp. Eye Res. 2009, 88:30-38.
259. Mokry J., Ehrmann J., Karbanova J., Cizkova D., Soukup T., Suchanek J., Filip S., Kolar Z. Expression of intermediate filament nestin in blood vessels of neural and non-neural tissues. Acta Med. (Hradec Kralove) 2008, 51:173-179.
260. Monje M.L., Toda H., Palmer T.D.L. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003, 302:1760-1765.
261. Monnin J., Morand-Villeneuve N., Michel G., Hicks D., Versaux-Botteri C. Production of neurospheres from mammalian Muller cells in culture. Neurosci. Lett. 2007, 421:22-26.
262. Mori T., Buffo A., Gotz M.L. The novel roles of glial cells revisited: the contribution of radial glia and astrocytes to neurogenesis. Curr. Top. Dev. Biol. 2005, 69:67-99.
263. Morshead C.M., Garcia A.D., Sofroniew M.V., Ian Der Kooy D.L. The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur. J. Neurosci. 2003, 18:76-84.
264. Moshiri A., Close J., Reh T.A. Retinal stem cells and regeneration. Int. J. Dev. Biol. 2004, 48:1003-1014.
265. Müller B.K., Bonhoeffer F., Drescher U. Novel gene families involved in neural pathfinding. Curr. Opin. Genet. Dev. 1996, 6:469-474.
266. Namiki J., Tator C.H. Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury. J. Neuropathol. Exp. Neurol. 1999, 58:489-498.
267. Neal M.J., Cunningham J.R., Hutson P.H., Hogg J. Effects of ischaemia on neurotransmitter release from the isolated retina. J. Neurochemistry 1994, 62:1025-1033.
268. Newman E., Reichenbach A. The Muller cell: a functional element of the retina. Trends Neurosci. 1996, 19:307-312.
269. Nickerson P.E., Emsley J.G., Myers T., Clarke D.B. Proliferation and expression of progenitor and mature retinal phenotypes in the adult mammalian ciliary body after retinal ganglion cell injury. Invest. Ophthalmol. Vis. Sci. 2007, 48:5266-5275.
270. Nickerson P.E., Da Silva N., Myers T., Stevens K., Clarke D.B. Neural progenitor potential in cultured Muller glia: effects of passaging and exogenous growth factor exposure. Brain Res. 2008, 1230:1-12.
271. Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
272. Nishida A., Takahashi M., Tanihara H., Nakano I., Takahashi J.B., Mizoguchi A., Ide C., Honda Y.L. Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest. Ophthalmol. Vis. Sci. 2000, 41:4268-4274.
273. Nishiguchi K.M., Kaneko H., Nakamura M., Kachi S., Terasaki H. Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury. Invest. Ophthalmol. Vis. Sci. 2008, 49:422-428.
274. Nishiyama A., Chang A., Trapp B.D. NG2+ glial cells: a novel glial cell population in the adult brain. J. Neuropathol. Exp. Neurol. 1999, 58:1113-1124.
275. Nishiyama A. NG2 cells in the brain: a novel glial cell population. Hum. Cell. 2001, 14:77-82.
276. Nishiyama A., Komitova M., Suzuki R., Zhu X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat. Rev. Neurosci. 2009, 10:9-22.
277. Noda M., Nakanishi H., Nabekura J., Akaike N. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J. Neurosci.: Official J. Soc. Neurosci. 2000, 20:251-258.
278. Ohira A., Stefansson E., de Juan E., Davidson R.C., Faberowski N. Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. Graefes Arch. Clin. Exp. Ophthalmol. 1990, 228:195-199.
279. Ohta K., Ito A., Tanaka H. Neuronal stem/progenitor cells in the vertebrate eye. Dev. Growth Differ. 2008, 50:253-259.
280. Okano H.L. Stem cell biology of the central nervous system. J. Neurosci. Res. 2002, 69:698-707.
281. Omlin F.X., Waldmeyer J. Differentiation of neuron-like cells in cultured rat optic nerves: a neuron or common neuron-glia progenitor?. Dev. Biology 1989, 133:247-253.
282. Ooto S., Akagi T., Kageyama R., Akita J., Mandai M., Honda Y., Takahashi M. Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc. Natl. Acad. Sci. U S A 2004, 101:13654-13659.
283. Osborne N.N., Block F., Sontag K.H. Reduction of ocular blood flow results in glial fibrillary acidic protein (GFAP) expression in rat retinal Muller cells. Vis. Neurosci. 1991, 7:637-639.
284. Osborne N.N., Larsen A., Barnett N.L. Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. Invest. Ophthalmol. Vis. Sci. 1995, 36:1692-1700.
285. Osborne N.N., Casson R.J., Wood J.P., Chidlow G., Graham M., Melena J. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog. Retin. Eye Res. 2004, 23:91-147.
286. Otteson D.C., Cirenza P.F., Hitchcock P.F. Persistent neurogenesis in the teleost retina: evidence for regulation by the growth-hormone/insulin-like growth factor-I axis. Mech. Dev. 2002, 117:137-149.
287. Otteson D.C., Hitchcock P.F. Stem cells in the teleost retina: persistent neurogenesis and injury-induced regeneration. Vis. Res. 2003, 43:927-936.
288. Palmer T.D., Markakis E.A., Willhoite A.R., Safar F., Gage F.H. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J. Neurosci. 1999, 19:8487-8497.
289. Panagis L., Thanos S., Fischer D., Dermon C.R. Unilateral optic nerve crush induces bilateral retinal glial cell proliferation. Eur. J. Neurosci. 2005, 21:2305-2309.
290. Park C.M., Hollenberg M.J. Basic fibroblast growth factor induces retinal regeneration in vivo. Dev. Biol. 1989, 134:201-205.
291. Perlman J.I., McCole S.M., Pulluru P., Chang C.J., Lam T.T., Tso M.O. Disturbances in the distribution of neurotransmitters in the rat retina after ischemia. Curr. Eye Res. 1996, 15:589-596.
292. Perron M., Kanekar S., Vetter M.L., Harris W.A. The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Dev. Biology 1998, 199:185-200.
293. Perron M., Harris W.A. Retinal stem cells in vertebrates. Bioessays 2000, 22:685-688.
294. Perry V.H., Lund R.D. Evidence that the lamina cribrosa prevents intraretinal myelination of retinal ganglion cell axons. J. Neurocytol. 1990, 19:265-272.
295. Pittack C., Grunwald G.B., Reh T.A. Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development 1997, 124:805-816.
296. Pollak J., Wilken M.S., Ueki Y., Taylor R.J., Reh T.A. Reprogramming Müller Glia into Retinal Neurons with Ascl1 2011, Program No 441.16. 2011 Neuroscience Meeting Planner, Society for Neuroscience, Washington, DC, Online.
297. Potten C.S., Loeffler M.L. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990, 110:1001-1020.
298. Pouly S., Becher B., Blain M., Antel J.P. Expression of a homologue of rat NG2 on human microglia. Glia 1999, 27:259-268.
299. Prada C., Puga J., Perez-Mendez L., Lopez, Ramirez G. Spatial and temporal patterns of neurogenesis in the chick retina. Eur. J. Neurosci. 1991, 3:1187.
300. Puro D.G., Yuan J.P., Sucher N.J. Activation of NMDA receptor-channels in human retinal Muller glial cells inhibits inward-rectifying potassium currents. Vis. Neurosci. 1996, 13:319-326.
301. Raff M.C., Miller R.H., Noble M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 1983, 303:390-396.
302. Ransohoff R.M., Cardona A.E. The myeloid cells of the central nervous system parenchyma. Nature 2010, 468:253-262.
303. Raymond P.A., Hitchcock P.F. Retinal regeneration: common principles but a diversity of mechanisms. Adv. Neurol. 1997, 72:171-184.
304. Raymond P.A., Hitchcock P.F. How the neural retina regenerates. Results Probl. Cell Differ. 2000, 31:197-218.
305. Raymond P.A., Barthel L.K., Bernardos R.L., Perkowski J.J. Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev. Biol. 2006, 6:36.
306. Reh T.A., Tully T. Regulation of tyrosine hydroxylase-containing amacrine cell number in larval frog retina. Dev. Biology 1986, 114:463-469.
307. Reh T.A. Cell-specific regulation of neuronal production in the larval frog retina. J. Neurosci.: Official J. Soc. Neurosci. 1987, 7:3317-3324.
308. Reh T.A., Kljavin I.J.L. Age of differentiation determines rat retinal germinal cell phenotype: induction of differentiation by dissociation. J. Neurosci. 1989, 9:4179-4189.
309. Reh T.A., Levine E.M.L. Multipotential stem cells and progenitors in the vertebrate retina. J. Neurobiol. 1998, 36:206-220.
310. Reh T.A., Fischer A.J.L. Stem cells in the vertebrate retina. Brain Behav. Evol. 2001, 58:296-305.
311. Reh T.A., Fischer A.J. Retinal stem cells. Methods Enzymology 2006, 419:52-73.
312. Reichenbach A., Wurm A., Pannicke T., Iandiev I., Wiedemann P., Bringmann A. Muller cells as players in retinal degeneration and edema. Graefes Arch. Clin. Exp. Ophthalmol. 2007, 245:627-636.
313. Reichenbach A., Bringmann A. Müller Cells in the Healthy and Diseased Retina 2010, Springer, New York, pp. 1-417.
314. Reichenbach A.L. Two types of neuronal precursor cells in the mammalian retina-a short review. J. Hirnforsch. 1993, 34:335-341.
315. Richardson W.D., Young K.M., Tripathi R.B., McKenzie I. NG2-glia as multipotent neural stem cells: fact or fantasy?. Neuron 2011, 70:661-673.
316. Rivers L.E., Young K.M., Rizzi M., Jamen F., Psachoulia K., Wade A., Kessaris N., Richardson W.D. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat. Neuroscience 2008, 11:1392-1401.
317. Roesch K., Jadhav A.P., Trimarchi J.M., Stadler M.B., Roska B., Sun B.B., Cepko C.L. The transcriptome of retinal Muller glial cells. J. Comp. Neurol. 2008, 509:225-238.
318. Rompani S.B., Cepko C.L. A common progenitor for retinal astrocytes and oligodendrocytes. J. Neurosci.: Official J. Soc. Neurosci. 2010, 30:4970-4980.
319. Sahin Kaya S., Mahmood A., Li Y., Yavuz E., Chopp M. Expression of nestin after traumatic brain injury in rat brain. Brain Res. 1999, 840:153-157.
320. Sahlgren C.M., Mikhailov A., Hellman J., Chou Y.H., Lendahl U., Goldman R.D., Eriksson J.E. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. J. Biol. Chem. 2001, 276:16456-16463.
321. Sakaguchi D.S., Janick L.M., Reh T.A.L. Basic fibroblast growth factor (FGF-2) induced transdifferentiation of retinal pigment epithelium: generation of retinal neurons and glia. Dev. Dyn. 1997, 209:387-398.
322. Sakakibara S., Imai T., Hamaguchi K., Okabe M., Aruga J., Nakajima K., Yasutomi D., Nagata T., Kurihara Y., Uesugi S., Miyata T., Ogawa M., Mikoshiba K., Okano H.L. Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev. Biol. 1996, 176:230-242.
323. Santambrogio L., Belyanskaya S.L., Fischer F.R., Cipriani B., Brosnan C.F., Ricciardi-Castagnoli P., Stern L.J., Strominger J.L., Riese R. Developmental plasticity of CNS microglia. Proc. Natl. Acad. Sci. U S A 2001, 98:6295-6300.
324. Schmeer C., Straten G., Kugler S., Gravel C., Bahr M., Isenmann S. Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo. Eur. J. Neurosci. 2002, 15:637-643.
325. Schmeer C., Gamez A., Tausch S., Witte O.W., Isenmann S. Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo. Invest. Ophthalmol. Vis. Sci. 2008, 49:4971-4981.
326. Sergent-Tanguy S., Michel D.C., Neveu I., Naveilhan P. Long-lasting coexpression of nestin and glial fibrillary acidic protein in primary cultures of astroglial cells with a major participation of nestin(+)/GFAP(-) cells in cell proliferation. J. Neurosci. Res. 2006, 83:1515-1524.
327. Seri B., Garcia-Verdugo J.M., McEwen B.S., Alvarez-Buylla A. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J. Neurosci. 2001, 21:7153-7160.
328. Shareef S.R., Garcia-Valenzuela E., Salierno A., Walsh J., Sharma S.C. Chronic ocular hypertension following episcleral venous occlusion in rats. Exp. Eye Res. 1995, 61:379-382.
329. Singhal S., Lawrence J.M., Bhatia B., Ellis J.S., Kwan A.S., Macneil A., Luthert P.J., Fawcett J.W., Perez M.T., Khaw P.T., Limb G.A. Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Muller stem cells into degenerating retina. Stem Cells 2008, 26:1074-1082.
330. Singhal S., Lawrence J.M., Salt T.E., Khaw P.T., Limb G.A. Triamcinolone attenuates macrophage/microglia accumulation associated with NMDA-induced RGC death and facilitates survival of Muller stem cell grafts. Exp. Eye Res. 2010, 90:308-315.
331. Stallcup W.B., Beasley L. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. J. Neurosci. 1987, 7:2737-2744.
332. Stefansson E., Wilson C.A., Schoen T., Kuwabara T. Experimental ischemia induces cell mitosis in the adult rat retina. Invest. Ophthalmol. Vis. Sci. 1988, 29:1050-1055.
333. Stefansson E. Oxygen and diabetic eye disease. Graefes Arch. Clin. Exp. Ophthalmol. 1990, 228:120-123.
334. Stefansson E., Novack R.L., Hatchell D.L. Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 1990, 31:284-289.
335. Stenkamp D.L., Powers M.K., Carney L.H., Cameron D.A. Evidence for two distinct mechanisms of neurogenesis and cellular pattern formation in regenerated goldfish retinas. J. Comp. Neurol. 2001, 431:363-381.
336. Stone L.S. Neural retina degeneration followed by regeneration from surviving retinal pigment cells in grafted adult salamander eyes. Anat. Rec. 1950, 106:89-109.
337. Straten G., Schmeer C., Kretz A., Gerhardt E., Kugler S., Schulz J.B., Gravel C., Bahr M., Isenmann S.L. Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis. Neurobiol. Dis. 2002, 11:123-133.
338. Strauss O. The retinal pigment epithelium in visual function. Physiol. Rev. 2005, 85:845-881.
339. Streit W.J., Walter S.A., Pennell N.A. Reactive microgliosis. Prog. Neurobiol. 1999, 57:563-581.
340. Sucher N.J., Aizenman E., Lipton S.A. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J. Neurosci.: Official J. Soc. Neurosci. 1991, 11:966-971.
341. Sun D., Lye-Barthel M., Masland R.H., Jakobs T.C. Structural remodeling of fibrous astrocytes after axonal injury. J. Neurosci.: Official J. Soc. Neurosci. 2010, 30:14008-14019.
342. Sun G., Asami M., Ohta H., Kosaka J., Kosaka M. Retinal stem/progenitor properties of iris pigment epithelial cells. Dev. Biol. 2006, 289:243-252.
343. Sunabori T., Tokunaga A., Nagai T., Sawamoto K., Okabe M., Miyawaki A., Matsuzaki Y., Miyata T., Okano H. Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors. J. Cell Sci. 2008, 121:1204-1212.
344. Susaki K., Chiba C. MEK mediates in vitro neural transdifferentiation of the adult newt retinal pigment epithelium cells: is FGF2 an induction factor?. Pigment Cell Res. 2007, 20:364-379.
345. Suzuki S., Namiki J., Shibata S., Mastuzaki Y., Okano H. The neural stem/progenitor cell marker nestin is expressed in proliferative endothelial cells, but not in mature vasculature. J. Histochem. Cytochem. 2010, 58:721-730.
346. Suzuki T., Akimoto M., Imai H., Ueda Y., Mandai M., Yoshimura N., Swaroop A., Takahashi M. Chondroitinase ABC treatment enhances synaptogenesis between transplant and host neurons in model of retinal degeneration. Cell Transplant. 2007, 16:493-503.
347. Tackenberg M.A., Tucker B.A., Swift J.S., Jiang C., Redenti S., Greenberg K.P., Flannery J.G., Reichenbach A., Young M.J. Muller cell activation, proliferation and migration following laser injury. Mol. Vis. 2009, 15:1886-1896.
348. Takahashi M., Palmer T.D., Takahashi J., Gage F.H.L. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol. Cell Neurosci. 1998, 12:340-348.
349. Takamori Y., Mori T., Wakabayashi T., Nagasaka Y., Matsuzaki T., Yamada H. Nestin-positive microglia in adult rat cerebral cortex. Brain Res. 2009, 1270:10-18.
350. Takeda M., Takamiya A., Jiao J.W., Cho K.S., Trevino S.G., Matsuda T., Chen D.F. Alpha-Aminoadipate induces progenitor cell properties of Muller glia in adult mice. Invest. Ophthalmol. Vis. Sci. 2008, 49:1142-1150.
351. Tamura Y., Kataoka Y., Cui Y., Takamori Y., Watanabe Y., Yamada H. Multi-directional differentiation of doublecortin- and NG2-immunopositive progenitor cells in the adult rat neocortex in vivo. Eur. J. Neurosci. 2007, 25:3489-3498.
352. Temple S., Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Curr. Opin. Neurobiol. 1999, 9:135-141.
353. Temple S.L. The development of neural stem cells. Nature 2001, 414:112-117.
354. Terskikh A.V., Easterday M.C., Li L., Hood L., Kornblum H.I., Geschwind D.H., Weissman I.L. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc. Natl. Acad. Sci. U S A 2001, 98:7934-7939.
355. Thoenen H., Barde Y.A., Edgar D., Hatanaka H., Otten U., Schwab M. Mechanism of action and possible sites of synthesis of nerve growth factor. Prog. Brain Res. 1979, 51:95-107.
356. Thoenen H., Barde Y.A. Physiology of nerve growth factor. Physiol. Rev. 1980, 60:1284-1335.
357. Thoenen H., Barde Y.A., Davies A.M., Johnson J.E. Neurotrophic factors and neuronal death. Ciba Found. Symp. 1987, 126:82-95.
358. Tomita M., Adachi Y., Yamada H., Takahashi K., Kiuchi K., Oyaizu H., Ikebukuro K., Kaneda H., Matsumura M., Ikehara S.L. Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina. Stem Cells 2002, 20:279-283.
359. Tropepe V., Coles B.L., Chiasson B.J., Horsford D.J., Elia A.J., McInnes R.R., van der Kooy D. Retinal stem cells in the adult mammalian eye. Science 2000, 287:2032-2036.
360. Trotter J., Karram K., Nishiyama A. NG2 cells: properties, progeny and origin. Brain Res. Rev. 2010, 63:72-82.
361. Turner D.L., Cepko C.L.L. A common progenitor for neurons and glia persists in rat retina late in development. Nature 1987, 328:131-136.
362. Van Hoffelen S.J., Young M.J., Shatos M.A., Sakaguchi D.S.L. Incorporation of murine brain progenitor cells into the developing mammalian retina. Invest. Ophthalmol. Vis. Sci. 2003, 44:426-434.
363. Vazquez-Chona F., Song B.K., Geisert E.E. Temporal changes in gene expression after injury in the rat retina. Invest. Ophthalmol. Vis. Sci. 2004, 45:2737-2746.
364. Villegas-Perez M.P., Vidal-Sanz M., Rasminsky M., Bray G.M., Aguayo A.J. Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats. J. Neurobiol. 1993, 24:23-36.
365. Vossmerbaeumer U., Kuehl S., Kern S., Kluter H., Jonas J.B., Bieback K. Induction of retinal pigment epithelium properties in ciliary margin progenitor cells. Clin. Exp. Ophthalmol. 2008, 36:358-366.
366. Walcott J.C., Provis J.M.L. Muller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina. Clin. Exp. Ophthalmol. 2003, 31:246-249.
367. Walker A.S., Goings G.E., Kim Y., Miller R.J., Chenn A., Szele F.G. Nestin reporter transgene labels multiple central nervous system precursor cells. Neural Plast. 2010, 2010:894374.
368. Walter J., Muller B., Bonhoeffer F. Axonal guidance by an avoidance mechanism. J. Physiol. (Paris) 1990, 84:104-110.
369. Wan J., Zheng H., Xiao H.L., She Z.J., Zhou G.M. Sonic hedgehog promotes stem-cell potential of Muller glia in the mammalian retina. Biochem. Biophys. Res. Commun. 2007, 363:347-354.
370. Wan J., Zheng H., Chen Z.L., Xiao H.L., Shen Z.J., Zhou G.M. Preferential regeneration of photoreceptor from Muller glia after retinal degeneration in adult rat. Vis. Res. 2008, 48:223-234.
371. Wang C., Pralong W.F., Schulz M.F., Rougon G., Aubry J.M., Pagliusi S., Robert A., Kiss J.Z. Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J. Cell Biol. 1996, 135:1565-1581.
372. Wang H., Lau B.W., Yau S.Y., Li S.Y., Leung N., Wang N.L., Tang S.W., Lee T.M., So K.F. Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation. Chin. Medical Journal 2010, 123:1305-1310.
373. Wang X., Tay S.S., Ng Y.K. An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma. Exp. Brain Res. 2000, 132:476-484.
374. Watanabe T., Raff M.C. Retinal astrocytes are immigrants from the optic nerve. Nature 1988, 332:834-837.
375. Weissman I.L., Anderson D.J., Gage F.L. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 2001, 17:387-403.
376. Wen R., Song Y., Cheng T., Matthes M.T., Yasumura D., LaVail M.M., Steinberg R.H.L. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J. Neurosci. 1995, 15:7377-7385.
377. Whiteley S.J., Klassen H., Coffey P.J., Young M.J. Photoreceptor rescue after low-dose intravitreal IL-1beta injection in the RCS rat. Exp. Eye Res. 2001, 73:557-568.
378. Wiese C., Rolletschek A., Kania G., Navarrete-Santos A., Anisimov S.V., Steinfarz B., Tarasov K.V., Brugh S.A., Zahanich I., Ruschenschmidt C., Beck H., Blyszczuk P., Czyz J., Heubach J.F., Ravens U., Horstmann O., St-Onge L., Braun T., Brustle O., Boheler K.R., Wobus A.M. Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells 2006, 24:2085-2097.
379. Wohl S.G., Schmeer C.W., Kretz A., Witte O.W., Isenmann S. Optic nerve lesion increases cell proliferation and nestin expression in the adult mouse eye in vivo. Exp. Neurology 2009, 219:175-186.
380. Wohl S.G., Schmeer C.W., Witte O.W., Isenmann S. Proliferative response of microglia and macrophages in the adult mouse eye after optic nerve lesion. Invest. Ophthalmol. Vis. Sci. 2010, 51:2686-2696.
381. Wohl S.G., Schmeer C.W., Friese T., Witte O.W., Isenmann S. In situ dividing and phagocytosing retinal microglia express nestin, vimentin, and NG2 in vivo. PLoS One 2011, 6:e22408.
382. Wolburg H., Buerle C. Astrocytes in the lamina cribrosa of the rat optic nerve: are their morphological peculiarities involved in an altered blood-brain barrier?. J. Hirnforsch. 1993, 34:445-459.
383. Wolswijk G., Noble M. Identification of an adult-specific glial progenitor cell. Development 1989, 105:387-400.
384. Wren D., Wolswijk G., Noble M. In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells. J. Cell Biol. 1992, 116:167-176.
385. Wu D., Miyamoto O., Shibuya S., Mori S., Norimatsu H., Janjua N.A., Itano T. Co-expression of radial glial marker in macrophages/microglia in rat spinal cord contusion injury model. Brain Res. 2005, 1051:183-188.
386. Wu D.M., Schneiderman T., Burgett J., Gokhale P., Barthel L., Raymond P.A.L. Cones regenerate from retinal stem cells sequestered in the inner nuclear layer of adult goldfish retina. Invest. Ophthalmol. Vis. Sci. 2001, 42:2115-2124.
387. Xu H., Sta Iglesia D.D., Kielczewski J.L., Valenta D.F., Pease M.E., Zack D.J., Quigley H.A. Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes. Invest. Ophthalmol. Vis. Sci. 2007, 48:1674-1682.
388. Xue L., Ding P., Xiao L., Hu M., Hu Z. Nestin, a new marker, expressed in Muller cells following retinal injury. Can. J. Neurol. Sci. 2010, 37:643-649.
389. Xue L.P., Lu J., Cao Q., Hu S., Ding P., Ling E.A. Muller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina. Neuroscience 2006, 139:723-732.
390. Xue L.P., Lu J., Cao Q., Kaur C., Ling E.A. Nestin expression in Muller glial cells in postnatal rat retina and its upregulation following optic nerve transection. Neuroscience 2006, 143:117-127.
391. Xue X.J., Yuan X.B. Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells. Mol. Cell Neurosci. 2010, 45:26-36.
392. Yamaguchi M., Saito H., Suzuki M., Mori K. Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice. Neuroreport 2000, 11:1991-1996.
393. Yanagi Y., Inoue Y., Kawase Y., Uchida S., Tamaki Y., Araie M., Okochi H. Properties of growth and molecular profiles of rat progenitor cells from ciliary epithelium. Exp. Eye Res. 2006, 82:471-478.
394. Yau J., Klassen H., Zahir T., Young M. Stem Cells and Retinal Transplantation; Retinal Degenerations 2007, 385-399. Humana Press. J. Tombran-Tink, C.J. Barnstable (Eds.).
395. Yokoyama A., Yang L., Itoh S., Mori K., Tanaka J.L. Microglia, a potential source of neurons, astrocytes, and oligodendrocytes. Glia 2004, 45:96-104.
396. Yokoyama A., Sakamoto A., Kameda K., Imai Y., Tanaka J. NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains. Glia 2006, 53:754-768.
397. Young M.J.L. Stem cells in the mammalian eye: a tool for retinal repair. Apmis 2005, 113:845-857.
398. Young R.W.L. Cell differentiation in the retina of the mouse. Anat. Rec. 1985, 212:199-205.
399. Yurco P., Cameron D.A. Responses of Muller glia to retinal injury in adult zebrafish. Vis. Res. 2005, 45:991-1002.
400. Zhang S.C., Fedoroff S. Expression of stem cell factor and c-kit receptor in neural cells after brain injury. Acta Neuropathol. 1999, 97:393-398.
401. Zhao S., Thornquist S.C., Barnstable C.J. In vitro transdifferentiation of embryonic rat retinal pigment epithelium to neural retina. Brain Res. 1995, 677:300-310.
402. Zhao X., Das A.V., Soto-Leon F., Ahmad I.L. Growth factor-responsive progenitors in the postnatal mammalian retina. Dev. Dyn. 2005, 232:349-358.
403. Zhou Y., Li H.L., Zhao R., Yang L.T., Dong Y., Yue X., Ma Y.Y., Wang Z., Chen J., Cui C.L., Yu A.C. Astrocytes express N-methyl-D-aspartate receptor subunits in development, ischemia and post-ischemia. Neurochem. Research 2010, 35:2124-2134.
404. Zhu L., Lu J., Tay S.S., Jiang H., He B.P. Induced NG2 expressing microglia in the facial motor nucleus after facial nerve axotomy. Neuroscience 2010, 166:842-851.
405. Zhu X., Hill R.A., Dietrich D., Komitova M., Suzuki R., Nishiyama A. Age-dependent fate and lineage restriction of single NG2 cells. Development 2011, 138:745-753. picture upload may, 2010. http://www.mpih-frankfurt.mpg.de.