Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion

GLIA

Volumn 34, Issue 4, 2001, Pages 296-310

  Bu, Jie ^a   Akhtar, Nadia ^b   Nishiyama, Akiko ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Pediatric Neurology Associates   (United States)

Author keywords

Hippocampus; Kainate; Macrophage; Microglia; NG2; Oligodendrocyte progenitor

Indexed keywords

ANTIGEN; CD11B ANTIGEN; CHONDROITIN SULFATE PROTEOGLYCAN 4; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; MEMBRANE PROTEIN; NEUROTOXIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEOGLYCAN;

ANIMAL; ARTICLE; ASTROCYTE; BRAIN DISEASE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; FEMALE; HIPPOCAMPUS; HUMAN; MACROPHAGE; METABOLISM; MICROGLIA; PATHOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANTIGENS; ASTROCYTES; BRAIN DISEASES; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HUMANS; KAINIC ACID; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MEMBRANE PROTEINS; MICROGLIA; NEUROTOXINS; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0034950456     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.1063     Document Type: Article

References (75)

1. The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration
2. The astroglial response to stabbing: Immunofluorescence studies with antibodies to astrocyte-specific protein (GFA) in mammalian and submammalian vertebrates
3. Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules
4. NG2 proteoglycan-binding peptides target tumor neovasculature
5. Oligodendrocyte population dynamics and the role of PDGF in vivo
6. An investigation into the early stages of the inflammatory response following ibotenic acid-induced neuronal degeneration
7. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1
8. Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non-radioactive in situ hybridization and immunoperoxidase techniques
9. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
10. Glial changes following an excitotoxic lesion in the CNS. II. Astrocytes
11. PDGF α- and β-receptors activate unique and common signal transduction pathways
12. O2A progenitor cells transplanted into the neonatal rat brain develop into oligodendrocytes but not astrocytes
13. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting
14. Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter
15. Characterization of ameboid microglia isolated from developing mammalian brain
16. Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to pletelet-derived growth factor
17. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: Evidence for more than one receptor class
18. Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells
19. Leukocyte traffic in the central nervous system: The participants and their roles
20. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
21. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
22. Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: Association with smooth protoplasmic astrocytes
23. Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen
24. Development and differentiation of glial precursor cells in the rat cerebellum
25. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
26. Reactions of oligodendrocyte precursor cells to alpha herpesvirus infection of the central nervous system
27. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain
28. The origin and nature of ramified and amoeboid microglia: A historical review and current concepts
29. Glial changes following an excitotoxic lesion in the CNS. I. Microglia/macrophages
30. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
31. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
32. The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar
33. Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain
34. Brain macrophages and microglia respond differently to lesions of the developing and adult visual system
35. Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection
36. Separate blood and brain origins of proliferating cells during gliosis in adult brains
37. Morphological studies on neuroglia. II. Response to glial cells to kainic acid-induced lesions
38. Morphological studies on neuroglia. III. Macrophage response and "microgliocytosis" in kainic acid-induced lesions
39. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
40. Developmental expression of platelet-derived growth factor α-receptor in neurons and glial cells of the mouse CNS
41. Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration
42. The primary structure of NG2, a novel membrane-spanning proteoglycan
43. The expression of NG2 proteoglycan in the developing rat limb
44. Expression of NG2 proteoglycan causes retention of type VI collagen on the cell surface
45. Generation of truncated forms of the NG2 proteoglycan by cell surface proteolysis
46. Interaction between NG2 proteoglycan and PDGF α receptor on O2A progenitor cells is required for optimal response to PDGF
47. Co-localization of NG2 proteoglycan and PDGF α receptor on O2A progenitor cells in the developing rat brain
48. Normal and reactive NG2+ glial cells are distinct from resting and activated microglia
49. NG2+ glial cells: A novel glial cell population in the adult brain
50. Kainic acid: A powerful neurotoxic analogue of glutamate
51. A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus
52. Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor
53. Expression of a homologue of rat NG2 on human microglia
54. PDGF receptors in the rat CNS: During late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage
55. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
56. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture
57. Reactive astrocytes in the kainic acid-damaged hippocampus have the phenotypic features of type-2 astrocytes
58. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo
59. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system
60. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX41 and OX42, the latter recognizing complement receptor type 3f
61. Clonal cell lines from the rat central nervous system
62. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
63. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve
64. Actions of several anthelmintics and insecticides on rat cortical neurones
65. Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors
66. The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23
67. Cell-surface molecules that characterize different stages in the development of cerebellar interneurons
68. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan
69. Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen
70. Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene
71. A simple method for organotypic cultures of nervous tissue
72. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain
73. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant