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Volumn 52, Issue 5, 2011, Pages 2606-2618

Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice

Author keywords

[No Author keywords available]

Indexed keywords

SIMVASTATIN;

EID: 79956006280     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6005     Document Type: Article
Times cited : (25)

References (54)
  • 1
    • 0037126984 scopus 로고    scopus 로고
    • Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult
    • Lafuente MP, Villegas-Perez MP, Selles-Navarro I, et al. Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. Neuroscience. 2002;109:157-168.
    • (2002) Neuroscience. , vol.109 , pp. 157-168
    • Lafuente, M.P.1    Villegas-Perez, M.P.2    Selles-Navarro, I.3
  • 2
    • 0032829893 scopus 로고    scopus 로고
    • Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases
    • Katai N, Yoshimura N. Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci. 1999;40:2697-2705.
    • (1999) Invest Ophthalmol Vis Sci. , vol.40 , pp. 2697-2705
    • Katai, N.1    Yoshimura, N.2
  • 3
    • 33846916279 scopus 로고    scopus 로고
    • Retinal ischemia and reperfusion causes capillary degeneration: Similarities to diabetes
    • Zheng L, Gong B, Hatala DA, Kern TS. Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest Ophthalmol Vis Sci. 2007;48:361-367.
    • (2007) Invest Ophthalmol Vis Sci. , vol.48 , pp. 361-367
    • Zheng, L.1    Gong, B.2    Hatala, D.A.3    Kern, T.S.4
  • 4
    • 56149102958 scopus 로고    scopus 로고
    • Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo
    • Schmeer C, Gamez A, Tausch S, Witte OW, Isenmann S. Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo. Invest Ophthalmol Vis Sci. 2008;49:4971-4981.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , pp. 4971-4981
    • Schmeer, C.1    Gamez, A.2    Tausch, S.3    Witte, O.W.4    Isenmann, S.5
  • 6
    • 0029785595 scopus 로고    scopus 로고
    • Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: A quantitative in vivo study
    • Selles-Navarro I, Villegas-Perez MP, Salvador-Silva M, Ruiz-Gomez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: a quantitative in vivo study. Invest Ophthalmol Vis Sci. 1996;37: 2002-2014.
    • (1996) Invest Ophthalmol Vis Sci. , vol.37 , pp. 2002-2014
    • Selles-Navarro, I.1    Villegas-Perez, M.P.2    Salvador-Silva, M.3    Ruiz-Gomez, J.M.4    Vidal-Sanz, M.5
  • 7
    • 0029893016 scopus 로고    scopus 로고
    • High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats
    • Adachi M, Takahashi K, Nishikawa M, Miki H, Uyama M. High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats. Graefes Arch Clin Exp Ophthalmol. 1996;234:445-451.
    • (1996) Graefes Arch Clin Exp Ophthalmol. , vol.234 , pp. 445-451
    • Adachi, M.1    Takahashi, K.2    Nishikawa, M.3    Miki, H.4    Uyama, M.5
  • 8
    • 0026076156 scopus 로고
    • Quantitation of ischemic damage in the rat retina
    • Hughes WF. Quantitation of ischemic damage in the rat retina. Exp Eye Res. 1991;53:573-582.
    • (1991) Exp Eye Res. , vol.53 , pp. 573-582
    • Hughes, W.F.1
  • 9
    • 0020331786 scopus 로고
    • Clinical and experimental evidence that the pattern electroretinogram (PERG) is generated in more proximal retinal layers than the focal electroretinogram (FERG)
    • Arden GB, Vaegan, Hogg CR. Clinical and experimental evidence that the pattern electroretinogram (PERG) is generated in more proximal retinal layers than the focal electroretinogram (FERG). Ann N Y Acad Sci. 1982;388:580-607.
    • (1982) Ann N Y Acad Sci. , vol.388 , pp. 580-607
    • Arden, G.B.1    Vaegan2    Hogg, C.R.3
  • 11
    • 0141653785 scopus 로고    scopus 로고
    • Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy
    • Bernstein SL, Guo Y, Kelman SE, Flower RW, Johnson MA. Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci. 2003;44: 4153-4162.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , pp. 4153-4162
    • Bernstein, S.L.1    Guo, Y.2    Kelman, S.E.3    Flower, R.W.4    Johnson, M.A.5
  • 12
    • 0032033296 scopus 로고    scopus 로고
    • The b-wave of the electroretinogram as an index of retinal ischemia
    • Block F, Schwarz M. The b-wave of the electroretinogram as an index of retinal ischemia. Gen Pharmacol. 1998;30:281-287.
    • (1998) Gen Pharmacol. , vol.30 , pp. 281-287
    • Block, F.1    Schwarz, M.2
  • 13
    • 0018186202 scopus 로고
    • Light-evoked potassium activity in mudpuppy retina: Its relationship to the b-wave of the electroretinogram
    • Dick E, Miller RF. Light-evoked potassium activity in mudpuppy retina: its relationship to the b-wave of the electroretinogram. Brain Res. 1978;154:388-394.
    • (1978) Brain Res. , vol.154 , pp. 388-394
    • Dick, E.1    Miller, R.F.2
  • 14
    • 0037421994 scopus 로고    scopus 로고
    • The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina
    • Dick O, tom Dieck S, Altrock WD, et al. The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Neuron. 2003;37:775-786.
    • (2003) Neuron. , vol.37 , pp. 775-786
    • Dick, O.1    tom Dieck, S.2    Altrock, W.D.3
  • 15
    • 70749145248 scopus 로고    scopus 로고
    • Vision and visual cortical maps in mice with a photoreceptor synaptopathy: Reduced but robust visual capabilities in the absence of synaptic ribbons
    • Goetze B, Schmidt KF, Lehmann K, Altrock WD, Gundelfinger ED, Löwel S. Vision and visual cortical maps in mice with a photoreceptor synaptopathy: reduced but robust visual capabilities in the absence of synaptic ribbons. Neuroimage. 2010;49:1622-1631.
    • (2010) Neuroimage. , vol.49 , pp. 1622-1631
    • Goetze, B.1    Schmidt, K.F.2    Lehmann, K.3    Altrock, W.D.4    Gundelfinger, E.D.5    Löwel, S.6
  • 16
    • 9444222740 scopus 로고    scopus 로고
    • Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system
    • Prusky GT, Alam NM, Beekman S, Douglas RM. Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest Ophthalmol Vis Sci. 2004;45:4611-4616.
    • (2004) Invest Ophthalmol Vis Sci. , vol.45 , pp. 4611-4616
    • Prusky, G.T.1    Alam, N.M.2    Beekman, S.3    Douglas, R.M.4
  • 17
    • 0038350763 scopus 로고    scopus 로고
    • New paradigm for optical imaging: Temporally encoded maps of intrinsic signal
    • Kalatsky VA, Stryker MP. New paradigm for optical imaging: temporally encoded maps of intrinsic signal. Neuron. 2003;38:529-545.
    • (2003) Neuron. , vol.38 , pp. 529-545
    • Kalatsky, V.A.1    Stryker, M.P.2
  • 18
    • 52349094744 scopus 로고    scopus 로고
    • Age-dependent ocular dominance plasticity in adult mice
    • Lehmann K, Löwel S. Age-dependent ocular dominance plasticity in adult mice. PLoS One. 2008;3:e3120.
    • (2008) PLoS One. , vol.3
    • Lehmann, K.1    Löwel, S.2
  • 19
    • 0035104054 scopus 로고    scopus 로고
    • Advantages of lipid-lowering therapy in cerebral ischemia: Role of HMG-CoA reductase inhibitors
    • Gil-Nunez AC, Villanueva JA. Advantages of lipid-lowering therapy in cerebral ischemia: role of HMG-CoA reductase inhibitors. Cerebrovasc Dis. 2001;11(suppl 1):85-95.
    • (2001) Cerebrovasc Dis. , vol.11 , Issue.SUPPL. 1 , pp. 85-95
    • Gil-Nunez, A.C.1    Villanueva, J.A.2
  • 21
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001;21:1712-1719.
    • (2001) Arterioscler Thromb Vasc Biol. , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 22
    • 34547769227 scopus 로고    scopus 로고
    • Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the treatment of retinal and eye diseases
    • Schmeer C, Kretz A, Isenmann S. Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the treatment of retinal and eye diseases. CNS Neurol Disord Drug Targets. 2007;6:282-287.
    • (2007) CNS Neurol Disord Drug Targets. , vol.6 , pp. 282-287
    • Schmeer, C.1    Kretz, A.2    Isenmann, S.3
  • 24
    • 32544436444 scopus 로고    scopus 로고
    • Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual reality optokinetic system
    • Douglas RM, Alam NM, Silver BD, McGill TJ, Tschetter WW, Prusky GT. Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual reality optokinetic system. Vis Neurosci. 2005;22:677-684.
    • (2005) Vis Neurosci. , vol.22 , pp. 677-684
    • Douglas, R.M.1    Alam, N.M.2    Silver, B.D.3    McGill, T.J.4    Tschetter, W.W.5    Prusky, G.T.6
  • 25
    • 32544442342 scopus 로고    scopus 로고
    • Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse
    • Cang J, Kalatsky VA, Lowel S, Stryker MP. Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse. Vis Neurosci. 2005;22:685-691.
    • (2005) Vis Neurosci. , vol.22 , pp. 685-691
    • Cang, J.1    Kalatsky, V.A.2    Lowel, S.3    Stryker, M.P.4
  • 26
    • 28744457099 scopus 로고    scopus 로고
    • Development of precise maps in visual cortex requires patterned spontaneous activity in the retina
    • Cang J, Renteria RC, Kaneko M, Liu X, Copenhagen DR, Stryker MP. Development of precise maps in visual cortex requires patterned spontaneous activity in the retina. Neuron. 2005;48:797-809.
    • (2005) Neuron. , vol.48 , pp. 797-809
    • Cang, J.1    Renteria, R.C.2    Kaneko, M.3    Liu, X.4    Copenhagen, D.R.5    Stryker, M.P.6
  • 27
    • 41949135163 scopus 로고    scopus 로고
    • Quantification of ischemic damage in the rat retina: A comparative study using evoked potentials, electroretinography, and histology
    • Jehle T, Wingert K, Dimitriu C, et al. Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology. Invest Ophthalmol Vis Sci. 2008;49:1056-1064.
    • (2008) Invest Ophthalmol Vis Sci. , vol.49 , pp. 1056-1064
    • Jehle, T.1    Wingert, K.2    Dimitriu, C.3
  • 28
    • 58149226569 scopus 로고    scopus 로고
    • Measuring vision in the awake behaving mouse
    • In: Chalupa LM, Williams RW, eds, Cambridge, MA: MIT Press
    • Prusky GT, Douglas RM. Measuring vision in the awake behaving mouse. In: Chalupa LM, Williams RW, eds. Eye, Retina, and Visual System of the Mouse. Cambridge, MA: MIT Press; 2008:107-117.
    • (2008) Eye, Retina, and Visual System of the Mouse , pp. 107-117
    • Prusky, G.T.1    Douglas, R.M.2
  • 29
    • 67349129691 scopus 로고    scopus 로고
    • Influence of narcotics on luminance and frequency modulated visual evoked potentials in rats
    • Jehle T, Ehlken D, Wingert K, Feuerstein TJ, Bach M, Lagreze WA. Influence of narcotics on luminance and frequency modulated visual evoked potentials in rats. Doc Ophthalmol. 2009;118:217-224.
    • (2009) Doc Ophthalmol. , vol.118 , pp. 217-224
    • Jehle, T.1    Ehlken, D.2    Wingert, K.3    Feuerstein, T.J.4    Bach, M.5    Lagreze, W.A.6
  • 31
    • 0025987335 scopus 로고
    • Pressure-induced retinal ischemia in rats: An experimental model for quantitative study
    • Buchi ER, Suivaizdis I, Fu J. Pressure-induced retinal ischemia in rats: an experimental model for quantitative study. Ophthalmologica. 1991;203:138-147.
    • (1991) Ophthalmologica. , vol.203 , pp. 138-147
    • Buchi, E.R.1    Suivaizdis, I.2    Fu, J.3
  • 32
    • 0029004596 scopus 로고
    • Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells
    • Osborne NN, Larsen A, Barnett NL. Influence of excitatory amino acids and ischemia on rat retinal choline acetyltransferase-containing cells. Invest Ophthalmol Vis Sci. 1995;36:1692-1700.
    • (1995) Invest Ophthalmol Vis Sci. , vol.36 , pp. 1692-1700
    • Osborne, N.N.1    Larsen, A.2    Barnett, N.L.3
  • 33
    • 0028111549 scopus 로고
    • A paired comparison of two models of experimental retinal ischemia
    • Gehlbach PL, Purple RL. A paired comparison of two models of experimental retinal ischemia. Curr Eye Res. 1994;13:597-602.
    • (1994) Curr Eye Res. , vol.13 , pp. 597-602
    • Gehlbach, P.L.1    Purple, R.L.2
  • 35
  • 36
    • 85013164509 scopus 로고    scopus 로고
    • Functional and morphologic comparison of two methods to produce transient retinal ischemia in the rat
    • Rosenbaum DM, Rosenbaum PS, Singh M, et al. Functional and morphologic comparison of two methods to produce transient retinal ischemia in the rat. J Neuroophthalmol. 2001;21:62-68.
    • (2001) J Neuroophthalmol. , vol.21 , pp. 62-68
    • Rosenbaum, D.M.1    Rosenbaum, P.S.2    Singh, M.3
  • 37
    • 0036353967 scopus 로고    scopus 로고
    • Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: A dose response in vivo study
    • Lafuente MP, Villegas-Perez MP, Mayor S, Aguilera ME, Miralles de Imperial J, Vidal-Sanz M. Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: a dose response in vivo study. Exp Eye Res. 2002;74:181-189.
    • (2002) Exp Eye Res. , vol.74 , pp. 181-189
    • Lafuente, M.P.1    Villegas-Perez, M.P.2    Mayor, S.3    Aguilera, M.E.4    Miralles de Imperial, J.5    Vidal-Sanz, M.6
  • 38
    • 38549118959 scopus 로고    scopus 로고
    • Intraocular CNTF reduces vision in normal rats in a dose-dependent manner
    • McGill TJ, Prusky GT, Douglas RM, et al. Intraocular CNTF reduces vision in normal rats in a dose-dependent manner. Invest Ophthalmol Vis Sci. 2007;48:5756-5766.
    • (2007) Invest Ophthalmol Vis Sci. , vol.48 , pp. 5756-5766
    • McGill, T.J.1    Prusky, G.T.2    Douglas, R.M.3
  • 39
    • 0026041512 scopus 로고
    • Short-term expansion of receptive fields in rat primary somatosensory cortex after hindpaw digit denervation
    • Byrne JA, Calford MB. Short-term expansion of receptive fields in rat primary somatosensory cortex after hindpaw digit denervation. Brain Res. 1991;565:218-224.
    • (1991) Brain Res. , vol.565 , pp. 218-224
    • Byrne, J.A.1    Calford, M.B.2
  • 40
    • 0025942712 scopus 로고
    • Immediate expansion of receptive fields of neurons in area 3b of macaque monkeys after digit denervation
    • Calford MB, Tweedale R. Immediate expansion of receptive fields of neurons in area 3b of macaque monkeys after digit denervation. Somatosens Mot Res. 1991;8:249-260.
    • (1991) Somatosens Mot Res. , vol.8 , pp. 249-260
    • Calford, M.B.1    Tweedale, R.2
  • 41
    • 0026514669 scopus 로고
    • Receptive field dynamics in adult primary visual cortex
    • Gilbert CD, Wiesel TN. Receptive field dynamics in adult primary visual cortex. Nature. 1992;356:150-152.
    • (1992) Nature. , vol.356 , pp. 150-152
    • Gilbert, C.D.1    Wiesel, T.N.2
  • 42
    • 0742323527 scopus 로고    scopus 로고
    • Homeostatic plasticity in the developing nervous system
    • Turrigiano GG, Nelson SB. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci. 2004;5:97-107.
    • (2004) Nat Rev Neurosci. , vol.5 , pp. 97-107
    • Turrigiano, G.G.1    Nelson, S.B.2
  • 43
    • 34250205193 scopus 로고    scopus 로고
    • Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity
    • Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T, Hubener M. Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron. 2007; 54:961-972.
    • (2007) Neuron. , vol.54 , pp. 961-972
    • Mrsic-Flogel, T.D.1    Hofer, S.B.2    Ohki, K.3    Reid, R.C.4    Bonhoeffer, T.5    Hubener, M.6
  • 44
    • 43749089126 scopus 로고    scopus 로고
    • Multiple modes of network homeostasis in visual cortical layer 2/3
    • Maffei A, Turrigiano GG. Multiple modes of network homeostasis in visual cortical layer 2/3. J Neurosci. 2008;28:4377-4384.
    • (2008) J Neurosci. , vol.28 , pp. 4377-4384
    • Maffei, A.1    Turrigiano, G.G.2
  • 45
    • 26444561886 scopus 로고    scopus 로고
    • Neuroprotective effect of simvastatin in stroke: A comparison between adult and neonatal rat models of cerebral ischemia
    • Cimino M, Balduini W, Carloni S, et al. Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia. Neurotoxicology. 2005;26:929-933.
    • (2005) Neurotoxicology. , vol.26 , pp. 929-933
    • Cimino, M.1    Balduini, W.2    Carloni, S.3
  • 46
    • 0029555545 scopus 로고
    • Modulation and mechanisms of electroretinogram recovery after short-term retinal ischemic injury
    • Tarn DM, Marmor MF. Modulation and mechanisms of electroretinogram recovery after short-term retinal ischemic injury. Doc Ophthalmol. 1995;91:109-116.
    • (1995) Doc Ophthalmol. , vol.91 , pp. 109-116
    • Tarn, D.M.1    Marmor, M.F.2
  • 47
    • 0036180956 scopus 로고    scopus 로고
    • Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia
    • Sen K, Misra A, Kumar A, Pandey RM. Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia. Diabetes Res Clin Pract. 2002;56:1-11.
    • (2002) Diabetes Res Clin Pract. , vol.56 , pp. 1-11
    • Sen, K.1    Misra, A.2    Kumar, A.3    Pandey, R.M.4
  • 48
    • 33846439745 scopus 로고    scopus 로고
    • Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
    • Franke C, Noldner M, Abdel-Kader R, et al. Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiol Dis. 2007;25:438-445.
    • (2007) Neurobiol Dis. , vol.25 , pp. 438-445
    • Franke, C.1    Noldner, M.2    Abdel-Kader, R.3
  • 50
    • 33646473699 scopus 로고    scopus 로고
    • Effect of systemic administration of simvastatin on retinal circulation
    • Nagaoka T, Takahashi A, Sato E, et al. Effect of systemic administration of simvastatin on retinal circulation. Arch Ophthalmol. 2006;124:665-670.
    • (2006) Arch Ophthalmol. , vol.124 , pp. 665-670
    • Nagaoka, T.1    Takahashi, A.2    Sato, E.3
  • 51
    • 33847717468 scopus 로고    scopus 로고
    • Simvastatin elicits dilation of isolated porcine retinal arterioles: Role of nitric oxide and mevalonate-rho kinase pathways
    • Nagaoka T, Hein TW, Yoshida A, Kuo L. Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways. Invest Ophthalmol Vis Sci. 2007; 48:825-832.
    • (2007) Invest Ophthalmol Vis Sci. , vol.48 , pp. 825-832
    • Nagaoka, T.1    Hein, T.W.2    Yoshida, A.3    Kuo, L.4
  • 52
    • 0037326964 scopus 로고    scopus 로고
    • Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage
    • Sironi L, Cimino M, Guerrini U, et al. Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol. 2003;23:322-327.
    • (2003) Arterioscler Thromb Vasc Biol. , vol.23 , pp. 322-327
    • Sironi, L.1    Cimino, M.2    Guerrini, U.3
  • 53
    • 70349577808 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy
    • Bartoli M, Al-Shabrawey M, Labazi M, et al. HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2009;50: 4934-4940.
    • (2009) Invest Ophthalmol Vis Sci. , vol.50 , pp. 4934-4940
    • Bartoli, M.1    Al-Shabrawey, M.2    Labazi, M.3
  • 54
    • 50249141649 scopus 로고    scopus 로고
    • The pleiotropic effects of simvastatin on retinal microvascular endothelium have important implications for ischaemic retinopathies
    • Medina RJ, O'Neill CL, Devine AB, Gardiner TA, Stitt AW. The pleiotropic effects of simvastatin on retinal microvascular endothelium have important implications for ischaemic retinopathies. PLoS One. 2008;3:e2584.
    • (2008) PLoS One. , vol.3
    • Medina, R.J.1    O'Neill, C.L.2    Devine, A.B.3    Gardiner, T.A.4    Stitt, A.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.