Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: A quantitative bromodeoxyuridine-labelling study

European Journal of Neuroscience

Volumn 11, Issue 9, 1999, Pages 3359-3364

  Hailer, Nils P ^a,b   Grampp, Anne ^a   Nitsch, Robert ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Astrocytes; Bromodeoxyuridine; Entorhinal cortex lesion; Hippocampus; Microglial proliferation

Indexed keywords

BROXURIDINE; CELL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; LECTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INJURY; CELL ACTIVATION; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; ENTORHINAL CORTEX; GLIA CELL; GRANULE CELL; IMMUNOCYTOCHEMISTRY; MICROGLIA; NONHUMAN; PERFORANT NERVE TRACT; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT;

ANIMALS; ANTIMETABOLITES; ASTROCYTES; BROMODEOXYURIDINE; DENTATE GYRUS; ENTORHINAL CORTEX; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; LECTINS; MICROGLIA; PLANT LECTINS; RATS; RATS, WISTAR;

EID: 0032823758     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00808.x     Document Type: Article

References (22)

1. Amaral, D.G. & Witter, M.P. (1995) Hippocampal Formation. In Paxinos, G. (ed.), The Rat Nervous System. Academic Press, San Diego, pp. 443-493.
2. Bachelor, P.E., Liberatore, G.T., Wong, J.Y.F., Porritt, M.J., Frerichs, F., Donnan, G.A. & Howells, D.W. (1999) Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express BDNF and GCLD neurotrophic factor. J. Neurosci., 19, 1708-1716.
3. Bechmann, I. & Nitsch, R. (1997) Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion. A light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia, 20, 145-154.
4. Diekmann, S., Ohm, T.G. & Nitsch, R. (1996) Long-lasting transneuronal changes in rat dentate granule cell dendrites after entorhinal cortex lesion. A combined intracellular injection and electron microscopic study. Brain Pathol., 6, 205-215.
5. Eddleston, M. & Mucke, L. (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience, 54, 15-36.
6. Fagan, A.M. & Gage, F.H. (1994) Mechanisms of sprouting in the adult central nervous system: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience, 58, 705-725.
7. Fagan, A.M., Suhr, S.T., Lucidi-Philippi, C.A., Peterson, D.A., Holtzman, D.M. & Gage, F.H. (1997) Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus. J. Neurosci., 17, 2499-2511.
8. Frotscher, M., Heimrich, B. & Deller, T. (1997) Sprouting in the hippocampus is layer-specific. Trends Neurosci., 20, 218-223.
9. Gage, F.H., Olejniczak, P. & Armstrong, D.M. (1988) Astrocytes are important for sprouting in the septohippocampal circuit. Exp. Neurol., 102, 2-13.
10. Gall, C., Rose, G. & Lynch, G. (1979) Proliferative and migratory activity of glial cells in the partially deafferented hippocampus. J. Comp. Neurol, 183, 539-549.
11. Gehrmann, J., Schoen, S.W. & Kreutzberg, G.W. (1991) Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus: a light and electron microscopical study. Acta Neuropathol., 82, 442-455.
12. Hailer, N.P., Bechmann, I., Heizmann, S. & Nitsch, R. (1997) Adhesion molecule expression on phagocytic microglial cells following anterograde degeneration of perforant path axons. Hippocampus, 7, 341-349.
13. Jensen, M.B., Gonzalez, B., Castellano, B. & Zimmer, J. (1994) Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions. Exp. Brain Res., 98, 245-260.
14. Lee, M.Y., Deller, T., Kirsch, M., Frotscher, M. & Hofmann, H.D. (1997) Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion. J. Neurosci., 17, 1137-1146.
15. Nitsch, R. (1993) Transneuronal changes in the lesioned entorhinalhippocampal system. Hippocampus, 3, Special Issue, 247-256.
16. Nitsch, R. & Frotscher, M. (1993) Transneuronal changes in dendrites of GABAergic parvalbumin-containing neurons of the rat fascia dentata following entorhinal lesion. Hippocampus, 3, Special Issue, 481-490.
17. Peterson, D.A., Lucidi Phillipi, C.A., Eagle, K.L. & Gage, F.H. (1994) Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J. Neurosci., 14, 6872-6885.
18. Schousboe, A., Bachevalier, J., Braak, H., Heinemann, U., Nitsch, R., Schroder, H. & Wetmore, C. (1993) Structural correlates and cellular mechanisms in entorhinal-hippocampal dysfunction. Hippocampus, 3, Special Issue, 293-301.
19. Sloviter, R.S. (1994) The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann. Neurol., 35, 640-654.
20. Soriano, E. & Del Rio, J.A. (1991) Simultaneous immunocytochemical visualization of bromodeoxyuridine and neural tissue antigens. J. Histochem. Cytochem., 39 (3), 255-263.
21. Steward, O. (1991) Synapse replacement on cortical neurons following denervation. Cereb. Cortex, 9, 81-132.
22. Steward, O., Kelley, M.S. & Torre, E.R. (1993) The process of reinnervation in the dentate gyrus of adult rats: Temporal relationship between changes in the level of glial fibrillary acidic protein (GFAP) and GFAP mRNA in reactive astrocytes. Exp. Neurol., 124, 167-183.