Synantocytes: New functions for novel NG2 expressing glia

Journal of Neurocytology

Volumn 31, Issue 6-7, 2002, Pages 551-ppl=-565

  Butt, Arthur M ^a   Kiff, Jennifer ^a   Hubbard, Paul ^a   Berry, Martin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NG2 PROTEOGLYCAN; PROTEOCHONDROITIN SULFATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ASTROCYTE; CELL SURVIVAL; CONTROLLED STUDY; DEMYELINATION; GENE EXPRESSION; GLIA CELL; GLIOSIS; GRAY MATTER; MACROPHAGE; MICROGLIA; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; REVIEW; STEM CELL; SYNANTOCYTE; WHITE MATTER;

ANIMALIA;

EID: 0242725514     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025751900356     Document Type: Review

References (86)

1. 2+ currents. Glia 17, 181-194.
2. ANDERSON, C. M. & SWANSON, R. A. (2000) Astrocyte glutamate transport: Review of properties, regulation, and physiological functions. Glia 32, 1-14.
3. ARMSTRONG, R. C., DORN, H. H., KUFTA, C. V., FRIEDMAN, E. & DUBOIS-DALCQ, M. E. (1992) Pre-oligodendrocytes from adult human CNS. Journal of Neuroscience 12, 1538-1547.
4. ARMSTRONG, R. C., HARVATH, L. & DUBOIS-DALCQ, M. E. (1990) Type 1 astrocytes and oligodendrocyte-type 2 astrocyte glial progenitors migrate toward distinct molecules. Journal of Neuroscience Research 27, 400-407.
5. ARMSTRONG, R. C., LE, T. Q., FROST, E. E., BORKE, R. C. & VANA, A. C. (2002) Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter. Journal of Neuroscience 22, 8574-8585.
6. ASHER, R. A., MORGENSTERN, D. A., FIDLER, P. S., ADCOCK, K. H., OOHIRA, A., BRAISTEAD, J. E., LEVINE, J. M., MARGOLIS, R. U., ROGERS, J. H. & FAWCETT, J. W. (2000) Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. Journal of Neuroscience 20, 2427-2438.
7. ASHER, R. A., MORGENSTERN, D. A., SHEARER, M. C., ADCOCK, K. H., PESHEVA, P. & FAWCETT, J. W. (2002) Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. Journal of Neuroscience 22, 2225-2236.
8. BARRES, B. A. & RAFF, M. C. (1993) Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature 361, 258-260.
9. BARRES, B. A. & RAFF, M. C. (1999) Axonal control of oligodendrocyte development. Journal of Cell Biology 147, 1123-1128.
10. BERGLES, D. E., ROBERTS, J. D. B., SOMOGYI, P. & JAHR, C. E. (2000) Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405, 187-191.
11. BERRY, M., BUTT, A. M., WILKIN, G. & PERRY, H. (2002) Structure and Function of Glia. In Greenfield's Pathology (edited by GRAHAM, D. I. & LANTOS, L.). pp. 75-121. Sevenoaks, Kent: Edward Arnold.
12. BERRY, M., HUNTER, A. S., DUNCAN, A., LORDAN, J., KIRVELL, S., TSANG, W.-L. & BUTT, A. M. (1998a) Axon-glial relations during regeneration of axons in the adult rat anterior medullary velum. Journal of Neurocytology 27, 915-937.
13. BERRY, M., LOGAN, A. & BUTT, A. M. (1998b) Cellular responses to penetrant CNS injury. In CNS Injuries: Cellular Responses and Pharmacological Strategies (edited by BERRY, M. & LOGAN, A.), pp. 1-18. Boca Raton: CRC Press.
14. BRUCKNER, G., GROSCHE, J., SCHMIDT, S., HARTIG, W., MARGOLIS, R. U., DELPECH, B., SEIDENBECHER, C. I., CZANIERA, R. & SCHACHNER, M. (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. Journal of Comparative Neurology 428, 616-629.
15. BU, J., AKHTAR, N. & NISHIYAMA, A. (2001) Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion. Glia 34, 296-310.
16. BURG, M. A., TILLET, E., TIMPL, R. & STALLCUP, W. B. (1996) Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. Journal of Biological Chemistry 271, 26110-26116.
17. BUTT, A. M. & BERRY, M. (2000) Oligodendrocytes and the control of myelination in vivo: New insights from the rat anterior medullary velum. Journal of Neuroscience Research 59, 477-488.
18. BUTT, A. M., COLQUHOUN, K., TUTTON, M. & BERRY, M. (1994) Three-dimensional morphology of astrocytes and oligodendrocytes in the intact mouse optic nerve. Journal of Neurocytology 23, 469-485.
19. BUTT, A. M., DUNCAN, A. & BERRY, M. (1994) Astrocyte associations with nodes of Ranvier. Ultrastructural analysis of HRP-filled astrocytes in the mouse optic nerve. Journal of Neurocytology 23, 486-499.
20. BUTT, A. M., DUNCAN, A., HORNBY, M. F., KIRVELL, S. L., HUNTER, A., LEVINE, J. M. & BERRY, M. (1999) Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter. Glia 26, 84-91.
21. BUTT, A. M., HORNBY, M. F., IBRAHIM, M., GRAHAM, A., KIRVELL, S. & BERRY, M. (1997b) PDGF-α receptor and myelin basic protein mRNAs are not coexpressed by oligodendrocytes in vivo: A double in situ hybridization study in the anterior medullary velum of the neonatal rat. Molecular and Cellular Neuroscience 8, 311-322.
22. BUTT, A. M., HORNBY, M. F., KIRVELL, S. & BERRY, M. (1997c) Platelet-derived growth factor delays oligodendrocyte differentiation and axonal myelination in vivo in the anterior medullary velum of the developing rat. Journal of Neuroscience Research 48, 588-596.
23. BUTT, A. M., IBRAHIM, M. & BERRY, M. (1997a) The relationship between developing oligodendrocyte units and maturing axons during myelinogenesis in the anterior medullary velum of neonatal rats. Journal of Neurocytology 26, 327-338.
24. CANOLL, P. D., MUSACCHIO, J. M., HARDY, R., REYNOLDS, R., MARCHIONNI, M. & SALZER, J. L. (1996) GGF/Neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17, 229-243.
25. CHAN, C. L., WIGLEY, C. B. & BERRY, M. (1990) Oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells from neonatal and adult rat optic nerve differ in their responsiveness to platelet-derived growth factor. Brain Research, Developmental Brain Research 55, 275-282.
26. CHANG, A., NISHIYAMA, A., PETERSON, J., PRINEAS, J. & TRAPP, B. D. (2000) NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. Journal of Neuroscience 20, 6404-6412.
27. CHARI, D. M. & BLAKEMORE, W. F. (2002) Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia 37, 307-313.
28. CHEKENYA, M., HJELSTUEN, M., ENGER, P. Ø., THORSEN, F., JACOB, A. L., PROBST, B., HARALDSETH, O., PILKINGTON, G., BUTT, A., LEVINE, J. M. & BJERKVIG, R. (2002) The NG2 proteoglycan promotes angiogenesis dependent tumor growth in CNS by sequestering angiostatin. FASEB Journal 16, 586-588.
29. DAVID, S., MILLER, R. H., PATEL, R. & RAFF, M. C. (1984) Effects of neonatal transection on glial cell development in the rat optic nerve: Evidence that the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survival. Journal of Neurocytology 13, 961-974.
30. DAWSON, R. L., LEVINE, J. M. & REYNOLDS, R. (2000) NG2-expressing cells in the central nervous system: Are they oligodendrocyte progenitors? Journal of Neuroscience Research 61, 471-479.
31. DI BELLO, I. C., DAWSON, M. R., LEVINE, J. M. & REYNOLDS, R. (1999) Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brainstem is associated with demyelination rather than inflammation. Journal of Neurocytology 28, 365-381.
32. EDDLESTON, M. & MUCKE, L. (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience 54, 15-36.
33. FANG, X., BURG, M. A., BARRITT, D., DAHLIN-HUPPE, K., NISHIYAMA, A. & STALLCUP, W. B. (1999) Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration. Molecular Biology of the Cell 10, 3373-3387.
34. FERNANDEZ, P. A., TANG, D. G., CHENG, L., PROCHIANTZ, A., MUDGE, A. W. & RAFF, M. C. (2000) Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 28, 81-90.
35. FFRENCH-CONSTANT, C. & RAFF, M. C. (1986) Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature 319, 499-502.
36. FULTON, B. P., BURNE, J. F. & RAFF, M. C. (1992) Visualization of O-2A progenitor cells in developing and adult rat optic nerve by quisqualate-stimulated cobalt uptake. Journal of Neuroscience 12, 4816-4833.
37. GODDARD, D. R., BERRY, M. & BUTT, A. M. (1999) In vivo actions of fibroblast growth factor-2 and insulin-like growth factor-I on oligodendrocyte development and myelination in the central nervous system. Journal of Neuroscience Research 57, 74-85.
38. GODDARD, D. R., BERRY, M., KIRVELL, S. L. & BUTT, A. M. (2001) Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo. Molecular and Cellular Neuroscience 18, 557-569.
39. GODDARD, D. R., BERRY, M., KIRVELL, S. L. & BUTT, A. M. (2002) Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo. Journal of Anatomy 200, 57-67.
40. GONZALEZ, A. M., BERRY, M., MAHER, P. A., LOGAN, A. & BAIRD, A. (1995) A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain. Brain Research 701, 201-226.
41. GORETZKI, L., BURG, M. A., GRAKO, K. A. & STALLCUP, W. B. (1999) High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. Journal of Biological Chemistry 274, 16831-16837.
42. GORETZKI, L., LOMBARDO, C. R. & STALLCUP, W. B. (2000) Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen). Journal of Biological Chemistry 275, 28625-28633.
43. GREENWOOD, K. & BUTT, A. M. (2003) Evidence that perinatal and adult NG2 expressing glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival. Molecular and Cellular Neuroscience, in press.
44. HAYDON, P. G. (2001) GLIA: Listening and talking to the synapse. Nature Reviews Neuroscience 2, 185-193.
45. HINKS, G. L. & FRANKLIN, R. J. M. (1999) Distinctive patterns of PDGF-A, FGF-2, IGF-I and TGF-β1 gene expression during remyelination of experimentally-induced spinal cord demyelination. Molecular and Cellular Neuroscience 14, 153-168.
46. HORNER, P. J., POWER, A. E., KEMPERMANN, G., KUHN, H. G., PALMER, T. D., WINKLER, J., THAL, L. J. & GAGE, F. H. (2000) Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. Journal of Neuroscience 20, 2218-2228.
47. JONES, L. L., YAMAGUCHI, Y., STALLCUP, W. B. & TUSZYNSKI, M. H. (2002) NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. Journal of Neuroscience 22, 2792-2803.
48. KAPLAN, M. R., CHO, M. H., ULLIAN, E. M., ISOM, L. L., LEVINSON, S. R. & BARRES, B. A. (2001) Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 30, 105-119.
49. KEIRSTEAD, H. S., LEVINE, J. M. & BLAKEMORE, W. F. (1998) Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 22, 161-170.
50. LEVINE, J. M. (1994) Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury. Journal of Neuroscience 14, 4716-4730.
51. LEVINE, J. M. & CARD, J. P. (1987) Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: Association with smooth protoplasmic astrocytes. Journal of Neuroscience 7, 2711-2720.
52. LEVINE, J. M., ENQUIST, L. W. & CARD, J. P. (1998) Reactions of oligodendrocyte precursor cells to alpha herpesvirus infection of the central nervous system. Glia 23, 316-328.
53. LEVINE, J. M. & REYNOLDS, R. (1999) Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Experimental Neurology 160, 333-347.
54. LEVINE, J. M. & STALLCUP, W. B. (1987) Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. Journal of Neuroscience 7, 2721-2731.
55. LEVINE, J. M., STINCONE, F. & LEE, Y. S. (1993) Development and differentiation of glial precursor cells in the rat cerebellum. Glia 7, 307-321.
56. LIN, X. H., GRAKO, K. A., BURG, M. A. & STALLCUP, W. B. (1996) NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. Molecular Biology of the Cell 7, 1977-1993.
57. LOGAN, A., FRAUTSCHY, S. A., GONZALEZ, A. M. & BAIRD, A. (1992) A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. Journal of Neuroscience 12, 3828-3837.
58. LOGAN, A., FRAUTSCHY, S. A., GONZALEZ, A. M., SPORN, M. B. & BAIRD, A. (1992) Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral injury. Brain Research 587, 216-225.
59. LOGAN, A., GREEN, J., HUNTER, A., JACKSON, R. & BERRY, M. (1999) Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor-beta2. European Journal of Neuroscience 11, 2367-2374.
60. MAJUMDAR, M., VUORI, K. & STALLCUP, W. B. (2003) Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Cell Signalling 15, 79-84.
61. MALLON, B. S., SHICK, H. E., KIDD, G. J. & MACKLIN, W. B. (2002) Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. Journal of Neuroscience 22, 876-885.
62. MASON, J. L. & GOLDMAN, J. E. (2002) A2B5+ and 04+ cycling progenitors in the adult forebrain white matter respond differentially to PDGF-AA, FGF-2, and IGF-1. Molecular and Cellular Neuroscience 20, 30-42.
63. MESSERSMITH, D. J., MURTIE, J. C., LE, T. Q., FROST, E. E. & ARMSTRONG, R. C. (2000) Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Journal of Neuroscience Research 62, 241-256.
64. NISHIYAMA, A., CHANG, A. & TRAPP, B. D. (1999) NG2+ glial cells: A novel glial cell population in the adult brain. Journal of Neuropathology and Experimental Neurology 58, 1113-1124.
65. NISHIYAMA, A., LIN, X. H., GIESE, N., HELDIN, C. H. & STALLCUP, W. B. (1996a) Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. Journal of Neuroscience Research 43, 299-314.
66. NISHIYAMA, A., LIN, X. H., GIESE, N., HELDIN, C. H. & STALLCUP, W. B. (1996b) Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF. Journal of Neuroscience Research 43, 315-330.
67. NISHIYAMA, A., YU, M., DRAZBA, J. A. & TUOHY, V. K. (1997) Normal and reactive NG2+ glial cells are distinct from resting and activated microglia. Journal of Neuroscience Research 48, 299-312.
68. ONG, W. Y. & LEVINE, J. M. (1999) A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus. Neuroscience 92, 83-95.
69. RAFF, M. C., MILLER, R. H. & NOBLE, M. (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303, 390-396.
70. RAMON Y CAJAL (1909) Histologie du system nerveux de l'home et disvertebres, p. 238, Paris: Maloine.
71. REYNOLDS, R. & HARDY, R. (1997) Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo. Journal of Neuroscience Research 47, 455-470.
72. STALLCUP, W. B. & BEASLEY, L. (1987) Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. Journal of Neuroscience 7, 2737-2744.
73. STEINHAUSER, C., BERGER, T., FROTSCHER, M. & KETTENMANN, H. (1992) Heterogeneity in the membrane current pattern of identified glial cells in the hippocampal slice. European Journal of Neuroscience 4, 472-484.
74. STEINHAUSER, C. & GALLO, V. (1996) News on glutamate receptors in glial cells. Trends in Neurosciences 19, 339-345.
75. TANG, X., DAVIES, J. E. & DAVIES, J. A. (2002) Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Journal of Neuroscience Research 71, 427-444.
76. TILLET, E., GENTIAL, B., GARRONE, R. & STALLCUP, W. B. (2002) NG2 proteoglycan mediates betal integrin-independent cell adhesion and spreading on collagen VI. Journal of Cell Biochemistry 86, 726-736.
77. TILLET, E., RUGGIERO, F., NISHIYAMA, A. & STALLCUP, W. B. (1997) The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein. Journal of Biological Chemistry 272, 10769-10776.
78. ULLIAN, E. M., SAPPERSTEIN, S. K., CHRISTOPHERSON, K. S. & BARRES, B. A. (2001) Control of synapse number by glia. Science 291, 657-661.
79. WALZ, W. (2000) Controversy surrounding the existence of discrete functional classes of astrocytes in adult gray matter. Glia 31, 95-103.
80. WALZ, W. & LANG, M. K. (1998) Immunocytochemical evidence for a distinct GFAP-negative subpopulation of astrocytes in the adult rat hippocampus. Neuroscience Letters 257, 127-130.
81. WOLSWIJK, G. & NOBLE, M. (1989) Identification of an adult-specific glial progenitor cell. Development 105, 387-400.
82. WOLSWIJK, G., RIDDLE, P. N. & NOBLE, M. (1990) Coexistence of perinatal and adult forms of a glial progenitor cell during development of the rat optic nerve. Development 109, 691-698.
83. YUAN, X., EISEN, A. M., MCBAIN, C. J. & GALLO, V. (1998) A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices. Development 125, 2901-2914.
84. ZHANG, Y., TOHYAMA, K., WINTERBOTTOM, J. K., HAQUE, N. S., SCHACHNER, M., LIEBERMAN, A. R. & ANDERSON, P. N. (2001) Correlation between putative inhibitory molecules at the dorsal root entry zone and failure of dorsal root axonal regeneration. Molecular and Cellular Neuroscience 17, 444-459.
85. ZHOU, M. & KIMELBERG, H. K. (2001) Freshly isolated hippocampal CA1 astrocytes comprise two populations differing in glutamate transporter and AMPA receptor expression. Journal of Neuroscience 21, 7901-7908.
86. ZHOU, M., SCHOOLS, G. P. & KIMELBERG, H. K. (2000) GFAP mRNA positive glia acutely isolated from rat hippocampus predominantly show complex current patterns. Brain Research, Molecular Brain Research 76, 121-131.