An objective appraisal of the free radical theory of aging

Handbook of the Biology of Aging

Volumn , Issue , 2011, Pages 177-202

  Lustgarten, Michael ^a,b   Muller, Florian L ^c   Van Remmen, Holly ^a,b,d  

^a Department of Physiology ^*  (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84859823408     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-378638-8.00008-7     Document Type: Chapter

References (164)

1. Ali S.S., Hardt J.I., Quick K.L., Kim-Han J.S., Erlanger B.F., Huang T.T., et al. A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. Free Radical Biology & Medicine 2004, 37(8):1191-1202.
2. Amer M.A. Modulation of age-related biochemical changes and oxidative stress by vitamin C and glutathione supplementation in old rats. Annals of Nutrition and Metabolism 2002, 46:165-168.
3. Andreassen O.A., Ferrante R.J., Klivenyi P., Klein A.M., Shinobu L.A., Epstein C.J., et al. Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis. Annals of Neurology 2000, 47(4):447-455.
4. Andziak B., O'Connor T.P., Qi W., DeWaal E.M., Pierce A., Chaudhuri A.R., et al. High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell 2006, 5(6):463-471.
5. Asimakis G.K., Lick S., Patterson C. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Circulation 2002, 105(8):981-986.
6. Becker L., Genius J., Rujescu D., Irmler M., Mijalski T., Mader M., et al. Creatine improves health and survival of mice. Neurobiology of Aging 2008, 29(9):1404-1411.
7. Beckman K.B., Ames B.N. The free radical theory of aging matures. Physiological Reviews 1998, 78:547-581.
8. Bezlepkin V.G., Sirota N.P., Gaziev A.I. The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet. Mechanisms of Ageing and Development 1996, 92:227-234.
9. Blackett A.D., Hall D.A. The effects of vitamin E on mouse fitness and survival. Gerontology 1981, 27(3):133-139.
10. Blackett A.D., Hall D.A. Vitamin E-its significance in mouse ageing. Age and Ageing 1981, 10(3):191-195.
11. Brewer G.J., Jones T.T., Wallimann T., Schlattner U. Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants. Mitochondrion 2004, 4(1):49-57.
12. Brigelius-Flohé R. Tissue-specific functions of individual glutathione peroxidases. Free Radical Biology & Medicine 1999, 27(9-10):951-965.
13. Bus J.S., Aust S.D., Gibson J.E. Paraquat toxicity: Proposed mechanism of action involving lipid peroxidation. Environmental Health Perspectives 1976, 16:139-146.
14. Busuttil R.A., Garcia A.M., Cabrera C., Rodriguez A., Suh Y., Kim W.H., et al. Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Research 2005, 65(24):11271-11275.
15. Carr A., Frei B. Does vitamin C act as a pro-oxidant under physiological conditions?. FASEB Journal 1999, 13:1007-1024.
16. Carty J.L., Bevan R., Waller H., Mistry N., Cooke M., Lunec J., et al. The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochemical and Biophysical Research Communications 2000, 273:729-735.
17. Chan S.H., Higgins E. Uncoupling activity of endogenous free fatty acids in rat liver mitochondria. Canadian Journal of Biochemistry 1978, 56:111-116.
18. Chu F.F., Esworthy R.S., Chu P.G., Longmate J.A., Huycke M.M., Wilczynski S., et al. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Research 2004, 64(3):962-968.
19. Conrad M., Jakupoglu C., Moreno S.G., Lippl S., Banjac A., Schneider M., et al. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Molecular and Cellular Biology 2004, 24(21):9414-9423.
20. Crane F.L. Comments on the discovery of coenzyme Q: A commentary on 'Isolation of a quinone from beef heart mitochondria.'. Biochimica et Biophysica Acta 1989, 1000:358-361.
21. Ebihara S., Marks T., Hudson D.J., Menaker M. Genetic control of melatonin synthesis in the pineal gland of the mouse. Science 1986, 231(4737):491-493.
22. Edamatsu R., Mori A., Packer L. The spin-trap N-tert-α-phenylbutylnitrone prolongs the life span of the senescence accelerated mouse. Biochemical and Biophysical Research Communications 1995, 211:847-849.
23. Edwards M.G., Anderson R.M., Yuan M., Kendziorski C.M., Weindruch R., Prolla T.A. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics 2007, 8:80.
24. Elchuri S., Oberley T.D., Qi W., Eisenstein R.S., Jackson Roberts L., Van Remmen H., et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 2005, 24(3):367-380.
25. Enstrom E., Kanim L.E., Klein M.A. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992, 3:194-202.
26. Epe B. Role of endogenous oxidative DNA damage in carcinogenesis: what can we learn from repair-deficient mice?. Biological Chemistry 2002, 383(3-4):467-475.
27. Erker L., Schubert R., Elchuri S., Huang T.T., Tarin D., Mueller K., et al. Effect of the reduction of superoxide dismutase 1 and 2 or treatment with α-tocopherol on tumorigenesis in Atm-deficient mice. Free Radical Biology & Medicine 2006, 41(4):590-600.
28. Esworthy R.S., Aranda R., Martín M.G., Doroshow J.H., Binder S.W., Chu F.F. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. American Journal of Physiology: Gastrointestinal and Liver Physiology 2001, 281(3):G848-G855.
29. Evans H.M., Bishop K.S. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 1922, 56:650-651.
30. Festing M.F., Blackmore D.K. Life span of specified-pathogen-free (MRC category 4) mice and rats. Laboratory Animals 1971, 5(2):179-192.
31. Fletcher A.E., Breeze E., Shetty P.S. Antioxidant vitamins and mortality in older persons: findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community. American Journal of Clinical Nutrition 2003, 78(5):999-1010.
32. Fomenko D.E., Novoselov S.V., Natarajan S.K., Lee B.C., Koc A., Carlson B.A., et al. Methionine-R-sulfoxide reductase 1 (MsrB1) knockout mice: Roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. Journal of Biological Chemistry 2008, 284:5986-5993.
33. Forsmark P., Aberg F., Norling B., Nordenbrand K., Dallner G., Ernster L. Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E. FEBS Letters 1991, 285:39-43.
34. Gardner P.R. Aconitase: sensitive target and measure of superoxide. Methods in Enzymology 2002, 349:9-23.
35. Gardner P.R., Nguyen D.D., White C.W. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proceedings of the National Academy of Sciences of the United States of America 1994, 91(25):12248-12252.
36. Garinis G.A., van der Horst G.T., Vijg J., Hoeijmakers J.H. DNA damage and ageing: New-age ideas for an age-old problem. Nature Cell Biology 2008, 10(11):1241-1247.
37. Gasdaska P.Y., Berggren M.M., Berry M.J., Powis G. Cloning, sequencing and functional expression of a novel human thioredoxin reductase. FEBS Letters 1999, 442(1):105-111.
38. Gladyshev V.N., Jeang K.T., Stadtman T.C. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proceedings of the National Academy of Sciences of the United States of America 1996, 93(12):6146-6151.
39. Goodrick C.L. Life-span and the inheritance of longevity of inbred mice. Journal of Gerontology 1975, 30(3):257-263.
40. Gutteridge J.M. Aspects to consider when detecting and measuring lipid peroxidation. Free Radical Research Communications 1986, 1(3):173-184.
41. Guyton A.C., Hall J.E. Textbook of medical physiology. 1996, Saunders, Philadelphia.
42. Hamberg M., Svensson J., Samuelsson B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America 1975, 72(8):2994-2998.
43. Hamilton M.L., Guo Z., Fuller C.D., Van Remmen H., Ward W.F., Austad S.N., et al. A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. Nucleic Acids Research 2001, 29(10):2117-2126.
44. Han E.S., Muller F.L., Pérez V.I., Qi W., Liang H., Xi L., et al. The in vivo gene expression signature of oxidative stress. Physiological Genomics 2008, 34(1):112-126.
45. Harman D. Aging: A theory based on free radical and radiation chemistry. Journal of Gerontology 1956, 11:298-300.
46. Harman D. The biologic clock: the mitochondria?. Journal of the American Geriatrics Society 1972, 20:145-147.
47. Hasty P., Vijg J. Accelerating aging by mouse reverse genetics: A rational approach to understanding longevity. Aging Cell 2004, 3(2):55-65.
48. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 2003, 299(5611):1355-1359.
49. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.B., Woodall A.A., Yeo H.C., et al. DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proceedings of the National Academy of Sciences of the United States of America 1998, 95(1):288-293.
50. Ho Y.S., Gargano M., Cao J., Bronson R.T., Heimler I., Hutz R.J. Reduced fertility in female mice lacking copper-zinc superoxide dismutase. Journal of Biological Chemistry 1998, 273:7765-7769.
51. Ho Y.S., Xiong Y., Ma W., Spector A., Ho D.S. Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. Journal of Biological Chemistry 2004, 279(31):32804-32812.
52. Hoffman H.J. Survival for selected laboratory rat strains and stocks. Development of the rodent as a model system of aging stocks 1978, II:19-34. U.S. Government Printing Office, Washington, DC.
53. Holloszy J.O. Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mechanisms of Ageing and Development 1998, 100(3):211-219.
54. Holloszy J.O., Smith E.K., Vining M., Adams S. Effect of voluntary exercise on longevity of rats. Journal of Applied Physiology 1985, 59(3):826-831.
55. Hu D., Cao P., Thiels E., Chu C.T., Wu G.Y., Oury T.D., et al. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiology of Learning and Memory 2007, 87(3):372-384.
56. Huang H.Y., Appel L.J., Croft K.D., Miller E.R., Mori T.A., Puddey I.B. Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. American Journal of Clinical Nutrition 2002, 76:549-555.
57. Huang T.T., Carlson E.J., Gillespie A.M., Shi Y., Epstein C.J. Ubiquitous overexpression of Cu, Zn superoxide dismutase does not extend life span in mice. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2000, 55:B5-B9.
58. Huang T.T., Carlson E.J., Kozy H.M., Mantha S., Goodman S.I., Ursell P.C., et al. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Free Radical Biology & Medicine 2001, 31:1101-1110.
59. Huang T.T., Yasunami M., Carlson E.J., Gillespie A.M., Reaume A.G., Hoffman E.K., et al. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Archives of Biochemistry and Biophysics 1997, 344(2):424-432.
60. Imai H., Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radical Biology & Medicine 2003, 34:145-169.
61. Imamura Y., Noda S., Hashizume K., Shinoda K., Yamaguchi M., Uchiyama S., et al. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(30):11282-11287.
62. Ingold K.U., Webb A.C., Witter D., Burton G.W., Metcalfe T.A., Muller D.P. Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Archives of Biochemistry and Biophysics 1987, 259:224-225.
63. Inoue S., Koya-Miyata S., Ushio S., Iwaki K., Ikeda M., Kurimoto M. Royal jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Experimental Gerontology 2003, 38(9):965-969.
64. Jakupoglu C., Przemeck G.K., Schneider M., Moreno S.G., Mayr N., Hatzopoulos A.K., et al. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Molecular and Cellular Biology 2005, 25(5):1980-1988.
65. James A.M., Smith R.A.J., Murphy M.P. Antioxidant and prooxidant properties of mitochondrial coenzyme CoQ. Archives of Biochemistry and Biophysics 2004, 423:47-56.
66. Jang Y.C., Pérez V.I., Song W., Lustgarten M.S., Salmon A.B., Mele J., et al. Overexpression of Mn superoxide dismutase does not increase life span in mice. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64(11):1114-1125.
67. Jung T., Bader N., Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Annals of the New York Academy of Sciences 2007, 1119:97-111.
68. Kitani K., Osawa T., Yokozawa T. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology 2007, 8(5):567-573.
69. Klungland A., Bjelland S. Oxidative damage to purines in DNA: role of mammalian Ogg1. DNA Repair (Amsterdam) 2007, 6(4):481-488.
70. Klungland A., Rosewell I., Hollenbach S., Larsen E., Daly G., Epe B., et al. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:13300-13305.
71. Kosugi H., Kato T., Kikugawa K. Formation of yellow, orange, and red pigments in the reaction of alk-2-enals with 2-thiobarbituric acid. Analytical Biochemistry 1987, 165(2):456-464.
72. Kraemer W.J., Volek J.S. Creatine supplementation: its role in human performance. Clinics in Sports Medicine 1999, 18:651-666.
73. Lawler J.M., Barnes W.S., Wu G., Song W., Demaree S. Direct antioxidant properties of creatine. Biochemical and Biophysical Research Communication 2002, 290:47-52.
74. Lebovitz R.M., Zhang H., Vogel H., Cartwright J., Dionne L., Lu N., et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:9782-9787.
75. Lee C.K., Pugh T.D., Klopp R.G., Edwards J., Allison D.B., Weindruch R., et al. The impact of α-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radical Biology & Medicine 2004, 36(8):1043-1057.
76. Lee I.M., Cook N.R., Gaziano J.M., Gordon D., Ridker P.M., Manson J.E., et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's HealthStudy: a randomized controlled trial. Journal of the American Medical Association 2005, 294:56-65.
77. Lee T.H., Kim S.U., Yu S.L., Kim S.H., Park D.S., Moon H.B., et al. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 2003, 101(12):5033-5038.
78. Lemon J.A., Boreham D.R., Rollo C.D. A complex dietary supplement extends longevity of mice. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2005, 60(3):275-279.
79. Lewén A., Matz P., Chan P.H. Free radical pathways in CNS injury. Journal of Neurotrauma 2000, 17(10):871-890.
80. Li L., Shoji W., Takano H., Nishimura N., Aoki Y., Takahashi R., et al. Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress. Biochemical and Biophysical Research Communications 2007, 355(3):715-721.
81. Li Y., Huang T.T., Carlson E.J., Melov S., Ursell P.C., Olson J.L., et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genetics 1995, 11:376-381.
82. Lipman R.D., Bronson R.T., Wu D., Smith D.E., Prior R., Cao G., et al. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice. Mechanisms of Ageing and Development 1998, 103(3):269-284.
83. Lonn E., Bosch J., Yusuf S., Sheridan P., Pogue J., Arnold J.M., the HOPE and HOPE-TOO Trial Investigators, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial. Journal of the American Medical Association 2005, 293:1338-1347.
84. Lönnrot K., Holm P., Lagerstedt A., Huhtala H., Alho H. The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice. Biochemistry and Molecular Biology International 1998, 44(4):727-737.
85. Lynn S., Van Remmen H., Epstein C.J., Huang T.T. Investigation of mitochondrial DNA deletions in post-mitotic tissues of the heterozygous superoxide dismutase 2 knockout mouse: effect of ageing and genotype on the tissue-specific accumulation. Free Radical Biology & Medicine 2001, 31:S58.
86. Mansouri A., Muller F.L., Liu Y., Ng R., Faulkner J., Hamilton M., et al. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mechanisms of Ageing and Development 2006, 127(3):298-306.
87. Marshall K.A., Reiter R.J., Poeggeler B., Aruoma O.I., Halliwell B. Evaluation of the antioxidant activity of melatonin in vitro. Free Radical Biology & Medicine 1996, 21(3):307-315.
88. Massie H.R., Aiello V.R., Doherty T.J. Dietary vitamin C improves the survival of mice. Gerontology 1984, 30(6):371-375.
89. Massie H.R., Ferreira J.R., DeWolfe L.K. Effect of dietary beta-carotene on the survival of young and old mice. Gerontology 1986, 32(4):189-195.
90. Matsui M., Oshima M., Oshima H., Takaku K., Maruyama T., Yodoi J., et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Developmental Biology 1996, 178(1):179-185.
91. McFadden S.L., Ding D., Reaume A.G., Flood D.G., Salvi R.J. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiology of Aging 1999, 20(1):1-8.
92. Miller R.A., Harrison D.E., Astle C.M., Floyd R.A., Flurkey K., Hensley K.C., et al. An Aging Interventions Testing Program: Study design and interim report. Aging Cell 2007, 6(4):565-575. Erratum in: Aging Cell, 2008 Jun, 7(3), 445.
93. Minowa O., Arai T., Hirano M., Monden Y., Nakai S., Fukuda M., et al. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:4156-4161.
94. Mitsui A., Hamuro J., Nakamura H., Kondo N., Hirabayashi Y., Ishizaki-Koizumi S., et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxidants and Redox Signaling 2002, 4:693-696.
95. Morley A.A., Trainor K.J. Lack of an effect of vitamin E on lifespan of mice. Biogerontology 2001, 2(2):109-112.
96. Moskovitz J., Bar-Noy S., Williams W.M., Requena J., Berlett B.S., Stadtman E.R. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:12920-12925.
97. Muller F. The nature and mechanism of superoxide production by the electron transport chain: its relevance to aging. Journal of the American Aging Association 2000, 23:227-253.
98. Muller F.L., Liu Y., Jernigan A., Borchelt D., Richardson A., Van Remmen H. MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models. Muscle & Nerve 2008, 38(3):1173-1183.
99. Muller F.L., Lustgarten M.S., Jang Y., Richardson A., Van Remmen H. Trends in oxidative aging theories. Free Radical Biology & Medicine 2007, 43(4):477-503.
100. Muller F.L., Song W., Liu Y., Chaudhuri A., Pieke-Dahl S., Strong R., et al. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radical Biology & Medicine 2006, 40(11):1993-2004.
101. Murakami K., Kondo T., Kawase M., Li Y., Sato S., Chen S.F., et al. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. Journal of Neuroscience 1998, 18(1):205-213.
102. Nagai T., Inoue R. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chemistry 2004, 84:181-186.
103. Nagai T., Inoue R., Suzuki N., Nagashima T. Antioxidant properties of enzymatic hydrolysates from royal jelly. Journal of Medicinal Food 2006, 9(3):363-367.
104. Navarro A., Gomez C., Sanchez-Pino M.J., González H., Bández M.J., Boveris A.D., et al. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 2005, 289:R1392-R1399.
105. Neumann C.A., Krause D.S., Carman C.V., Das S., Dubey D.P., Abraham J.L., et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 2003, 424(6948):561-565.
106. Nishimura S. Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA. Free Radical Biology & Medicine 2002, 32:813-821.
107. Nojiri H., Shimizu T., Funakoshi M., Yamaguchi O., Zhou H., Kawakami S., et al. Oxidative stress causes heart failure with impaired mitochondrial respiration. Journal of Biological Chemistry 2006, 281(44):33789-33801.
108. Nonn L., Williams R.R., Erickson R.P., Powis G. The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Molecular and Cellular Biology 2003, 23(3):916-922.
109. Osawa T., Sugiyama Y., Inayoshi M., Kawakishi S. Antioxidative activity of tetrahydrocurcuminoids. Bioscience, Biotechnology and Biochemistry 1995, 59:1609-1612.
110. Osterod M., Hollenbach S., Hengstler J.G., Barnes D.E., Lindahl T., Epe B. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis 2001, 22:1459-1463.
111. Osterod M., Larsen E., Le Page F., Hengstler J.G., Van Der Horst G.T., Boiteux S., et al. A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene 2002, 21(54):8232-8239.
112. Packer L., Roy S., Sen C.K. Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Advances in Pharmacology 1997, 38:79-101.
113. Pérez V.I., Bokov A., Van Remmen H., Mele J., Ran Q., Ikeno Y., et al. Is the oxidative stress theory of aging dead?. Biochimica et Biophysica Acta 2009, 1790(10):1005-1014.
114. Pérez V.I., Lew C.M., Cortez L.A., Webb C.R., Rodriguez M., Liu Y., et al. Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. Free Radical Biology & Medicine 2008, 44(5):882-892.
115. Pérez V.I., Van Remmen H., Bokov A., Epstein C.J., Vijg J., Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 2009, 8(1):73-75.
116. Podmore I.D., Griffiths H.R., Herbert K.E., Mistry N., Mistry P., Lunec J. Vitamin C exhibits pro-oxidant properties. Nature (London) 1998, 392(6676):559.
117. Porta E.A., Joun N.S., Nitta R.T. Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Life span, serum biochemical parameters and pathological changes. Mechanisms of Ageing and Development 1980, 13:1-39.
118. Powis G., Montfort W.R. Properties and biological activities of thioredoxins. Annual Review of Biophysical and Biomolecular Structure 2001, 30:421-455.
119. Quick K.L., Ali S.S., Arch R., Xiong C., Wozniak D., Dugan L.L. A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiology of Aging 2008, 29(1):117-128.
120. Rai P., Onder T.T., Young J.J., McFaline J.L., Pang B., Dedon P.C., et al. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(1):169-174.
121. Raineri I., Carlson E.J., Gacayan R., Carra S., Oberley T.D., Huang T.T., Epstein C.J. Strain dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility. Free Radical Biology & Medicine 2001, 31:1018-1030.
122. Ran Q., Liang H., Ikeno Y., Qi W., Prolla T.A., Roberts L.J., et al. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2007, 62(9):932-942.
123. Ran Q., Liang H., Gu M., Qi W., Walter C.A., Roberts L.J., et al. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. Journal of Biological Chemistry 2004, 279(53):55137-55146.
124. Rando T.A., Epstein C.J. Copper/zinc superoxide dismutase: more is not necessarily better!. Annals of Neurology 1999, 46:135-136.
125. Reaume A.G., Elliott J.L., Hoffman E.K., Kowall N.W., Ferrante R.J., Siwek D.F., et al. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nature Genetics 1996, 13:43-47.
126. Rebrin I., Sohal R.S. Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevities. Experimental Gerontology 2004, 39:1513-1519.
127. Rebrin I., Sohal R.S. Pro-oxidant shift in glutathione redox state during aging. Advanced Drug Delivery Reviews 2008, 60(13-14):1545-1552.
128. Reddy V.N., Giblin F.J., Lin L.R., Dang L., Unakar N.J., Musch D.C., et al. Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice. Investigative Ophthalmology and Visual Science 2001, 42:3247-3255.
129. Reddy V.N., Kasahara E., Hiraoka M., Lin L.R., Ho Y.S. Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Experimental Eye Research 2004, 79(6):859-868.
130. Rhee S.G., Kang S.W., Chang T.S., Jeong W., Kim K. Peroxiredoxin, a novel family of peroxidases. IUBMB Life 2001, 52(1-2):35-41.
131. Roberts L.J., Milne G.L. Isoprostanes. Journal of Lipid Research 2009, 50(Suppl):S219-S223.
132. Roberts L.J., Oates J.A., Linton M.F., Fazio S., Meador B.P., Gross M.D., et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radical Biology & Medicine 2007, 43(10):1388-1393.
133. Saito K., Yoshioka H., Cutler R.G. A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice. Bioscience Biotechnology and Biochemistry 1998, 62(4):792-794.
134. Salmon A.B., Pérez V.I., Bokov A., Jernigan A., Kim G., Zhao H., et al. Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB Journal 2009, 23(10):3601-3608.
135. Scheer B.T. Comparative physiology 1948, John Wiley, New York.
136. Schriner S.E., Ogburn C.E., Smith A.C., Newcomb T.G., Ladiges W.C., Dollé M.E., et al. Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei. Free Radical Biology & Medicine 2000, 29(7):664-673.
137. Schriner S.E., Linford N.J., Martin G.M., Treuting P., Ogburn C.E., Emond M., et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005, 308(5730):1909-1911.
138. Seiler A., Schneider M., Förster H., Roth S., Wirth E.K., Culmsee C., et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metabolism 2008, 8(3):237-248.
139. Sentman M.L., Granström M., Jakobson H., Reaume A., Basu S., Marklund S.L. Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase. Journal of Biological Chemistry 2006, 281(11):6904-6909.
140. Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta 2009, 1790(10):1149-1160.
141. Sies H., Stahl W., Sundquist A.R. Antioxidant functions of vitamins: vitamins E and C, beta-carotene, and other carotenoids. Annals of the New York Academy of Sciences 1992, 669:7-20.
142. Silver I., Erecinska M. Oxygen and ion concentrations in normoxic and hypoxic brain cells. Advances in Experimental Medicine and Biology 1988, 454:7-16.
143. Sohal R.S., Kamzalov S., Sumien N., Ferguson M., Rebrin I., Heinrich K.R., et al. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radical Biology & Medicine 2006, 40(3):480-487.
144. Stuart J.A., Bourque B.M., de Souza-Pinto N.C., Bohr V.A. No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Free Radical Biology & Medicine 2005, 38(6):737-745.
145. Sumien N., Forster M.J., Sohal R.S. Supplementation with vitamin E fails to attenuate oxidative damage in aged mice. Experimental Gerontology 2003, 38(6):699-704.
146. Takayanagi R., Takeshige K., Minakami S. NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles: dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol. Biochemical Journal 1980, 192:853-860.
147. Terman A., Brunk U.T. Lipofuscin. International Journal of Biochemistry and Cell Biology 2004, 36(8):1400-1404.
148. Traber M.G., Atkinson J. Vitamin E, antioxidant and nothing more. Free Radical Biology & Medicine 2007, 43(1):4-15.
149. Trapp C., McCullough A.K., Epe B. The basal levels of 8-oxoG and other oxidative modifications in intact mitochondrial DNA are low even in repair-deficient (Ogg1(-/-)/Csb(-/-)) mice. Mutation Research 2007, 625(1-2):155-163.
150. Treuting P.M., Linford N.J., Knoblaugh S.E., Emond M.J., Morton J.F., Martin G.M., et al. Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2008, 63(8):813-822.
151. Tsao C.S., Leung P.Y., Young M. Effect of dietary ascorbic acid intake on tissue vitamin C in mice. Journal of Nutrition 1987, 117(2):291-297.
152. Tsuzuki T., Egashira A., Igarashi H., Iwakuma T., Nakatsuru Y., Tominaga Y., et al. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:11456-11461.
153. Ursini F., Bindoli A. The role of selenium peroxidases in the protection against oxidative damage of membranes. Chemistry and Physics of Lipids 1987, 44(2-4):255-276.
154. Van Remmen H., Ikeno Y., Hamilton M., Pahlavani M., Wolf N., Thorpe S.R., et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiological Genomics 2003, 16:29-37.
155. Van Remmen H., Salvador C., Yang H., Huang T.T., Epstein C.J., Richardson A. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Archives of Biochemistry and Biophysics 1999, 363:91-97.
156. Van Remmen H., Williams M.D., Guo Z., Estlack L., Yang H., Carlson E.J., et al. Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. American Journal of Physiology: Heart and Circulatory Physiology 2001, 281:H1422-H1432.
157. Wang C., Li Q., Redden D.T., Weindruch R., Allison D.B. Statistical methods for testing effects on "maximum lifespan.". Mechanisms
158. Weisiger R.A., Fridovich I. Mitochondrial superoxide dismutase: site of synthesis and intramitochondrial localization. Journal of Biological Chemistry 1973, 248(13):4793-4796.
159. Williams M.D., Van Remmen H., Conrad C.C., Huang T.T., Epstein C.J., Richardson A. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. Journal of Biological Chemistry 1998, 273:28510-28515.
160. Wu X., Beecher G.R., Holden J.M., Haytowitz D.B., Gebhardt S.E., Prior R.L. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. Journal of Agricultural and Food Chemistry 2004, 52(12):4026-4037.
161. Yant L.J., Ran Q., Rao L., Van Remmen H., Shibatani T., Belter J.G., et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radical Biology & Medicine 2003, 34:496-502.
162. Yeo H.C., Helbock H.J., Chyu D.W., Ames B.N. Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry. Analytical Biochemistry 1994, 220(2):391-396.
163. Yoshida T., Oka S., Masutani H., Nakamura H., Yodoi J. The role of thioredoxin in the aging process: involvement of oxidative stress. Antioxidants and Redox Signaling 2003, 5(5):563-570.
164. Zhang Y., Ikeno Y., Qi W., Chaudhuri A., Li Y., Bokov A., et al. Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64(12):1212-1220.