Role of endogenous oxidative DNA damage in carcinogenesis: What can we learn from repair-deficient mice?

Biological Chemistry

Volumn 383, Issue 3-4, 2002, Pages 467-475

  Epe, Bernd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

7,8 dihydro 8 oxo 2 deoxyguanosine; DNA repair; Endogenous DNA damage; Knockout mice; Mutation rate; Reactive oxygen species

Indexed keywords

8 HYDROXYGUANINE; ANTIOXIDANT; DNA BASE; REACTIVE OXYGEN METABOLITE;

BASE PAIRING; CANCER INCIDENCE; CARCINOGENESIS; CELL METABOLISM; CONTROLLED STUDY; DNA DAMAGE; DNA MODIFICATION; DNA REPAIR; GENE EXPRESSION; GENE MUTATION; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER; MOUSE; MUTATION RATE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION; STEADY STATE; TRANSGENIC MOUSE; TUMOR PROMOTION;

ANIMALS; DNA DAMAGE; DNA REPAIR; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

ANIMALIA; MUS MUSCULUS;

EID: 0036254568     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.049     Document Type: Review

References (95)

1. Oxidative stress and gene regulation
2. Paracelsus to parascience: The environmental cancer distraction
3. The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with 'low' or 'high' cholesterol levels
4. Ultrasensitive and specific detection methods for exocylic DNA adducts: Markers for lipid peroxidation and oxidative stress
5. A simpler, more robust method for the analysis of 8-oxoguanine in DNA
6. Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humans
7. The human OGG1 gene: Structure, functions, and its implication in the process of carcinogenesis
8. Substrate specificity of the Escherichia coli Epg protein (formamidopyrimidine-DNA glycosylase): Excision of purine lesions in DNA produced by ionizing radiation or photosensitization
9. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
10. Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and α-tocopherol
11. Oxidative damage to DNA: Formation, measurement, and biological significance
12. Does vitamin C act as a pro-oxidant under physiological conditions?
13. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions
14. Oxidative DNA damage, antioxidants, and cancer
15. Carotenoids and genomic stability
16. Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA
17. Oxidative DNA damage in human cells: The influence of antioxidants and DNA repair
18. Novel repair action of vitamin C upon in vivo oxidative DNA damage
19. Urinary 8-oxo-2′-deoxyguanosine - Source, significance and supplements
20. Induction and repair of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells
21. Regulation of gene expression by reactive oxygen species
22. Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the OGG1 gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1 defective mice
23. 32P-postlabeling assay and the basal levels in rat tissues
24. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
25. Observation and prevention of an artefactual formation of oxidized DNA bases and nucleosides in the GC-EIMS method
26. In vitro DNA synthesis opposite oxazolone and repair of this DNA damage using modified oligonucleotides
27. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
28. DNA damage profiles induced by oxidizing agents
29. Oxidative DNA damage: Endonuclease fingerprinting
30. Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage
31. Effect of ascorbate and 5-aminosalicylic acid on light-induced 8-hydroxyguanosine formation in V79 Chinese hamster cells
32. Hydroxyl free radical adduct of deoxyguanosine: Sensitive detection and mechanisms of formation
33. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm
34. High-performance liquid chromatography-tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA
35. Rodent carcinogens: Setting priorities
36. Vitamin C: Antioxidant or oxidant in vivo?
37. Vitamin C: Poison, prophylactic or panacea?
38. Vitamin C and genomic stability
39. Sensitive analysis of oxidative DNA damage in mammalian cells: Use of the bacterial Fpg protein in combination with alkaline unwinding
40. DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxodeoxyguanosine and 8-oxo-guanine
41. Overexpression of Ogg1 in mammalian cells: Effects on induced and spontaneous oxidative DNA damage and mutagenesis
42. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
43. Reactive oxygen species and programmed cell death
44. Endogenous oxidative DNA base modifications analysed with repair enzymes and GC/MS technique
45. Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide
46. Comparison of results from different laboratories in measuring 8-oxo-2′-deoxyguanosine in synthetic oligonucleotides
47. Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein
48. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
49. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ
50. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
51. Toxicity and carcinogenicity of potassium bromate - A new renal carcinogen
52. Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
53. Transcription-coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in non-transcribed sequences but not in transcribed sequences
54. Inducible repair of thymine glycol detected by an ultra-sensitive assay for DNA damage
55. Glutathione and ascorbate are negatively correlated with oxidative DNA damage in human lymphocytes
56. Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay
57. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland
58. Cancer risk and oxidative DNA damage in man
59. Experimental study of oxidative DNA damage
60. Lipid peroxidation-DNA by malondialdehyde
61. Endogenous DNA damage and mutation
62. The GO system protects organisms from the mutagenic effects of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
63. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
64. 32P]-postlabeling assay
65. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted GC → TA transversions in simian kidney cells
66. DNA base damage in chromatin of γ-irradiated cultured human cells
67. High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects
68. Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions
69. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
70. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice
71. Correlation of DNA adduct levels with tumor incidence: Carcinogenic potency of DNA adducts
72. Antioxidants and multistage carcinogenesis in mouse skin
73. Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases
74. Oxidative DNA damage induced by visible light in mammalian cells: Extent, inhibition by antioxidants and genotoxic effects
75. Vitamin C exhibits pro-oxidant properties
76. Antioxidants, DNA damage and gene expression
77. Singlet oxygen induces oxidation of cellular DNA
78. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers
79. The genetic epidemiology of cancer: Interpreting family and twin studies and their implications for molecular genetic approaches
80. Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid
81. Oxidative Stress interference with the nuclear factor κB activation pathways
82. 33P-postlabeling and electrochemical detection
83. Determination of 8-hydroxyguanosine in biological tissues by liquid chromatography/electrospray ionization-mass spectrometry/mass spectrometry
84. Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture
85. Substrate specificity of Fpg protein
86. Inactivation of OGG1 increases the incidence of G:C→T:A transversions in Saccharomyces cerevisiae: Evidence for endogenous oxidative damage to DNA in eukaryotic cells
87. Use of the comet assay to investigate the role of superoxide in glutathione-induced DNA damage
88. Cancer: Causes, occurrence, and control
89. Kinetics of induction of DNA adducts, cell proliferation and gene mutations in the liver of Muta™Mice treated with 5,9-dimethydibenzo[c,g]carbazole
90. The cockayne syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA
91. Mutagenicity and repair of oxidative DNA damage: Insights from studies using defined lesions
92. Influence of glutathione levels and heat-shock on the steady-state levels of oxidative DNA base modifications in mammalian cells
93. Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022
94. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
95. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome