Modulation of age-related biochemical changes and oxidative stress by vitamin C and glutathione supplementation in old rats

Annals of Nutrition and Metabolism

Volumn 46, Issue 5, 2002, Pages 165-168

  Amer, M A ^a  

^a Mansoura University   (Egypt)

Author keywords

Aging; Antioxidants; Copper; Hormones; Lipids; Zinc

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CHOLESTEROL; COPPER; GLUTATHIONE; LIOTHYRONINE; LIPID; TESTOSTERONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THYROXINE; TRIACYLGLYCEROL; ZINC;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; COPPER BLOOD LEVEL; LIOTHYRONINE BLOOD LEVEL; LIVER LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TESTIS; TESTOSTERONE BLOOD LEVEL; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ZINC BLOOD LEVEL;

AGING; ANIMALS; ASCORBIC ACID; CHOLESTEROL; COPPER; DIETARY SUPPLEMENTS; GLUTATHIONE; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; THYROXINE; TRIGLYCERIDES; ZINC;

EID: 0036969757     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065402     Document Type: Article

References (19)

1. Byung PY: Aging and oxidative stress: Modulation by dietary restriction. Free Radic Biol Med 1996;21:651-668.
2. Harman D: Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
3. Harman D: Aging prospects for further increases in the functional life spans. Aging 1994;17:119-146.
4. Hussain S, Slikker JRW, Ali SF: Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain. Int J Dev Neurosci 1995;13:811-817.
5. Chakarborty S, Nandi A, Mukhopadhyay M, Mukhopadhyay CK, Chatterjee IB: Ascorbate protects guinea pig tissues against lipid peroxidation. Free Radic Biol Med 1994;16:417-426.
6. El-Missiry M: Enhanced testicular antioxidant system ascorbic acid in alloxan diabetic rats. Comp Biochem Physiol C 1999;124:233-237.
7. Kurata M, Suzuki M, Agar N: Antioxidant systems and erythrocyte life span in mammals. Comp Biochem Physiol 1993;106B:477-487.
8. Levine M, Morita K: Ascorbic acid in endocrine systems; in Aurbochand G, McCormick D (eds): Vitamins and Hormones. New York, Academic Press, 1985, vol 42, pp 2-53.
9. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
10. Beutler E: Red Cell Metabolism. A Manual of Biochemical Methods. New York, Grune & Stratton, 1982, vol 89, pp 137-140.
11. Ratiff CR, Hall F: Laboratory Manual of Clinical Biochemistry. Temple/Tex., Scott & White Memorial Publications, 1973.
12. Royer ME: A calorimetric determination of triglycerides. Anal Biochem 1969;29:405.
13. Rodriguez-Martinez MA, Garcia-Cohen A, Briones-Baena AB, Marin E, Salaices M, Marian J: Changes in plasma antioxidative state with age and their influence on concentrations elicited by noradrenaline in the rat-tail artery. Life Sci 1999;65:915-924.
14. Shindo Y, Witt E, Han D, Tzeng B, Aziz T, Nguyen L, Pocker L: Recovery of antioxidants and reduction in lipid hydroperoxides in murine epidermis and dermis after acute ultraviolet radiation exposure. Photodermatol Photoimmunol Photomed 1994;10:183-191.
15. El-Missiry M, Othman A, El-Desoky H: Maintenance of glutathione by ascorbic acid against sulphahydryl oxidation in erythrocytes of rat. J Egypt Ger Soc Zool 1995;16:303-313.
16. Lopez-Torres M, Perez-Campo R, Rojas C, Cadenas S, Barja G: Simultaneous induction of SOD, glutathione reductase, GSH and ascorbate in liver and kidney correlates with survival during aging. Free Radic Biol Med 1993;15:133-142.
17. Barja G, Lopez-Torres M, Perez-Campo R, Rojas C, Cadenas S, Prat J, Pamplona R: Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde and lipid peroxidation and maintains fatty acid unsaturation in guinea pig liver. Free Radic Biol Med 1994;17:105-115.
18. Bolzan AD, Brown OA, Goya RG, Bianchi MS: Hormonal modulation of antioxidant enzyme activities in young and old rats. Exp Gerontol 1995;30:169-175.
19. Prohaska JR: Changes in Cu, Zn-superoxide dismutase, cytochrome c, oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats. J Nutr 1991;121:355-363.