Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility

Free Radical Biology and Medicine

Volumn 31, Issue 8, 2001, Pages 1018-1030

  Raineri, Ines ^a   Carlson, Elaine J ^a   Gacayan, Rhodora ^a   Carra, Scott ^a   Oberley, Terry D ^b   Huang, Ting Ting ^a   Epstein, Charles J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Free radicals; Genetic modifiers; Infertility; Leydig cells; MnSOD; Transgenic mice

Indexed keywords

DNA; MANGANESE SUPEROXIDE DISMUTASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CELL DIFFERENTIATION; CELL GROWTH; CELL PROTECTION; CONTROLLED STUDY; FEMALE INFERTILITY; FERTILITY; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GROWTH RETARDATION; HEART; IN VIVO STUDY; KIDNEY; MALE INFERTILITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; TRANSGENIC ANIMAL;

ANIMALS; BONE MARROW CELLS; BRAIN; CATALASE; FEMALE; FETAL GROWTH RETARDATION; FIBROBLASTS; GLUTATHIONE REDUCTASE; INFERTILITY; LEYDIG CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MYOCARDIUM; SPECIES SPECIFICITY; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC; TRANSGENES; UP-REGULATION; ZYGOTE INTRAFALLOPIAN TRANSFER;

ANIMALIA; MUS MUSCULUS;

EID: 0035887747     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00686-4     Document Type: Article

References (39)

1. Superoxide radical and hydrogen peroxide in mitochondria
2. Induction of manganous superoxide dismutase by tumor necrosis factor: Possible protective mechanism
3. Induction of mitochondrial manganese superoxide dismutase by interleukin 1
4. Manganese superoxide dismutase is induced by IFN-gamma in multiple cell types. Synergistic induction by IFN-gamma and tumor necrosis factor or IL-1
5. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice
6. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
7. Superoxide sensitivity of the Escherichia coli aconitase
8. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
9. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs
10. Superoxide radical and iron modulate aconitase activity in mammalian cells
11. Antioxidant enzyme levels as a function of growth state in cell culture
12. Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle
13. Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies
14. Decreased expression of manganese superoxide dismutase mRNA and protein after immortalization and transformation of mouse liver cells
15. Lowered antioxidant enzymes in spontaneously transformed embryonic mouse liver cells in culture
16. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells
17. Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase
18. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase
19. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
20. Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury
21. Use of polymerase chain reaction for screening transgenic mice
22. An assay for superoxide dismutase activity in mammalian tissue homogenates
23. Expression of manganese superoxide dismutase is not altered in transgenic mice with elevated level of copper-zinc superoxide dismutase
24. Assays of gluthathione peroxidase
25. Sequence of a cDNA coding for mouse manganese superoxide dismutase
26. The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: Evidence for multiple mRNA species
27. Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB
28. Differential induction and decay of manganese superoxide dismutase mRNAs
29. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
30. Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation
31. NF-kappaB p65 subunit is indispensable for activating manganese superoxide dismutase gene transcription mediated by tumor necrosis factor-alpha
32. Expression of manganese superoxide dismutase in ovine kidney cortex during development
33. Expression and developmental profile of antioxidant enzymes in human lung and liver
34. Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme
35. Effect of inhibition of oxygen free radical on ovulation and progesterone production by the in-vitro perfused rabbit ovary
36. Dynamic aspects of ovarian superoxide dismutase isozymes during the ovulatory process in the rat