Effects of vitamin C and vitamin E on in vivo lipid peroxidation: Results of a randomized controlled trial

American Journal of Clinical Nutrition

Volumn 76, Issue 3, 2002, Pages 549-555

  Huang, Han Yao ^a   Appel, Lawrence J ^a   Croft, Kevin D ^c   Miller III, Edgar R ^b   Mori, Trevor A ^c   Puddey, Ian B ^c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Antioxidants; Free radicals; Lipid peroxidation; Malondialdehyde; Oxygen radical absorbance capacity; Prostaglandins; Vitamin C; Vitamin E

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ALKENE DERIVATIVE; ALPHA TOCOPHEROL; ASCORBIC ACID; MALONALDEHYDE;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PATHOGENESIS; RANDOMIZED CONTROLLED TRIAL; VITAMIN SUPPLEMENTATION;

EID: 0036721156     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/76.3.549     Document Type: Article

References (40)

1. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
2. Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
3. The measurement and mechanism of lipid peroxidation in biological systems
4. The measurement of free radical reactions in humans. Some thoughts for future experimentation
5. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism
6. The isoprostanes. Current knowledge and directions for future research
7. 2-isoprostanes in human atherosclerotic lesions
8. 2-isoprostanes, are present in increased amounts in human atherosclerotic lesions
9. Modulation of oxidant stress in vivo in chronic cigarette smokers
10. 2-isoprostanes) in smokers: Smoking as a cause of oxidative damage
11. 2α concentrations are elevated in individuals with non-insulin dependent diabetes mellitus
12. 2α and platelet activation in diabetes mellitus. Effects of improved metabolic control and vitamin E supplementation
13. 2α is increased in hypercholesterolemia
14. 2α generation during coronary reperfusion: A potential quantitative marker of oxidant stress in vivo
15. Ascorbate is an outstanding antioxidant in human blood plasma
16. Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage
17. Partners in defense, vitamin E and vitamin C
18. Free radical-medicated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C
19. Interaction of dietary vitamin C and vitamin E on guinea pig immune responses to mitogens
20. Synergistic action of vitamin E and vitamin C in vivo using a new mutant of Wistar-strain rats, ODS, unable to synthesize vitamin C
21. Biokinetics of dietary RRR-alpha-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not "spare" vitamin E in vivo
22. An increase in vitamin E requirement induced by high supplementation of vitamin C in rats
23. Oxygen-radical absorbance capacity assay for antioxidants
24. 2-isoprostanes using gas chromatography-mass spectrometry
25. Tissue ascorbic acid analysis using ferrozine compared with the dinitrophenylhydrazine method
26. Liquid chromatographic method for the determination of carotenoids, retinoids and tocopherols in human serum and in food
27. Automated reaction-rate method for determination of serum creatinine with the centrifichem
28. Effects of vitamin E on lipid peroxidation in healthy persons
29. Vitamin E consumption and the risk of coronary disease in women
30. Vitamin E consumption and the risk of coronary heart disease in men
31. Vitamin C intake and mortality among a sample of the United States population
32. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
33. Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
34. Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease
35. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevention trial
36. Vitamin E supplementation and cardiovascular events in high-risk patients
37. Do vitamin E and fish oil protect against ischaemic heart disease?
38. Prevalence and extent of atherosclerosis in adolescents and young adults: Implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study
39. Clinical trials of antioxidants in atherosclerosis: Are we doing the right thing?