메뉴 건너뛰기




Volumn 247, Issue 1, 2012, Pages 36-51

S1PR2 links germinal center confinement and growth regulation

Author keywords

Affinity maturation; Antibody; Apoptosis; Chemokine; Migration; Sphingosine 1 phosphate

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; FAS ANTIGEN; FC RECEPTOR IIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; LYMPHOTOXIN; LYMPHOTOXIN BETA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 6; PROTEIN KINASE B; RAC PROTEIN; RHO KINASE; SECONDARY LYMPHOID TISSUE CHEMOKINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84859729872     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2012.01114.x     Document Type: Article
Times cited : (87)

References (128)
  • 1
    • 0021246815 scopus 로고
    • Functional anatomy of germinal centers
    • Nieuwenhuis P, Opstelten D. Functional anatomy of germinal centers. Am J Anat 1984;170:421-435.
    • (1984) Am J Anat , vol.170 , pp. 421-435
    • Nieuwenhuis, P.1    Opstelten, D.2
  • 3
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen CD, Okada T, Cyster JG. Germinal-center organization and cellular dynamics. Immunity 2007;27:190-202.
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 4
    • 0011084483 scopus 로고
    • Variations in affinities of antibodies during the immune response
    • Eisen HN, Siskind GW. Variations in affinities of antibodies during the immune response. Biochemistry 1964;3:996-1008.
    • (1964) Biochemistry , vol.3 , pp. 996-1008
    • Eisen, H.N.1    Siskind, G.W.2
  • 5
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek C, Berger A, Apel M. Maturation of the immune response in germinal centers. Cell 1991;67:1121-1129.
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 6
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991;354:389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 7
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011;29:621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 8
    • 0028153996 scopus 로고
    • B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells
    • Lane P, et al. B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells. J Exp Med 1994;179:819-830.
    • (1994) J Exp Med , vol.179 , pp. 819-830
    • Lane, P.1
  • 9
    • 0032127301 scopus 로고    scopus 로고
    • The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    • Futterer A, Mink K, Luz A, Kosco-Vilbois MH, Pfeffer K. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 1998;9:59-70.
    • (1998) Immunity , vol.9 , pp. 59-70
    • Futterer, A.1    Mink, K.2    Luz, A.3    Kosco-Vilbois, M.H.4    Pfeffer, K.5
  • 10
    • 0006379753 scopus 로고    scopus 로고
    • Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
    • Matsumoto M, et al. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature 1996;382:462-466.
    • (1996) Nature , vol.382 , pp. 462-466
    • Matsumoto, M.1
  • 11
    • 0033838426 scopus 로고    scopus 로고
    • Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin
    • Wang Y, Huang G, Wang J, Molina H, Chaplin DD, Fu YX. Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin. Eur J Immunol 2000;30:2226-2234.
    • (2000) Eur J Immunol , vol.30 , pp. 2226-2234
    • Wang, Y.1    Huang, G.2    Wang, J.3    Molina, H.4    Chaplin, D.D.5    Fu, Y.X.6
  • 12
    • 77954150116 scopus 로고    scopus 로고
    • Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses
    • Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol 2010;22:413-419.
    • (2010) Int Immunol , vol.22 , pp. 413-419
    • Pereira, J.P.1    Kelly, L.M.2    Cyster, J.G.3
  • 13
    • 0033821807 scopus 로고    scopus 로고
    • Follicular stromal cells and lymphocyte homing to follicles
    • Cyster JG, et al. Follicular stromal cells and lymphocyte homing to follicles. Immunol Rev 2000;176:181-193.
    • (2000) Immunol Rev , vol.176 , pp. 181-193
    • Cyster, J.G.1
  • 14
    • 70249085585 scopus 로고    scopus 로고
    • Stromal cell contributions to the homeostasis and functionality of the immune system
    • Mueller SN, Germain RN. Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol 2009;9:618-629.
    • (2009) Nat Rev Immunol , vol.9 , pp. 618-629
    • Mueller, S.N.1    Germain, R.N.2
  • 15
    • 77958126430 scopus 로고    scopus 로고
    • B cell follicles and antigen encounters of the third kind
    • Cyster JG. B cell follicles and antigen encounters of the third kind. Nat Immunol 2010;11:989-996.
    • (2010) Nat Immunol , vol.11 , pp. 989-996
    • Cyster, J.G.1
  • 16
    • 21844450539 scopus 로고    scopus 로고
    • Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    • e150.
    • Okada T, et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 2005;3:e150.
    • (2005) PLoS Biol , vol.3
    • Okada, T.1
  • 17
    • 64049084826 scopus 로고    scopus 로고
    • Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles
    • Coffey F, Alabyev B, Manser T. Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity 2009;30:599-609.
    • (2009) Immunity , vol.30 , pp. 599-609
    • Coffey, F.1    Alabyev, B.2    Manser, T.3
  • 18
    • 68649108084 scopus 로고    scopus 로고
    • Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
    • Gatto D, Paus D, Basten A, Mackay CR, Brink R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009;31:259-269.
    • (2009) Immunity , vol.31 , pp. 259-269
    • Gatto, D.1    Paus, D.2    Basten, A.3    Mackay, C.R.4    Brink, R.5
  • 19
    • 80053055261 scopus 로고    scopus 로고
    • EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues
    • Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol 2011;187:3026-3032.
    • (2011) J Immunol , vol.187 , pp. 3026-3032
    • Kelly, L.M.1    Pereira, J.P.2    Yi, T.3    Xu, Y.4    Cyster, J.G.5
  • 20
    • 69349087555 scopus 로고    scopus 로고
    • EBI2 mediates B cell segregation between the outer and centre follicle
    • Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009;460:1122-1126.
    • (2009) Nature , vol.460 , pp. 1122-1126
    • Pereira, J.P.1    Kelly, L.M.2    Xu, Y.3    Cyster, J.G.4
  • 21
    • 79960909447 scopus 로고    scopus 로고
    • Oxysterols direct immune cell migration via EBI2
    • Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature 2011;475:524-527.
    • (2011) Nature , vol.475 , pp. 524-527
    • Hannedouche, S.1
  • 22
    • 79960908110 scopus 로고    scopus 로고
    • Oxysterols direct B-cell migration through EBI2
    • Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature 2011;475:519-523.
    • (2011) Nature , vol.475 , pp. 519-523
    • Liu, C.1
  • 24
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 2011;34:947-960.
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1
  • 25
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 2011;34:961-972.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1
  • 26
    • 77649222742 scopus 로고    scopus 로고
    • Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells
    • Basso K, et al. Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood 2010;115:975-984.
    • (2010) Blood , vol.115 , pp. 975-984
    • Basso, K.1
  • 27
    • 0034802541 scopus 로고    scopus 로고
    • Signatures of the immune response
    • Shaffer AL, et al. Signatures of the immune response. Immunity 2001; 15:375-385.
    • (2001) Immunity , vol.15 , pp. 375-385
    • Shaffer, A.L.1
  • 28
    • 0034691531 scopus 로고    scopus 로고
    • A chemokine-driven positive feedback loop organizes lymphoid follicles
    • Ansel KM, et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000;406:309-314.
    • (2000) Nature , vol.406 , pp. 309-314
    • Ansel, K.M.1
  • 29
    • 0033955708 scopus 로고    scopus 로고
    • CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone
    • Voigt I, Camacho SA, de Boer BA, Lipp M, Forster R, Berek C. CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone. Eur J Immunol 2000;30:560-567.
    • (2000) Eur J Immunol , vol.30 , pp. 560-567
    • Voigt, I.1    Camacho, S.A.2    de Boer, B.A.3    Lipp, M.4    Forster, R.5    Berek, C.6
  • 30
    • 39649094515 scopus 로고    scopus 로고
    • Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function
    • Allen CD, Cyster JG. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol 2008;20:14-25.
    • (2008) Semin Immunol , vol.20 , pp. 14-25
    • Allen, C.D.1    Cyster, J.G.2
  • 31
    • 84862908273 scopus 로고    scopus 로고
    • Follicular dendritic cells help establish follicle identitiy and promote B cell retention in germinal centers
    • Wang X, et al.. Follicular dendritic cells help establish follicle identitiy and promote B cell retention in germinal centers. J Exp Med 2011;208:2497-2510.
    • (2011) J Exp Med , vol.208 , pp. 2497-2510
    • Wang, X.1
  • 32
    • 79959377393 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
    • Green JA, et al. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol 2011;12:672-680.
    • (2011) Nat Immunol , vol.12 , pp. 672-680
    • Green, J.A.1
  • 33
    • 79957610938 scopus 로고    scopus 로고
    • The outs and the ins of sphingosine-1-phosphate in immunity
    • Spiegel S, Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol 2011;11:403-415.
    • (2011) Nat Rev Immunol , vol.11 , pp. 403-415
    • Spiegel, S.1    Milstien, S.2
  • 34
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: lymphocyte egress from lymphoid organs
    • Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 2007;8:1295-1301.
    • (2007) Nat Immunol , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 35
    • 38449083151 scopus 로고    scopus 로고
    • Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation
    • Bhattacharya D, et al. Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation. J Immunol 2007;179:6808-6819.
    • (2007) J Immunol , vol.179 , pp. 6808-6819
    • Bhattacharya, D.1
  • 36
    • 12544253058 scopus 로고    scopus 로고
    • Structural and functional characteristics of S1P receptors
    • Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem 2004;92:913-922.
    • (2004) J Cell Biochem , vol.92 , pp. 913-922
    • Sanchez, T.1    Hla, T.2
  • 37
    • 20144363126 scopus 로고    scopus 로고
    • The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation
    • Goparaju SK, et al. The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol 2005;25:4237-4249.
    • (2005) Mol Cell Biol , vol.25 , pp. 4237-4249
    • Goparaju, S.K.1
  • 38
    • 18144420388 scopus 로고    scopus 로고
    • The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration
    • Lepley D, Paik JH, Hla T, Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res 2005;65:3788-3795.
    • (2005) Cancer Res , vol.65 , pp. 3788-3795
    • Lepley, D.1    Paik, J.H.2    Hla, T.3    Ferrer, F.4
  • 39
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    • Okamoto H, et al. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol 2000;20:9247-9261.
    • (2000) Mol Cell Biol , vol.20 , pp. 9247-9261
    • Okamoto, H.1
  • 40
    • 0037370012 scopus 로고    scopus 로고
    • Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
    • Sugimoto N, Takuwa N, Okamoto H, Sakurada S, Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol 2003;23:1534-1545.
    • (2003) Mol Cell Biol , vol.23 , pp. 1534-1545
    • Sugimoto, N.1    Takuwa, N.2    Okamoto, H.3    Sakurada, S.4    Takuwa, Y.5
  • 41
    • 52449133460 scopus 로고    scopus 로고
    • G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase
    • Takashima S, et al. G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. Cardiovasc Res 2008;79:689-697.
    • (2008) Cardiovasc Res , vol.79 , pp. 689-697
    • Takashima, S.1
  • 42
    • 2142851264 scopus 로고    scopus 로고
    • Lysophospholipid receptors: signaling and biology
    • Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 2004;73:321-354.
    • (2004) Annu Rev Biochem , vol.73 , pp. 321-354
    • Ishii, I.1    Fukushima, N.2    Ye, X.3    Chun, J.4
  • 43
    • 17944375813 scopus 로고    scopus 로고
    • Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
    • Fukui Y, et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 2001;412:826-831.
    • (2001) Nature , vol.412 , pp. 826-831
    • Fukui, Y.1
  • 44
    • 4444335344 scopus 로고    scopus 로고
    • Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing
    • Nombela-Arrieta C, et al. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 2004;21:429-441.
    • (2004) Immunity , vol.21 , pp. 429-441
    • Nombela-Arrieta, C.1
  • 45
    • 0036672791 scopus 로고    scopus 로고
    • The CDM protein DOCK2 in lymphocyte migration
    • Reif K, Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol 2002;12:368-373.
    • (2002) Trends Cell Biol , vol.12 , pp. 368-373
    • Reif, K.1    Cyster, J.2
  • 46
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
    • Welch HC, et al. P-Rex1, a PtdIns(3, 4, 5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 2002;108:809-821.
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.1
  • 47
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005;21:247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 48
    • 0032568868 scopus 로고    scopus 로고
    • Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
    • Hart MJ, et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 1998;280:2112-2114.
    • (1998) Science , vol.280 , pp. 2112-2114
    • Hart, M.J.1
  • 49
    • 0033604638 scopus 로고    scopus 로고
    • Signaling to Rho GTPases
    • Kjoller L, Hall A. Signaling to Rho GTPases. Exp Cell Res 1999;253:166-179.
    • (1999) Exp Cell Res , vol.253 , pp. 166-179
    • Kjoller, L.1    Hall, A.2
  • 50
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004;265:23-32.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 51
    • 33746658154 scopus 로고    scopus 로고
    • FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
    • Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol 2006;8:803-814.
    • (2006) Nat Cell Biol , vol.8 , pp. 803-814
    • Ohta, Y.1    Hartwig, J.H.2    Stossel, T.P.3
  • 52
    • 54549088877 scopus 로고    scopus 로고
    • Rac activation and inactivation control plasticity of tumor cell movement
    • Sanz-Moreno V, et al. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008;135:510-523.
    • (2008) Cell , vol.135 , pp. 510-523
    • Sanz-Moreno, V.1
  • 53
    • 34247379074 scopus 로고    scopus 로고
    • Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    • Pappu R, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007;316:295-298.
    • (2007) Science , vol.316 , pp. 295-298
    • Pappu, R.1
  • 54
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005;309:1735-1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5    Cyster, J.G.6
  • 55
    • 84859385704 scopus 로고    scopus 로고
    • Sphingosine-1-phosphates and lymphocyte egress from lymphoid organs
    • Cyster JG, Schwab SR. Sphingosine-1-phosphates and lymphocyte egress from lymphoid organs. Annu Rev Immunol 2012;30:???-??? in press.
    • (2012) Annu Rev Immunol , vol.30
    • Cyster, J.G.1    Schwab, S.R.2
  • 56
    • 41449112571 scopus 로고    scopus 로고
    • Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    • Venkataraman K, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res 2008;102:669-676.
    • (2008) Circ Res , vol.102 , pp. 669-676
    • Venkataraman, K.1
  • 57
    • 76149126108 scopus 로고    scopus 로고
    • Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    • Pham TH, et al. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med 2010;207:17-27.
    • (2010) J Exp Med , vol.207 , pp. 17-27
    • Pham, T.H.1
  • 58
    • 79958257954 scopus 로고    scopus 로고
    • Lipid phosphate phosphatase 3 enables efficient thymic egress
    • Breart B, et al. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med 2011;208:1267-1278.
    • (2011) J Exp Med , vol.208 , pp. 1267-1278
    • Breart, B.1
  • 59
    • 62049084843 scopus 로고    scopus 로고
    • B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis
    • Sinha RK, Park C, Hwang IY, Davis MD, Kehrl JH. B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity 2009;30:434-446.
    • (2009) Immunity , vol.30 , pp. 434-446
    • Sinha, R.K.1    Park, C.2    Hwang, I.Y.3    Davis, M.D.4    Kehrl, J.H.5
  • 60
    • 34147178810 scopus 로고    scopus 로고
    • Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
    • Ito K, et al. Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. Biochem Biophys Res Commun 2007;357:212-217.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 212-217
    • Ito, K.1
  • 61
    • 4644219817 scopus 로고    scopus 로고
    • Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    • Allen CD, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 2004;5:943-952.
    • (2004) Nat Immunol , vol.5 , pp. 943-952
    • Allen, C.D.1
  • 62
    • 0030938635 scopus 로고    scopus 로고
    • Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers
    • Matsumoto M, Fu YX, Molina H, Chaplin DD. Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol Rev 1997;156:137-144.
    • (1997) Immunol Rev , vol.156 , pp. 137-144
    • Matsumoto, M.1    Fu, Y.X.2    Molina, H.3    Chaplin, D.D.4
  • 63
    • 0033521542 scopus 로고    scopus 로고
    • Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells
    • Endres R, et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 1999;189:159-168.
    • (1999) J Exp Med , vol.189 , pp. 159-168
    • Endres, R.1
  • 64
    • 0033579821 scopus 로고    scopus 로고
    • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    • Ngo VN, et al. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 1999;189:403-412.
    • (1999) J Exp Med , vol.189 , pp. 403-412
    • Ngo, V.N.1
  • 65
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science 2007;315:528-531.
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 66
    • 34248585765 scopus 로고    scopus 로고
    • Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
    • Hauser AE, et al. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 2007;26:655-667.
    • (2007) Immunity , vol.26 , pp. 655-667
    • Hauser, A.E.1
  • 67
    • 33847206141 scopus 로고    scopus 로고
    • In vivo imaging of germinal centres reveals a dynamic open structure
    • Schwickert TA, et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 2007;446:83-87.
    • (2007) Nature , vol.446 , pp. 83-87
    • Schwickert, T.A.1
  • 68
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora GD, et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010;143:592-605.
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1
  • 69
    • 10244261528 scopus 로고    scopus 로고
    • Tracking CD40 signaling during germinal center development
    • Basso K, et al. Tracking CD40 signaling during germinal center development. Blood 2004;104:4088-4096.
    • (2004) Blood , vol.104 , pp. 4088-4096
    • Basso, K.1
  • 70
    • 79957671415 scopus 로고    scopus 로고
    • B cells within germinal centers migrate preferentially from dark to light zone
    • Beltman JB, Allen CD, Cyster JG, de Boer RJ. B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci USA 2011;108:8755-8760.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8755-8760
    • Beltman, J.B.1    Allen, C.D.2    Cyster, J.G.3    de Boer, R.J.4
  • 71
    • 67649221652 scopus 로고    scopus 로고
    • Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation
    • Phan TG, Green JA, Gray EE, Xu Y, Cyster JG. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol 2009;10:786-793.
    • (2009) Nat Immunol , vol.10 , pp. 786-793
    • Phan, T.G.1    Green, J.A.2    Gray, E.E.3    Xu, Y.4    Cyster, J.G.5
  • 72
    • 80052649061 scopus 로고    scopus 로고
    • Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development
    • Baumjohann D, Okada T, Ansel KM. Cutting edge: distinct waves of BCL6 expression during T follicular helper cell development. J Immunol 2011;187:2089-2092.
    • (2011) J Immunol , vol.187 , pp. 2089-2092
    • Baumjohann, D.1    Okada, T.2    Ansel, K.M.3
  • 73
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 2007;179:5099-5108.
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 74
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • Arnold CN, Campbell DJ, Lipp M, Butcher EC. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 2007;37:100-109.
    • (2007) Eur J Immunol , vol.37 , pp. 100-109
    • Arnold, C.N.1    Campbell, D.J.2    Lipp, M.3    Butcher, E.C.4
  • 75
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • Hardtke S, Ohl L, Forster R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 2005;106:1924-1931.
    • (2005) Blood , vol.106 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Forster, R.3
  • 76
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage T cell: B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    • Cannons JL, et al. Optimal germinal center responses require a multistage T cell: B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity 2010;32:253-265.
    • (2010) Immunity , vol.32 , pp. 253-265
    • Cannons, J.L.1
  • 77
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 2008;455:764-769.
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 78
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009;325:1006-1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 79
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva RI, et al. Bcl6 mediates the development of T follicular helper cells. Science 2009;325:1001-1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 80
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009;31:457-468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 81
    • 72249096210 scopus 로고    scopus 로고
    • Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
    • Cattoretti G, et al. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res 2009;69:8686-8692.
    • (2009) Cancer Res , vol.69 , pp. 8686-8692
    • Cattoretti, G.1
  • 82
    • 15444373513 scopus 로고    scopus 로고
    • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
    • Sanchez T, et al. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci USA 2005;102:4312-4317.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4312-4317
    • Sanchez, T.1
  • 83
    • 20244379418 scopus 로고    scopus 로고
    • Regulation of PTEN by Rho small GTPases
    • Li Z, et al. Regulation of PTEN by Rho small GTPases. Nat Cell Biol 2005;7:399-404.
    • (2005) Nat Cell Biol , vol.7 , pp. 399-404
    • Li, Z.1
  • 84
    • 0033912699 scopus 로고    scopus 로고
    • The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
    • Genot EM, Arrieumerlou C, Ku G, Burgering BM, Weiss A, Kramer IM. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol 2000;20:5469-5478.
    • (2000) Mol Cell Biol , vol.20 , pp. 5469-5478
    • Genot, E.M.1    Arrieumerlou, C.2    Ku, G.3    Burgering, B.M.4    Weiss, A.5    Kramer, I.M.6
  • 85
    • 33645644184 scopus 로고    scopus 로고
    • Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells
    • Gonzalez E, Kou R, Michel T. Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J Biol Chem 2006;281:3210-3216.
    • (2006) J Biol Chem , vol.281 , pp. 3210-3216
    • Gonzalez, E.1    Kou, R.2    Michel, T.3
  • 86
    • 0035846549 scopus 로고    scopus 로고
    • Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells
    • Higuchi M, Masuyama N, Fukui Y, Suzuki A, Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr Biol 2001;11:1958-1962.
    • (2001) Curr Biol , vol.11 , pp. 1958-1962
    • Higuchi, M.1    Masuyama, N.2    Fukui, Y.3    Suzuki, A.4    Gotoh, Y.5
  • 87
    • 53149135853 scopus 로고    scopus 로고
    • Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII
    • Jiang LI, Collins J, Davis R, Fraser ID, Sternweis PC. Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem 2008;283:23429-23439.
    • (2008) J Biol Chem , vol.283 , pp. 23429-23439
    • Jiang, L.I.1    Collins, J.2    Davis, R.3    Fraser, I.D.4    Sternweis, P.C.5
  • 88
    • 0037192820 scopus 로고    scopus 로고
    • Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation
    • Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 2002;277:11497-11504.
    • (2002) J Biol Chem , vol.277 , pp. 11497-11504
    • Mei, F.C.1    Qiao, J.2    Tsygankova, O.M.3    Meinkoth, J.L.4    Quilliam, L.A.5    Cheng, X.6
  • 89
    • 77949332336 scopus 로고    scopus 로고
    • Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
    • Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol 2010;184:1475-1483.
    • (2010) J Immunol , vol.184 , pp. 1475-1483
    • Michaud, J.1    Im, D.S.2    Hla, T.3
  • 91
    • 1542377328 scopus 로고    scopus 로고
    • B cell receptor signal strength determines B cell fate
    • Casola S, et al. B cell receptor signal strength determines B cell fate. Nat Immunol 2004;5:317-327.
    • (2004) Nat Immunol , vol.5 , pp. 317-327
    • Casola, S.1
  • 92
    • 33749168166 scopus 로고    scopus 로고
    • B cell recruitment and selection in mouse GALT germinal centers
    • Casola S, Rajewsky K. B cell recruitment and selection in mouse GALT germinal centers. Curr Top Microbiol Immunol 2006;308:155-171.
    • (2006) Curr Top Microbiol Immunol , vol.308 , pp. 155-171
    • Casola, S.1    Rajewsky, K.2
  • 93
    • 0343932758 scopus 로고    scopus 로고
    • CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches
    • Gardby E, Lycke NY. CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches. Eur J Immunol 2000;30:1861-1871.
    • (2000) Eur J Immunol , vol.30 , pp. 1861-1871
    • Gardby, E.1    Lycke, N.Y.2
  • 94
    • 0037342166 scopus 로고    scopus 로고
    • Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
    • Anzelon AN, Wu H, Rickert RC. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 2003;4:287-294.
    • (2003) Nat Immunol , vol.4 , pp. 287-294
    • Anzelon, A.N.1    Wu, H.2    Rickert, R.C.3
  • 95
    • 20444501371 scopus 로고    scopus 로고
    • CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers
    • Wang Y, Carter RH. CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers. Immunity 2005;22:749-761.
    • (2005) Immunity , vol.22 , pp. 749-761
    • Wang, Y.1    Carter, R.H.2
  • 96
    • 0037119630 scopus 로고    scopus 로고
    • A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
    • Clayton E, et al. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med 2002;196:753-763.
    • (2002) J Exp Med , vol.196 , pp. 753-763
    • Clayton, E.1
  • 97
    • 0037695593 scopus 로고    scopus 로고
    • Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
    • Jou ST, et al. Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 2002;22:8580-8591.
    • (2002) Mol Cell Biol , vol.22 , pp. 8580-8591
    • Jou, S.T.1
  • 98
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
    • Okkenhaug K, et al. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002;297:1031-1034.
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1
  • 99
    • 77958134778 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    • Rolf J, et al. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol 2010;185:4042-4052.
    • (2010) J Immunol , vol.185 , pp. 4042-4052
    • Rolf, J.1
  • 100
    • 4344671730 scopus 로고    scopus 로고
    • Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
    • Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M. Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol 2004;173:3209-3214.
    • (2004) J Immunol , vol.173 , pp. 3209-3214
    • Vigorito, E.1    Bardi, G.2    Glassford, J.3    Lam, E.W.4    Clayton, E.5    Turner, M.6
  • 101
    • 70350304558 scopus 로고    scopus 로고
    • PI3 kinase signals BCR-dependent mature B cell survival
    • Srinivasan L, et al. PI3 kinase signals BCR-dependent mature B cell survival. Cell 2009;139:573-586.
    • (2009) Cell , vol.139 , pp. 573-586
    • Srinivasan, L.1
  • 102
    • 40449110080 scopus 로고    scopus 로고
    • The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells
    • Janas ML, et al. The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol 2008;180:739-746.
    • (2008) J Immunol , vol.180 , pp. 739-746
    • Janas, M.L.1
  • 103
    • 77956636063 scopus 로고    scopus 로고
    • The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development
    • ra60.
    • Ramadani F, et al. The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Sci Signal 2010;3:ra60.
    • (2010) Sci Signal , vol.3
    • Ramadani, F.1
  • 104
    • 46149106818 scopus 로고    scopus 로고
    • The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    • Guillermet-Guibert J, et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci USA 2008;105:8292-8297.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8292-8297
    • Guillermet-Guibert, J.1
  • 105
    • 4043082729 scopus 로고    scopus 로고
    • Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    • Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG. Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 2004;173:2236-2240.
    • (2004) J Immunol , vol.173 , pp. 2236-2240
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Penninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 106
    • 70449718702 scopus 로고    scopus 로고
    • Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
    • Randall KL, et al. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol 2009;10:1283-1291.
    • (2009) Nat Immunol , vol.10 , pp. 1283-1291
    • Randall, K.L.1
  • 107
    • 77953643796 scopus 로고    scopus 로고
    • Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells
    • Al-Alwan M, Hou S, Zhang TT, Makondo K, Marshall AJ. Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells. J Immunol 2010;184:6961-6969.
    • (2010) J Immunol , vol.184 , pp. 6961-6969
    • Al-Alwan, M.1    Hou, S.2    Zhang, T.T.3    Makondo, K.4    Marshall, A.J.5
  • 108
    • 73949091167 scopus 로고    scopus 로고
    • The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression
    • Zhang TT, Al-Alwan M, Marshall AJ. The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression. J Immunol 2010;184:164-172.
    • (2010) J Immunol , vol.184 , pp. 164-172
    • Zhang, T.T.1    Al-Alwan, M.2    Marshall, A.J.3
  • 110
    • 17344362824 scopus 로고    scopus 로고
    • Cell growth control by G protein-coupled receptors: from signal transduction to signal integration
    • Gutkind JS. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 1998;17:1331-1342.
    • (1998) Oncogene , vol.17 , pp. 1331-1342
    • Gutkind, J.S.1
  • 111
    • 0032563295 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B by G protein-coupled receptors: a role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma
    • Murga C, Laguinge L, Wetzker R, Cuadrado A, Gutkind JS. Activation of Akt/protein kinase B by G protein-coupled receptors: a role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. J Biol Chem 1998;273:19080-19085.
    • (1998) J Biol Chem , vol.273 , pp. 19080-19085
    • Murga, C.1    Laguinge, L.2    Wetzker, R.3    Cuadrado, A.4    Gutkind, J.S.5
  • 113
    • 0033486065 scopus 로고    scopus 로고
    • The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
    • Sotsios Y, Whittaker GC, Westwick J, Ward SG. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J Immunol 1999;163:5954-5963.
    • (1999) J Immunol , vol.163 , pp. 5954-5963
    • Sotsios, Y.1    Whittaker, G.C.2    Westwick, J.3    Ward, S.G.4
  • 114
    • 0034618052 scopus 로고    scopus 로고
    • Signal transduction by CXC chemokine receptor 4 Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes
    • Tilton B, et al. Signal transduction by CXC chemokine receptor 4 Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J Exp Med 2000;192:313-324.
    • (2000) J Exp Med , vol.192 , pp. 313-324
    • Tilton, B.1
  • 115
    • 0035839450 scopus 로고    scopus 로고
    • A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation
    • Arron JR, et al. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem 2001;276:30011-30017.
    • (2001) J Biol Chem , vol.276 , pp. 30011-30017
    • Arron, J.R.1
  • 117
    • 34548390650 scopus 로고    scopus 로고
    • IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade
    • Ostiguy V, Allard EL, Marquis M, Leignadier J, Labrecque N. IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascade. J Leukoc Biol 2007;82:645-656.
    • (2007) J Leukoc Biol , vol.82 , pp. 645-656
    • Ostiguy, V.1    Allard, E.L.2    Marquis, M.3    Leignadier, J.4    Labrecque, N.5
  • 119
    • 79251542927 scopus 로고    scopus 로고
    • Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1
    • Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY. Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol 2011;186:499-507.
    • (2011) J Immunol , vol.186 , pp. 499-507
    • Joung, S.M.1    Park, Z.Y.2    Rani, S.3    Takeuchi, O.4    Akira, S.5    Lee, J.Y.6
  • 120
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
    • Lee JY, et al. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem 2003;278:37041-37051.
    • (2003) J Biol Chem , vol.278 , pp. 37041-37051
    • Lee, J.Y.1
  • 121
  • 122
    • 33746926779 scopus 로고    scopus 로고
    • Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
    • Michaud J, Kohno M, Proia RL, Hla T. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett 2006;580:4607-4612.
    • (2006) FEBS Lett , vol.580 , pp. 4607-4612
    • Michaud, J.1    Kohno, M.2    Proia, R.L.3    Hla, T.4
  • 123
    • 78650866759 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis
    • Skoura A, et al. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 2011;31:81-85.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 81-85
    • Skoura, A.1
  • 124
    • 78049422010 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice
    • Wang F, et al. Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest 2010;120:3979-3995.
    • (2010) J Clin Invest , vol.120 , pp. 3979-3995
    • Wang, F.1
  • 125
    • 78650413566 scopus 로고    scopus 로고
    • Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo
    • Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med 2010;207:2793-2798.
    • (2010) J Exp Med , vol.207 , pp. 2793-2798
    • Ishii, M.1    Kikuta, J.2    Shimazu, Y.3    Meier-Schellersheim, M.4    Germain, R.N.5
  • 126
    • 1842682019 scopus 로고    scopus 로고
    • Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
    • Jolly PS, et al. Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004;199:959-970.
    • (2004) J Exp Med , vol.199 , pp. 959-970
    • Jolly, P.S.1
  • 127
    • 77949518621 scopus 로고    scopus 로고
    • Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    • Oskeritzian CA, et al. Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med 2010;207:465-474.
    • (2010) J Exp Med , vol.207 , pp. 465-474
    • Oskeritzian, C.A.1
  • 128
    • 22244480680 scopus 로고    scopus 로고
    • Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane
    • Nishida K, et al. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol 2005;170:115-126.
    • (2005) J Cell Biol , vol.170 , pp. 115-126
    • Nishida, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.