Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

Immunity

Volumn 32, Issue 2, 2010, Pages 253-265

  Cannons, Jennifer L ^a   Qi, Hai ^b   Lu, Kristina T ^a   Dutta, Mala ^a,c   Gomez Rodriguez, Julio ^a   Cheng, Jun ^a   Wakeland, Edward K ^d   Germain, Ronald N ^b   Schwartzberg, Pamela L ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

MOLIMMUNO

Indexed keywords

CD84 ANTIGEN; INTEGRIN; LYMPHOCYTE ANTIGEN; PROTEIN LY108; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL CONTACT; CELL INTERACTION; CONTROLLED STUDY; DENDRITIC CELL; GERMINAL CENTER; HELPER CELL; HUMORAL IMMUNITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, LY; B-LYMPHOCYTES; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; GERMINAL CENTER; INTERFERON-GAMMA; INTERLEUKINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES;

EID: 76949091588     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2010.01.010     Document Type: Article

References (41)

1. Al-Alwan M.M., Rowden G., Lee T.D.G., and West K.A. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166 (2001) 1452-1456
2. Allen C.D.C., Okada T., and Cyster J.G. Germinal-center organization and cellular dynamics. Immunity 27 (2007) 190-202
3. Barber D.F., and Long E.O. Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells. J. Immunol. 170 (2003) 294-299
4. Benvenuti F., Hugues S., Walmsley M., Ruf S., Fetler L., Popoff M., Tybulewicz V.L.J., and Amigorena S. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305 (2004) 1150-1153
5. Bryceson Y.T., March M.E., Barber D.F., Ljunggren H.-G., and Long E.O. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J. Exp. Med. 202 (2005) 1001-1012
6. Burbach B.J., Medeiros R.B., Mueller K.L., and Shimizu Y. T-cell receptor signaling to integrins. Immunol. Rev. 281 (2007) 65-81
7. Calpe S., Wang N., Romero X., Berger S.B., Lanyi A., Engel P., and Terhorst C. The SLAM and SAP gene families control innate and adaptive immune responses. Adv. Immunol. 97 (2008) 177-250
8. Cannons J.L., Yu L.J., Jankovic D., Crotty S., Horai R., Kirby M., Anderson S., Cheever A.W., Sher A., and Schwartzberg P.L. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J. Exp. Med. 203 (2006) 1551-1565
9. Cao E., Ramagopal U.A., Fedorov A., Fedorov E., Yan Q., Lary J.W., Cole J.L., Nathenson S.G., and Almo S.C. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. Immunity 25 (2006) 559-570
10. Chan A.Y., Westcott J.M., Mooney J.M., Wakeland E.K., and Schatzle J.D. The role of SAP and the SLAM family in autoimmunity. Curr. Opin. Immunol. 18 (2006) 656-664
11. Chen R., Relouzat F., Roncagalli R., Aoukaty A., Tan R., Latour S., and Veillette A. Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors. Mol. Cell. Biol. 24 (2004) 5144-5156
12. Cheng J., Dutra A., Takesono A., Garrett-Beal L., and Schwartzberg P.L. Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media. Genesis 39 (2004) 100-104
13. Chtanova T., Tangye S.G., Newton R., Frank N., Hodge M.R., Rolph M.S., and Mackay C.R. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173 (2004) 68-78
14. Crotty S., Kersh E.N., Cannons J., Schwartzberg P.L., and Ahmed R. SAP is required for generating long-term humoral immunity. Nature 421 (2003) 282-287
15. Czar M.J., Kersh E.N., Mijares L.A., Lanier G., Lewis J., Yap G., Chen A., Sher A., Duckett C.S., Ahmed R., and Schwartzberg P.L. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc. Natl. Acad. Sci. USA 98 (2001) 7449-7454
16. Fazilleau N., Mark L., McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Follicular helper T cells: Lineage and location. Immunity 30 (2009) 324-335
17. Finkelstein L.D., Shimizu Y., and Schwartzberg P.L. Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. J. Immunol. 175 (2005) 5923-5930
18. Griewank K., Borowski C., Rietdijk S., Wang N., Julien A., Wei D.G., Mamchak A.A., Terhorst C., and Bendelac A. Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27 (2007) 751-762
19. high germinal center-associated subpopulation. J. Immunol. 179 (2007) 5099-5108
20. Howie D., Simarro M., Sayos J., Guirado M., Sancho J., and Terhorst C. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood 99 (2002) 957-965
21. Howie D., Laroux F.S., Morra M., Satoskar A.R., Rosas L.E., Faubion W.A., Julien A., Rietdijk S., Coyle A.J., Fraser C., and Terhorst C. Cutting edge: The SLAM family receptor Ly108 controls T cell and neutrophil functions. J. Immunol. 174 (2005) 5931-5935
22. Johnston R.J., Poholek A.C., DiToro D., Yusuf I., Eto D., Barnett B., Dent A.L., Craft J., and Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325 (2009) 1006-1010
23. Li C., Iosef C., Jia C.Y.H., Gkourasas T., Han V.K.M., and Shun-Cheng Li S. Disease-causing SAP mutants are defective in ligand binding and protein folding. Biochemistry 42 (2003) 14885-14892
24. Linterman M.A., Rigby R.J., Wong R.K., Yu D., Brink R., Cannons J.L., Schwartzberg P.L., Cook M.C., Walters G.D., and Vinuesa C.G. Follicular helper T cells are required for systemic autoimmunity. J. Exp. Med. 206 (2009) 561-576
25. Ma C.S., Nichols K.E., and Tangye S.G. Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu. Rev. Immunol. 25 (2007) 337-379
26. McCausland M.M., Yusuf I., Tran H., Ono N., Yanagi Y., and Crotty S. SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J. Immunol. 178 (2007) 817-828
27. Nanda N., Andre P., Bao M., Clauser K., Deguzman F., Howie D., Conley P.B., Terhorst C., and Phillips D.R. Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. Blood 106 (2005) 3028-3034
28. Nurieva R.I., Chung Y., Hwang D., Yang X.O., Kang H.S., Ma L., Wang Y.H., Watowich S.S., Jetten A.M., Tian Q., and Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29 (2008) 138-149
29. Nurieva R.I., Chung Y., Martinez G.J., Yang X.O., Tanaka S., Matskevitch T.D., Wang Y.-H., and Dong C. Bcl6 mediates the development of T follicular helper cells. Science 325 (2009) 1001-1005
30. Okada T., Miller M.J., Parker I., Krummel M.F., Neighbors M., Hartley S.B., O'Garra A., Cahalan M.D., and Cyster J.G. Antigen-engaged B cells undergo chemotaxis toward the T zone and form mobile conjugates with helper T cells. PLoS Biol. 3 (2005) 1047-1061
31. Qi H., Cannons J.L., Klauschen F., Schwartzberg P.L., and Germain R.N. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455 (2008) 764-769
32. Riteau B., Barber D.F., and Long E.O. Vav1 phosphorylation is induced by β2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J. Exp. Med. 198 (2003) 469-474
33. Schwartzberg P.L., Mueller K.L., Qi H., and Cannons J.L. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat. Rev. Immunol. 9 (2009) 39-46
34. + T cells. J. Exp. Med. 205 (2008) 1369-1379
35. Tangye S.G., Nichols K.E., Hare N.J., and van de Weerdt B.C. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J. Immunol. 171 (2003) 2485-2495
36. Vinuesa C.G., Cook M.C., Angelucci C., Athanasopoulos V., Rui L., Hill K.M., Yu D., Domaschenz H., Whittle B., Lambe T., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435 (2005) 452-458
37. Wandstrat A.E., Nguyen C., Limaye N., Chan A.Y., Subramanian S., Tian X.-H., Yim Y.-S., Pertsemlidis A., Garner Jr. H.R., Morel L., and Wakeland E.K. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 21 (2004) 769-780
38. Wang N., Satoskar A., Faubion W., Howie D., Okamoto S., Feske S., Gullo C., Clarke K., Sosa M.R., Sharpe A.H., and Terhorst C. The cell surface receptor SLAM controls T cell and macrophage functions. J. Exp. Med. 199 (2004) 1255-1264
39. Yan Q., Malashkevich V.N., Fedorov A., Fedorov E., Cao E., Lary J.W., Cole J.L., Nathenson S.G., and Almo S.C. Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. USA 104 (2007) 10583-10588
40. Yu D., Rao S., Tsai L.M., Lee S.K., He Y., Sutcliffe E.L., Srivastava M., Linterman M., Zheng L., Simpson N., et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31 (2009) 457-468
41. Zhong M.-C., and Veillette A. Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity. J. Biol. Chem. 283 (2008) 19255-19264