-
2
-
-
0030006070
-
Clonal selection and learning in the antibody system
-
Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-758.
-
(1996)
Nature
, vol.381
, pp. 751-758
-
-
Rajewsky, K.1
-
3
-
-
33749021665
-
B-cell memory: are subsets necessary?
-
Tarlinton D. B-cell memory: are subsets necessary? Nat Rev Immunol 2006;6:785-790.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 785-790
-
-
Tarlinton, D.1
-
4
-
-
0011084483
-
Variations in affinities of antibodies during the immune response
-
Eisen HN, Siskind GN. Variations in affinities of antibodies during the immune response. Biochem 1964;3:996-1008.
-
(1964)
Biochem
, vol.3
, pp. 996-1008
-
-
Eisen, H.N.1
Siskind, G.N.2
-
5
-
-
0030001674
-
Immunological memory and protective immunity: understanding their relation
-
Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996;272:54-60.
-
(1996)
Science
, vol.272
, pp. 54-60
-
-
Ahmed, R.1
Gray, D.2
-
7
-
-
0034281199
-
What is missing in immunology to understand immunity?
-
Zinkernagel RM. What is missing in immunology to understand immunity? Nat Immunol 2000;1:181-185.
-
(2000)
Nat Immunol
, vol.1
, pp. 181-185
-
-
Zinkernagel, R.M.1
-
8
-
-
78449282121
-
Mcl-1 is essential for germinal center formation and B cell memory
-
Vikstrom I, et al. Mcl-1 is essential for germinal center formation and B cell memory. Science 2010;330:1095-1099.
-
(2010)
Science
, vol.330
, pp. 1095-1099
-
-
Vikstrom, I.1
-
9
-
-
14944348965
-
The role of BH3-only proteins in the immune system
-
Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005;5:189-200.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 189-200
-
-
Strasser, A.1
-
10
-
-
84860389354
-
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
-
Strasser A, Cory S, Adams JM. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J 2011;30:3667-3683.
-
(2011)
EMBO J
, vol.30
, pp. 3667-3683
-
-
Strasser, A.1
Cory, S.2
Adams, J.M.3
-
11
-
-
0029589915
-
FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
-
Smith KG, Nossal GJ, Tarlinton DM. FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen. Proc Natl Acad Sci USA 1995;92:11628-11632.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11628-11632
-
-
Smith, K.G.1
Nossal, G.J.2
Tarlinton, D.M.3
-
12
-
-
0029917123
-
Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2
-
Martinez-Valdez H, Guret C, de Bouteiller O, Fugier I, Banchereau J, Liu YJ. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J Exp Med 1996;183:971-977.
-
(1996)
J Exp Med
, vol.183
, pp. 971-977
-
-
Martinez-Valdez, H.1
Guret, C.2
de Bouteiller, O.3
Fugier, I.4
Banchereau, J.5
Liu, Y.J.6
-
13
-
-
0035099037
-
Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire
-
Takahashi Y, Ohta H, Takemori T. Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire. Immunity 2001;14:181-192.
-
(2001)
Immunity
, vol.14
, pp. 181-192
-
-
Takahashi, Y.1
Ohta, H.2
Takemori, T.3
-
14
-
-
53349167095
-
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis
-
Hao Z, et al. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 2008;29:615-627.
-
(2008)
Immunity
, vol.29
, pp. 615-627
-
-
Hao, Z.1
-
15
-
-
0034614896
-
bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
-
Smith KG, Light A, O'Reilly LA, Ang SM, Strasser A, Tarlinton D. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J Exp Med 2000;191:475-484.
-
(2000)
J Exp Med
, vol.191
, pp. 475-484
-
-
Smith, K.G.1
Light, A.2
O'Reilly, L.A.3
Ang, S.M.4
Strasser, A.5
Tarlinton, D.6
-
16
-
-
0028675668
-
Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers
-
Smith KG, Weiss U, Rajewsky K, Nossal GJ, Tarlinton DM. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. Immunity 1994;1:803-813.
-
(1994)
Immunity
, vol.1
, pp. 803-813
-
-
Smith, K.G.1
Weiss, U.2
Rajewsky, K.3
Nossal, G.J.4
Tarlinton, D.M.5
-
17
-
-
0030925491
-
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
-
Smith KG, Light A, Nossal GJ, Tarlinton DM. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J 1997;16:2996-3006.
-
(1997)
EMBO J
, vol.16
, pp. 2996-3006
-
-
Smith, K.G.1
Light, A.2
Nossal, G.J.3
Tarlinton, D.M.4
-
18
-
-
33750502877
-
High affinity germinal center B cells are actively selected into the plasma cell compartment
-
Phan TG, et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med 2006;203:2419-2424.
-
(2006)
J Exp Med
, vol.203
, pp. 2419-2424
-
-
Phan, T.G.1
-
19
-
-
0033517153
-
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice
-
Takahashi Y, et al. Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med 1999;190:399-410.
-
(1999)
J Exp Med
, vol.190
, pp. 399-410
-
-
Takahashi, Y.1
-
21
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science 2007;315:528-531.
-
(2007)
Science
, vol.315
, pp. 528-531
-
-
Allen, C.D.1
Okada, T.2
Tang, H.L.3
Cyster, J.G.4
-
22
-
-
33847206141
-
In vivo imaging of germinal centres reveals a dynamic open structure
-
Schwickert TA, et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 2007;446:83-87.
-
(2007)
Nature
, vol.446
, pp. 83-87
-
-
Schwickert, T.A.1
-
23
-
-
34248585765
-
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
-
Hauser AE, et al. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 2007;26:655-667.
-
(2007)
Immunity
, vol.26
, pp. 655-667
-
-
Hauser, A.E.1
-
24
-
-
78149477766
-
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
-
Victora GD, et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010;143:592-605.
-
(2010)
Cell
, vol.143
, pp. 592-605
-
-
Victora, G.D.1
-
25
-
-
0141576692
-
Reassessing the function of immune-complex retention by follicular dendritic cells
-
Haberman AM, Shlomchik MJ. Reassessing the function of immune-complex retention by follicular dendritic cells. Nat Rev Immunol 2003;3:757-764.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 757-764
-
-
Haberman, A.M.1
Shlomchik, M.J.2
-
26
-
-
0141465063
-
Are follicular dendritic cells really good for nothing?
-
Kosco-Vilbois MH. Are follicular dendritic cells really good for nothing? Nat Rev Immunol 2003;3:764-769.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 764-769
-
-
Kosco-Vilbois, M.H.1
-
27
-
-
39749195560
-
Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre
-
Tarlinton DM. Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre. Immunol Cell Biol 2008;86:133-138.
-
(2008)
Immunol Cell Biol
, vol.86
, pp. 133-138
-
-
Tarlinton, D.M.1
-
28
-
-
0344953578
-
Transcriptional analysis of the B cell germinal center reaction
-
Klein U, et al. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci USA 2003;100:2639-2644.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2639-2644
-
-
Klein, U.1
-
29
-
-
0031984937
-
Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival
-
Ghia P, et al. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 1998;91:244-251.
-
(1998)
Blood
, vol.91
, pp. 244-251
-
-
Ghia, P.1
-
30
-
-
0028226620
-
Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes
-
Yoshino T, et al. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood 1994;83:1856-1861.
-
(1994)
Blood
, vol.83
, pp. 1856-1861
-
-
Yoshino, T.1
-
31
-
-
34250823638
-
Expression of apoptosis regulators in germinal centers and germinal center-derived B-cell lymphomas: insight into B-cell lymphomagenesis
-
Kondo E, Yoshino T. Expression of apoptosis regulators in germinal centers and germinal center-derived B-cell lymphomas: insight into B-cell lymphomagenesis. Pathol Int 2007;57:391-397.
-
(2007)
Pathol Int
, vol.57
, pp. 391-397
-
-
Kondo, E.1
Yoshino, T.2
-
32
-
-
0027956645
-
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes
-
Krajewski S, Bodrug S, Gascoyne R, Berean K, Krajewska M, Reed JC. Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am J Pathol 1994;145:515-525.
-
(1994)
Am J Pathol
, vol.145
, pp. 515-525
-
-
Krajewski, S.1
Bodrug, S.2
Gascoyne, R.3
Berean, K.4
Krajewska, M.5
Reed, J.C.6
-
33
-
-
0029043811
-
Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
-
Krajewski S, et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995;146:1309-1319.
-
(1995)
Am J Pathol
, vol.146
, pp. 1309-1319
-
-
Krajewski, S.1
-
34
-
-
84856852791
-
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
-
Wensveen FM, et al. BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. Blood 2012;119:1440-1449.
-
(2012)
Blood
, vol.119
, pp. 1440-1449
-
-
Wensveen, F.M.1
-
35
-
-
0027326012
-
Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2
-
Lin EY, Orlofsky A, Berger MS, Prystowsky MB. Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol 1993;151:1979-1988.
-
(1993)
J Immunol
, vol.151
, pp. 1979-1988
-
-
Lin, E.Y.1
Orlofsky, A.2
Berger, M.S.3
Prystowsky, M.B.4
-
36
-
-
37049020279
-
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
-
Fischer SF, Bouillet P, O'Donnell K, Light A, Tarlinton DM, Strasser A. Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells. Blood 2007;110:3978-3984.
-
(2007)
Blood
, vol.110
, pp. 3978-3984
-
-
Fischer, S.F.1
Bouillet, P.2
O'Donnell, K.3
Light, A.4
Tarlinton, D.M.5
Strasser, A.6
-
37
-
-
0035803554
-
Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation
-
Xiang Z, Ahmed AA, Moller C, Nakayama K, Hatakeyama S, Nilsson G. Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. J Exp Med 2001;194:1561-1569.
-
(2001)
J Exp Med
, vol.194
, pp. 1561-1569
-
-
Xiang, Z.1
Ahmed, A.A.2
Moller, C.3
Nakayama, K.4
Hatakeyama, S.5
Nilsson, G.6
-
38
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
-
39
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006;10:375-388.
-
(2006)
Cancer Cell
, vol.10
, pp. 375-388
-
-
Konopleva, M.1
-
40
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft MF, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2006;10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
van Delft, M.F.1
-
41
-
-
77954649027
-
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
-
Carrington EM, et al. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci USA 2010;107:10967-10971.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10967-10971
-
-
Carrington, E.M.1
-
42
-
-
0036884742
-
Progressive differentiation and selection of the fittest in the immune response
-
Lanzavecchia A, Sallusto F. Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2002;2:982-987.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 982-987
-
-
Lanzavecchia, A.1
Sallusto, F.2
-
44
-
-
0028964162
-
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2
-
Liu YJ, Barthelemy C, de Bouteiller O, Arpin C, Durand I, Banchereau J. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 1995;2:239-248.
-
(1995)
Immunity
, vol.2
, pp. 239-248
-
-
Liu, Y.J.1
Barthelemy, C.2
de Bouteiller, O.3
Arpin, C.4
Durand, I.5
Banchereau, J.6
-
45
-
-
2342575532
-
Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
-
Ellyard JI, Avery DT, Phan TG, Hare NJ, Hodgkin PD, Tangye SG. Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood 2004;103:3805-3812.
-
(2004)
Blood
, vol.103
, pp. 3805-3812
-
-
Ellyard, J.I.1
Avery, D.T.2
Phan, T.G.3
Hare, N.J.4
Hodgkin, P.D.5
Tangye, S.G.6
-
46
-
-
0032476611
-
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
-
Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-1689.
-
(1998)
J Exp Med
, vol.188
, pp. 1679-1689
-
-
Klein, U.1
Rajewsky, K.2
Kuppers, R.3
-
47
-
-
0032476617
-
Identification of functional human splenic memory B cells by expression of CD148 and CD27
-
Tangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998;188:1691-1703.
-
(1998)
J Exp Med
, vol.188
, pp. 1691-1703
-
-
Tangye, S.G.1
Liu, Y.J.2
Aversa, G.3
Phillips, J.H.4
de Vries, J.E.5
-
48
-
-
34548061234
-
Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses
-
Good KL, Tangye SG. Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses. Proc Natl Acad Sci USA 2007;104:13420-13425.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13420-13425
-
-
Good, K.L.1
Tangye, S.G.2
-
49
-
-
34250883267
-
Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
-
Tangye SG, Good KL. Human IgM+CD27+ B cells: memory B cells or "memory" B cells? J Immunol 2007;179:13-19.
-
(2007)
J Immunol
, vol.179
, pp. 13-19
-
-
Tangye, S.G.1
Good, K.L.2
-
50
-
-
33745074368
-
Intrinsic properties of human and murine memory B cells
-
Anderson SM, Tomayko MM, Shlomchik MJ. Intrinsic properties of human and murine memory B cells. Immunol Rev 2006;211:280-294.
-
(2006)
Immunol Rev
, vol.211
, pp. 280-294
-
-
Anderson, S.M.1
Tomayko, M.M.2
Shlomchik, M.J.3
-
51
-
-
47949091743
-
Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities
-
Tomayko MM, et al. Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol 2008;181:27-38.
-
(2008)
J Immunol
, vol.181
, pp. 27-38
-
-
Tomayko, M.M.1
-
53
-
-
80054113592
-
Regulation of memory B-cell survival by the BH3-only protein Puma
-
Clybouw C, et al. Regulation of memory B-cell survival by the BH3-only protein Puma. Blood 2011;118:4120-4128.
-
(2011)
Blood
, vol.118
, pp. 4120-4128
-
-
Clybouw, C.1
-
54
-
-
0029936947
-
Induction of long-lived germinal centers associated with persisting antigen after viral infection
-
Bachmann MF, Odermatt B, Hengartner H, Zinkernagel RM. Induction of long-lived germinal centers associated with persisting antigen after viral infection. J Exp Med 1996;183:2259-2269.
-
(1996)
J Exp Med
, vol.183
, pp. 2259-2269
-
-
Bachmann, M.F.1
Odermatt, B.2
Hengartner, H.3
Zinkernagel, R.M.4
-
55
-
-
0023761867
-
B-cell memory is short-lived in the absence of antigen
-
Gray D, Skarvall H. B-cell memory is short-lived in the absence of antigen. Nature 1988;336:70-73.
-
(1988)
Nature
, vol.336
, pp. 70-73
-
-
Gray, D.1
Skarvall, H.2
-
56
-
-
0019500008
-
Long-term antigen retention by dendritic cells in the popliteal lymph node of immunized mice
-
Mandel TE, Phipps RP, Abbot AP, Tew JG. Long-term antigen retention by dendritic cells in the popliteal lymph node of immunized mice. Immunology 1981;43:353-362.
-
(1981)
Immunology
, vol.43
, pp. 353-362
-
-
Mandel, T.E.1
Phipps, R.P.2
Abbot, A.P.3
Tew, J.G.4
-
57
-
-
0034609775
-
Memory B-cell persistence is independent of persisting immunizing antigen
-
Maruyama M, Lam KP, Rajewsky K. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 2000;407:636-642.
-
(2000)
Nature
, vol.407
, pp. 636-642
-
-
Maruyama, M.1
Lam, K.P.2
Rajewsky, K.3
-
58
-
-
0024989657
-
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors
-
Schittek B, Rajewsky K. Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature 1990;346:749-751.
-
(1990)
Nature
, vol.346
, pp. 749-751
-
-
Schittek, B.1
Rajewsky, K.2
-
59
-
-
33645795240
-
Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells
-
Anderson SM, Hannum LG, Shlomchik MJ. Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J Immunol 2006;176:4515-4519.
-
(2006)
J Immunol
, vol.176
, pp. 4515-4519
-
-
Anderson, S.M.1
Hannum, L.G.2
Shlomchik, M.J.3
-
60
-
-
63449105305
-
PLC-gamma2 is essential for formation and maintenance of memory B cells
-
Hikida M, et al. PLC-gamma2 is essential for formation and maintenance of memory B cells. J Exp Med 2009;206:681-689.
-
(2009)
J Exp Med
, vol.206
, pp. 681-689
-
-
Hikida, M.1
-
61
-
-
1842405428
-
Evidence for a large compartment of IgM-expressing memory B cells in humans
-
Klein U, Kuppers R, Rajewsky K. Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 1997;89:1288-1298.
-
(1997)
Blood
, vol.89
, pp. 1288-1298
-
-
Klein, U.1
Kuppers, R.2
Rajewsky, K.3
-
62
-
-
0034686497
-
Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone
-
White H, Gray D. Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J Exp Med 2000;191:2209-2220.
-
(2000)
J Exp Med
, vol.191
, pp. 2209-2220
-
-
White, H.1
Gray, D.2
-
63
-
-
32444437410
-
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease
-
Ma CS, et al. Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest 2006;116:322-333.
-
(2006)
J Clin Invest
, vol.116
, pp. 322-333
-
-
Ma, C.S.1
-
64
-
-
33645735643
-
Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency
-
Warnatz K, et al. Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency. Blood 2006;107:3045-3052.
-
(2006)
Blood
, vol.107
, pp. 3045-3052
-
-
Warnatz, K.1
-
65
-
-
4043164158
-
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
-
Weller S, et al. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004;104:3647-3654.
-
(2004)
Blood
, vol.104
, pp. 3647-3654
-
-
Weller, S.1
-
66
-
-
0035970105
-
CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans
-
Weller S, et al. CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci USA 2001;98:1166-1170.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1166-1170
-
-
Weller, S.1
-
67
-
-
60549092755
-
Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells
-
Good KL, Avery DT, Tangye SG. Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells. J Immunol 2009;182:890-901.
-
(2009)
J Immunol
, vol.182
, pp. 890-901
-
-
Good, K.L.1
Avery, D.T.2
Tangye, S.G.3
-
68
-
-
70449722777
-
Multiple layers of B cell memory with different effector functions
-
Dogan I, et al. Multiple layers of B cell memory with different effector functions. Nat Immunol 2009;10:1292-1299.
-
(2009)
Nat Immunol
, vol.10
, pp. 1292-1299
-
-
Dogan, I.1
-
69
-
-
79952282195
-
Different B cell populations mediate early and late memory during an endogenous immune response
-
Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK. Different B cell populations mediate early and late memory during an endogenous immune response. Science 2011;331:1203-1207.
-
(2011)
Science
, vol.331
, pp. 1203-1207
-
-
Pape, K.A.1
Taylor, J.J.2
Maul, R.W.3
Gearhart, P.J.4
Jenkins, M.K.5
-
70
-
-
77954175674
-
Mcl-1; the molecular regulation of protein function
-
Thomas LW, Lam C, Edwards SW. Mcl-1; the molecular regulation of protein function. FEBS Lett 2010;584:2981-2989.
-
(2010)
FEBS Lett
, vol.584
, pp. 2981-2989
-
-
Thomas, L.W.1
Lam, C.2
Edwards, S.W.3
-
71
-
-
0027480450
-
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
-
Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA 1993;90:3516-3520.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 3516-3520
-
-
Kozopas, K.M.1
Yang, T.2
Buchan, H.L.3
Zhou, P.4
Craig, R.W.5
-
72
-
-
0022971952
-
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis
-
Rogers S, Wells R, Rechsteiner M. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 1986;234:364-368.
-
(1986)
Science
, vol.234
, pp. 364-368
-
-
Rogers, S.1
Wells, R.2
Rechsteiner, M.3
-
73
-
-
33646697347
-
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
-
Babon JJ, et al. The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell 2006;22:205-216.
-
(2006)
Mol Cell
, vol.22
, pp. 205-216
-
-
Babon, J.J.1
-
74
-
-
7644231187
-
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
-
Herrant M, et al. Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene 2004;23:7863-7873.
-
(2004)
Oncogene
, vol.23
, pp. 7863-7873
-
-
Herrant, M.1
-
75
-
-
0348014686
-
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
-
Cuconati A, Mukherjee C, Perez D, White E. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 2003;17:2922-2932.
-
(2003)
Genes Dev
, vol.17
, pp. 2922-2932
-
-
Cuconati, A.1
Mukherjee, C.2
Perez, D.3
White, E.4
-
76
-
-
3042686666
-
Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1
-
Derouet M, Thomas L, Cross A, Moots RJ, Edwards SW. Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1. J Biol Chem 2004;279:26915-26921.
-
(2004)
J Biol Chem
, vol.279
, pp. 26915-26921
-
-
Derouet, M.1
Thomas, L.2
Cross, A.3
Moots, R.J.4
Edwards, S.W.5
-
77
-
-
20144388905
-
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis
-
Nencioni A, et al. Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis. Blood 2005;105:3255-3262.
-
(2005)
Blood
, vol.105
, pp. 3255-3262
-
-
Nencioni, A.1
-
78
-
-
0038046166
-
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
-
Nijhawan D, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 2003;17:1475-1486.
-
(2003)
Genes Dev
, vol.17
, pp. 1475-1486
-
-
Nijhawan, D.1
-
79
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 2005;121:1085-1095.
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
Gao, W.2
Du, F.3
Wang, X.4
-
80
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Ding Q, et al. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol 2007;27:4006-4017.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
-
81
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
Inuzuka H, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011;471:104-109.
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
-
82
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz IE, et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 2011;471:110-114.
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
-
83
-
-
73849083434
-
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
-
Schwickart M, et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010;463:103-107.
-
(2010)
Nature
, vol.463
, pp. 103-107
-
-
Schwickart, M.1
-
84
-
-
0035966107
-
Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway
-
Lin MT, Lee RC, Yang PC, Ho FM, Kuo ML. Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2001;276:48997-49002.
-
(2001)
J Biol Chem
, vol.276
, pp. 48997-49002
-
-
Lin, M.T.1
Lee, R.C.2
Yang, P.C.3
Ho, F.M.4
Kuo, M.L.5
-
85
-
-
0035898449
-
Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation
-
Liu H, Perlman H, Pagliari LJ, Pope RM. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J Exp Med 2001;194:113-126.
-
(2001)
J Exp Med
, vol.194
, pp. 113-126
-
-
Liu, H.1
Perlman, H.2
Pagliari, L.J.3
Pope, R.M.4
-
86
-
-
49449108291
-
mTORC1 promotes survival through translational control of Mcl-1
-
Mills JR, et al. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci USA 2008;105:10853-10858.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10853-10858
-
-
Mills, J.R.1
-
87
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006;21:749-760.
-
(2006)
Mol Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
88
-
-
51049101063
-
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer
-
Ding Q, et al. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Res 2008;68:6109-6117.
-
(2008)
Cancer Res
, vol.68
, pp. 6109-6117
-
-
Ding, Q.1
-
89
-
-
0037113878
-
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
-
Inoshita S, et al. Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress. J Biol Chem 2002;277:43730-43734.
-
(2002)
J Biol Chem
, vol.277
, pp. 43730-43734
-
-
Inoshita, S.1
-
90
-
-
67650076845
-
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
-
Morel C, Carlson SM, White FM, Davis RJ. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol 2009;29:3845-3852.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3845-3852
-
-
Morel, C.1
Carlson, S.M.2
White, F.M.3
Davis, R.J.4
-
92
-
-
0034682837
-
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
-
Bae J, Leo CP, Hsu SY, Hsueh AJ. MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J Biol Chem 2000;275:25255-25261.
-
(2000)
J Biol Chem
, vol.275
, pp. 25255-25261
-
-
Bae, J.1
Leo, C.P.2
Hsu, S.Y.3
Hsueh, A.J.4
-
93
-
-
69249226222
-
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
-
Kim JH, Sim SH, Ha HJ, Ko JJ, Lee K, Bae J. MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death. FEBS Lett 2009;583:2758-2764.
-
(2009)
FEBS Lett
, vol.583
, pp. 2758-2764
-
-
Kim, J.H.1
Sim, S.H.2
Ha, H.J.3
Ko, J.J.4
Lee, K.5
Bae, J.6
-
94
-
-
0037452080
-
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
-
Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 2003;422:726-730.
-
(2003)
Nature
, vol.422
, pp. 726-730
-
-
Chaudhuri, J.1
Tian, M.2
Khuong, C.3
Chua, K.4
Pinaud, E.5
Alt, F.W.6
-
96
-
-
0037926476
-
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
-
Pham P, Bransteitter R, Petruska J, Goodman MF. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003;424:103-107.
-
(2003)
Nature
, vol.424
, pp. 103-107
-
-
Pham, P.1
Bransteitter, R.2
Petruska, J.3
Goodman, M.F.4
-
97
-
-
0038293484
-
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
-
Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 2003;4:452-456.
-
(2003)
Nat Immunol
, vol.4
, pp. 452-456
-
-
Ramiro, A.R.1
Stavropoulos, P.2
Jankovic, M.3
Nussenzweig, M.C.4
-
98
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
99
-
-
0035839959
-
Mechanisms of chromosomal translocations in B cell lymphomas
-
Kuppers R, Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001;20:5580-5594.
-
(2001)
Oncogene
, vol.20
, pp. 5580-5594
-
-
Kuppers, R.1
Dalla-Favera, R.2
-
101
-
-
0035913362
-
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
-
Pasqualucci L, et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001;412:341-346.
-
(2001)
Nature
, vol.412
, pp. 341-346
-
-
Pasqualucci, L.1
-
102
-
-
0026425685
-
Ig VH gene expression among human follicular lymphomas
-
Bahler DW, Campbell MJ, Hart S, Miller RA, Levy S, Levy R. Ig VH gene expression among human follicular lymphomas. Blood 1991;78:1561-1568.
-
(1991)
Blood
, vol.78
, pp. 1561-1568
-
-
Bahler, D.W.1
Campbell, M.J.2
Hart, S.3
Miller, R.A.4
Levy, S.5
Levy, R.6
-
103
-
-
0022540466
-
Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma
-
Cleary ML, et al. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell 1986;44:97-106.
-
(1986)
Cell
, vol.44
, pp. 97-106
-
-
Cleary, M.L.1
-
104
-
-
0344528777
-
Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells
-
Brauninger A, et al. Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells. Blood 1999;93:2679-2687.
-
(1999)
Blood
, vol.93
, pp. 2679-2687
-
-
Brauninger, A.1
-
105
-
-
0028820580
-
Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
-
Hsu FJ, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995;86:3072-3082.
-
(1995)
Blood
, vol.86
, pp. 3072-3082
-
-
Hsu, F.J.1
Levy, R.2
-
106
-
-
1842290375
-
Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression
-
Kuppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 1997;27:1398-1405.
-
(1997)
Eur J Immunol
, vol.27
, pp. 1398-1405
-
-
Kuppers, R.1
Rajewsky, K.2
Hansmann, M.L.3
-
107
-
-
57749171165
-
The biology of Hodgkin's lymphoma
-
Kuppers R. The biology of Hodgkin's lymphoma. Nat Rev Cancer 2009;9:15-27.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 15-27
-
-
Kuppers, R.1
-
108
-
-
0028985744
-
Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity
-
Chapman CJ, Mockridge CI, Rowe M, Rickinson AB, Stevenson FK. Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 1995;85:2176-2181.
-
(1995)
Blood
, vol.85
, pp. 2176-2181
-
-
Chapman, C.J.1
Mockridge, C.I.2
Rowe, M.3
Rickinson, A.B.4
Stevenson, F.K.5
-
109
-
-
0029328401
-
Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes
-
Klein U, Klein G, Ehlin-Henriksson B, Rajewsky K, Kuppers R. Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes. Mol Med 1995;1:495-505.
-
(1995)
Mol Med
, vol.1
, pp. 495-505
-
-
Klein, U.1
Klein, G.2
Ehlin-Henriksson, B.3
Rajewsky, K.4
Kuppers, R.5
-
110
-
-
0028866548
-
Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations
-
Tamaru J, et al. Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations. Am J Pathol 1995;147:1398-1407.
-
(1995)
Am J Pathol
, vol.147
, pp. 1398-1407
-
-
Tamaru, J.1
-
111
-
-
0030988806
-
Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas
-
Bahler DW, Miklos JA, Swerdlow SH. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood 1997;89:3335-3344.
-
(1997)
Blood
, vol.89
, pp. 3335-3344
-
-
Bahler, D.W.1
Miklos, J.A.2
Swerdlow, S.H.3
-
112
-
-
0030035101
-
Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion
-
Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 1996;10:1190-1197.
-
(1996)
Leukemia
, vol.10
, pp. 1190-1197
-
-
Du, M.1
Diss, T.C.2
Xu, C.3
Peng, H.4
Isaacson, P.G.5
Pan, L.6
-
113
-
-
0029813167
-
Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human
-
Kuppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML. Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol 1996;26:1794-1800.
-
(1996)
Eur J Immunol
, vol.26
, pp. 1794-1800
-
-
Kuppers, R.1
Hajadi, M.2
Plank, L.3
Rajewsky, K.4
Hansmann, M.L.5
-
114
-
-
0030898114
-
Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis
-
Qin Y, Greiner A, Hallas C, Haedicke W, Muller-Hermelink HK. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest 1997;76:477-485.
-
(1997)
Lab Invest
, vol.76
, pp. 477-485
-
-
Qin, Y.1
Greiner, A.2
Hallas, C.3
Haedicke, W.4
Muller-Hermelink, H.K.5
-
115
-
-
0032055813
-
Mutation analysis of the rearranged immunoglobulin heavy chain genes of marginal zone cell lymphomas indicates an origin from different marginal zone B lymphocyte subsets
-
Tierens A, Delabie J, Pittaluga S, Driessen A, DeWolf-Peeters C. Mutation analysis of the rearranged immunoglobulin heavy chain genes of marginal zone cell lymphomas indicates an origin from different marginal zone B lymphocyte subsets. Blood 1998;91:2381-2386.
-
(1998)
Blood
, vol.91
, pp. 2381-2386
-
-
Tierens, A.1
Delabie, J.2
Pittaluga, S.3
Driessen, A.4
DeWolf-Peeters, C.5
-
116
-
-
0032532668
-
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
-
Fais F, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998;102:1515-1525.
-
(1998)
J Clin Invest
, vol.102
, pp. 1515-1525
-
-
Fais, F.1
-
117
-
-
0028968889
-
Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes
-
Zhu D, Oscier DG, Stevenson FK. Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes. Blood 1995;85:1603-1607.
-
(1995)
Blood
, vol.85
, pp. 1603-1607
-
-
Zhu, D.1
Oscier, D.G.2
Stevenson, F.K.3
-
118
-
-
10544250651
-
High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia
-
Davi F, et al. High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia. Blood 1996;88:3953-3961.
-
(1996)
Blood
, vol.88
, pp. 3953-3961
-
-
Davi, F.1
-
119
-
-
0032533621
-
VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching
-
Aarts WM, Willemze R, Bende RJ, Meijer CJ, Pals ST, van Noesel CJ. VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching. Blood 1998;92:3857-3864.
-
(1998)
Blood
, vol.92
, pp. 3857-3864
-
-
Aarts, W.M.1
Willemze, R.2
Bende, R.J.3
Meijer, C.J.4
Pals, S.T.5
van Noesel, C.J.6
-
120
-
-
0032055530
-
Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas
-
Ivanovski M, et al. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 1998;91:2433-2442.
-
(1998)
Blood
, vol.91
, pp. 2433-2442
-
-
Ivanovski, M.1
-
121
-
-
0028100367
-
Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma
-
Baker BW, Deane M, Gilleece MH, Johnston D, Scarffe JH, Norton JD. Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma. Leuk Lymphoma 1994;14:291-301.
-
(1994)
Leuk Lymphoma
, vol.14
, pp. 291-301
-
-
Baker, B.W.1
Deane, M.2
Gilleece, M.H.3
Johnston, D.4
Scarffe, J.H.5
Norton, J.D.6
-
122
-
-
0026786675
-
Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation
-
Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 1992;80:2326-2335.
-
(1992)
Blood
, vol.80
, pp. 2326-2335
-
-
Bakkus, M.H.1
Heirman, C.2
Van Riet, I.3
Van Camp, B.4
Thielemans, K.5
-
123
-
-
84859729059
-
-
Clinical hematology: theory and procedures. ; ISBN0-7817-5007-5.
-
Turgeon M. Clinical hematology: theory and procedures. 2005; ISBN0-7817-5007-5.
-
(2005)
-
-
Turgeon, M.1
-
124
-
-
34249704600
-
Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis
-
Schulz H BJ, et al. Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. J Natl Cancer Inst 2007;99:706-714.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 706-714
-
-
Schulz, H.B.1
-
125
-
-
24644454339
-
Improved survival of follicular lymphoma patients in the United States
-
Swenson WT, Wooldridge JE, Lynch CF, Forman-Hoffman VL, Chrischilles E, Link BK. Improved survival of follicular lymphoma patients in the United States. J Clin Oncol 2005;23:5019-5026.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5019-5026
-
-
Swenson, W.T.1
Wooldridge, J.E.2
Lynch, C.F.3
Forman-Hoffman, V.L.4
Chrischilles, E.5
Link, B.K.6
-
126
-
-
0021679848
-
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
-
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984;226:1097-1099.
-
(1984)
Science
, vol.226
, pp. 1097-1099
-
-
Tsujimoto, Y.1
Finger, L.R.2
Yunis, J.3
Nowell, P.C.4
Croce, C.M.5
-
127
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988;335:440-442.
-
(1988)
Nature
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
Cory, S.2
Adams, J.M.3
-
128
-
-
0026053958
-
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)
-
McDonnell TJ, Korsmeyer SJ. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 1991;349:254-256.
-
(1991)
Nature
, vol.349
, pp. 254-256
-
-
McDonnell, T.J.1
Korsmeyer, S.J.2
-
129
-
-
0025251664
-
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
-
Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990;348:331-333.
-
(1990)
Nature
, vol.348
, pp. 331-333
-
-
Strasser, A.1
Harris, A.W.2
Bath, M.L.3
Cory, S.4
-
130
-
-
0027461627
-
E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells
-
Strasser A, Harris AW, Cory S. E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene 1993;8:1-9.
-
(1993)
Oncogene
, vol.8
, pp. 1-9
-
-
Strasser, A.1
Harris, A.W.2
Cory, S.3
-
131
-
-
75149125289
-
New targets for the treatment of follicular lymphoma
-
Tageja N, Padheye S, Dandawate P, Al-Katib A, Mohammad RM. New targets for the treatment of follicular lymphoma. J Hematol Oncol 2009;2:50.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 50
-
-
Tageja, N.1
Padheye, S.2
Dandawate, P.3
Al-Katib, A.4
Mohammad, R.M.5
-
132
-
-
33745872296
-
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
-
Zhai D, Jin C, Satterthwait AC, Reed JC. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ 2006;13:1419-1421.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1419-1421
-
-
Zhai, D.1
Jin, C.2
Satterthwait, A.C.3
Reed, J.C.4
-
133
-
-
55749084366
-
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
-
Ackler S, et al. ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo. Mol Cancer Ther 2008;7:3265-3274.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3265-3274
-
-
Ackler, S.1
-
134
-
-
40849129529
-
A Phase 1/2a Study Evaluating the Safety, Pharmacokinetics, and Efficacy of ABT-263 in Subjects with Refractory or Relapsed Lymphoid Malignancies
-
Wilson WH TA, et al. A Phase 1/2a Study Evaluating the Safety, Pharmacokinetics, and Efficacy of ABT-263 in Subjects with Refractory or Relapsed Lymphoid Malignancies. Blood 2007;110:1371.
-
(2007)
Blood
, vol.110
, pp. 1371
-
-
Wilson, W.T.1
-
135
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, et al.. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000;97:7124-7129.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
-
136
-
-
30144441345
-
HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
-
Skommer J, Wlodkowic D, Matto M, Eray M, Pelkonen J. HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leuk Res 2006;30:322-331.
-
(2006)
Leuk Res
, vol.30
, pp. 322-331
-
-
Skommer, J.1
Wlodkowic, D.2
Matto, M.3
Eray, M.4
Pelkonen, J.5
-
137
-
-
51649111684
-
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
-
Lenz G, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci USA 2008;105:13520-13525.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13520-13525
-
-
Lenz, G.1
-
138
-
-
33645279862
-
Molecular diagnosis of Burkitt's lymphoma
-
Dave SS, et al. Molecular diagnosis of Burkitt's lymphoma. N Engl J Med 2006;354:2431-2442.
-
(2006)
N Engl J Med
, vol.354
, pp. 2431-2442
-
-
Dave, S.S.1
-
139
-
-
20144382754
-
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
-
Monti S, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005;105:1851-1861.
-
(2005)
Blood
, vol.105
, pp. 1851-1861
-
-
Monti, S.1
-
140
-
-
23744486988
-
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
-
Feuerhake F, et al. NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood 2005;106:1392-1399.
-
(2005)
Blood
, vol.106
, pp. 1392-1399
-
-
Feuerhake, F.1
-
141
-
-
34548161868
-
Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis
-
Brien G, Trescol-Biemont MC, Bonnefoy-Berard N. Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis. Oncogene 2007;26:5828-5832.
-
(2007)
Oncogene
, vol.26
, pp. 5828-5832
-
-
Brien, G.1
Trescol-Biemont, M.C.2
Bonnefoy-Berard, N.3
-
142
-
-
77951442337
-
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
-
Yecies D, Carlson NE, Deng J, Letai A. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010;115:3304-3313.
-
(2010)
Blood
, vol.115
, pp. 3304-3313
-
-
Yecies, D.1
Carlson, N.E.2
Deng, J.3
Letai, A.4
-
143
-
-
84856698334
-
BCL2A1: the underdog in the BCL2 family
-
Vogler M. BCL2A1: the underdog in the BCL2 family. Cell Death Differ 2012;19:67-74.
-
(2012)
Cell Death Differ
, vol.19
, pp. 67-74
-
-
Vogler, M.1
-
144
-
-
84859729062
-
-
Chemical inhibitors of BFL-1 and related methods. ; US Patent 20090069324.
-
Reed JC, Zhai D, Kitada S, Sergienko E. Chemical inhibitors of BFL-1 and related methods. 2009; US Patent 20090069324.
-
(2009)
-
-
Reed, J.C.1
Zhai, D.2
Kitada, S.3
Sergienko, E.4
-
145
-
-
0038336667
-
Neoplastic development in plasma cells
-
Potter M. Neoplastic development in plasma cells. Immunol Rev 2003;194:177-195.
-
(2003)
Immunol Rev
, vol.194
, pp. 177-195
-
-
Potter, M.1
-
146
-
-
21744457447
-
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
-
Wuilleme-Toumi S, et al. Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. Leukemia 2005;19:1248-1252.
-
(2005)
Leukemia
, vol.19
, pp. 1248-1252
-
-
Wuilleme-Toumi, S.1
-
147
-
-
0036699925
-
Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival
-
Spets H, Stromberg T, Georgii-Hemming P, Siljason J, Nilsson K, Jernberg-Wiklund H. Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival. Eur J Haematol 2002;69:76-89.
-
(2002)
Eur J Haematol
, vol.69
, pp. 76-89
-
-
Spets, H.1
Stromberg, T.2
Georgii-Hemming, P.3
Siljason, J.4
Nilsson, K.5
Jernberg-Wiklund, H.6
-
148
-
-
0036659905
-
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells
-
Derenne S, et al. Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. Blood 2002;100:194-199.
-
(2002)
Blood
, vol.100
, pp. 194-199
-
-
Derenne, S.1
-
149
-
-
0037085778
-
Myeloid cell factor-1 is a critical survival factor for multiple myeloma
-
Zhang B, Gojo I, Fenton RG. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood 2002;99:1885-1893.
-
(2002)
Blood
, vol.99
, pp. 1885-1893
-
-
Zhang, B.1
Gojo, I.2
Fenton, R.G.3
-
150
-
-
84863012484
-
Identification of molecular vulnerabilities in human multiple myeloma cells by RNAi lethality screening of the druggable genome
-
Tiedemann RE, et al. Identification of molecular vulnerabilities in human multiple myeloma cells by RNAi lethality screening of the druggable genome. Cancer Res 2012;72:757-768.
-
(2012)
Cancer Res
, vol.72
, pp. 757-768
-
-
Tiedemann, R.E.1
-
151
-
-
0038021146
-
A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells
-
Jourdan M, Veyrune JL, De Vos J, Redal N, Couderc G, Klein B. A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells. Oncogene 2003;22:2950-2959.
-
(2003)
Oncogene
, vol.22
, pp. 2950-2959
-
-
Jourdan, M.1
Veyrune, J.L.2
De Vos, J.3
Redal, N.4
Couderc, G.5
Klein, B.6
-
152
-
-
0037468570
-
IL-6-independent expression of Mcl-1 in human multiple myeloma
-
Zhang B, Potyagaylo V, Fenton RG. IL-6-independent expression of Mcl-1 in human multiple myeloma. Oncogene 2003;22:1848-1859.
-
(2003)
Oncogene
, vol.22
, pp. 1848-1859
-
-
Zhang, B.1
Potyagaylo, V.2
Fenton, R.G.3
-
153
-
-
11144355586
-
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
-
Moreaux J, et al. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood 2004;103:3148-3157.
-
(2004)
Blood
, vol.103
, pp. 3148-3157
-
-
Moreaux, J.1
-
154
-
-
80053653073
-
ABT-737 is highly effective against molecular subgroups of multiple myeloma
-
Bodet L, et al. ABT-737 is highly effective against molecular subgroups of multiple myeloma. Blood 2011;118:3901-3910.
-
(2011)
Blood
, vol.118
, pp. 3901-3910
-
-
Bodet, L.1
-
155
-
-
0142244338
-
The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells
-
Pei XY, Dai Y, Grant S. The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. Leukemia 2003;17:2036-2045.
-
(2003)
Leukemia
, vol.17
, pp. 2036-2045
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
156
-
-
12344252927
-
The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism
-
Pei XY, Dai Y, Grant S. The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. Mol Cancer Ther 2004;3:1513-1524.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1513-1524
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
157
-
-
42249110185
-
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells
-
Kline MP, et al. R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp Hematol 2008;36:568-576.
-
(2008)
Exp Hematol
, vol.36
, pp. 568-576
-
-
Kline, M.P.1
-
158
-
-
45949094910
-
Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma
-
Paoluzzi L, et al. Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood 2008;111:5350-5358.
-
(2008)
Blood
, vol.111
, pp. 5350-5358
-
-
Paoluzzi, L.1
-
159
-
-
65649130832
-
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
-
Liu G, Kelly WK, Wilding G, Leopold L, Brill K, Somer B. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res 2009;15:3172-3176.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3172-3176
-
-
Liu, G.1
Kelly, W.K.2
Wilding, G.3
Leopold, L.4
Brill, K.5
Somer, B.6
-
160
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 2007;104:19512-19517.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
-
161
-
-
34249982915
-
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
-
Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007;109:5430-5438.
-
(2007)
Blood
, vol.109
, pp. 5430-5438
-
-
Trudel, S.1
Li, Z.H.2
Rauw, J.3
Tiedemann, R.E.4
Wen, X.Y.5
Stewart, A.K.6
-
162
-
-
77955102504
-
Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma
-
Hwang JJ, et al. Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma. Clin Cancer Res 2010;16:4038-4045.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4038-4045
-
-
Hwang, J.J.1
-
163
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002;2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
|