bcl-2 Transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

Journal of Experimental Medicine

Volumn 191, Issue 3, 2000, Pages 475-484

  Smith, Kenneth G C ^b   Light, Amanda ^a   O'Reilly, Lorraine A ^a   Ang, Soon Meng ^a   Strasser, Andreas ^a   Tarlinton, David ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Affinity maturation; B cell; Immunologic memory; Plasma cell; Somatic mutation

Indexed keywords

PROTEIN BCL 2;

ANIMAL CELL; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SELECTION; GENE EXPRESSION; GENE MUTATION; GERMINAL CENTER; IMMUNOLOGICAL MEMORY; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE;

ADP-RIBOSYL CYCLASE; ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; APOPTOSIS; B-LYMPHOCYTES; BONE MARROW CELLS; GENE EXPRESSION; GENES, BCL-2; GERMINAL CENTER; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NAD+ NUCLEOSIDASE; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0034614896     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.3.475     Document Type: Article

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