Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: Evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis

Laboratory Investigation

Volumn 76, Issue 4, 1997, Pages 477-485

  Qin, Yufen ^a,b   Greiner, Axel ^b   Hallas, Cora ^b   Haedicke, Wolfgang ^b   Müller Hermelink, Hans Konrad ^b  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE ISOLATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LYMPHOMA; MEMORY CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR GROWTH;

BASE SEQUENCE; CLONE CELLS; CLONING, MOLECULAR; DNA PRIMERS; DNA, NEOPLASM; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; RNA, NEOPLASM; STOMACH NEOPLASMS;

EID: 0030898114     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bahler DW and Levy R (1992). Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 89:6770-6774.
2. Bakkus MH, Heirman C, van Camp B, and Thielemans K (1992). Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no interclonal variation. Blood 80:2326-2335.
3. Berek C and Milstein C (1988). The dynamic nature of the antibody repertoire. Immunol Rev 105:5-26.
4. μ gene and identification of a new DH locus. EMBO J 7:2003-2010.
5. Callard RE, Armitage RJ, Fanslow WC, and Spriggs MK (1993). CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol Today 14:559-564.
6. Chen PP, Liu MF, Glass CA, Sinha S, Kipps TJ, and Carson DA (1989). Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. Arthritis Rheum 32:72-76.
7. Dunn-Walters DK, Isaacson PG, and Spencer J (1995). Analysis of mutation in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells. J Exp Med 182:559-566.
8. Greiner A, Kirchner T, Ott G, Marx A, Fischbach W, and Müller-Hermelink HK (1996). Occurrence of multiple lymphoepithelioma-like carcinomas and MALT-type lymphoma in the stomach: Detection of EBV in carcinomas but not in lymphoma. Histopathology 29:51-56.
9. Greiner A, Knörr C, Qin Y, Schimpl A, Banchereaun J, and Müller-Hermelink HK (in press, 1997). Low grade B-cell lymphoma of MALT-type require CD40-signaling and Th2 cytokines for growth and differentiation in vitro. Am J Pathol.
10. Greiner A, Marx A, Heesemann J, Leebmann J, Schmausser B, and Müller-Hermelink HK (1994). Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis. Lab Invest 70:572-578.
11. Greiner A and Müller-Hermelink HK (1996). Recent advances in gastric extranodal B-cell lymphoma. Curr Diagn Pathol 3:91-98.
12. Gubler U and Hoffman BJ (1983). A simple and very efficient method for generating cDNA libraries. Gene 25:263-269.
13. Hussell T, Isaacson PG, Crabtree JE, Dogan A, Spencer J (1993). Immunoglobulin specificity of low-grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Am J Pathol 140:285-292.
14. Ichihara Y, Matsuoka H, and Kurosawa Y (1988). Organization of human immunoglobulin heavy-chain diversity gene loci. EMBO J 7:4141-4150.
15. Isaacson PG, Wotherspoon AC, Diss T, and Pan L (1991). Follicular colonization in B cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 15:819-828.
16. Jacob J, Kelsoe G, Rajewsky K, and Weiss U (1991). Intraclonal generation of antibody mutations in germinal centers. Nature 354:352-353.
17. Kochs C and Rajewsky K (1988). Stepwise intraclonal mutation of antibody affinity through somatic hypermutation. Proc Natl Acad Sci USA 85:8206-8210.
18. Liu YJ, Joshua DE, Williams GT, Smith CA, Gordon J, and MacLennan IC (1989). Mechanism of antigen-driven selection in germinal centers. Nature 342:929-931.
19. Liu YJ, Oldfield S, MacLennan IC. Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones (1988). Eur J Immunol 18:355-362.
20. MacLennan ICM (1994). Germinal centers. Annu Rev Immunol 12:117-139.
21. Manser T, Wysocki LJ, Margolies MN, and Gefter ML (1987). Evolution of antibody variable region structure during the immune response. Immunol Rev 96:141-62.
22. Matsuda F, Lee KH, Nakai S, Sato T, Kodaira M, Zong SQ, Ohno H, Fukuhara S, and Honjo T (1988). Dispersed localization of D segments in the human immunoglobulin heavy-chain locus. EMBO J 7:1047-1051.
23. Oste C (1988). Polymerase chain reaction. Biotechniques 6:162-167.
24. Ott G, Kirchner T, Seidl S, and Müller-Hermelink HK (1993). Primary gastric lymphoma is rarely associated with Epstein-Barr virus. Virchows Arch 64:287-291.
25. Pascual V and Capra JD (1991). Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and expression. Adv Immunol 49:1-74.
26. Peng H, Chen G, Du M, Singh N, Isaacson PG, and Pan L (1996). Replication error phenotype and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue. Am J Pathol 148:643-648.
27. Qin Y, Greiner A, Trunk MJF, Schmausser B, Ott MM, and Müller-Hermelink HK (1995). Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B cell lymphoma. Blood 86:3528-3533.
28. Radaszkiewicz T, Dragosics B, and Bauer P (1992). Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: Factors relevant to prognosis. Gastroenterology 102:1628-1638.
29. Renshaw BR, Fanslow WC III, Armitage RJ, Campbell KA, Liggitt D, Wright B, Davison BL, and Maliszewski CR (1994). Humoral immune responses in CD40 ligand-deficient mice. J Exp Med 180:1889-1900.
30. Sanger F, Nackle S, and Coulson AR (1977). DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467.
31. Sanz I, Kelly P, Williams C, Scholl S, Tucker P, and Capra JD (1989). The smaller human VH gene families display remarkably little polymorphism. EMBO J 8:3741-3748.
32. Schroeder HW Jr, Hillson JL, and Perlmutter RM (1987). Early restriction of the human antibody repertoire. Science 238: 791-793.
33. Sharon J, Gefter ML, Wysocki LJ, and Margolies MN (1989). Recurrent somatic mutations in mouse antibodies to P-azophennylarsonate increase affinity for hapten. J Immunol 142:596-601.
34. Smith KG, Weiss U, Rajewsky K, Nossal GJ, and Tarlinton DM (1994). Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. Immunity 1:803-813.
35. Tindall KR and Kunkel TA (1988). Fidelity of DNA synthesis by the thermos aquaticus DNA polymerase. Biochemistry 27: 6008-6013.
36. Wotherspoon AC, Pan LX, Diss TC, and lsaacson PG (1990). A genotypic study of low-grade B-cell lymphomas, including lymphomas of mucosa associated lymphoid tissue. J Pathol 162:135-140.
37. Wotherspoon AC, Pan LX, Diss TC, and lsaacson PG (1992). Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet 58:35-38.