Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human

European Journal of Immunology

Volumn 26, Issue 8, 1996, Pages 1794-1800

  Küppers, Ralf ^a   Hajadi, Mande ^a   Plank, Lukas ^a   Rajewsky, Klaus ^a   Hansmann, Martin Leo ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Kappa deleting element; Monocytoid B cell lymphoma; Somatic mutation; V genes

Indexed keywords

CD5 ANTIGEN; IMMUNOGLOBULIN KAPPA CHAIN;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CELLULAR IMMUNITY; CLINICAL ARTICLE; DELETION MUTANT; ENHANCER REGION; FEMALE; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN GENE; MALE; MONOCYTIC LEUKEMIA; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0029813167     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830260820     Document Type: Article

References (58)

1. Sheibani, K., Sohn, C. C., Burke, J. S., Winberd, C. D., Wu, A. M. and Rappaport, H., Am. J. Pathol. 1986. 124: 310.
2. Sheibani, K., in Knowles, D. M. (Ed.), Neoplastic Hematophatology. Wiliams and Wilkins, Baltimore 1992, p. 629.
3. Sheibani, K., Burke, J. S., Swartz, W. G., Nademanee, A. and Winberg, C. D., Cancer 1988. 62: 1531.
4. Cogliatti, S. B., Lennert, K., Hansmann, M. L. and Zwingers, T. L., J. Clin. Pathol. 1990. 43: 619.
5. Ngan, B., Warnke, R., Wilson, M., Takagi, K., Cleary, M. L. and Dorfman, R. F., Hum. Pathol. 1991. 22: 409.
6. Traweek, S. T., Sheibani, K., Winberg, C. D., Mena, R. R., Wu, A. M. and Rappaport, H., Blood 1989. 73: 573.
7. van den Oord, J. J., de Wolf-Peeters, C., De Vos, R. and Desmet, V. J., Am. J. Pathol. 1985. 118: 266.
8. Klein, U., Küppers, R. and Rajewsky, K., Eur. J. Immunol. 1993. 23: 3272.
9. Klein, U., Küppers, R. and Rajewsky, K., J. Exp. Med. 1994. 180: 1383.
10. Pascual, V., Liu, Y. J., Magalski, A., de Bouteiller, O., Banchereau, J. and Capra, J. D., J. Exp. Med. 1994. 180: 329.
11. Kocks, C. and Rajewsky, K., Annu. Rev. Immunol. 1989. 7: 537.
12. Jacob, J., Kelsoe, G., Rajewsky, K. and Weiss, U., Nature 1991. 354: 389.
13. Berek, C., Berger, A. and Apel, M., Cell 1991. 67: 1121.
14. Küppers, R., Zhao, M., Hansmann, M. L. and Rajewsky, K., EMBO J. 1993. 12: 4955.
15. Küppers, R., Zhao, M., Rajewsky, K. and Hansmann, M. L., Am J. Pathol. 1993. 143: 230.
16. Merz, H., Malisius, R., Mannweiler, S., Zhou, R., Hartmann, W., Orscherek, K., Moubayed, P. and Feller, A. C., Lab. Invest. 1995. 73: 149.
17. Hsu, F. J. and Levy, R., Blood 1995. 86: 3072.
18. Chou, C. L. and Morrison, S. L., J. Immunol. 1993. 150: 5350.
19. Siminovitch, K. A., Bakhshi, A., Goldman, P. and Korsmeyer, S. J., Nature 1985. 316: 260.
20. Klobeck, H. G. and Zachau, H. G., Nucleic Acids Res. 1986. 14: 4591.
21. Feddersen, R. M., Martin, D. J. and Ness, B. G., J. Immunol. 1990. 144: 1088.
22. Graninger, W. B., Goldman, P. L., Morton, C. C., O'Brien, S. J. and Korsmeyer, S. J., J. Exp. Med. 1988. 167: 488.
23. Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. and Neuberger, M. S., Cell 1994. 77: 239.
24. Küppers, R., Willenbrock, K., Rajewsky, K. and Hansmann, M. L., Am. J. Pathol. 1995. 147: 806.
25. Harada, K. and Yamagishi, H., J. Exp. Med. 1991. 173: 409.
26. Huber, C., Klobeck, H. G. and Zachau, H. G., Eur. J. Immunol. 1992. 22: 1561.
27. Schäble, K. F. and Zachau, H. G., Biol. Chem. Hoppe-Seyler 1993. 374: 1001.
28. Sanz, I., Kelly, P., Williams, C., Scholl, S., Tucker, P. and Capra, J. D., EMBO J. 1989. 8: 3741.
29. Weng, N., Snyder, J. G., Yu-Lee, L. and Marcus, D. M., Eur. J. Immunol. 1992. 22: 1075.
30. van Es, J. H., Heutnik, M., Aanstoot, H. and Logtenberg, T., J. Immunol. 1992. 149: 492.
31. Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B. and Winter, G., J. Mol. Biol. 1992. 227: 776.
32. van der Maarel, S., van Dijk, K. W., Alexander, C. M., Sasso, E. H., Bull, B. and Milner, E. C. B., J. Immunol. 1993. 150: 2858.
33. Matsuda, F., Shin, E. K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Taka-ishi, S., Imai, T., Riley, J. H., Anand, R., Soeda, E. and Honjo, T., Nature Genet. 1993. 3: 88.
34. Campbell, M. J., Zelenetz, A. D., Levy, S. and Levy, R., Mol. Immunol. 1992. 29: 193.
35. Nizze, H., Cogliatti, S. B., von Schilling, C., Feller, A. C. and Lennert, K., Histopathology 1991. 18: 403.
36. Agnarsson, B. A., Kadin, M. E., Am. J. Clin. Pathol. 1987. 88: 752.
37. Traweek, S. T. and Sheibani, K., Am. J. Clin. Pathol. 1992. 97: 591.
38. Adami, F., Chilosi, M., Lestani, M., Scarpa, A., Zambello, R., Pomponi, F., Semenzato, G. and Menestrina, F., Acta Haematol. 1993. 89: 94.
39. Pratt, L. F., Rassenti, L., Larrick, J., Robbins, B., Banks, P. M. and Kipps, T. J., J. Immunol. 1989. 143: 699.
40. Küppers, R., Gause, A. and Rajewsky, K., Leuk. Res. 1991. 15: 487.
41. Rassenti, L. Z. and Kipps, T. J., J. Exp. Med. 1993. 177; 1039.
42. Reynaud, C. A., Garcia, C., Hein, W. R. and Weill, J. C., Cell 1995. 80: 115.
43. Plank, L., Hell, K., Hansmann, M. L., Pringle, J. H., Lauder, I. and Fischer, R., J. Clin. Pathol. 1995. 103: 330.
44. David, G. G., York, J. C., Glick, A. D., McCurley, T. L., Collins, R. D. and Cousar, J. B., Am. J. Surg. Pathol. 1992. 16: 1006.
45. Oka, K., Mori, N. and Yatabe, Y., Acta Haematol. 1993. 90: 84.
46. Dunn-Walters, D. K., Isaacson, P. G. and Spencer, J., J. Exp. Med. 1995. 182: 559.
47. Liu, Y. J., Barthelemy, C., de Bouteiller, O., Arpin, C., Durand, I. and Banchereau, J., Immunity 1995. 2: 239.
48. Harris, N. L., Arch. Pathol. Lab. Med. 1993. 117: 771.
49. Qin, Y., Greiner, A., Trunk, J. F., Schmausser, B., Ott, M. and Müller-Hermelink, H. K., Blood 1995. 86: 3528.
50. Chapman, C. J., Dunn-Walters, D. K., Stevenson, F. K., Hussel, T., Isaacson, P. G. and Spencer, J., J. Clin. Pathol. Mol. Pathol. 1996. 49: M29.
51. Shin, E. K., Matsuda, F., Nagaoka, H., Fukita, Y., Imai, T., Yokoyama, K., Soeda, E. and Honjo, T., EMBO J. 1991. 10: 3641.
52. Pratt, L. P., Szubin, R., Carson, D. A. and Kipps, T. J., J. Immunol. 1991. 147: 2041.
53. van der Heijden, R. W. J., Bunschoten, H., Pascual, V., Uytdehaag, F. G. C. M., Osterhaus, A. D. M. E. and Capra, J. D., J. Immunol. 1990. 144: 2835.
54. Ichihara, Y., Matsuoka, H. and Kurosawa, Y., EMBO J. 1988. 7: 4141.
55. Siebenlist, U., Ravetch, J. V., Korsmeyer, S., Waldmann, T. and Leder, P., Nature 1981. 294: 631.
56. Sanz, I., J. Immunol. 1991. 147: 1720.
57. Yamada, M., Wasserman, R., Reichard, B. A., Shane, S., Caton, A. J. and Rovera, G., J. Exp. Med. 1991. 173: 395.
58. Hieter, P. A., Maizel, J. V. and Leder, P., J. Biol. Chem. 1982. 257: 1516.