Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-x(L) transgenic mice

Journal of Experimental Medicine

Volumn 190, Issue 3, 1999, Pages 399-409

  Takahashi, Yoshimasa ^a   Cerasoli, Douglas M ^a   Dal Porto, Joseph M ^a   Shimoda, Michiko ^a   Freund, Robert ^a   Fang, Wei ^b   Telander, David G ^b   Malvey, Erika Nell ^b   Mueller, Daniel L ^b   Behrens, Timothy W ^b   Kelsoe, Garnett ^c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Affinity maturation; Apoptosis; Bcl x(L); Clonal selection; Germinal center

Indexed keywords

3 NITROPHENOL; ANTIBODY; IMMUNOGLOBULIN G1; PROTEIN BCL X;

ANIMAL CELL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCING CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE REARRANGEMENT; GERMINAL CENTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; APOPTOSIS; B-LYMPHOCYTE SUBSETS; BCL-X PROTEIN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GERMINAL CENTER; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-BCL-2; SPLEEN; TRANSGENES;

EID: 0033517153     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.3.399     Document Type: Article

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