메뉴 건너뛰기




Volumn 93, Issue 8, 1999, Pages 2679-2687

Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; CELL TRANSFORMATION; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FRAMESHIFT MUTATION; GENE REARRANGEMENT; GENETIC ANALYSIS; GERMINAL CENTER; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0344528777     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.8.2679     Document Type: Article
Times cited : (84)

References (55)
  • 3
    • 0028211413 scopus 로고
    • T-cell-rich large B-cell lymphoma. A study of 30 cases, supporting its histologic heterogeneity and lack of clinical distinctiveness
    • Krishnan J, Wallberg K, Frizzera G: T-cell-rich large B-cell lymphoma. A study of 30 cases, supporting its histologic heterogeneity and lack of clinical distinctiveness. Am J Surg Pathol 18:455, 1994
    • (1994) Am J Surg Pathol , vol.18 , pp. 455
    • Krishnan, J.1    Wallberg, K.2    Frizzera, G.3
  • 5
    • 0029804394 scopus 로고    scopus 로고
    • Morphological variability of tumour cells in T-cell-rich B-cell lymphoma. A histopathological study of 14 cases
    • Camilleri-Broet S, Molina T, Audouin J, Tourneau AL, Diebold J: Morphological variability of tumour cells in T-cell-rich B-cell lymphoma. A histopathological study of 14 cases. Virchows Arch 429:243, 1996
    • (1996) Virchows Arch , vol.429 , pp. 243
    • Camilleri-Broet, S.1    Molina, T.2    Audouin, J.3    Tourneau, A.L.4    Diebold, J.5
  • 7
    • 0026591488 scopus 로고
    • Clonal Epstein-Barr virus genome in T-cell-rich lymphomas of B or probable B lineage
    • Loke SL, Ho F, Srivastava G, Fu KH, Leung B, Liang R: Clonal Epstein-Barr virus genome in T-cell-rich lymphomas of B or probable B lineage. Am J Pathol 140:981, 1992
    • (1992) Am J Pathol , vol.140 , pp. 981
    • Loke, S.L.1    Ho, F.2    Srivastava, G.3    Fu, K.H.4    Leung, B.5    Liang, R.6
  • 8
    • 0028933225 scopus 로고
    • A study of the association of Epstein-Barr virus with Burkitt's lymphoma occurring in a Chinese population
    • Chan JK, Tsang WY, Ng CS, Wong CS, Lo ES: A study of the association of Epstein-Barr virus with Burkitt's lymphoma occurring in a Chinese population. Histopathology 26:239, 1995
    • (1995) Histopathology , vol.26 , pp. 239
    • Chan, J.K.1    Tsang, W.Y.2    Ng, C.S.3    Wong, C.S.4    Lo, E.S.5
  • 9
    • 0024987766 scopus 로고
    • The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: Lineage confirmed by JH rearrangement
    • Osborne BM, Butler JJ, Pugh WC: The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: Lineage confirmed by JH rearrangement. Am J Surg Pathol 14:933, 1990
    • (1990) Am J Surg Pathol , vol.14 , pp. 933
    • Osborne, B.M.1    Butler, J.J.2    Pugh, W.C.3
  • 11
    • 0030031613 scopus 로고    scopus 로고
    • T-cell rich B-cell non-Hodgkin's lymphoma: A progressed form of follicle centre cell lymphoma and lymphocyte predominance hodgkin's disease
    • De Jong D, Van Gorp J, Sie-Go D, Van Heerde P: T-cell rich B-cell non-Hodgkin's lymphoma: A progressed form of follicle centre cell lymphoma and lymphocyte predominance hodgkin's disease. Histopathology 28:15, 1996
    • (1996) Histopathology , vol.28 , pp. 15
    • De Jong, D.1    Van Gorp, J.2    Sie-Go, D.3    Van Heerde, P.4
  • 14
    • 0028989568 scopus 로고
    • T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease: Two closely related entities?
    • Schmidt U, Metz KA, Leder LD: T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease: Two closely related entities? Br J Haematol 90:398, 1995
    • (1995) Br J Haematol , vol.90 , pp. 398
    • Schmidt, U.1    Metz, K.A.2    Leder, L.D.3
  • 15
    • 0027453460 scopus 로고
    • The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines
    • Delabie J, Ceuppens JL, Vandenberghe P, de Boer M, Coorevits L, De Wolf-Peeters C: The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines. Blood 82:2845, 1993
    • (1993) Blood , vol.82 , pp. 2845
    • Delabie, J.1    Ceuppens, J.L.2    Vandenberghe, P.3    De Boer, M.4    Coorevits, L.5    De Wolf-Peeters, C.6
  • 16
    • 0027452879 scopus 로고
    • Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular sclerosing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma
    • Kamel OW, Gelb AB, Shibuya RB, Warnke RA: Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular sclerosing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma. Am J Pathol 142:541, 1993
    • (1993) Am J Pathol , vol.142 , pp. 541
    • Kamel, O.W.1    Gelb, A.B.2    Shibuya, R.B.3    Warnke, R.A.4
  • 17
    • 0029069941 scopus 로고
    • The germinal center reaction
    • Kelsoe G: The germinal center reaction. Immunol Today 16:324, 1995
    • (1995) Immunol Today , vol.16 , pp. 324
    • Kelsoe, G.1
  • 19
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K: Clonal selection and learning in the antibody system. Nature 381:751, 1996
    • (1996) Nature , vol.381 , pp. 751
    • Rajewsky, K.1
  • 20
    • 1842290375 scopus 로고    scopus 로고
    • Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression
    • Küppers R, Rajewsky K, Hansmann ML: Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 27:1398, 1997
    • (1997) Eur J Immunol , vol.27 , pp. 1398
    • Küppers, R.1    Rajewsky, K.2    Hansmann, M.L.3
  • 22
    • 0026316328 scopus 로고
    • Epstein-Barr virus infection in oral hairy leukoplakia: Virus replication in the absence of a detectable latent phase
    • Niedobitek G, Young LS, Lau R, Brooks L, Greenspan D, Greenspan JS, Rickinson AB: Epstein-Barr virus infection in oral hairy leukoplakia: Virus replication in the absence of a detectable latent phase. J Gen Virol 72:3035, 1991
    • (1991) J Gen Virol , vol.72 , pp. 3035
    • Niedobitek, G.1    Young, L.S.2    Lau, R.3    Brooks, L.4    Greenspan, D.5    Greenspan, J.S.6    Rickinson, A.B.7
  • 23
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    • Küppers R, Zhao M, Hansmann ML, Rajewsky K: Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 12:4955, 1993
    • (1993) EMBO J , vol.12 , pp. 4955
    • Küppers, R.1    Zhao, M.2    Hansmann, M.L.3    Rajewsky, K.4
  • 24
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
    • Kanzler H, Küppers R, Hansmann ML, Rajewsky K: Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184:1495, 1996
    • (1996) J Exp Med , vol.184 , pp. 1495
    • Kanzler, H.1    Küppers, R.2    Hansmann, M.L.3    Rajewsky, K.4
  • 25
    • 0030834265 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells
    • published erratum appeared in Proc Natl Acad Sci USA 94:14211, 1997
    • Braeuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML: Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells [published erratum appeared in Proc Natl Acad Sci USA 94:14211, 1997]. Proc Natl Acad Sci USA 94:9337, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9337
    • Braeuninger, A.1    Küppers, R.2    Strickler, J.G.3    Wacker, H.H.4    Rajewsky, K.5    Hansmann, M.L.6
  • 27
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/ matrix attachment region
    • Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS: Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/ matrix attachment region. Cell 77:239, 1994
    • (1994) Cell , vol.77 , pp. 239
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 28
    • 0025096953 scopus 로고
    • The frequency of multiple recombination events occurring at the human Ig kappa L chain locus
    • Feddersen RM, Martin DJ, Van Ness BG: The frequency of multiple recombination events occurring at the human Ig kappa L chain locus. J Immunol 144:1088, 1990
    • (1990) J Immunol , vol.144 , pp. 1088
    • Feddersen, R.M.1    Martin, D.J.2    Van Ness, B.G.3
  • 29
    • 0022559806 scopus 로고
    • The human CK gene segment and the kappa deleting element are closely linked
    • Klobeck HG, Zachau HG: The human CK gene segment and the kappa deleting element are closely linked. Nucleic Acids Res 14:4591, 1986
    • (1986) Nucleic Acids Res , vol.14 , pp. 4591
    • Klobeck, H.G.1    Zachau, H.G.2
  • 30
    • 0029813167 scopus 로고    scopus 로고
    • Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human
    • Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML: Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol 26:1794, 1996
    • (1996) Eur J Immunol , vol.26 , pp. 1794
    • Küppers, R.1    Hajadi, M.2    Plank, L.3    Rajewsky, K.4    Hansmann, M.L.5
  • 31
    • 0021870867 scopus 로고
    • A uniform deleting element mediates the loss of kappa genes in human B cells
    • Siminovitch KA, Bakhshi A, Goldman P, Korsmeyer SJ: A uniform deleting element mediates the loss of kappa genes in human B cells. Nature 316:260, 1985
    • (1985) Nature , vol.316 , pp. 260
    • Siminovitch, K.A.1    Bakhshi, A.2    Goldman, P.3    Korsmeyer, S.J.4
  • 32
    • 0020429363 scopus 로고
    • Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains
    • Lesk AM, Chothia C: Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains. J Mol Biol 160:325, 1982
    • (1982) J Mol Biol , vol.160 , pp. 325
    • Lesk, A.M.1    Chothia, C.2
  • 35
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • Goossens T, Klein U, Küppers R: Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc Natl Acad Sci USA 95:2463, 1998
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2463
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 37
    • 0011244327 scopus 로고
    • Functional antibody lacking a variable-region disulfide bridge
    • Rudikoff S, Pumphrey JG: Functional antibody lacking a variable-region disulfide bridge. Proc Natl Acad Sci USA 83:7875, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 7875
    • Rudikoff, S.1    Pumphrey, J.G.2
  • 38
    • 0029904295 scopus 로고    scopus 로고
    • DNA copy number changes in diffuse large B-cell lymphoma - A comparative genomic hybridization study
    • Monni O, Joensuu H, Franssila K, Knuutila S: DNA copy number changes in diffuse large B-cell lymphoma - a comparative genomic hybridization study. Blood 87:5269, 1996
    • (1996) Blood , vol.87 , pp. 5269
    • Monni, O.1    Joensuu, H.2    Franssila, K.3    Knuutila, S.4
  • 41
    • 0030957372 scopus 로고    scopus 로고
    • Lack of allelic exclusion in B cell chronic lymphocytic leukemia
    • Rassenti LZ, Kipps TJ: Lack of allelic exclusion in B cell chronic lymphocytic leukemia. J Exp Med 185:1435, 1997
    • (1997) J Exp Med , vol.185 , pp. 1435
    • Rassenti, L.Z.1    Kipps, T.J.2
  • 42
    • 0028820580 scopus 로고
    • Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
    • Hsu FJ, Levy R: Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 86:3072, 1995
    • (1995) Blood , vol.86 , pp. 3072
    • Hsu, F.J.1    Levy, R.2
  • 43
    • 0030723676 scopus 로고    scopus 로고
    • Detection of minimal disease using rearranged immunoglobulin heavy chain genes from intermediate-and high-grade malignant B cell non-Hodgkins lymphoma
    • van Beizen N, Hupkes PE, Doekharan D, Hoogeveen-Westerveld M, Dorssers LC, van't Veer MB: Detection of minimal disease using rearranged immunoglobulin heavy chain genes from intermediate-and high-grade malignant B cell non-Hodgkins lymphoma. Leukemia 11:1742, 1997
    • (1997) Leukemia , vol.11 , pp. 1742
    • Van Beizen, N.1    Hupkes, P.E.2    Doekharan, D.3    Hoogeveen-Westerveld, M.4    Dorssers, L.C.5    Van't Veer, M.B.6
  • 44
    • 0032081314 scopus 로고    scopus 로고
    • Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression
    • Ottensmeier CH, Thompsett AR, Zhu D, Wilkins BS, Sweetenham JW, Stevenson FK: Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood 91:4292, 1998
    • (1998) Blood , vol.91 , pp. 4292
    • Ottensmeier, C.H.1    Thompsett, A.R.2    Zhu, D.3    Wilkins, B.S.4    Sweetenham, J.W.5    Stevenson, F.K.6
  • 45
    • 0022540466 scopus 로고
    • Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma
    • Cleary ML, Meeker TC, Levy S, Lee E, Trela M, Sklar J, Levy R: Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell 44:97, 1986
    • (1986) Cell , vol.44 , pp. 97
    • Cleary, M.L.1    Meeker, T.C.2    Levy, S.3    Lee, E.4    Trela, M.5    Sklar, J.6    Levy, R.7
  • 48
    • 0028985744 scopus 로고
    • Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity
    • Chapman CJ, Mockridge CI, Rowe M, Rickinson AB, Stevenson FK: Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 85:2176, 1995
    • (1995) Blood , vol.85 , pp. 2176
    • Chapman, C.J.1    Mockridge, C.I.2    Rowe, M.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 49
    • 0029661825 scopus 로고    scopus 로고
    • VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection
    • Chapman CJ, Zhou JX, Gregory C, Rickinson AB, Stevenson FK: VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood 88:3562, 1996
    • (1996) Blood , vol.88 , pp. 3562
    • Chapman, C.J.1    Zhou, J.X.2    Gregory, C.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 50
    • 0030898114 scopus 로고    scopus 로고
    • Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: Evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis
    • Qin Y, Greiner A, Hallas C, Haedicke W, Müller-Hermelink HK: Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest 76:477, 1997
    • (1997) Lab Invest , vol.76 , pp. 477
    • Qin, Y.1    Greiner, A.2    Hallas, C.3    Haedicke, W.4    Müller-Hermelink, H.K.5
  • 52
    • 0027688019 scopus 로고
    • The variable genes of the human immunoglobulin kappa locus
    • Schäble KF, Zachau HG: The variable genes of the human immunoglobulin kappa locus. Biol Chem Hoppe Seyler 374:1001, 1993
    • (1993) Biol Chem Hoppe Seyler , vol.374 , pp. 1001
    • Schäble, K.F.1    Zachau, H.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.