Constitutively activated AKT-1 is vital for the survival of human monocyte-differentiated macrophages: Role of Mcl-1, independent of nuclear factor (NF)-κB, bad, or caspase activation

Journal of Experimental Medicine

Volumn 194, Issue 2, 2001, Pages 113-125

  Liu, Hongtao ^a   Perlman, Harris ^a   Pagliari, Lisa J ^a   Pope, Richard M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell death; Dominant negative Akt 1; Mitochondrial transmembrane potential; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTISENSE OLIGONUCLEOTIDE; CASPASE 3; CASPASE 9; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN MCL 1; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMOSOME 10; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE REPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CASPASES; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMONES; DNA PRIMERS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MACROPHAGES; MICE; MITOCHONDRIA; MONOCYTES; MORPHOLINES; NEOPLASM PROTEINS; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0035898449     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.2.113     Document Type: Article

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