Pistachio nuts: Composition and potential health benefits

Nutrition Reviews

Volumn 70, Issue 4, 2012, Pages 234-240

  Dreher, Mark L ^a  

^a Nutrition Science Solutions   (United States)

Author keywords

Cardiovascular health; Lutein; Monounsaturated fat; Phytosterols; Weight control

Indexed keywords

ANTHOCYANIN; BETA CAROTENE; C REACTIVE PROTEIN; CAROTENOID; GAMMA TOCOPHEROL; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN; MAGNESIUM; OLEIC ACID; PHYTOSTEROL; PLANT MEDICINAL PRODUCT; POTASSIUM; PROTEIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNSATURATED FATTY ACID; VITAMIN K GROUP; XANTHOPHYLL;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BILE ACID METABOLISM; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BODY MASS; CALORIC INTAKE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DIETARY FIBER; ENERGY METABOLISM; FOOD COMPOSITION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART PROTECTION; HUMAN; LIPID BLOOD LEVEL; NON INSULIN DEPENDENT DIABETES MELLITUS; PISTACHIO; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT CONTROL;

ANTIOXIDANTS; BLOOD GLUCOSE; BODY WEIGHT; CARDIOVASCULAR DISEASES; HUMANS; NUTRITIVE VALUE; PHYTOSTEROLS; PISTACIA;

PISTACIA VERA;

EID: 84859125506     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2011.00467.x     Document Type: Review

References (94)

1. Salas-Salvado J, Casas-Agustench P, Salas-Huetos A. Cultural and historical aspects of Mediterranean nuts with emphasis on their attributed healthy and nutritional properties. Nutr Metab Cardiov Dis 2011;21(Suppl 1):S1-S6.
2. Heber D, Bowerman S. The pistachio: a surprising and colorful nut. Nutr Today 2008;43:36-40.
3. King JC, Blumberg J, Ingwersen L, etal. Tree nuts and peanuts as components of a healthy diet. J Nutr 2008;138:S1736-S1740.
4. th ed. Washington, DC: US Dept of Agriculture and US Dept of Health and Human Services; 2010.
5. Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. Part D. Section 3: Fatty Acids and Cholesterol. Washington, DC: US Dept of Agriculture and Dept of Health and Human Services; 2010: D3-41-D3-44.
6. Ros E, Tapsell LC, Sabaté J. Nuts and berries for heart health. Curr Atheroscler Rep 2010;12:397-406.
7. Kris-Etherton PM, Hu FB, Ros E, etal. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr 2008;138:S1746-S1751.
8. Sabaté J, Ang Y. Nuts and health outcomes: new epidemiologic evidence. Am J Clin Nutr 2009;89:S1643-S1648.
9. Lloyd-Jones DM, Hong Y, Labarthe D, etal. Defining and setting national goals for strategic impact goal through 2020 and beyond. Circulation 2010;121:586-613.
10. Lin C-TJ, Yen ST. Knowledge of dietary fats among US consumers. J Am Diet Assoc 2010;110:613-618.
11. US Food and Drug Administration. Letter of Enforcement Discretion - Nuts and Coronary Heart Disease. Qualified Health Claim. College Park, MD: US Food and Drug Administration. Center for Food Safety and Applied Nutrition. Office of Nutritional Products, Labeling and Dietary Supplements. Docket No. 02P-0505; 2003. Available at: Accessed 11 February 2012.
12. US Food and Drug Administration. Letter of Enforcement Discretion - Walnuts and Coronary Heart Disease. Qualified Health Claim. College Park, MD: US Food and Drug Administration. Center for Food Safety and Applied Nutrition. Office of Nutritional Products, Labeling and Dietary Supplements. Docket No. 02P-029; 2004. Available at: Accessed 12 February 2012.
13. US Department of Agriculture, Agricultural Research Service. USDA National Nutrient Database for Standard Reference, Release 24. Pistachios (dry roasted, with salt added) (NDB no. 12652), almonds (raw [NDB no. 12061], blanched [NDB no. 12062], dry roasted, with salt added [NDB no. 12563]), walnuts (English) (NDB no. 12155). Beltsville, MD: Agricultural Research Service, US Dept of Agriculture; 2011. Available at: Accessed 11 February 2012.
14. Sari I, Baltaci Y, Bagci C, etal. Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: a prospective study. Nutrition 2010;26:399-404.
15. Gebauer SK, West SG, Kay CD, etal. Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study. Am J Clin Nutr 2008;88:651-659.
16. Sheridan MJ, Cooper JN, Erario M, etal. Pistachio nut consumption and serum lipid levels. J Am Coll Nutr 2007;26:141-148.
17. Edwards K, Kwaw I, Matud J, etal. Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. J Am Coll Nutr 1999;18:229-232.
18. Kocyigit A, Koylu AA, Keles H. Effects of pistachio nuts consumption on plasma lipid profile and oxidative status in healthy volunteers. Nutr Metab Cardiovasc Dis 2006;16:202-209.
19. Aldemir M, Okulu E, Neselioglu S, etal. Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int J Impot Res 2011;23:32-38.
20. Baer DJ, Gebauer SK, Novotny JA. Measured energy value of pistachios in the human diet. Br J Nutr 2012;107:120-125.
21. Mustad VA, Etherton TD, Cooper AD, etal. Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women. J Lipid Res 1997;38:459-468.
22. Berglund L, Lefevre M, Ginsberg HN, etal. Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. Am J Clin Nutr 2007;86:1611-1620.
23. Segura R, Javierre C, Lizarraga A, etal. Other relevant components of nuts: phytosterols, folate and minerals. Br J Nutr 2008;96(Suppl 2):S36-S44.
24. Phillips KM, Ruggio DM, Ashraf-Khorassani M. Phytosterol composition of nuts and seeds commonly consumed in the United States. J Agric Food Chem 2005;53:9436-9466.
25. Racette SB, Spearie CA, Phillips KM, etal. Phytosterol-deficient and high-phytosterol diets developed for controlled feeding studies. J Am Diet Assoc 2009;109:2043-2051.
26. Ostlund RE. Phytosterols, cholesterol absorption and healthy diets. Lipids 2007;42:41-45.
27. Lichtenstein AH, Deckelbaum RJ. AHA Science Advisory. Stanol/sterol ester-containing foods and blood cholesterol levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation 2001;103:1177-1179.
28. Law D. Plant sterol and stanol margarines and health. BMJ 2000;320:861-864.
29. Katan MB, Grundy SM, Jones P, etal. Efficacy and safety of plant stanols and sterols in management of blood cholesterol levels. Mayo Clin Proc 2003;78:965-978.
30. Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F. New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2009;203:18-31.
31. Ostlund RE, Racette SB, Okeke A, etal. Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am J Clin Nutr 2002;75:1000-1004.
32. Ostlund RE, Racette SB, Stenson WF. Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ. Am J Clin Nutr 2003;77:1385-1389.
33. Lin X, Ma L, Racette SB, etal. Phytosterol glycosides reduce cholesterol absorption in humans. Am J Physiol Gastrointest Liver Physiol 2009;296:G931-G935.
34. Racette SB, Lin X, Lefevre M, etal. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr 2010;91:32-38.
35. Escurriol V, Cofan M, Serra M, etal. Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet. Eur J Nutr 2009;48:373-382.
36. Lin X, Racette SB, Lefevre M, etal. The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial. Eur J Clin Nutr 2010;64:1481-1487.
37. US Department of Health and Human Services. 21 CFR Part 101. Food Labeling; Health Claim; Phytosterols and Risk of Coronary Heart Disease. Proposed Rule. College Park, MD: US Food and Drug Administration. Center for Food Safety and Applied Nutrition. Federal Register 2010;75 (no. 235):76526-76570.
38. Salas-Salvado J, Bullo M, Perez-Heras A, etal. Dietary fibre, nuts and cardiovascular diseases. Br J Nutr 2006;96(Suppl 2):S45-S51.
39. Liu S, Buring JE, Sesso HD, etal. A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol 2002;39:49-56.
40. Wolfe BM, Giovannetti PM. Short-term effects of substituting protein for carbohydrate in the diets of moderately hypercholesterolemic human subjects. Metabolism 1991;40:338-343.
41. Bernstein AM, Sun Q, Hu FB, etal. Major dietary protein sources and risk of coronary heart disease in women. Circulation 2010;122:876-883.
42. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. 1997. Washington, DC: National Academy Press.
43. Champagne CM. Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review. Nutr Clin Pract 2008;23:142-151.
44. Al-Delaimy WK, Rimm EB, Willett WC, etal. Magnesium intake and risk of coronary heart disease among men. J Am Coll Nutr 2004;23:63-70.
45. Kishimoto Y, Tani M, Uto-Kondo H, etal. Effects of magnesium on postprandial serum lipid response in healthy human subjects. Br J Nutr 2009;103:469-472.
46. US Department of Agriculture. Database for the oxygen radical absorbance capacity (ORAC) of selected foods, release 2. Nutrient Data Laboratory [updated May 2010]. Available at: Accessed 24 February 2012.
47. Bolling BW, McKay DL, Blumberg JB. The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr 2010;19:117-123.
48. Kay CD, Sarah K, Gebauer SK, etal. Pistachios increase serum antioxidants and lower serum oxidized-LDL in hypercholesterolemic adults. J Nutr 2010;140:1093-1098.
49. McNulty H, Jacob RF, Mason RP. Biologic activity of carotenoids related to distinct membrane physiochemical interactions. Am J Cardiol 2008;101:20D-29D.
50. Koh WP, Yuan JM, Wang R, etal. Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study. Nutr Metab Cardiovasc Dis 2011;21:685-690.
51. Karppi J, Numi KJ, Rissanen TH, etal. Lycopene, lutein, and beta carotene as determinants of LDL conjugated dienes in serum. Atherosclerosis 2009;209:565-572.
52. Dietrich M, Traber MG, Jacques PF, etal. Does γ-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr 2006;25:292-299.
53. Jiang Q, Moreland M, Ames BN, etal. A combination of aspirin and gamma-tocopherol is better than that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuating aspirin-caused adverse effects. J Nutr Biochem 2009;20:894-900.
54. Hernandez LM. Effect of consuming pistachios on dietary intakes and serum concentrations of γ-tocopherol and magnesium and on serum lipid profile in adults [dissertation 3399056:61-67]. Denton, TX: Texas Woman's University; 2009.
55. Heiss C, Keen CL, Kelm M. Flavanols and cardiovascular disease prevention. Eur Heart J 2010;31:2583-2592.
56. Hooper L, Kroon PA, Rimm EB, etal. Flavonoids, flavonoid-rich foods, and cardiovascular risk: meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88:38-50.
57. Nicholson SK, Tucker GA, Brameld JM. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc 2008;67:42-47.
58. Hodgson JM, Croft KD. Dietary flavonoids: effects on endothelial function and blood pressure. J Sci Food Agric 2006;86:2492-2498.
59. Fito M, Guxens M, Corella D, etal. Effect of a traditional Mediterranean diet on lipoprotein oxidation. Arch Intern Med 2007;167:1195-1203.
60. Institute of Medicine. Panel on Dietary Reference Intakes for Electrolytes and Water, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Water, Potassium, Sodium Chloride and Sulfate. Washington DC: National Academies Press; 2004;186-255.
61. US Food and Drug Administration. Potassium and the risk of high blood pressure and stroke. Health Claim. College Park, MD: Center for Food Safety and Applied Nutrition. Office of Nutritional Products, Labeling and Dietary Supplements US Food and Drug Administration. Docket No. OOQ-1582; 2000. Available at: Accessed 12 February 2012.
62. Myers VH, Champagne CM. Nutritional effects on blood pressure. Curr Opin Lipidol 2007;18:20-24.
63. Khaw KT, Thom S. Randomized double-blind crossover trial of potassium on blood pressure in normal subjects. Lancet 2001;982:1127-1129.
64. Braschi A, Naismith DJ. The effect of a dietary supplement of potassium or potassium citrate on blood pressure in predominately normotensive volunteers. Br J Nutr 2008;99:1284-1292.
65. Chang HY, Hu YW, Yue CS. Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men. Am J Clin Nutr 2006;83:1289-1296.
66. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14.
67. Barrett-Connor E, Wingard DL. Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol 1983;118:489-496.
68. Pan WH, Cedres LB, Liu K, etal. Relationship of clinical diabetes and asymptomatic hyperglycemia to risk of coronary heart disease mortality in men and women. Am J Epidemiol 1986;123:504-516.
69. Adeghate E, Schattner P, Dunn E. An update on the etiology and epidemiology of diabetes mellitus. Ann N Y Acad Sci 2006;1084:1-29.
70. Kannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care 1979;2:120-126.
71. Shichiri M, Kishikawa H, Ohkubo Y, etal. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 2000;23(Suppl 2):B21-B29.
72. Stratton IM, Adler AI, Neil HA, etal. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-412.
73. Gaede P, Vedel P, Larsen N, etal. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003;348:383-393.
74. Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 2007;86:S836-S842.
75. Xue F, Michels KB. Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am J Clin Nutr 2007;86:S823-S835.
76. Shaffer EA. Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 2006;20:981-996.
77. Kochar J, Gaziano JM, Djoussé L. Nut consumption and risk of type II diabetes in the Physicians' Health Study. Eur J Clin Nutr 2010;64:75-79.
78. Sabaté J, Salas-Salvadó J, Ros E. Nuts: nutrition and health outcomes. Br J Nutr 2006;96(Suppl 2):S1-S2.
79. King JC, Rechkemmer G, Geiger CJ. Second International Nuts and Health Symposium, 2007; Introduction. J Nutr 2008;138(Suppl):S1734-S1765.
80. Nash SD, Nash DT. Nuts as part of a healthy cardiovascular diet. Curr Atheroscler Rep 2008;10:529-535.
81. Casas-Agustench P, López-Uriarte P, Bulló M, etal. Effects of one serving of mixed nuts on serum lipids, insulin resistance and inflammatory markers in patients with the metabolic syndrome. Nutr Metab Cardiovasc Dis 2011;21:126-135.
82. Kendall CWC, Josse AR, Esfahani A, etal. The impact of pistachio intake alone or in combination with high-carbohydrate foods on post-prandial glycemia. Eur J Clin Nutr 2011;65:696-702.
83. Pi-Sunyer FX. The medical risks of obesity. Postgrad Med 2009;121:21-33.
84. Mattes RD, Kris-Etherton PM, Foster GD. Impact of peanuts and tree nuts on body weight and healthy weight loss in adults. J Nutr 2008;138:S1741-S1745.
85. Mattes RD, Dreher ML. Nuts and healthy body weight maintenance mechanisms. Asia Pac J Clin Nutr 2010;19:137-141.
86. Bes-Rastrollo M, Sabaté J, Gómez-Gracia E, etal. Nut consumption and weight gain in a Mediterranean cohort: the SUN Study. Obesity 2007;15:107-116.
87. Bes-Rastrollo M, Wedick NM, Martínez-González MA, etal. Prospective study of nut consumption, long-term weight change, and obesity risk in women. Am J Clin Nutr 2009;89:1913-1919.
88. Casas-Agustench P, Bulló M, Ros E, etal. Cross-sectional association of nut intake with adiposity in a Mediterranean population. Nutr Metab Cardiovasc Dis 2011;21:518-525.
89. Mozaffarian D, Hao T, Rimm EB, etal. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 2011;364:2392-2404.
90. Zhaoping LL, Song R, Nguyen C, etal. Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program. J Am Coll Nutr 2010;29:198-203.
91. Kirkmeyer SV, Mattes RD. Effects of food attributes on hunger and food intake. Int J Obes Relat Metab Disord 2000;24:1167-1175.
92. Kennedy-Hagan K, Painter JE, Honselman CS, etal. The effect of pistachio shells as a visual cue in reducing caloric consumption. Appetite 2011;57:418-420.
93. Honselman CS, Painter JE, Kennedy-Hagan KJ, etal. In-shell pistachio nuts reduce caloric intake compared to shelled nuts. Appetite 2011;57:414-417.
94. Trivedi B. The calorie delusion. New Sci 2009;2717:203-205.