Dose effects of dietary phytosterols on cholesterol metabolism: A controlled feeding study

American Journal of Clinical Nutrition

Volumn 91, Issue 1, 2010, Pages 32-38

  Racette, Susan B ^a   Lin, Xiaobo ^a   Lefevre, Michael ^b   Spearie, Catherine Anderson ^a   Most, Marlene M ^b   Ma, Lina ^a   Ostlund Jr , Richard E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; PLACEBO; STABLE ISOTOPE;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; DIET SUPPLEMENTATION; DIETARY INTAKE; FECES; FEEDING; FEMALE; FOOD PROCESSING; HEPATOBILIARY SYSTEM; HUMAN; INTESTINE ABSORPTION; KITCHEN; LIPOPROTEIN BLOOD LEVEL; MALE; MEAL; NUTRITIONAL DEFICIENCY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TREATMENT DURATION; ADOLESCENT; BLOOD; BLOOD PRESSURE; BODY MASS; METABOLISM; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; BLOOD PRESSURE; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIET; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MIDDLE AGED; PHYTOSTEROLS; YOUNG ADULT;

EID: 74049140808     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.28070     Document Type: Article

References (37)

1. Normén L, Dutta P, Lia A, Andersson H. Soy sterol esters and betasitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am J Clin Nutr 2000;71:908-13.
2. Piironen V, Lindsay DG, Miettinen TA, Toivo J, Lampi AM. Plant sterols: biosynthesis, biological function and their importance to human nutrition. J Sci Food Agric 2000;80:939-66.
3. Ostlund RE Jr. Phytosterols in human nutrition. Annu Rev Nutr 2002;22: 533-49.
4. Peterson DW. Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc Soc Exp Biol Med 1951;78:143-7.
5. Pollak OJ. Reduction of blood cholesterol in man. Circulation 1953;7: 702-6.
6. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
7. Nair PP, Turjman N, Kessie G, et al. Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Dietary cholesterol, beta-sitosterol, and stigmasterol. Am J Clin Nutr 1984;40: 927-30.
8. Racette SB, Spearie CA, Phillips KM, Lin X, Ma L, Ostlund RE. Phytosterol-deficient and high-phytosterol diets developed for controlled feeding studies. J Am Diet Assoc (in press).
9. Weihrauch JL, Gardner JM. Sterol content of foods of plant origin. J Am Diet Assoc 1978;73:39-47.
10. Piironen V, Toivo J, Lampi AM. Natural sources of dietary plant sterols. J Food Comp Anal 2000;13:619-24.
11. Normén L, Bryngelsson S, Johnsson M, et al. The phytosterol content of some cereal foods commonly consumed in Sweden and in the Netherlands. J Food Comp Anal 2002;15:693-704.
12. Abidi SL. Chromatographic analysis of plant sterols in foods and vegetable oils. J Chromatogr A 2001;935:173-201.
13. Ostlund RE Jr, Racette SB, StensonWF. Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ. Am J Clin Nutr 2003;77:1385-9.
14. US Department of Health and Human Services, US Department of Agriculture. Dietary guidelines for Americans. Washington, DC: US Government Printing Office; 2005.
15. Harris JA, Benedict FG. A biometric study of basal metabolism in man. Washington, DC: Carnegie Institute of Washington; 1919.
16. Food and Agricultural Organization/World Health Organization/United Nations University. Energy and protein requirements. Report of a Joint FAO/WHO/UNU Expert Consultation. Geneva, Switzerland: WHO, 1985:1-206.
17. Crouse JR, Grundy SM. Evaluation of a continuous isotope feeding method for measurement of cholesterol absorption in man. J Lipid Res 1978;19:967-71.
18. Lutjohann D, Meese CO, Crouse JR III, von Bergmann K. Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans. J Lipid Res 1993;34:1039-46.
19. Miettinen TA, Tilvis RS, Kesäniemi YA. Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism 1989;38:136-40.
20. Warnick GR, Benderson J, Albers JJ. Dextran sulfate-Mg 2+ precipitation procedure for quantification of high-density lipoprotein cholesterol. Clin Chem 1982;28:1379-88.
21. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
22. Salen G, Ahrens EH Jr, Grundy SM. Metabolism of beta-sitosterol in man. J Clin Invest 1970;49:952-67.
23. Jenkins DJ, Kendall CW, Popovich DG, et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism 2001;50:494-503.
24. Cuchel M, Rader DJ. Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?. Circulation 2006;113:2548-55.
25. Nestel P, Cehun M, Pomeroy S, Abbey M, Weldon G. Cholesterollowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods. Eur J Clin Nutr 2001;55:1084-90.
26. Demonty I, Ras RT, van der Knaap HCM, et al. Continuous Dose-Response Relationship of the LDL-Cholesterol-Lowering Effect of Phytosterol Intake. J Nutr 2009;139:271-84.
27. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R. Ef-ficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003;78:965-78.
28. Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006;114:82-96.
29. Pelletier X, Belbraouet S, Mirabel D, et al. A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann Nutr Metab 1995;39:291-5.
30. Kurokawa M, Masuda Y, Noda M, et al. Minimal effective dose on serum cholesterol concentration and the safety evaluation of dressing containing plant sterol in Japanese subjects. J Oleo Sci 2008;57:23-33.
31. Sierksma A, Weststrate JA, Meijer GW. Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. Br J Nutr 1999; 82:273-82.
32. US Food and Drug Administration. Code of Federal Regulations. Title 21, Volume 2-Food and Drugs, 2008.
33. Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C. Metabolic syndrome, low-density lipoprotein cholesterol, and risk of cardiovascular disease: a population-based study. Atherosclerosis 2006; 189:369-74.
34. Ingelsson E, Schaefer EJ, Contois JH, et al. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. JAMA 2007;298:776-85.
35. Weingärtner O, Lütjohann D, Ji S, et al. Vascular effects of diet supplementation with plant sterols. J Am Coll Cardiol 2008;51:1553-61.
36. Schoenhagen P, Tuzcu EM, Apperson-Hansen C, et al. Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial. Circulation 2006;113:2826-34.
37. Mensink RP, Katan MB. Effect of dietary trans fatty acids on highdensity and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 1990;323:439-45.