메뉴 건너뛰기




Volumn 44, Issue 2, 2012, Pages 166-180

Pharmacogenetic screening for drug therapy: From single gene markers to decision making in the next generation sequencing era

Author keywords

Genome wide association studies; Individualised drug therapy; Next generation sequencing; Pharmacogenetics

Indexed keywords


EID: 84858322966     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e32834f4d69     Document Type: Article
Times cited : (17)

References (246)
  • 1
    • 49749154208 scopus 로고
    • Familial incidence of low pseudocholinesterase level
    • Kalow W. Familial incidence of low pseudocholinesterase level. Lancet 1956; 268: 576-7.
    • (1956) Lancet , vol.268 , pp. 576-577
    • Kalow, W.1
  • 2
    • 0014383735 scopus 로고
    • Genetic control of dicumarol levels in man
    • Vesell ES, Page JG. Genetic control of dicumarol levels in man. J Clin Invest 1968; 47: 2657-63.
    • (1968) J Clin Invest , vol.47 , pp. 2657-2663
    • Vesell, E.S.1    Page, J.G.2
  • 4
    • 78951495386 scopus 로고    scopus 로고
    • Why, when, and how should pharmacogenetics be applied in clinical studies?: Current and future approaches to study designs
    • Stingl Kirchheiner JC, Brockmoller J. Why, when, and how should pharmacogenetics be applied in clinical studies?: current and future approaches to study designs. Clin Pharmacol Ther 2011; 89: 198-209.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 198-209
    • Stingl Kirchheiner, J.C.1    Brockmoller, J.2
  • 7
    • 77954365622 scopus 로고    scopus 로고
    • Pharmacogenetics of drug hypersensitivity
    • Phillips EJ, Mallal SA. Pharmacogenetics of drug hypersensitivity. Pharmacogenomics 2011; 11: 973-87.
    • (2011) Pharmacogenomics , vol.11 , pp. 973-987
    • Phillips, E.J.1    Mallal, S.A.2
  • 8
    • 77949619309 scopus 로고    scopus 로고
    • HLA: A pharmacogenomics success story
    • Becquemont L. HLA: a pharmacogenomics success story. Pharmacoge-nomics 2011; 11: 277-81.
    • (2011) Pharmacoge-nomics , vol.11 , pp. 277-281
    • Becquemont, L.1
  • 9
    • 34547618083 scopus 로고    scopus 로고
    • Drinking from the fire hose - Statistical issues in genomewide association studies
    • DOI 10.1056/NEJMp078120
    • Hunter DJ, Kraft P. Drinking from the fire hose - Statistical issues in genomewide association studies. N Engl J Med 2007; 357: 436-9. (Pubitemid 47204871)
    • (2007) New England Journal of Medicine , vol.357 , Issue.5 , pp. 436-439
    • Hunter, D.J.1    Kraft, P.2
  • 10
    • 77951589703 scopus 로고    scopus 로고
    • Clinical assessment incorporating a personal genome
    • Ashley EA, Butte AJ, Wheeler MT, et al. Clinical assessment incorporating a personal genome. Lancet 2010; 375: 1525-35.
    • (2010) Lancet , vol.375 , pp. 1525-1535
    • Ashley, E.A.1    Butte, A.J.2    Wheeler, M.T.3
  • 11
    • 71749100887 scopus 로고    scopus 로고
    • A practical guide to interpretation and clinical application of personal genomic screening
    • Edelman E, Eng C. A practical guide to interpretation and clinical application of personal genomic screening. BMJ 2009; 339: b4253.
    • (2009) BMJ , vol.339
    • Edelman, E.1    Eng, C.2
  • 12
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med 2011; 363: 166-76.
    • (2011) N Engl J Med , vol.363 , pp. 166-176
    • Manolio, T.A.1
  • 13
    • 77952101271 scopus 로고    scopus 로고
    • Challenges in the clinical application of whole-genome sequencing
    • Ormond KE, Wheeler MT, Hudgins L, et al. Challenges in the clinical application of whole-genome sequencing. Lancet 2011; 375: 1749-51.
    • (2011) Lancet , vol.375 , pp. 1749-1751
    • Ormond, K.E.1    Wheeler, M.T.2    Hudgins, L.3
  • 14
    • 78049234740 scopus 로고    scopus 로고
    • Genomic risk prediction
    • Sandhu M, Wood A, Young E. Genomic risk prediction. Lancet 2011; 376: 1366-7.
    • (2011) Lancet , vol.376 , pp. 1366-1367
    • Sandhu, M.1    Wood, A.2    Young, E.3
  • 16
    • 33644840600 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia: A model for the pharmacogenomics of cancer therapy
    • DOI 10.1038/nrc1800, PII N1800
    • Cheok MH, Evans WE. Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy. Nat Rev Cancer 2006; 6: 117-29. (Pubitemid 43361544)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.2 , pp. 117-129
    • Cheok, M.H.1    Evans, W.E.2
  • 17
    • 50249142263 scopus 로고    scopus 로고
    • A pharmacogenomics primer
    • Court MH. A pharmacogenomics primer. J Clin Pharmacol 2007; 47: 1087-103.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1087-1103
    • Court, M.H.1
  • 19
    • 76749143669 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and tamoxifen metabolism: Clinical relevance
    • Higgins MJ, Stearns V. CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep 2011; 12: 7-15.
    • (2011) Curr Oncol Rep , vol.12 , pp. 7-15
    • Higgins, M.J.1    Stearns, V.2
  • 20
    • 67749114265 scopus 로고    scopus 로고
    • CYP2D6 and tamoxifen: DNA matters in breast cancer
    • Hoskins JM, Carey LA, McLeod HL. CYP2D6 and tamoxifen: DNA matters in breast cancer. Nat Rev Cancer 2009; 9: 576-86.
    • (2009) Nat Rev Cancer , vol.9 , pp. 576-586
    • Hoskins, J.M.1    Carey, L.A.2    McLeod, H.L.3
  • 21
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • DOI 10.1038/sj.tpj.6500285
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 2005; 5: 6-13. (Pubitemid 40220611)
    • (2005) Pharmacogenomics Journal , vol.5 , Issue.1 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 22
    • 23844516328 scopus 로고    scopus 로고
    • Pharmacogenetics-based therapeutic recommendations - Ready for clinical practice?
    • DOI 10.1038/nrd1801
    • Kirchheiner J, Fuhr U, Brockmöller J. Pharmacogenetics-based therapeutic recommendationsready for clinical practice? Nat Rev Drug Discov 2005; 4: 639-47. (Pubitemid 41149757)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.8 , pp. 639-647
    • Kirchheiner, J.1    Fuhr, U.2    Brockmoller, J.3
  • 23
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • DOI 10.1038/sj.mp.4001494
    • Kirchheiner J, Nickchen K, Bauer M, et al. Pharmacogenetics of anti-depressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry 2004; 9: 442-73. (Pubitemid 38903502)
    • (2004) Molecular Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.-L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 24
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • DOI 10.1007/s00210-003-0832-2
    • Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 2004; 369: 23-37. (Pubitemid 38161221)
    • (2004) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.369 , Issue.1 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 25
    • 70449371633 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II
    • Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet 2009; 48: 761-804.
    • (2009) Clin Pharmacokinet , vol.48 , pp. 761-804
    • Zhou, S.F.1
  • 26
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part i
    • Zhou SF. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet 2009; 48: 689-723.
    • (2009) Clin Pharmacokinet , vol.48 , pp. 689-723
    • Zhou, S.F.1
  • 29
    • 4344613464 scopus 로고    scopus 로고
    • Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    • DOI 10.1373/clinchem.2003.030825
    • Steimer W, Zopf K, von AS, et al. Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers. Clin Chem 2004; 50: 1623-33. (Pubitemid 39121231)
    • (2004) Clinical Chemistry , vol.50 , Issue.9 , pp. 1623-1633
    • Steimer, W.1    Zopf, K.2    Von Amelunxen, S.3    Pfeiffer, H.4    Bachofer, J.5    Popp, J.6    Messner, B.7    Kissling, W.8    Leucht, S.9
  • 30
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmöller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997; 60: 284-95. (Pubitemid 27058401)
    • (1997) American Journal of Human Genetics , vol.60 , Issue.2 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 32
    • 0023773272 scopus 로고
    • The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole
    • Jordan VC. The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole. Breast Cancer Res Treat 1988; 11: 197-209.
    • (1988) Breast Cancer Res Treat , vol.11 , pp. 197-209
    • Jordan, V.C.1
  • 33
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. The Lancet 2005; 365: 1687-717.
    • (2005) The Lancet , vol.365 , pp. 1687-1717
  • 35
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005; 20: 9312-8.
    • (2005) J Clin Oncol , vol.20 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 40
    • 79551604866 scopus 로고    scopus 로고
    • Pharmacogenetics of endocrine therapy for breast cancer
    • Higgins MJ, Stearns V. Pharmacogenetics of endocrine therapy for breast cancer. Annu Rev Med 2011; 62: 281-93.
    • (2011) Annu Rev Med , vol.62 , pp. 281-293
    • Higgins, M.J.1    Stearns, V.2
  • 41
    • 77955661193 scopus 로고    scopus 로고
    • Orally administered endoxifen is a new therapeutic agent for breast cancer
    • Ahmad A, Ali SM, Ahmad MU, Sheikh S, Ahmad I. Orally administered endoxifen is a new therapeutic agent for breast cancer. Breast Cancer Res Treat 2011; 122: 579-84.
    • (2011) Breast Cancer Res Treat , vol.122 , pp. 579-584
    • Ahmad, A.1    Ali, S.M.2    Ahmad, M.U.3    Sheikh, S.4    Ahmad, I.5
  • 42
    • 54349116753 scopus 로고    scopus 로고
    • Drug interactions and pharmacogenomics in the treatment of breast cancer and depression
    • Henry NL, Stearns V, Flockhart DA, Hayes DF, Riba M. Drug interactions and pharmacogenomics in the treatment of breast cancer and depression. Am J Psychiatry 2008; 165: 1251-5.
    • (2008) Am J Psychiatry , vol.165 , pp. 1251-1255
    • Henry, N.L.1    Stearns, V.2    Flockhart, D.A.3    Hayes, D.F.4    Riba, M.5
  • 43
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype,antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y, Desta Z,Stearns V, et al. CYP2D6 genotype,antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 2005; 97: 30-9.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Jin, Y.1    Desta Zstearns, V.2
  • 44
    • 76649089656 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: A population based cohort study
    • Kelly CM, Juurlink DN, Gomes T, et al. Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ 2010; 340: c693.
    • (2010) BMJ , vol.340
    • Kelly, C.M.1    Juurlink, D.N.2    Gomes, T.3
  • 46
    • 79952838781 scopus 로고    scopus 로고
    • CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark
    • Lash TL, Cronin-Fenton D, Ahern TP, et al. CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark. J Natl Cancer Inst 2011; 103: 489-500.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 489-500
    • Lash, T.L.1    Cronin-Fenton, D.2    Ahern, T.P.3
  • 47
    • 77950893913 scopus 로고    scopus 로고
    • Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen
    • Lash TL, Cronin-Fenton D, Ahern TP, et al. Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen. Acta Oncol 2010; 49: 305-12.
    • (2010) Acta Oncol , vol.49 , pp. 305-312
    • Lash, T.L.1    Cronin-Fenton, D.2    Ahern, T.P.3
  • 48
    • 38749113914 scopus 로고    scopus 로고
    • Pharmacogenomics of tamoxifen and aromatase inhibitors
    • DOI 10.1002/cncr.23192
    • Ingle JN. Pharmacogenomics of tamoxifen and aromatase inhibitors. Cancer 2008; 112: 695-9. (Pubitemid 351186391)
    • (2008) Cancer , vol.112 , Issue.SUPPL. 3 , pp. 695-699
    • Ingle, J.N.1
  • 49
    • 80053153296 scopus 로고    scopus 로고
    • The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: A systematic review
    • Fleeman N, Martin Saborido C, Payne K, et al. The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review. Health Technol Assess 2011; 15: 1-102.
    • (2011) Health Technol Assess , vol.15 , pp. 1-102
    • Fleeman, N.1    Martin Saborido, C.2    Payne, K.3
  • 51
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid NA, Kurihara A, Wrighton SA. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol 2010; 50: 126-42.
    • (2010) J Clin Pharmacol , vol.50 , pp. 126-142
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3
  • 52
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopido-grel: A possible mechanism for clopidogrel resistance
    • Kim KA, Park PW, Hong SJ, Park JY. The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopido-grel: a possible mechanism for clopidogrel resistance. Clin Pharmacol Ther 2008; 84: 236-42.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 53
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • DOI 10.1182/blood-2006-04-013052
    • Hulot JS, Bura A, Villard E, et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006; 108: 2244-7. (Pubitemid 44497506)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6    Aiach, M.7    Lechat, P.8    Gaussem, P.9
  • 54
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet JP, Hulot JS, Pena A, et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 2009; 373: 309-17.
    • (2009) Lancet , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 55
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360: 354-62.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 56
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, O'Connell JR, Bliden KP, et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009; 302: 849-57.
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 57
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360: 363-75.
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 58
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    • Pare G, Mehta SR, Yusuf S, et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N Engl J Med 2010; 363: 1704-1714.
    • (2010) N Engl J Med , vol.363 , pp. 1704-1714
    • Pare, G.1    Mehta, S.R.2    Yusuf, S.3
  • 59
    • 84858999257 scopus 로고    scopus 로고
    • Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: Systematic review and meta-analysis
    • Bauer T, Bouman HJ, van Werkum JW, Ford NF, ten Berg JM, Taubert D. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ 2011; 343: d4588.
    • (2011) BMJ , vol.343
    • Bauer, T.1    Bouman, H.J.2    Van Werkum, J.W.3    Ford, N.F.4    Ten Berg, J.M.5    Taubert, D.6
  • 60
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010; 304: 1821-30.
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 62
    • 76649115043 scopus 로고    scopus 로고
    • Pharmacoge-netics of CYP2C19: Functional and clinical implications of a new variant CYP2C19 17
    • Li-Wan-Po A, Girard T, Farndon P, Cooley C, Lithgow J. Pharmacoge-netics of CYP2C19: functional and clinical implications of a new variant CYP2C19 17. Br J Clin Pharmacol 2010; 69: 222-30.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 222-230
    • Li-Wan-Po, A.1    Girard, T.2    Farndon, P.3    Cooley, C.4    Lithgow, J.5
  • 63
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 2010; 121: 512-8.
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 64
    • 67649645191 scopus 로고    scopus 로고
    • Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease
    • Varenhorst C, James S, Erlinge D, et al. Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease. Eur Heart J 2009; 30: 1744-52.
    • (2009) Eur Heart J , vol.30 , pp. 1744-1752
    • Varenhorst, C.1    James, S.2    Erlinge, D.3
  • 65
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms onoutcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms onoutcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 2010; 376: 1320-8.
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 66
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 2009; 119: 2553-60.
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 67
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 2002; 41: 913-58. (Pubitemid 35168437)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.12 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.-G.3    Flockhart, D.A.4
  • 68
    • 77957372907 scopus 로고    scopus 로고
    • Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopido-grel use: A nationwide cohort study
    • Charlot M, Ahlehoff O, Norgaard ML, et al. Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopido-grel use: a nationwide cohort study. Ann Intern Med 2010; 153: 378-386.
    • (2010) Ann Intern Med , vol.153 , pp. 378-386
    • Charlot, M.1    Ahlehoff, O.2    Norgaard, M.L.3
  • 69
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 2009; 301: 937-44.
    • (2009) JAMA , vol.301 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 70
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009; 374: 989-97.
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 71
    • 77950895115 scopus 로고    scopus 로고
    • Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: A cohort study
    • Ray WA, Murray KT, Griffin MR, et al. Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study. Ann Intern Med 2010; 152: 337-45.
    • (2010) Ann Intern Med , vol.152 , pp. 337-345
    • Ray, W.A.1    Murray, K.T.2    Griffin, M.R.3
  • 72
    • 70249144272 scopus 로고    scopus 로고
    • Risk of combining PPIs with thienopyridines: Fact or fiction?
    • Sibbing D, Kastrati A. Risk of combining PPIs with thienopyridines: fact or fiction? Lancet 2009; 374: 952-4.
    • (2009) Lancet , vol.374 , pp. 952-954
    • Sibbing, D.1    Kastrati, A.2
  • 73
    • 78650517232 scopus 로고    scopus 로고
    • Differential effects of ome-prazole and pantoprazole on the pharmacodynamics and pharmacoki-netics of clopidogrel in healthy subjects: Randomized, placebo-controlled, crossover comparison studies
    • Angiolillo DJ, Gibson CM, Cheng S, et al. Differential effects of ome-prazole and pantoprazole on the pharmacodynamics and pharmacoki-netics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther 2011; 89: 65-74.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 65-74
    • Angiolillo, D.J.1    Gibson, C.M.2    Cheng, S.3
  • 76
  • 78
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
    • DOI 10.1182/blood-2005-03-1108
    • Sconce EA, Khan TI, Wynne HA, et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 2005; 106: 2329-33. (Pubitemid 41510803)
    • (2005) Blood , vol.106 , Issue.7 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3    Avery, P.4    Monkhouse, L.5    King, B.P.6    Wood, P.7    Kesteven, P.8    Daly, A.K.9    Kamali, F.10
  • 80
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • The International Warfarin Pharmacogenetics Consortium
    • The International Warfarin Pharmacogenetics Consortium. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 2009; 360: 753-64.
    • (2009) N Engl J Med , vol.360 , pp. 753-764
  • 81
    • 49549107264 scopus 로고    scopus 로고
    • Pharmacogenetics of oral anticoagulants: A basis for dose individualization
    • Stehle S, Kirchheiner J, Lazar A, Fuhr U. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. Clin Pharmacokinet 2008; 47: 565-94.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 565-594
    • Stehle, S.1    Kirchheiner, J.2    Lazar, A.3    Fuhr, U.4
  • 83
    • 63449117825 scopus 로고    scopus 로고
    • A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    • Takeuchi F, McGinnis R, Bourgeois S, et al. A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet 2009; 5: e1000433.
    • (2009) PLoS Genet , vol.5
    • Takeuchi, F.1    McGinnis, R.2    Bourgeois, S.3
  • 84
    • 77951931834 scopus 로고    scopus 로고
    • Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements
    • Cadamuro J, Dieplinger B, Felder T, et al. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. Eur J Clin Pharmacol 2010; 66: 253-60
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 253-260
    • Cadamuro, J.1    Dieplinger, B.2    Felder, T.3
  • 85
    • 79953777152 scopus 로고    scopus 로고
    • Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters
    • Geisen C, Luxembourg B, Watzka M, et al. Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. Eur J Clin Pharmacol 2011; 67: 371-81.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 371-381
    • Geisen, C.1    Luxembourg, B.2    Watzka, M.3
  • 86
    • 77954915353 scopus 로고    scopus 로고
    • VKORC1-1639GA and CYP2C9 3 are the major genetic predictors of phenprocoumon dose requirement
    • Puehringer H, Loreth R, Klose G, et al. VKORC1-1639GA and CYP2C9 3 are the major genetic predictors of phenprocoumon dose requirement. Eur J Clin Pharmacol 2010; 66: 591-8.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 591-598
    • Puehringer, H.1    Loreth, R.2    Klose, G.3
  • 87
    • 64149087950 scopus 로고    scopus 로고
    • Counterpoint: Pharmacogenetic-based initial dosing of warfarin: Not ready for prime time
    • Eby CS. Counterpoint: Pharmacogenetic-based initial dosing of warfarin: Not ready for prime time. Clin Chem 2009; 55: 712-4.
    • (2009) Clin Chem , vol.55 , pp. 712-714
    • Eby, C.S.1
  • 88
    • 64149084499 scopus 로고    scopus 로고
    • Point: Use of pharmacogenetics in guiding treatment with warfarin
    • Wadelius M. Point: Use of pharmacogenetics in guiding treatment with warfarin. Clin Chem 2009; 55: 709-11.
    • (2009) Clin Chem , vol.55 , pp. 709-711
    • Wadelius, M.1
  • 89
    • 77951898626 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin
    • Kamali F, Wynne H. Pharmacogenetics of warfarin. Annu Rev Med 2010; 61: 63-75.
    • (2010) Annu Rev Med , vol.61 , pp. 63-75
    • Kamali, F.1    Wynne, H.2
  • 90
    • 77949462773 scopus 로고    scopus 로고
    • Pharmacogenetics of oral anticoagulant therapy
    • Schalekamp T, de Boer A. Pharmacogenetics of oral anticoagulant therapy. Curr Pharm Des 2010; 16: 187-203.
    • (2010) Curr Pharm des , vol.16 , pp. 187-203
    • Schalekamp, T.1    De Boer, A.2
  • 91
    • 79251489782 scopus 로고    scopus 로고
    • Pathology consultation on warfarin pharmacogenetic testing
    • Stack G. Pathology consultation on warfarin pharmacogenetic testing. Am J Clin Pathol 2011; 135: 13-9.
    • (2011) Am J Clin Pathol , vol.135 , pp. 13-19
    • Stack, G.1
  • 92
    • 34548456509 scopus 로고    scopus 로고
    • Beyond unfractionated heparin and warfarin: Current and future advances
    • DOI 10.1161/CIRCULATIONAHA.106.685974, PII 0000301720070731000015
    • Hirsh J, O'Donnell M, Eikelboom JW. Beyond unfractionated heparin and warfarin: current and future advances. Circulation 2007; 116: 552-60. (Pubitemid 47450264)
    • (2007) Circulation , vol.116 , Issue.5 , pp. 552-560
    • Hirsh, J.1    O'Donnell, M.2    Eikelboom, J.W.3
  • 93
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365: 981-92.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 94
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: mono-genic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32: 651-62. (Pubitemid 10061685)
    • (1980) American Journal of Human Genetics , vol.32 , Issue.5 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 95
    • 0035056404 scopus 로고    scopus 로고
    • Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase
    • Weinshilboum R. Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. Drug Metab Dispos 2001; 29: 601-5. (Pubitemid 32275544)
    • (2001) Drug Metabolism and Disposition , vol.29 , Issue.4 , pp. 601-605
    • Weinshilboum, R.1
  • 96
    • 3242724021 scopus 로고    scopus 로고
    • Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography
    • DOI 10.1258/0004563041201617
    • Ford LT, Cooper SC, Lewis MJ, Berg JD. Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography. Ann Clin Biochem 2004; 41: 303-8. (Pubitemid 38954879)
    • (2004) Annals of Clinical Biochemistry , vol.41 , Issue.4 , pp. 303-308
    • Ford, L.T.1    Cooper, S.C.2    Lewis, M.J.V.3    Berg, J.D.4
  • 97
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-caucasians and identification of novel TPMT variants
    • DOI 10.1097/01.fpc.0000114745.08559.db
    • Schaeffeler E, Fischer C, Brockmeier D, et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 2004; 14: 407-17. (Pubitemid 38971231)
    • (2004) Pharmacogenetics , vol.14 , Issue.7 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3    Wernet, D.4    Moerike, K.5    Eichelbaum, M.6    Zanger, U.M.7    Schwab, M.8
  • 98
    • 0024554561 scopus 로고
    • The purine path to chemotherapy
    • Elion GB. The purine path to chemotherapy. Science 1989; 244: 41-7. (Pubitemid 19130741)
    • (1989) Science , vol.244 , Issue.4900 , pp. 41-47
    • Elion, G.B.1
  • 99
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
    • Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 1995; 123: 132-42.
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3    Sutherland, L.R.4
  • 100
    • 3242885920 scopus 로고    scopus 로고
    • Efficacy and safety of thiopurinic immunomodulators (azathioprine and mercaptopurine) in steroid-dependent ulcerative colitis
    • DOI 10.1111/j.1365-2036.2004.02030.x
    • Lopez-Sanroman A, Bermejo F, Carrera E, Garcia-Plaza A. Efficacy and safetyofthiopurinic immunomodulators (azathioprine and mercaptopurine) in steroid-dependent ulcerative colitis. Aliment Pharmacol Ther 2004; 20: 161-6. (Pubitemid 38998213)
    • (2004) Alimentary Pharmacology and Therapeutics , vol.20 , Issue.2 , pp. 161-166
    • Lopez-Sanroman, A.1    Bermejo, F.2    Carrera, E.3    Garcia-Plaza, A.4
  • 101
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • DOI 10.1016/S0140-6736(08)60457-2, PII S0140673608604572
    • Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371: 1030-43. (Pubitemid 351389536)
    • (2008) The Lancet , vol.371 , Issue.9617 , pp. 1030-1043
    • Pui, C.-H.1    Robison, L.L.2    Look, A.T.3
  • 105
    • 27744461917 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
    • DOI 10.1111/j.1440-1746.2005.03832.x
    • Gearry RB, Barclay ML. Azathioprine and 6-mercaptopurine pharmaco-genetics and metabolite monitoring in inflammatory bowel disease. J Gastroenterol Hepatol 2005; 20: 1149-57. (Pubitemid 41602556)
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.8 , pp. 1149-1157
    • Gearry, R.B.1    Barclay, M.L.2
  • 108
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltansferase gene locus - Implications for clinical pharmacogenomics
    • DOI 10.1517/14622416.3.1.89
    • McLeod HL, Siva C. The thiopurine S-methyltransferase gene locus -implications for clinical pharmacogenomics. Pharmacogenomics 2002; 3: 89-98. (Pubitemid 34285242)
    • (2002) Pharmacogenomics , vol.3 , Issue.1 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 111
    • 77950387206 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; A pharmacogenomic test whose time has come
    • Ford LT, Berg JD. Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come. J Clin Pathol 2010; 63: 288-95.
    • (2010) J Clin Pathol , vol.63 , pp. 288-295
    • Ford, L.T.1    Berg, J.D.2
  • 113
    • 0033762202 scopus 로고    scopus 로고
    • Genotyping of eight thiopurine methyltransferase mutations: Three-color multiplexing 'Two-Color/Shared' anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design
    • Schütz E, von Ahsen N, Oellerich M. Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, 'Two-Color/Shared' anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design. Clin Chem 2000; 46: 1728-37.
    • (2000) Clin Chem , vol.46 , pp. 1728-1737
    • Schütz, E.1    Von Ahsen, N.2    Oellerich, M.3
  • 114
    • 79953201846 scopus 로고    scopus 로고
    • Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies
    • Donnan JR, Ungar WJ, Mathews M, Rahman P. Systematic review of thiopurine methyltransferase genotype and enzymatic testing strategies. Ther Drug Monit 2011; 33: 192-9.
    • (2011) Ther Drug Monit , vol.33 , pp. 192-199
    • Donnan, J.R.1    Ungar, W.J.2    Mathews, M.3    Rahman, P.4
  • 115
    • 79958830285 scopus 로고    scopus 로고
    • A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia
    • Donnan JR, Ungar WJ, Mathews M, Hancock-Howard RL, Rahman P. A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2011; 57: 231-9.
    • (2011) Pediatr Blood Cancer , vol.57 , pp. 231-239
    • Donnan, J.R.1    Ungar, W.J.2    Mathews, M.3    Hancock-Howard, R.L.4    Rahman, P.5
  • 116
    • 27744574836 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercapto-purine
    • Dubinsky MC, Reyes E, Ofman J, Chiou CF, Wade S, Sandborn WJ. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercapto-purine. Am J Gastroenterol 2005; 100: 2239-47.
    • (2005) Am J Gastroenterol , vol.100 , pp. 2239-2247
    • Dubinsky, M.C.1    Reyes, E.2    Ofman, J.3    Chiou, C.F.4    Wade, S.5    Sandborn, W.J.6
  • 117
    • 0036894866 scopus 로고    scopus 로고
    • Practical pharmacogenetics: The cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine
    • Marra CA, Esdaile JM, Anis AH. Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine. J Rheumatol 2002; 29: 2507-12. (Pubitemid 35416953)
    • (2002) Journal of Rheumatology , vol.29 , Issue.12 , pp. 2507-2512
    • Marra, C.A.1    Esdaile, J.M.2    Anis, A.H.3
  • 118
    • 1242297064 scopus 로고    scopus 로고
    • Pharmacoeconomic analysis of thiopurine methyltransferase polymorphism screening by polymerase chain reaction for treatment with azathioprine in Korea
    • DOI 10.1093/rheumatology/keh001
    • Oh KT, Anis AH, Bae SC. Pharmacoeconomic analysis of thiopurine methyltransferase polymorphism screening by polymerase chain reaction for treatment with azathioprine in Korea. Rheumatology (Oxford) 2004; 43: 156-63. (Pubitemid 38219668)
    • (2004) Rheumatology , vol.43 , Issue.2 , pp. 156-163
    • Oh, K.-T.1    Anis, A.H.2    Bae, S.-C.3
  • 119
    • 4644241129 scopus 로고    scopus 로고
    • Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease
    • DOI 10.1111/j.1365-2036.2004.02124.x
    • Winter J, Walker A, Shapiro D, Gaffney D, Spooner RJ, Mills PR. Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2004; 20: 593-599. (Pubitemid 39279046)
    • (2004) Alimentary Pharmacology and Therapeutics , vol.20 , Issue.6 , pp. 593-599
    • Winter, J.1    Walker, A.2    Shapiro, D.3    Gaffney, D.4    Spooner, R.J.5    Mills, P.R.6
  • 121
    • 26444447579 scopus 로고    scopus 로고
    • Thiopurine therapies: Problems, complexities, and progress with monitoring thioguanine nucleotides
    • DOI 10.1097/01.ftd.0000169061.52715.3e
    • Duley JA, Florin TH. Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides. Ther Drug Monit 2005; 27: 647-54. (Pubitemid 41437645)
    • (2005) Therapeutic Drug Monitoring , vol.27 , Issue.5 , pp. 647-654
    • Duley, J.A.1    Florin, T.H.J.2
  • 122
    • 0026465403 scopus 로고
    • High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantita-tion of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantita-tion of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992; 583: 83-90.
    • (1992) J Chromatogr , vol.583 , pp. 83-90
    • Lennard, L.1    Singleton, H.J.2
  • 123
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP- glucuronosyltransferase 1 in Gilbert's syndrome
    • Bosma PJ, Chowdhury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP- glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171-5.
    • (1995) N Engl J Med , vol.333 , pp. 1171-1175
    • Bosma, P.J.1    Chowdhury, J.R.2    Bakker, C.3
  • 124
    • 0034652640 scopus 로고    scopus 로고
    • Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans
    • Guillemette C, Millikan RC, Newman B, Housman DE. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Cancer Res 2000; 60: 950-6. (Pubitemid 30129531)
    • (2000) Cancer Research , vol.60 , Issue.4 , pp. 950-956
    • Guillemette, C.1    Millikan, R.C.2    Newman, B.3    Housman, D.E.4
  • 125
    • 0036148810 scopus 로고    scopus 로고
    • Polymorphisms of UDP-glucuronosyltransferase and pharmacokinetics of irinotecan
    • DOI 10.1097/00007691-200202000-00018
    • Ando Y, Ueoka H, Sugiyama T, Ichiki M, Shimokata K, Hasegawa Y. Polymorphisms of UDP-glucuronosyltransferase and pharmacokinetics of irinotecan. Ther Drug Monit 2002; 24: 111-6. (Pubitemid 34106739)
    • (2002) Therapeutic Drug Monitoring , vol.24 , Issue.1 , pp. 111-116
    • Ando, Y.1    Ueoka, H.2    Sugiyama, T.3    Ichiki, M.4    Shimokata, K.5    Hasegawa, Y.6
  • 128
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer L, King CD, Whitington PF, et al. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 1998; 101: 847-54. (Pubitemid 28096082)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.4 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 131
    • 77950921374 scopus 로고    scopus 로고
    • A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation
    • Cai H, Nguyen N, Peterkin V, et al. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos 2010; 38: 879-86.
    • (2010) Drug Metab Dispos , vol.38 , pp. 879-886
    • Cai, H.1    Nguyen, N.2    Peterkin, V.3
  • 132
    • 77954358129 scopus 로고    scopus 로고
    • Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: Results from North American Gastrointestinal Intergroup Trial N9741
    • McLeod HL, Sargent DJ, Marsh S, et al. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. J Clin Oncol 2010; 28: 3227-33.
    • (2010) J Clin Oncol , vol.28 , pp. 3227-3233
    • McLeod, H.L.1    Sargent, D.J.2    Marsh, S.3
  • 133
    • 48249145381 scopus 로고    scopus 로고
    • UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: A Dutch Colorectal Cancer Group study
    • Kweekel DM, Gelderblom H, Van der Straaten T, Antonini NF, Punt CJ, Guchelaar HJ. UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. Br J Cancer 2008; 99: 275-82.
    • (2008) Br J Cancer , vol.99 , pp. 275-282
    • Kweekel, D.M.1    Gelderblom, H.2    Van Der Straaten, T.3    Antonini, N.F.4    Punt, C.J.5    Guchelaar, H.J.6
  • 135
    • 77956398850 scopus 로고    scopus 로고
    • Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05
    • Boige V, Mendiboure J, Pignon JP, et al. Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05. J Clin Oncol 2011; 28: 2556-64.
    • (2011) J Clin Oncol , vol.28 , pp. 2556-2564
    • Boige, V.1    Mendiboure, J.2    Pignon, J.P.3
  • 136
    • 73949096486 scopus 로고    scopus 로고
    • Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: The FOCUS trial
    • Braun MS, Richman SD, Thompson L, et al. Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial. J Clin Oncol 2009; 27: 5519-28.
    • (2009) J Clin Oncol , vol.27 , pp. 5519-5528
    • Braun, M.S.1    Richman, S.D.2    Thompson, L.3
  • 138
    • 33644525291 scopus 로고    scopus 로고
    • Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy
    • Massacesi C, Terrazzino S, Marcucci F, et al. Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. Cancer 2006; 106: 1007-16.
    • (2006) Cancer , vol.106 , pp. 1007-1016
    • Massacesi, C.1    Terrazzino, S.2    Marcucci, F.3
  • 140
    • 77955166242 scopus 로고    scopus 로고
    • Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: Low doses also increase risk
    • Hu ZY, Yu Q, Pei Q, Guo C. Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: low doses also increase risk. Clin Cancer Res 2010; 16: 3832-42.
    • (2010) Clin Cancer Res , vol.16 , pp. 3832-3842
    • Hu, Z.Y.1    Yu, Q.2    Pei, Q.3    Guo, C.4
  • 142
    • 84870715513 scopus 로고    scopus 로고
    • Pfizer Approved 05/14/2010 by FDA. May 2010 (cited November 2011)
    • Pfizer. Camptosar label. Approved 05/14/2010 by FDA. May 2010 (cited November 2011). http://www.accessdata.fda.gov/drugsatfda-docs/label/2010/ 020571s031s032s033s036s037lbl.pdf
    • Camptosar Label
  • 143
    • 79953737378 scopus 로고    scopus 로고
    • Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1*28/6 polymorphisms
    • Okuyama Y, Hazama S, Nozawa H, et al. Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1*28/6 polymorphisms. Jpn J Clin Oncol 2011; 41: 477-82.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 477-482
    • Okuyama, Y.1    Hazama, S.2    Nozawa, H.3
  • 144
    • 79951783259 scopus 로고    scopus 로고
    • Cost-Effectiveness of UGT1A1*28 genotyping in preventing severe neutropenia following FOLFIRI therapy in colorectal cancer
    • Le Guellec C, Pichereau S, Le Louarn A, Lecomte T, Blasco H, Bourgoin H. Cost-Effectiveness of UGT1A1*28 genotyping in preventing severe neutropenia following FOLFIRI therapy in colorectal cancer. J Pharm Pharm Sci 2010; 13: 615-25.
    • (2010) J Pharm Pharm Sci , vol.13 , pp. 615-625
    • Le Guellec, C.1    Pichereau, S.2    Le Louarn, A.3    Lecomte, T.4    Blasco, H.5    Bourgoin, H.6
  • 145
    • 79955893939 scopus 로고    scopus 로고
    • Regimen selection for first-line FOLFIRI and FOLFOX based on UGT1A1 genotype and physical background is feasible in Japanese patients with advanced colorectal cancer
    • Ishida H, Fujita K, Akiyama Y, et al. Regimen selection for first-line FOLFIRI and FOLFOX based on UGT1A1 genotype and physical background is feasible in Japanese patients with advanced colorectal cancer. Jpn J Clin Oncol 2011; 41: 617-23.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 617-623
    • Ishida, H.1    Fujita, K.2    Akiyama, Y.3
  • 146
    • 77649210559 scopus 로고    scopus 로고
    • Genotype-driven phase i study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer
    • Toffoli G, Cecchin E, Gasparini G, et al. Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28: 866-71.
    • (2010) J Clin Oncol , vol.28 , pp. 866-871
    • Toffoli, G.1    Cecchin, E.2    Gasparini, G.3
  • 147
    • 85171918278 scopus 로고    scopus 로고
    • US Food and Drug Administration. Cited November 2011 510(K) Premarket notification number K051824
    • US Food and Drug Administration. Cited November 2011. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMN/PMNSimpleSearch.cfm, 510(K) Premarket notification number K051824.
  • 148
    • 55949125072 scopus 로고    scopus 로고
    • Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28
    • Ehmer U, Lankisch TO, Erichsen TJ, et al. Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28. J Mol Diagn 2008; 10: 549-52.
    • (2008) J Mol Diagn , vol.10 , pp. 549-552
    • Ehmer, U.1    Lankisch, T.O.2    Erichsen, T.J.3
  • 149
    • 72449179315 scopus 로고    scopus 로고
    • Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis
    • Minucci A, Concolino P, Giardina B, Zuppi C, Capoluongo E. Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis. Clin Chim Acta 2010; 411: 246-9.
    • (2010) Clin Chim Acta , vol.411 , pp. 246-249
    • Minucci, A.1    Concolino, P.2    Giardina, B.3    Zuppi, C.4    Capoluongo, E.5
  • 150
    • 0033636291 scopus 로고    scopus 로고
    • DNA base bulge versus unmatched end formation in probe-based diagnostic insertion/deletion genotyping. Genotyping the UDP-glucuronosyltransferase 1 (UGT1A1) (TA)n polymorphism by real time fluorescence PCR
    • von Ahsen N, Oellerich M, Schütz E. DNA base bulge versus unmatched end formation in probe-based diagnostic insertion/deletion genotyping. Genotyping the UDP-glucuronosyltransferase 1 (UGT1A1) (TA)n polymorphism by real time fluorescence PCR. Clin Chem 2000; 46: 1939-45.
    • (2000) Clin Chem , vol.46 , pp. 1939-1945
    • Von Ahsen, N.1    Oellerich, M.2    Schütz, E.3
  • 152
    • 22544454498 scopus 로고    scopus 로고
    • Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15 + C1007G, by using transient expression systems of HeLa and HEK293 cells
    • Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K. Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1 15C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics 2005; 15: 513-22. (Pubitemid 41017600)
    • (2005) Pharmacogenetics and Genomics , vol.15 , Issue.7 , pp. 513-522
    • Kameyama, Y.1    Yamashita, K.2    Kobayashi, K.3    Hosokawa, M.4    Chiba, K.5
  • 153
    • 40949126593 scopus 로고    scopus 로고
    • Global analysis of genetic variation in SLCO1B1
    • DOI 10.2217/14622416.9.1.19
    • Pasanen MK, Neuvonen PJ, Niemi M. Global analysis of genetic variation in SLCO1B1. Pharmacogenomics 2008; 9: 19-33. (Pubitemid 351560529)
    • (2008) Pharmacogenomics , vol.9 , Issue.1 , pp. 19-33
    • Pasanen, M.K.1    Neuvonen, P.J.2    Niemi, M.3
  • 154
    • 33751096467 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
    • DOI 10.1097/01.fpc.0000230416.82349.90, PII 0121301120061200000004
    • Pasanen MK, Neuvonen M, Neuvonen PJ, Niemi M. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics 2006; 16: 873-9. (Pubitemid 44772805)
    • (2006) Pharmacogenetics and Genomics , vol.16 , Issue.12 , pp. 873-879
    • Pasanen, M.K.1    Neuvonen, M.2    Neuvonen, P.J.3    Niemi, M.4
  • 155
    • 72849141790 scopus 로고    scopus 로고
    • Transporter pharmacogenetics and statin toxicity
    • Niemi M. Transporter pharmacogenetics and statin toxicity. Clin Pharmacol Ther 2010; 87: 130-3.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 130-133
    • Niemi, M.1
  • 156
    • 27544515516 scopus 로고    scopus 로고
    • Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase
    • DOI 10.1211/jpp.57.10.0009
    • Fujino H, Saito T, Ogawa S, Kojima J. Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol 2005; 57: 1305-11. (Pubitemid 41545896)
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , Issue.10 , pp. 1305-1311
    • Fujino, H.1    Saito, T.2    Ogawa, S.-I.3    Kojima, J.4
  • 158
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
    • Ho RH, Tirona RG, Leake BF, et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 2006; 130: 1793-806.
    • (2006) Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1    Tirona, R.G.2    Leake, B.F.3
  • 159
    • 52949104006 scopus 로고    scopus 로고
    • Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin
    • Kitamura S, Maeda K, Wang Y, Sugiyama Y. Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos 2008; 36: 2014-23.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2014-2023
    • Kitamura, S.1    Maeda, K.2    Wang, Y.3    Sugiyama, Y.4
  • 160
    • 0038637144 scopus 로고    scopus 로고
    • Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane
    • DOI 10.1124/jpet.103.051300
    • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 2003; 306: 703-8. (Pubitemid 36886171)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.2 , pp. 703-708
    • Kobayashi, D.1    Nozawa, T.2    Imai, K.3    Nezu, J.-I.4    Tsuji, A.5    Tamai, I.6
  • 161
    • 25144494314 scopus 로고    scopus 로고
    • Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
    • DOI 10.1124/mol.105.014605
    • Kopplow K, Letschert K, Konig J, Walter B, Keppler D. Human hepa-tobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 2005; 68: 1031-8. (Pubitemid 41345794)
    • (2005) Molecular Pharmacology , vol.68 , Issue.4 , pp. 1031-1038
    • Kopplow, K.1    Letschert, K.2    Konig, J.3    Walter, B.4    Keppler, D.5
  • 163
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol 2006; 97: 52C-60C.
    • (2006) Am J Cardiol , vol.97
    • Law, M.1    Rudnicka, A.R.2
  • 164
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathya genomewide study
    • Link E, Parish S, Armitage J, et al. SLCO1B1 variants and statin-induced myopathya genomewide study. N Engl J Med 2008; 359: 789-799.
    • (2008) N Engl J Med , vol.359 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 165
    • 70349739250 scopus 로고    scopus 로고
    • The SLCO1B1*5 genetic variant is associated with statin-induced side effects
    • Voora D, Shah SH, Spasojevic I, et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol 2009; 54: 1609-16.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3
  • 166
    • 38349085099 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
    • Shu Y, Brown C, Castro RA, et al. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther 2008; 83: 273-80.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 273-280
    • Shu, Y.1    Brown, C.2    Castro, R.A.3
  • 169
    • 69449098951 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
    • Tzvetkov MV, Vormfelde SV, Balen D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009; 86: 299-306.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1    Vormfelde, S.V.2    Balen, D.3
  • 172
    • 3042634326 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity
    • DOI 10.1097/00008571-200406000-00002
    • Hughes DA, Vilar FJ, Ward CC, Alfirevic A, Park BK, Pirmohamed M. Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. Pharmacogenetics 2004; 14: 335-42. (Pubitemid 38813687)
    • (2004) Pharmacogenetics , vol.14 , Issue.6 , pp. 335-342
    • Hughes, D.A.1    Vilar, F.J.2    Ward, C.C.3    Alfirevic, A.4    Park, B.K.5    Pirmohamed, M.6
  • 175
    • 33745295856 scopus 로고    scopus 로고
    • Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
    • DOI 10.1086/504874
    • Rauch A, Nolan D, Martin A, McKinnon E, Almeida C, Mallal S. Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clin Infect Dis 2006; 43: 99-102. (Pubitemid 43939082)
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.1 , pp. 99-102
    • Rauch, A.1    Nolan, D.2    Martin, A.3    McKinnon, E.4    Almeida, C.5    Mallal, S.6
  • 176
    • 34247636623 scopus 로고    scopus 로고
    • Prospective screening for human leukocyte antigen-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population
    • DOI 10.1097/QAI.0b013e318046ea31
    • Zucman D, Truchis P, Majerholc C, Stegman S, Caillat-Zucman S. Prospective screening for human leukocyte antigen-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population. J Acquir Immune Defic Syndr 2007; 45: 1-3. (Pubitemid 46684436)
    • (2007) Journal of Acquired Immune Deficiency Syndromes , vol.45 , Issue.1 , pp. 1-3
    • Zucman, D.1    Truchis, P.D.2    Majerholc, C.3    Stegman, S.4    Caillat-Zucman, S.5
  • 177
    • 70149095523 scopus 로고    scopus 로고
    • Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America
    • Aberg JA, Kaplan JE, Libman H, et al. Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2009; 49: 651-81.
    • (2009) Clin Infect Dis , vol.49 , pp. 651-681
    • Aberg, J.A.1    Kaplan, J.E.2    Libman, H.3
  • 178
    • 85171903807 scopus 로고    scopus 로고
    • GlaxoSmithKline Approved 12/19/2008 by FDA. December 2008 cited November 2011)
    • GlaxoSmithKline. Ziagen label. Approved 12/19/2008 by FDA. December 2008 (cited November 2011). http://www.accessdata.fda.gov/drugsatfda-docs/label/2008/ 020977s019,020978s022lbl.pdf
    • Ziagen Label
  • 180
    • 77952012574 scopus 로고    scopus 로고
    • Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in Germany
    • Wolf E, Blankenburg M, Bogner JR, et al. Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in Germany. Eur J Med Res 2010; 15: 145-51.
    • (2010) Eur J Med Res , vol.15 , pp. 145-151
    • Wolf, E.1    Blankenburg, M.2    Bogner, J.R.3
  • 181
    • 77958582477 scopus 로고    scopus 로고
    • A fluorescence-based sequence-specific primer PCR for the screening of HLA-B(*)57:01
    • Giardina E, Stocchi L, Foti Cuzzola V, et al. A fluorescence-based sequence-specific primer PCR for the screening of HLA-B(*)57:01. Electrophoresis 2010; 31: 3525-30.
    • (2010) Electrophoresis , vol.31 , pp. 3525-3530
    • Giardina, E.1    Stocchi, L.2    Foti Cuzzola, V.3
  • 182
    • 79958694904 scopus 로고    scopus 로고
    • Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensi-tivity
    • Kostenko L, Kjer-Nielsen L, Nicholson I, et al. Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensi-tivity. Tissue Antigens 2011; 78: 11-20.
    • (2011) Tissue Antigens , vol.78 , pp. 11-20
    • Kostenko, L.1    Kjer-Nielsen, L.2    Nicholson, I.3
  • 183
    • 33645950777 scopus 로고    scopus 로고
    • A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome
    • Martin AM, Krueger R, Almeida CA, Nolan D, Phillips E, Mallal S. A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome. Pharmacogenet Genomics 2006; 16: 353-7.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 353-357
    • Martin, A.M.1    Krueger, R.2    Almeida, C.A.3    Nolan, D.4    Phillips, E.5    Mallal, S.6
  • 184
    • 79956333428 scopus 로고    scopus 로고
    • The phenotype standardization project: Improving pharmacogenetic studies of serious adverse drug reactions
    • Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D. The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions. Clin Pharmacol Ther 2010; 89: 784-5
    • (2010) Clin Pharmacol Ther , vol.89 , pp. 784-785
    • Pirmohamed, M.1    Aithal, G.P.2    Behr, E.3    Daly, A.4    Roden, D.5
  • 185
    • 67649859295 scopus 로고    scopus 로고
    • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    • Daly AK, Donaldson PT, Bhatnagar P, et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 2009; 41: 816-9.
    • (2009) Nat Genet , vol.41 , pp. 816-819
    • Daly, A.K.1    Donaldson, P.T.2    Bhatnagar, P.3
  • 186
    • 1842784823 scopus 로고    scopus 로고
    • Medical genetics: A marker for Stevens-Johnson syndrome
    • Chung WH, Hung SI, Hong HS, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428: 486.
    • (2004) Nature , vol.428 , pp. 486
    • Chung, W.H.1    Hung, S.I.2    Hong, H.S.3
  • 187
    • 79953197983 scopus 로고    scopus 로고
    • HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    • McCormack M, Alfirevic A, Bourgeois S, et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2004; 364: 1134-43.
    • (2004) N Engl J Med , vol.364 , pp. 1134-1143
    • McCormack, M.1    Alfirevic, A.2    Bourgeois, S.3
  • 188
    • 52549118408 scopus 로고    scopus 로고
    • Somatic pharmacogenomics in cancer
    • Ikediobi ON. Somatic pharmacogenomics in cancer. Pharmacogenomics J 2008; 8: 305-14.
    • (2008) Pharmacogenomics J , vol.8 , pp. 305-314
    • Ikediobi, O.N.1
  • 189
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E, Schellander G, Kofler K, Ludwig H. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71: 2454-60. (Pubitemid 23100476)
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3    Schellander, G.4    Kofler, K.5    Ludwig, H.6
  • 191
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008; 358: 1160-74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 192
    • 0024376173 scopus 로고
    • Ras Oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-9. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 193
    • 79551580548 scopus 로고    scopus 로고
    • Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer
    • Baker JB, Dutta D, Watson D, et al. Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer. Br J Cancer 2011; 104: 488-95.
    • (2011) Br J Cancer , vol.104 , pp. 488-495
    • Baker, J.B.1    Dutta, D.2    Watson, D.3
  • 194
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010; 19: 753-62.
    • (2010) Lancet Oncol , vol.19 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 196
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008; 26: 5705-12.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 198
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009; 27: 5924-30.
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3
  • 200
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le CorreD, etal. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66: 3992-5.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 201
    • 79251633445 scopus 로고    scopus 로고
    • Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in 2 line cetuximab-based therapy of colorectal cancer patients
    • SaridakiZ, TzardiM, PapadakiC, etal. Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in 2 line cetuximab-based therapy of colorectal cancer patients. PLoS One 2011; 6: e15980.
    • (2011) PLoS One , vol.6
    • Saridaki, Z.1    Tzardi, M.2    Papadaki, C.3
  • 202
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-34.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 203
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27: 663-671.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 204
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. NEngl JMed 2008; 359: 1757-65.
    • (2008) NEngl JMed , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 205
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011; 29: 2011-9.
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 206
    • 63049105404 scopus 로고    scopus 로고
    • KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer
    • KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer. Technol Eval Cent Asses Program Exec Summ 2009; 23: 1-3.
    • (2009) Technol Eval Cent Asses Program Exec Summ , vol.23 , pp. 1-3
  • 207
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra CJ, Jessup JM, Somerfield MR, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 2009; 27: 2091-6.
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 208
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou H, Dahabreh IJ, Kanaloupiti D, et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 2008; 9: 962-72.
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3
  • 209
    • 84857629208 scopus 로고    scopus 로고
    • National Cancer Comprehensive Network Version 3. 2011. cited November 2011
    • National Cancer Comprehensive Network. NCCN Guidelines. Version 3.2011. 2011 (cited November 2011). http://www.nccn.org/professionals/physician-gls/f- guidelines.asp
    • (2011) NCCN Guidelines
  • 210
    • 85171929359 scopus 로고    scopus 로고
    • Imclone Systems Incorporated and Bristol-Myers Squibb Approved 07/22/2009 by FDA. July 2009 (cited November 2011)
    • Imclone Systems Incorporated and Bristol-Myers Squibb. Erbitux label. Approved 07/22/2009 by FDA. July 2009 (cited November 2011). http://www.accessdata.fda.gov/drugsatfda-docs/label/2009/125084s167lbl. pdf
    • Erbitux Label
  • 211
    • 85171932159 scopus 로고    scopus 로고
    • Amgen Inc. Approved 07/17/2009 by FDA. July 2009 (cited November 2011)
    • Amgen Inc. Vectibix label. Approved 07/17/2009 by FDA. July 2009 (cited November 2011). http://www.accessdata.fda.gov/drugsatfda-docs/label/2009/ 125147s080lbl.pdf
    • Vectibix Label
  • 212
    • 67649652208 scopus 로고    scopus 로고
    • BRAF mutation in metastatic colorectal cancer
    • Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009; 361: 98-9.
    • (2009) N Engl J Med , vol.361 , pp. 98-99
    • Tol, J.1    Nagtegaal, I.D.2    Punt, C.J.3
  • 213
    • 79955364441 scopus 로고    scopus 로고
    • Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations
    • Lee J, Lee I, Han B. Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. J Natl Cancer Inst 2011; 103: 674-88.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 674-688
    • Lee, J.1    Lee, I.2    Han, B.3
  • 214
    • 78751480476 scopus 로고    scopus 로고
    • MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy
    • Yoon J, Koo KH, Choi KY. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res 2011; 71: 445-53.
    • (2011) Cancer Res , vol.71 , pp. 445-453
    • Yoon, J.1    Koo, K.H.2    Choi, K.Y.3
  • 215
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • De Roock W, Jonker DJ, Di Nicolantonio F, et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 2010; 304: 1812-20.
    • (2010) JAMA , vol.304 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3
  • 217
    • 61449154484 scopus 로고    scopus 로고
    • KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: Practical application of patient selection
    • Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG. KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol 2009; 27: 1130-6.
    • (2009) J Clin Oncol , vol.27 , pp. 1130-1136
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 218
    • 77950846704 scopus 로고    scopus 로고
    • A comparability study of 5 commercial KRAS tests
    • Oliner K, Juan T, Suggs S, et al. A comparability study of 5 commercial KRAS tests. Diagn Pathol 2010; 5: 23.
    • (2010) Diagn Pathol , vol.5 , pp. 23
    • Oliner, K.1    Juan, T.2    Suggs, S.3
  • 220
    • 22844448777 scopus 로고    scopus 로고
    • Priorities and standards in pharmacogenetic research
    • DOI 10.1038/ng1593
    • Need AC, Motulsky AG, Goldstein DB. Priorities and standards in pharmacogenetic research. Nat Genet 2005; 37: 671-81. (Pubitemid 41754883)
    • (2005) Nature Genetics , vol.37 , Issue.7 , pp. 671-681
    • Need, A.C.1    Motulsky, A.G.2    Goldstein, D.B.3
  • 221
    • 79955463893 scopus 로고    scopus 로고
    • Pharmacogenetics: From bench to byte - An update of guidelines
    • Swen JJ, Nijenhuis M, de Boer A, et al. Pharmacogenetics: from bench to byte - an update of guidelines. Clin Pharmacol Ther 2011; 89: 662-673.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 662-673
    • Swen, J.J.1    Nijenhuis, M.2    De Boer, A.3
  • 222
    • 33750332747 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Development, science, and translation
    • DOI 10.1146/annurev.genom.6.080604.162315
    • Weinshilboum RM, Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annu Rev Genomics Hum Genet 2006; 7: 223-45. (Pubitemid 44627929)
    • (2006) Annual Review of Genomics and Human Genetics , vol.7 , pp. 223-245
    • Weinshilboum, R.M.1    Wang, L.2
  • 223
    • 66349121862 scopus 로고    scopus 로고
    • The HapMap and genome-wide association studies in diagnosis and therapy
    • Manolio TA, Collins FS. The HapMap and genome-wide association studies in diagnosis and therapy. Annu Rev Med 2009; 60: 443-56.
    • (2009) Annu Rev Med , vol.60 , pp. 443-456
    • Manolio, T.A.1    Collins, F.S.2
  • 225
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747-53.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 226
    • 78049314943 scopus 로고    scopus 로고
    • A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses
    • Ripatti S, Tikkanen E, Orho-Melander M, et al. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet 2010; 376: 1393-400.
    • (2010) Lancet , vol.376 , pp. 1393-1400
    • Ripatti, S.1    Tikkanen, E.2    Orho-Melander, M.3
  • 227
    • 77949578084 scopus 로고    scopus 로고
    • Performance of common genetic variants in breast-cancer risk models
    • Wacholder S, Hartge P, Prentice R, et al. Performance of common genetic variants in breast-cancer risk models. N Engl J Med 2010; 362: 986-93.
    • (2010) N Engl J Med , vol.362 , pp. 986-993
    • Wacholder, S.1    Hartge, P.2    Prentice, R.3
  • 228
    • 52949096084 scopus 로고    scopus 로고
    • Next-generation DNA sequencing methods
    • Mardis ER. Next-generation DNA sequencing methods. Annu Rev Geno-mics Hum Genet 2008; 9: 387-402.
    • (2008) Annu Rev Geno-mics Hum Genet , vol.9 , pp. 387-402
    • Mardis, E.R.1
  • 229
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • Durbin RM, Abecasis GR, Altshuler DL, et al. A map of human genome variation from population-scale sequencing. Nature 2010; 467: 1061-73.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Durbin, R.M.1    Abecasis, G.R.2    Altshuler, D.L.3
  • 230
    • 79851493086 scopus 로고    scopus 로고
    • Effect of direct-to-consumer genomewide profiling to assess disease risk
    • Bloss CS, Schork NJ, Topol EJ. Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med 2011; 364: 524-34.
    • (2011) N Engl J Med , vol.364 , pp. 524-534
    • Bloss, C.S.1    Schork, N.J.2    Topol, E.J.3
  • 233
    • 43049122356 scopus 로고    scopus 로고
    • From human genetics and genomics to pharmacogenetics and pharmacogenomics: Past lessons, future directions
    • DOI 10.1080/03602530801952864, PII 792810082
    • Nebert DW, Zhang G, Vesell ES. From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. Drug Metab Rev 2008; 40: 187-224. (Pubitemid 352000946)
    • (2008) Drug Metabolism Reviews , vol.40 , Issue.2 , pp. 187-224
    • Nebert, D.W.1    Zhang, G.2    Vesell, E.S.3
  • 234
  • 235
    • 79952254324 scopus 로고    scopus 로고
    • US Food and Drug Administration (FDA) cited June 2011
    • US Food and Drug Administration (FDA). Table of Pharmacogenomic Biomarkers in Drug Labels. 2011 (cited June 2011). http://www.fda.gov/Drugs/ ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378. htm
    • (2011) Table of Pharmacogenomic Biomarkers in Drug Labels
  • 237
    • 14044279224 scopus 로고    scopus 로고
    • Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C>T (P229L) found in an African-American
    • DOI 10.1124/dmd.104.001800
    • Kaniwa N, Kurose K, Jinno H, et al. Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C T (P229L) found in an African-American. Drug Metab Dispos 2005; 33: 458-65. (Pubitemid 40279948)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.3 , pp. 458-465
    • Kaniwa, N.1    Kurose, K.2    Jinno, H.3    Tanaka-Kagawa, T.4    Saito, Y.5    Saeki, M.6    Sawada, J.-I.7    Tohkin, M.8    Hasegawa, R.9
  • 239
    • 70349929431 scopus 로고    scopus 로고
    • Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
    • Schroth W, Goetz MP, Hamann U, et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 2009; 302: 1429-36.
    • (2009) JAMA , vol.302 , pp. 1429-1436
    • Schroth, W.1    Goetz, M.P.2    Hamann, U.3
  • 241
    • 77952570889 scopus 로고    scopus 로고
    • Warfarin pharmacogenetics: A single VKORC1 polymorphism is predictive of dose across 3 racial groups
    • Limdi NA, Wadelius M, Cavallari L, et al. Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. Blood 2010; 115: 3827-34.
    • (2010) Blood , vol.115 , pp. 3827-3834
    • Limdi, N.A.1    Wadelius, M.2    Cavallari, L.3
  • 243
    • 75749085418 scopus 로고    scopus 로고
    • Prospective epidemiological study of the prevalence of human leukocyte antigen (HLA)-B*5701 in HIV-1-infected UK subjects
    • Orkin C, Sadiq ST, Rice L, Jackson F. Prospective epidemiological study of the prevalence of human leukocyte antigen (HLA)-B*5701 in HIV-1-infected UK subjects. HIV Med 2010; 11: 187-92.
    • (2010) HIV Med , vol.11 , pp. 187-192
    • Orkin, C.1    Sadiq, S.T.2    Rice, L.3    Jackson, F.4
  • 244
    • 77951621770 scopus 로고    scopus 로고
    • An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in Europe
    • Orkin C, Wang J, Bergin C, et al. An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in Europe. Pharmacogenet Genomics 2010; 20: 307-14.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 307-314
    • Orkin, C.1    Wang, J.2    Bergin, C.3
  • 245
    • 58749103488 scopus 로고    scopus 로고
    • Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
    • Park WB, Choe PG, Song KH, et al. Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir? Clin Infect Dis 2009; 48: 365-7.
    • (2009) Clin Infect Dis , vol.48 , pp. 365-367
    • Park, W.B.1    Choe, P.G.2    Song, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.