메뉴 건너뛰기




Volumn 118, Issue 6, 2000, Pages 1025-1030

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; AZATHIOPRINE; CAPTOPRIL; CORTICOSTEROID; COTRIMOXAZOLE; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; OLSALAZINE; THIOPURINE METHYLTRANSFERASE;

EID: 0034093057     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(00)70354-4     Document Type: Article
Times cited : (596)

References (37)
  • 1
    • 0024457688 scopus 로고
    • 6-Mercaptopurine in the management of inflammatory bowel disease: short-and long-term toxicity
    • DH Present SJ Meltzer MP Krumholz A Wolke BI. Korelitz 6-Mercaptopurine in the management of inflammatory bowel disease: short-and long-term toxicity Ann Intern Med 111 1989 641 649
    • (1989) Ann Intern Med , vol.111 , pp. 641-649
    • Present, DH1    Meltzer, SJ2    Krumholz, MP3    Wolke, A4    Korelitz, BI.5
  • 2
    • 0027164795 scopus 로고
    • Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience
    • WR Connell MA Kamm JK Ritchie JE. Lennard-Jones Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience Gut 34 1993 1081 1085
    • (1993) Gut , vol.34 , pp. 1081-1085
    • Connell, WR1    Kamm, MA2    Ritchie, JK3    Lennard-Jones, JE.4
  • 3
    • 0029073930 scopus 로고
    • Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
    • EY Krynetski NF Kr ynetskaia Y Yanishevski WE. Evans Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase Mol Pharmacol 47 1995 1141 1147
    • (1995) Mol Pharmacol , vol.47 , pp. 1141-1147
    • Krynetski, EY1    Kr ynetskaia, NF2    Yanishevski, Y3    Evans, WE.4
  • 4
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • RM Weinshilboum SL. Sladek Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity Am J Hum Genet 32 1980 651 662
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, RM1    Sladek, SL.2
  • 5
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • L Lennard JA Van Loon JS Lilleyman RM. Weinshilboum Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations Clin Pharmacol Ther 41 1987 18 25
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 18-25
    • Lennard, L1    Van Loon, JA2    Lilleyman, JS3    Weinshilboum, RM.4
  • 6
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • L Lennard JS Lilleyman J Van Loon RM. Weinshilboum Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia Lancet 336 1990 225 229
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L1    Lilleyman, JS2    Van Loon, J3    Weinshilboum, RM.4
  • 7
    • 0029932094 scopus 로고    scopus 로고
    • Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation
    • E Schutz J Gummert VW Armstrong FW Mohr M. Oellerich Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation Eur J Clin Chem Clin Biochem 34 1996 199 205
    • (1996) Eur J Clin Chem Clin Biochem , vol.34 , pp. 199-205
    • Schutz, E1    Gummert, J2    Armstrong, VW3    Mohr, FW4    Oellerich, M.5
  • 8
    • 0028861745 scopus 로고
    • A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
    • EY Krynetski JD Schuetz AJ Galpin CH Pui MV Relling WE. Evans A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase Proc Natl Acad Sci U S A 92 1995 949 953
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 949-953
    • Krynetski, EY1    Schuetz, JD2    Galpin, AJ3    Pui, CH4    Relling, MV5    Evans, WE.6
  • 9
    • 0009649472 scopus 로고    scopus 로고
    • Human thiopurine methyltransferase pharmacogenetics: identification of a novel variant allele (abstr)
    • D Otterness C Szumlanski RM. Weinshilboum Human thiopurine methyltransferase pharmacogenetics: identification of a novel variant allele (abstr) J Invest Med 44 1996 248A
    • (1996) J Invest Med , vol.44 , pp. 248A
    • Otterness, D1    Szumlanski, C2    Weinshilboum, RM.3
  • 11
    • 0032030953 scopus 로고    scopus 로고
    • Human thiopurine methyltransferase pharmacogenetics: kindred with a terminal exon splice junction mutation that results in loss of activity
    • D Otterness C Szumlanski T Wood RM. Weinshilboum Human thiopurine methyltransferase pharmacogenetics: kindred with a terminal exon splice junction mutation that results in loss of activity J Clin Invest 101 1998 1036 1044
    • (1998) J Clin Invest , vol.101 , pp. 1036-1044
    • Otterness, D1    Szumlanski, C2    Wood, T3    Weinshilboum, RM.4
  • 13
    • 0029919807 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    • HL Tai EY Krynetski CR Yates T Loennechen MY Fessing NF Krynetskaia WE. Evans Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians Am J Hum Genet 58 1996 694 702
    • (1996) Am J Hum Genet , vol.58 , pp. 694-702
    • Tai, HL1    Krynetski, EY2    Yates, CR3    Loennechen, T4    Fessing, MY5    Krynetskaia, NF6    Evans, WE.7
  • 14
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
    • CR Yates EY Krynetski T Loennechen MY Fessing HL Tai CH Pui MV Relling WE. Evans Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance Ann Intern Med 126 1997 608 614
    • (1997) Ann Intern Med , vol.126 , pp. 608-614
    • Yates, CR1    Krynetski, EY2    Loennechen, T3    Fessing, MY4    Tai, HL5    Pui, CH6    Relling, MV7    Evans, WE.8
  • 15
    • 0031880735 scopus 로고    scopus 로고
    • Detection of known and new mutations in the thiopurine S-methyltransferase gene by singlestrand conformation polymorphism analysis
    • C Spire-Vayron de la Moureyre N Sabbagh D Marez E Vinner ED Chevalier JM Lo Guidice F. Broly Detection of known and new mutations in the thiopurine S-methyltransferase gene by singlestrand conformation polymorphism analysis Hum Mutat 12 1998 177 185
    • (1998) Hum Mutat , vol.12 , pp. 177-185
    • Spire-Vayron de la Moureyre, C1    Sabbagh, N2    Marez, D3    Vinner, E4    Chevalier, ED5    Lo Guidice, JM6    Broly, F.7
  • 16
    • 0003903349 scopus 로고
    • Commonly used techniques in molecular cloning
    • T Maniatis J Sambrook EF. Fritsh Commonly used techniques in molecular cloning N Ford C Nolan M Ferguson M Ockler Molecular cloning; a laboratory manual. 1989 Cold Spring Harbor Laboratory Cold Spring Harbor, NY E1 E8
    • (1989) , pp. E1-E8
    • Maniatis, T1    Sambrook, J2    Fritsh, EF.3
  • 18
    • 0031820555 scopus 로고    scopus 로고
    • Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
    • T Loennechen CR Yates MY Fessing MV Relling EY Kr ynetski WE. Evans Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans Clin Pharmacol Ther 64 1998 46 51
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 46-51
    • Loennechen, T1    Yates, CR2    Fessing, MY3    Relling, MV4    Kr ynetski, EY5    Evans, WE.6
  • 21
    • 0001697036 scopus 로고    scopus 로고
    • Azathioprine metabolite levels predict clinical responsiveness to therapy in IBD (abstr)
    • C Cuffari M Picco S Hunt T. Bayless Azathioprine metabolite levels predict clinical responsiveness to therapy in IBD (abstr) Gastroenterology 116 1999 A694
    • (1999) Gastroenterology , vol.116 , pp. A694
    • Cuffari, C1    Picco, M2    Hunt, S3    Bayless, T.4
  • 22
    • 0000419269 scopus 로고    scopus 로고
    • Optimizing and individualizing 6-MP therapy in IBD: the role of 6-MP metabolite levels and TPMT genotyping (abstr)
    • MC Dubinsky S Lamothe HY Yang SR Targan D Sinnett Y Theoret EG. Seidman Optimizing and individualizing 6-MP therapy in IBD: the role of 6-MP metabolite levels and TPMT genotyping (abstr) Gastroenterology 116 1999 A702
    • (1999) Gastroenterology , vol.116 , pp. A702
    • Dubinsky, MC1    Lamothe, S2    Yang, HY3    Targan, SR4    Sinnett, D5    Theoret, Y6    Seidman, EG.7
  • 23
    • 0029953165 scopus 로고    scopus 로고
    • Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine?
    • E Schutz J Gummert FW Mohr VW Armstrong M. Oellerich Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine? Ther Drug Monit 18 1996 228 233
    • (1996) Ther Drug Monit , vol.18 , pp. 228-233
    • Schutz, E1    Gummert, J2    Mohr, FW3    Armstrong, VW4    Oellerich, M.5
  • 24
  • 25
    • 0026717661 scopus 로고
    • The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients
    • PR Chocair JA Duley HA Simmonds JS. Cameron The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients Transplantation 53 1992 1051 1056
    • (1992) Transplantation , vol.53 , pp. 1051-1056
    • Chocair, PR1    Duley, JA2    Simmonds, HA3    Cameron, JS.4
  • 26
    • 0018939350 scopus 로고
    • Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors
    • PA Pazmino SL Sladek RM. Weinshilboum Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors Clin Pharmacol Ther 28 1980 356 367
    • (1980) Clin Pharmacol Ther , vol.28 , pp. 356-367
    • Pazmino, PA1    Sladek, SL2    Weinshilboum, RM.3
  • 27
    • 0031663491 scopus 로고    scopus 로고
    • Clinical implications of thiopurine methyltransferase—optimization of drug dosage and potential drug interactions
    • L. Lennard Clinical implications of thiopurine methyltransferase—optimization of drug dosage and potential drug interactions Ther Drug Monit 20 1998 527 531
    • (1998) Ther Drug Monit , vol.20 , pp. 527-531
    • Lennard, L.1
  • 28
    • 0028841502 scopus 로고
    • Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients
    • J Mircheva C Legendre C Soria-Royer E Thervet P Beaune H. Kreis Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients Transplantation 60 1995 639 642
    • (1995) Transplantation , vol.60 , pp. 639-642
    • Mircheva, J1    Legendre, C2    Soria-Royer, C3    Thervet, E4    Beaune, P5    Kreis, H.6
  • 29
    • 0018628069 scopus 로고
    • Mechanisms of thrombocytopenia in varicella
    • JH Feusner SJ Slichter LA. Harker Mechanisms of thrombocytopenia in varicella Am J Hematol 7 1979 255 264
    • (1979) Am J Hematol , vol.7 , pp. 255-264
    • Feusner, JH1    Slichter, SJ2    Harker, LA.3
  • 30
    • 0028219445 scopus 로고
    • Parvovirus infection causing red cell aplasia and leukopenia in rheumatoid arthritis
    • AM Kamper M Malbrain P Zachee SL. Chew Parvovirus infection causing red cell aplasia and leukopenia in rheumatoid arthritis Clin Rheumatol 13 1994 129 131
    • (1994) Clin Rheumatol , vol.13 , pp. 129-131
    • Kamper, AM1    Malbrain, M2    Zachee, P3    Chew, SL.4
  • 32
    • 0025296537 scopus 로고
    • Azathioprine and allopurinol: a potentially dangerous combination
    • G Venkat Raman VL Sharman HA. Lee Azathioprine and allopurinol: a potentially dangerous combination J Intern Med 228 1990 69 71
    • (1990) J Intern Med , vol.228 , pp. 69-71
    • Venkat Raman, G1    Sharman, VL2    Lee, HA.3
  • 33
    • 0028917479 scopus 로고
    • Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine
    • CL Szumlanski RM. Weinshilboum Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine Br J Clin Pharmacol 39 1995 456 459
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 456-459
    • Szumlanski, CL1    Weinshilboum, RM.2
  • 35
    • 0025149727 scopus 로고
    • Trimethoprim-sulphamethoxazole-associated blood dyscrasias. Ten years' experience of the Swedish spontaneous reporting system
    • M Keisu BE Wiholm J. Palmblad Trimethoprim-sulphamethoxazole-associated blood dyscrasias. Ten years' experience of the Swedish spontaneous reporting system J Intern Med 228 1990 353 360
    • (1990) J Intern Med , vol.228 , pp. 353-360
    • Keisu, M1    Wiholm, BE2    Palmblad, J.3
  • 37
    • 0019310223 scopus 로고
    • Neutropenia associated with metronidazole therapy (letter)
    • JA. Smith Neutropenia associated with metronidazole therapy (letter) CMAJ 123 1980 202
    • (1980) CMAJ , vol.123 , pp. 202
    • Smith, JA.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.