Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28

Journal of Molecular Diagnostics

Volumn 10, Issue 6, 2008, Pages 549-552

  Ehmer, Ursula ^a   Lankisch, Tim O ^a   Erichsen, Thomas J ^a   Kalthoff, Sandra ^a   Freiberg, Nicole ^a   Wehmeier, Michael ^a   Manns, Michael P ^a   Strassburg, Christian P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATAZANAVIR; GLUCURONOSYLTRANSFERASE 1A1; IRINOTECAN;

ADULT; AGED; ALLELE; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; COLORECTAL CANCER; CONTROLLED STUDY; DIARRHEA; FEMALE; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; GILBERT DISEASE; HUMAN; LEUKOPENIA; LIVER METASTASIS; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; STOMACH CARCINOMA;

EID: 55949125072     PISSN: 15251578     EISSN: None     Source Type: Journal    
DOI: 10.2353/jmoldx.2008.080036     Document Type: Article

References (16)

1. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GNJ, Jansen PLM, Oude Elferink RPJ, Chowdhury NR: The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995, 333:1171-1175
2. Strassburg CP, Manns MP: Jaundice, genes and promoters. J Hepatol 2000, 33:476-479
3. Lankisch TO, Moebius U, Wehmeier M, Behrens G, Manns MP, Schmidt RE, Strassburg CP: Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. Hepatology 2006, 44:1324-1332
4. Ando Y, Saka H, Ando M, Sawa T, Muro K, Ueoka H, Yokoyama A, Saitoh S, Shimokata K, Hasegawa Y: Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res 2000, 60:6921-6926
5. Guillemette C, Millikan RC, Newman B, Housman DE: Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Cancer Res 2000, 60:950-956
6. Bosma PJ: Inherited disorders of bilirubin metabolism. J Hepatol 2003, 38:107-117
7. Aono S, Adachi Y, Uyama E, Yamada Y, Keino H, Nanno T, Koiwai O, Sato H: Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Lancet 1995, 345:958-959
8. Beutler E, Gelbart T, Demina A: Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?. Proc Natl Acad Sci USA 1998, 95:8170-8174
9. Skarke C, Grosch S, Geisslinger G, Lotsch J: Single-step identification of all length polymorphisms in the UGT1A1 gene promoter. Int J Clin Pharmacol Ther 2004, 42:133-138
10. Hasegawa Y, Sarashina T, Ando M, Kitagawa C, Mori A, Yoneyama M, Ando Y, Shimokata K: Rapid detection of UGT1A1 gene polymorphisms by newly developed Invader assay. Clin Chem 2004, 50:1479-1480
11. Watanabe J, Mitani Y, Kawai Y, Kikuchi T, Kogo Y, Oguchi-Katayama A, Kanamori H, Usui K, Itoh M, Cizdziel PE, Lezhava A, Tatsumi K, Ichikawa Y, Togo S, Shimada H, Hayashizaki Y: Use of a competitive probe in assay design for genotyping of the UGT1A1*28 microsatellite polymorphism by the smart amplification process. Biotechniques 2007, 43:479-484
12. Huang CK, Dulau A, Su-Rick CJ, Pan Q: Validation of rapid polymerase chain reaction-based detection of all length polymorphisms in the UGT 1A1 gene promoter. Diagn Mol Pathol 2007, 16:50-53
13. Pirulli D, Giordano M, Puzzer D, Crovella S, Rigato I, Tiribelli C, Momigliano-Richiardi P, Amoroso A: Rapid method for detection of extra (TA) in the promoter of the bilirubin-UDP-glucuronosyl transferase 1 gene associated with Gilbert syndrome. Clin Chem 2000, 46:129-131
14. Harraway JR, George PM: use of fully denaturing HPLC for UGT1A1 genotyping in Gilbert syndrome. Clin Chem 2005, 51:2183-2185
15. O'Dwyer PJ, Catalano RB: Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: practical pharmacogenomics arrives in cancer therapy. J Clin Oncol 2006, 24:4534-4538
16. Hoskins JM, Goldberg RM, Qu P, Ibrahim JG, McLeod HL: UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters. J Natl Cancer Inst 2007, 99:1290-1295