SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

Pharmacogenetics and Genomics

Volumn 16, Issue 12, 2006, Pages 873-879

  Pasanen, Marja K ^a   Neuvonen, Mikko ^a   Neuvonen, Pertti J ^a   Niemi, Mikko ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

OATP1B1; Organic anion transporting polypeptide; Pharmacogenetics; Pharmacokinetics; Simvastatin; Simvastatin acid; SLCO1B1

Indexed keywords

DRUG METABOLITE; ORGANIC ANION TRANSPORTER 2; SIMVASTATIN; SIMVASTATIN ACID; UNCLASSIFIED DRUG;

ADULT; ALLELE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG UPTAKE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIVER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; FEMALE; GENOTYPE; HALF-LIFE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; ORGANIC ANION TRANSPORTERS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; SIMVASTATIN;

EID: 33751096467     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/01.fpc.0000230416.82349.90     Document Type: Article

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