Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Nature

Volumn 427, Issue 6974, 2004, Pages 537-541

  Rost, Simone ^a,b   Fregin, Andreas ^a   Ivaskevicius, Vytautas ^c   Conzelmann, Ernst ^a   Hörtnagel, Konstanze ^b   Pelz, Hans Joachim ^d   Lappegard, Knut ^e   Seifried, Erhard ^c   Scharrer, Inge ^c   Tuddenham, Edward G D ^f   Müller, Clemens R ^a   Strom, Tim M ^b,g   Oldenburg, Johannes ^a,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d Vertebrate Research   (Germany)

^e NORDLAND HOSPITAL   (Norway)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; COAGULATION; GENES; VITAMINS;

MUTATIONS; WARFARIN INHIBITIONS;

NATURAL SCIENCES;

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR; COUMARIN DERIVATIVE; GENE PRODUCT; MEMBRANE PROTEIN; MENADIONE EPOXIDE; PROTHROMBIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1; VITAMIN K GROUP; WARFARIN;

MEDICINE;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING FACTOR DEFICIENCY; CARBOXYLATION; ENDOPLASMIC RETICULUM; GENE; GENE ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; GENETIC RESISTANCE; HUMAN; HUMAN TISSUE; LONG TERM CARE; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; THROMBOEMBOLISM; VKORC1 GENE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHROMOSOME MAPPING; COAGULATION PROTEIN DISORDERS; COS CELLS; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE; HUMANS; MICE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; RATS; RNA, MESSENGER; WARFARIN;

ANIMALIA;

EID: 10744228888     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02214     Document Type: Article

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