Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase

Drug Metabolism and Disposition

Volumn 29, Issue 4 II, 2001, Pages 601-605

  Weinshilboum, R ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

BONE MARROW SUPPRESSION; CONFERENCE PAPER; ENZYME ACTIVITY; GENE CONTROL; HIGH RISK POPULATION; HUMAN; LEUKEMIA; METHYLATION; MOLECULAR CLONING; PHARMACOGENETICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT;

HUMANS; METHYLTRANSFERASES; PHARMACOGENETICS; POLYMORPHISM, GENETIC; PURINES;

EID: 0035056404     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (48)

1. Thiopurine methyltransferase: Structure-activity relationships for benzoic acid inhibitors and thiophenol substrates
2. Pancytopenia related to azathioprine - An enzyme deficiency caused by a common genetic polymorphism: A review
3. Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis
4. The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations
5. Biochemistry and pharmacology of purine analogues
6. Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: A family study
7. Altered mercaptopurine metabolism, toxic effects and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphoblastic leukemia
8. Conventional drug therapy in inflammatory bowel disease
9. Drug therapy: Inflammatory bowel disease
10. Human thiopurine methyltransferase: Molecular cloning and expression of T84 colon carcinoma cell cDNA
11. Erythrocyte thiopurine methyltransferase activity in a Korean population
12. Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis
13. A single point mutation leading to loss of catalytic activity in human thiopurine methyltransferase
14. Thiopurine methyltransferase pharmacogenetics: Cloning of human liver cDNA and presence of a processed pseudogene on human chromosome 18q21.1
15. The clinical pharmacology of 6-mercaptopurine
16. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
17. Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells
18. Childhood leukemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia
19. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
20. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
21. Olsalazine and 6-mercaptopurine-related hematologic suppression: A possible drug-drug interaction
22. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
23. Human thiopurine methyltransferase pharmacogenetics: Kindred with a terminal exon splice junction mutation that results in loss of activity
24. Thiopurine methyltransferase activity in a Korean population sample of children
25. 6-Thiopurines
26. Thiol S-methylation in uremia: Erythrocyte enzyme activities and plasma inhibitors
27. Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: From the bedside to the target genes
28. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
29. Metabolism of thiopyrimidines and thiopurines: S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissue
30. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
31. Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter
32. Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population
33. Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
34. Thiopurine methyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism
35. Sulphasalazine inhibition of thiopurine methyltransferase: Possible mechanism for interaction with 6-mercaptopurine and azathioprine
36. Enhanced proteolysis of thiopurine methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
37. Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: Relation to thiopurine metabolism
38. Human kidney thiopurine methyltransferase: Photoaffinity labeling with S-adenosyl-L-methionine
39. Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity
40. Segregation analysis of human red blood cell (RBC) thiopurine methyltransferase (TPMT) activity
41. Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
42. Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
43. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
44. Thiopurine methyltransferase: Aromatic thiol substrates and inhibition by benzoic acid derivatives
45. Pharmacogenetics of human thiopurine methyltransferase: Kidney-erythrocyte correlation and immunotitration studies
46. Human kidney thiopurine methyltransferase: Purification and biochemical properties
47. Thiopurine methyltransferase (TPMT) promoter variable number tandem repeat (VNTR) polymorphism: Genotype-phenotype correlation analysis for 1211 patients