메뉴 건너뛰기




Volumn 356, Issue , 2012, Pages 165-188

The epigenetic landscape of lineage choice: Lessons from the heritability of Cd4 and Cd8 expression

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR RUNX3;

EID: 84857767452     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82_2011_175     Document Type: Article
Times cited : (13)

References (121)
  • 1
    • 0030976247 scopus 로고    scopus 로고
    • Positive selection induces CD4 promoter and enhancer function
    • DOI 10.1093/intimm/9.6.877
    • Adlam M, Duncan DD, Ng DK, Siu G (1997) Positive selection induces CD4 promoter and enhancer function. Int Immunol 9:877-887 (Pubitemid 27231967)
    • (1997) International Immunology , vol.9 , Issue.6 , pp. 877-887
    • Adlam, M.1    Duncan, D.D.2    Ng, D.K.3    Siu, G.4
  • 2
    • 0037331666 scopus 로고    scopus 로고
    • Hierarchical interactions control CD4 gene expression during thymocyte development
    • DOI 10.1016/S1074-7613(03)00021-9
    • Adlam M, Siu G (2003) Hierarchical interactions control CD4 gene expression during thymocyte development. Immunity 18:173-184 (Pubitemid 36262993)
    • (2003) Immunity , vol.18 , Issue.2 , pp. 173-184
    • Adlam, M.1    Siu, G.2
  • 3
    • 0033681250 scopus 로고    scopus 로고
    • Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
    • Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D (2000) Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell 103:667-678
    • (2000) Cell , vol.103 , pp. 667-678
    • Agalioti, T.1    Lomvardas, S.2    Parekh, B.3    Yie, J.4    Maniatis, T.5    Thanos, D.6
  • 4
    • 0013857650 scopus 로고
    • Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis
    • Allfrey VG (1966) Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis. Proc Can Cancer Conf 6:313-335
    • (1966) Proc Can Cancer Conf , vol.6 , pp. 313-335
    • Allfrey, V.G.1
  • 6
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • DOI 10.1016/j.cell.2007.05.009, PII S0092867407006009
    • Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I, Zhao K (2007) High-resolution profiling of histone methylations in the human genome. Cell 129:823-837 (Pubitemid 46802390)
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.-Y.4    Schones, D.E.5    Wang, Z.6    Wei, G.7    Chepelev, I.8    Zhao, K.9
  • 9
    • 0027395037 scopus 로고
    • Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: Identification of a human CD4 enhancer
    • Blum MD, Wong GT, Higgins KM, Sunshine MJ, Lacy E (1993) Reconstitution of the subclassspecific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J Exp Med 177:1343-1358 (Pubitemid 23117125)
    • (1993) Journal of Experimental Medicine , vol.177 , Issue.5 , pp. 1343-1358
    • Blum, M.D.1    Wong, G.T.2    Higgins, K.M.3    Sunshine, M.J.4    Lacy, E.5
  • 10
  • 11
    • 0028212159 scopus 로고
    • The human X-inactivation centre is not required for maintenance of X-chromosome inactivation
    • Brown CJ, Willard HF (1994) The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature 368:154-156
    • (1994) Nature , vol.368 , pp. 154-156
    • Brown, C.J.1    Willard, H.F.2
  • 12
    • 0031812122 scopus 로고    scopus 로고
    • Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II
    • DOI 10.1007/s002510050411
    • Bruniquel D, Borie N, Hannier S, Triebel F (1998) Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II. Immunogenetics 48:116-124 (Pubitemid 28302314)
    • (1998) Immunogenetics , vol.48 , Issue.2 , pp. 116-124
    • Bruniquel, D.1    Borie, N.2    Hannier, S.3    Triebel, F.4
  • 13
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    • DOI 10.1038/ni887
    • Bruniquel D, Schwartz RH (2003) Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol 4:235-240 (Pubitemid 36322132)
    • (2003) Nature Immunology , vol.4 , Issue.3 , pp. 235-240
    • Bruniquel, D.1    Schwartz, R.H.2
  • 15
    • 73349092441 scopus 로고    scopus 로고
    • Histones: Annotating chromatin
    • Campos EI, Reinberg D (2009) Histones: annotating chromatin. Annu Rev Genet 43:559-599
    • (2009) Annu Rev Genet , vol.43 , pp. 559-599
    • Campos, E.I.1    Reinberg, D.2
  • 16
    • 0024270410 scopus 로고
    • + precursors
    • Carbone AM, Marrack P, Kappler JW (1988) Demethylated CD8 gene in CD4+ T cells suggests that CD4+ cells develop from CD8+ precursors. Science 242:1174-1176 (Pubitemid 19007044)
    • (1988) Science , vol.242 , Issue.4882 , pp. 1174-1176
    • Carbone, A.M.1    Marrack, P.2    Kappler, J.W.3
  • 17
    • 0041429637 scopus 로고    scopus 로고
    • Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development
    • DOI 10.1016/S1074-7613(03)00199-7
    • Chi TH, Wan M, Lee PP, Akashi K, Metzger D, Chambon P, Wilson CB, Crabtree GR (2003) Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity 19:169-182 (Pubitemid 37011332)
    • (2003) Immunity , vol.19 , Issue.2 , pp. 169-182
    • Chi, T.H.1    Wan, M.2    Lee, P.P.3    Akashi, K.4    Metzger, D.5    Chambon, P.6    Wilson, C.B.7    Crabtree, G.R.8
  • 18
    • 0037062922 scopus 로고    scopus 로고
    • Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    • DOI 10.1038/nature00876
    • Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR (2002) Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418:195-199 (Pubitemid 34773775)
    • (2002) Nature , vol.418 , Issue.6894 , pp. 195-199
    • Chi, T.H.1    Wan, M.2    Zhao, K.3    Taniuchi, I.4    Chen, L.5    Uttman, D.R.6    Crabtree, G.R.7
  • 19
    • 77950484789 scopus 로고    scopus 로고
    • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
    • Chong MM, Simpson N, Ciofani M, Chen G, Collins A, Littman DR (2010) Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev 24:659-669
    • (2010) Genes Dev , vol.24 , pp. 659-669
    • Chong, M.M.1    Simpson, N.2    Ciofani, M.3    Chen, G.4    Collins, A.5    Littman, D.R.6
  • 20
    • 77956172807 scopus 로고    scopus 로고
    • Determining gammadelta versus alphass T cell development
    • Ciofani M, Zuniga-Pflucker JC (2010) Determining gammadelta versus alphass T cell development. Nat Rev Immunol 10:657-663
    • (2010) Nat Rev Immunol , vol.10 , pp. 657-663
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 22
    • 0032805149 scopus 로고    scopus 로고
    • Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation [1]
    • DOI 10.1038/11887
    • Csankovszki G, Panning B, Bates B, Pehrson JR, Jaenisch R (1999) Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet 22:323-324 (Pubitemid 29369518)
    • (1999) Nature Genetics , vol.22 , Issue.4 , pp. 323-324
    • Csankovszki, G.1    Panning, B.2    Bates, B.3    Pehrson, J.R.4    Jaenisch, R.5
  • 23
    • 10644289346 scopus 로고    scopus 로고
    • Dynamic repositioning of CD4 and CD8 genes during T cell development
    • DOI 10.1084/jem.20041041
    • Delaire S, Huang YH, Chan SW, Robey EA (2004) Dynamic repositioning of CD4 and CD8 genes during T cell development. J Exp Med 200:1427-1435 (Pubitemid 39657290)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.11 , pp. 1427-1435
    • Delaire, S.1    Huang, Y.H.2    Chan, S.W.3    Robey, E.A.4
  • 24
    • 0034650692 scopus 로고    scopus 로고
    • Human CD8β, but not mouse CD8β, can be expressed in the absence of CD8α as a ββ homodimer
    • Devine L, Kieffer LJ, Aitken V, Kavathas PB (2000) Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer. J Immunol 164: 833-838 (Pubitemid 30043707)
    • (2000) Journal of Immunology , vol.164 , Issue.2 , pp. 833-838
    • Devine, L.1    Kieffer, L.J.2    Aitken, V.3    Kavathas, P.B.4
  • 25
    • 52549101132 scopus 로고    scopus 로고
    • ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    • Egawa T, Littman DR (2008) ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol 9: 1131-1139
    • (2008) Nat Immunol , vol.9 , pp. 1131-1139
    • Egawa, T.1    Littman, D.R.2
  • 26
    • 80052557419 scopus 로고    scopus 로고
    • The transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
    • Egawa T, Littman DR (2011) The transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci USA 108:14873-14878
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14873-14878
    • Egawa, T.1    Littman, D.R.2
  • 27
    • 34547744867 scopus 로고    scopus 로고
    • The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    • DOI 10.1084/jem.20070133
    • Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR (2007) The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 204: 1945-1957 (Pubitemid 47236329)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1945-1957
    • Egawa, T.1    Tillman, R.E.2    Naoe, Y.3    Taniuchi, I.4    Littman, D.R.5
  • 28
    • 0030670312 scopus 로고    scopus 로고
    • An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
    • Ellmeier W, Sunshine MJ, Losos K, Hatam F, Littman DR (1997) An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7:537-547 (Pubitemid 27508705)
    • (1997) Immunity , vol.7 , Issue.4 , pp. 537-547
    • Ellmeier, W.1    Sunshine, M.J.2    Losos, K.3    Hatam, F.4    Littman, D.R.5
  • 29
    • 0032191963 scopus 로고    scopus 로고
    • Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
    • DOI 10.1016/S1074-7613(00)80632-9
    • Ellmeier W, Sunshine MJ, Losos K, Littman DR (1998) Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 9:485-496 (Pubitemid 28499200)
    • (1998) Immunity , vol.9 , Issue.4 , pp. 485-496
    • Ellmeier, W.1    Sunshine, M.J.2    Losos, K.3    Littman, D.R.4
  • 30
    • 0036285006 scopus 로고    scopus 로고
    • Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression
    • DOI 10.1016/S1074-7613(02)00309-6
    • Ellmeier W, Sunshine MJ, Maschek R, Littman DR (2002) Combined deletion of CD8 locus cisregulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16:623-634 (Pubitemid 34626684)
    • (2002) Immunity , vol.16 , Issue.5 , pp. 623-634
    • Ellmeier, W.1    Sunshine, M.J.2    Maschek, R.3    Littman, D.R.4
  • 31
    • 12444333478 scopus 로고    scopus 로고
    • Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development
    • Feik N, Bilic I, Tinhofer J, Unger B, Littman DR, Ellmeier W (2005) Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol 174:1513-1524
    • (2005) J Immunol , vol.174 , pp. 1513-1524
    • Feik, N.1    Bilic, I.2    Tinhofer, J.3    Unger, B.4    Littman, D.R.5    Ellmeier, W.6
  • 36
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • DOI 10.1038/nature05836, PII NATURE05836
    • Foster SL, Hargreaves DC, Medzhitov R (2007) Gene-specific control of inflammation by TLRinduced chromatin modifications. Nature 447:972-978 (Pubitemid 46975746)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 37
    • 77954960062 scopus 로고    scopus 로고
    • Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    • Frankel N, Davis GK, Vargas D, Wang S, Payre F, Stern DL (2010) Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature 466:490-493
    • (2010) Nature , vol.466 , pp. 490-493
    • Frankel, N.1    Davis, G.K.2    Vargas, D.3    Wang, S.4    Payre, F.5    Stern, D.L.6
  • 38
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • DOI 10.1038/71750
    • Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24:88-91 (Pubitemid 30041428)
    • (2000) Nature Genetics , vol.24 , Issue.1 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3    Hughes-Davies, L.4    Kouzarides, T.5
  • 40
    • 0036286001 scopus 로고    scopus 로고
    • Variegated expression of CD8α resulting from in situ deletion of regulatory sequences
    • DOI 10.1016/S1074-7613(02)00308-4
    • Garefalaki A, Coles M, Hirschberg S, Mavria G, Norton T, Hostert A, Kioussis D (2002) Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity 16:635-647 (Pubitemid 34626685)
    • (2002) Immunity , vol.16 , Issue.5 , pp. 635-647
    • Garefalaki, A.1    Coles, M.2    Hirschberg, S.3    Mavria, G.4    Norton, T.5    Hostert, A.6    Kioussis, D.7
  • 41
    • 77950681154 scopus 로고    scopus 로고
    • Gamma interferondependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies
    • Gialitakis M, Arampatzi P, Makatounakis T, Papamatheakis J (2010) Gamma interferondependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies. Mol Cell Biol 30:2046-2056
    • (2010) Mol Cell Biol , vol.30 , pp. 2046-2056
    • Gialitakis, M.1    Arampatzi, P.2    Makatounakis, T.3    Papamatheakis, J.4
  • 42
    • 0031202922 scopus 로고    scopus 로고
    • Distinct methylation states of the CD8β gene in peripheral T cells and intraepithelial lymphocytes
    • Hamerman JA, Page ST, Pullen AM (1997) Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes. J Immunol 159:1240-1246 (Pubitemid 127484101)
    • (1997) Journal of Immunology , vol.159 , Issue.3 , pp. 1240-1246
    • Hamerman, J.A.1    Page, S.T.2    Pullen, A.M.3
  • 43
    • 0027982808 scopus 로고
    • + T cells and in macrophages of transgenic mice
    • Hanna Z, Simard C, Laperriere A, Jolicoeur P (1994) Specific expression of the human CD4 gene in mature CD4+ CD8-and immature CD4+ CD8+ T cells and in macrophages of transgenic mice. Mol Cell Biol 14:1084-1094 (Pubitemid 24036559)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.2 , pp. 1084-1094
    • Hanna, Z.1    Simard, C.2    Laperriere, A.3    Jolicoeur, P.4
  • 46
    • 14544288635 scopus 로고    scopus 로고
    • The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    • DOI 10.1038/nature03338
    • He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ (2005) The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433:826-833 (Pubitemid 40314886)
    • (2005) Nature , vol.433 , Issue.7028 , pp. 826-833
    • He, X.1    He, X.2    Dave, V.P.3    Zhang, Y.4    Hua, X.5    Nicolas, E.6    Xu, W.7    Roe, B.A.8    Kappes, D.J.9
  • 48
    • 0038783583 scopus 로고    scopus 로고
    • GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation
    • DOI 10.1016/S1074-7613(03)00176-6
    • Hernandez-Hoyos G, Anderson MK, Wang C, Rothenberg EV, Alberola-Ila J (2003) GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19:83-94 (Pubitemid 36859903)
    • (2003) Immunity , vol.19 , Issue.1 , pp. 83-94
    • Hernandez-Hoyos, G.1    Anderson, M.K.2    Wang, C.3    Rothenberg, E.V.4    Alberola-Ila, J.5
  • 49
    • 0032192483 scopus 로고    scopus 로고
    • Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells
    • DOI 10.1016/S1074-7613(00)80633-0
    • Hostert A, Garefalaki A, Mavria G, Tolaini M, Roderick K, Norton T, Mee PJ, Tybulewicz VL, Coles M, Kioussis D (1998) Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity 9:497-508 (Pubitemid 28499201)
    • (1998) Immunity , vol.9 , Issue.4 , pp. 497-508
    • Hostert, A.1    Garefalaki, A.2    Mavria, G.3    Tolaini, M.4    Roderick, K.5    Norton, T.6    Mee, P.J.7    Tybulewicz, V.L.J.8    Coles, M.9    Kioussis, D.10
  • 51
    • 0030725991 scopus 로고    scopus 로고
    • A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice
    • Hostert A, Tolaini M, Roderick K, Harker N, Norton T, Kioussis D (1997b) A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 7:525-536 (Pubitemid 27508704)
    • (1997) Immunity , vol.7 , Issue.4 , pp. 525-536
    • Hostert, A.1    Tolaini, M.2    Roderick, K.3    Harker, N.4    Norton, T.5    Kioussis, D.6
  • 52
    • 79959948197 scopus 로고    scopus 로고
    • YY1 Tethers Xist RNA to the Inactive X nucleation center
    • Jeon Y, Lee JT (2011) YY1 Tethers Xist RNA to the Inactive X Nucleation Center. Cell 146:119-133
    • (2011) Cell , vol.146 , pp. 119-133
    • Jeon, Y.1    Lee, J.T.2
  • 54
    • 38549113035 scopus 로고    scopus 로고
    • Differential chromatin looping regulates CD4 expression in immature thymocytes
    • DOI 10.1128/MCB.00909-07
    • Jiang H, Peterlin BM (2008) Differential chromatin looping regulates CD4 expression in immature thymocytes. Mol Cell Biol 28:907-912 (Pubitemid 351160048)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.3 , pp. 907-912
    • Jiang, H.1    Peterlin, B.M.2
  • 55
    • 28544439524 scopus 로고    scopus 로고
    • Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: Possible mechanism of CD4 silencing
    • DOI 10.1128/MCB.25.24.10675-10683.2005
    • Jiang H, Zhang F, Kurosu T, Peterlin BM (2005) Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing. Mol Cell Biol 25:10675-10683 (Pubitemid 41747114)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.24 , pp. 10675-10683
    • Jiang, H.1    Zhang, F.2    Kurosu, T.3    Peterlin, B.M.4
  • 56
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a Functional T Cell Receptor during T Lymphocyte Development Is Enforced by HEB and E2A Transcription Factors
    • DOI 10.1016/j.immuni.2007.10.014, PII S1074761307005511
    • Jones ME, Zhuang Y (2007) Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27:860-870 (Pubitemid 350251224)
    • (2007) Immunity , vol.27 , Issue.6 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 58
    • 0031573227 scopus 로고    scopus 로고
    • Appropriate developmental expression of human CD8β in transgenic mice
    • Kieffer LJ, Yan L, Hanke JH, Kavathas PB (1997) Appropriate developmental expression of human CD8 beta in transgenic mice. J Immunol 159:4907-4912 (Pubitemid 127471027)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 4907-4912
    • Kieffer, L.J.1    Yan, L.2    Hanke, J.H.3    Kavathas, P.B.4
  • 59
    • 0027460824 scopus 로고
    • Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
    • Killeen N, Sawada S, Littman DR (1993) Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J 12:1547-1553 (Pubitemid 23112808)
    • (1993) EMBO Journal , vol.12 , Issue.4 , pp. 1547-1553
    • Killeen, N.1    Sawada, S.2    Littman, D.R.3
  • 61
    • 3543023310 scopus 로고    scopus 로고
    • Evidence for nucleosome depletion at active regulatory regions genome-wide
    • DOI 10.1038/ng1400
    • Lee CK, Shibata Y, Rao B, Strahl BD, Lieb JD (2004) Evidence for nucleosome depletion at active regulatory regions genome-wide. Nat Genet 36:900-905 (Pubitemid 39014111)
    • (2004) Nature Genetics , vol.36 , Issue.8 , pp. 900-905
    • Lee, C.-K.1    Shibata, Y.2    Rao, B.3    Strahl, B.D.4    Lieb, J.D.5
  • 62
    • 12344250807 scopus 로고    scopus 로고
    • H2 cytokine genes and for long-range intrachromosomal interactions
    • DOI 10.1038/ni1148
    • Lee GR, Spilianakis CG, Flavell RA (2005) Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 6:42-48 (Pubitemid 40136694)
    • (2005) Nature Immunology , vol.6 , Issue.1 , pp. 42-48
    • Lee, G.R.1    Spilianakis, C.G.2    Flavell, R.A.3
  • 63
    • 77956153243 scopus 로고    scopus 로고
    • The language of histone crosstalk
    • Lee JS, Smith E, Shilatifard A (2010) The language of histone crosstalk. Cell 142:682-685
    • (2010) Cell , vol.142 , pp. 682-685
    • Lee, J.S.1    Smith, E.2    Shilatifard, A.3
  • 67
    • 0035929147 scopus 로고    scopus 로고
    • Nucleosome sliding via TBP DNA binding in vivo
    • DOI 10.1016/S0092-8674(01)00490-1
    • Lomvardas S, Thanos D (2001) Nucleosome sliding via TBP DNA binding in vivo. Cell 106:685-696 (Pubitemid 32900660)
    • (2001) Cell , vol.106 , Issue.6 , pp. 685-696
    • Lomvardas, S.1    Thanos, D.2
  • 70
    • 40249085830 scopus 로고    scopus 로고
    • Regulation of an inducible promoter by an HP1β-HP1γ switch
    • DOI 10.1038/embor.2008.1, PII EMBOR20081
    • Mateescu B, Bourachot B, Rachez C, Ogryzko V, Muchardt C (2008) Regulation of an inducible promoter by an HP1beta-HP1gamma switch. EMBO Rep 9:267-272 (Pubitemid 351330992)
    • (2008) EMBO Reports , vol.9 , Issue.3 , pp. 267-272
    • Mateescu, B.1    Bourachot, B.2    Rachez, C.3    Ogryzko, V.4    Muchardt, C.5
  • 74
    • 36049032122 scopus 로고    scopus 로고
    • Antagonistic interactions between ikaros and the chromatin remodeler Mi-2β determine silencer activity and Cd4 gene expression
    • DOI 10.1016/j.immuni.2007.09.008, PII S107476130700489X
    • Naito T, Gomez-Del Arco P, Williams CJ, Georgopoulos K (2007) Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity 27:723-734 (Pubitemid 350102255)
    • (2007) Immunity , vol.27 , Issue.5 , pp. 723-734
    • Naito, T.1    Gomez-del Arco, P.2    Williams, C.J.3    Georgopoulos, K.4
  • 75
    • 77957366306 scopus 로고    scopus 로고
    • The network of transcription factors that underlie the CD4 versus CD8 lineage decision
    • Naito T, Taniuchi I (2010) The network of transcription factors that underlie the CD4 versus CD8 lineage decision. Int Immunol 22:791-796
    • (2010) Int Immunol , vol.22 , pp. 791-796
    • Naito, T.1    Taniuchi, I.2
  • 76
    • 0344022572 scopus 로고    scopus 로고
    • Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
    • DOI 10.1016/S1097-2765(03)00092-3
    • Ng HH, Robert F, Young RA, Struhl K (2003) Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell 11:709-719 (Pubitemid 36385124)
    • (2003) Molecular Cell , vol.11 , Issue.3 , pp. 709-719
    • Ng, H.H.1    Robert, F.2    Young, R.A.3    Struhl, K.4
  • 77
    • 37749051130 scopus 로고    scopus 로고
    • Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription
    • Ng RK, Gurdon JB (2008) Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nat Cell Biol 10:102-109
    • (2008) Nat Cell Biol , vol.10 , pp. 102-109
    • Ng, R.K.1    Gurdon, J.B.2
  • 78
    • 17444410031 scopus 로고    scopus 로고
    • The influence of non-coding RNAs on allele-specific gene expression in mammals
    • DOI 10.1093/hmg/ddi108
    • O'Neill MJ (2005) The influence of non-coding RNAs on allele-specific gene expression in mammals. Hum Mol Genet 14 Spec No 1, R113-120 (Pubitemid 40542627)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SPEC. ISS. 1
    • O'Neill, M.J.1
  • 79
    • 0015964401 scopus 로고
    • Spheroid chromatin units (v bodies)
    • Olins AL, Olins DE (1974) Spheroid chromatin units (v bodies). Science 183:330-332
    • (1974) Science , vol.183 , pp. 330-332
    • Olins, A.L.1    Olins, D.E.2
  • 80
    • 0034727102 scopus 로고    scopus 로고
    • RNA polymerase II elongation through chromatin
    • Orphanides G, Reinberg D (2000) RNA polymerase II elongation through chromatin. Nature 407:471-475
    • (2000) Nature , vol.407 , pp. 471-475
    • Orphanides, G.1    Reinberg, D.2
  • 82
    • 33846862405 scopus 로고    scopus 로고
    • High-throughput mapping of the chromatin structure of human promoters
    • DOI 10.1038/nbt1279, PII NBT1279
    • Ozsolak F, Song JS, Liu XS, Fisher DE (2007) High-throughput mapping of the chromatin structure of human promoters. Nat Biotechnol 25:244-248 (Pubitemid 46227125)
    • (2007) Nature Biotechnology , vol.25 , Issue.2 , pp. 244-248
    • Ozsolak, F.1    Song, J.S.2    Liu, X.S.3    Fisher, D.E.4
  • 83
    • 0348110327 scopus 로고    scopus 로고
    • Critical roles for transcription factor GATA-3 in thymocyte development
    • DOI 10.1016/S1074-7613(03)00328-5
    • Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC (2003) Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19:863-875 (Pubitemid 37542306)
    • (2003) Immunity , vol.19 , Issue.6 , pp. 863-875
    • Pai, S.-Y.1    Truitt, M.L.2    Ting, C.-N.3    Leiden, J.M.4    Glimcher, L.H.5    Ho, I.-C.6
  • 84
    • 46149108345 scopus 로고    scopus 로고
    • Rapid, Transcription-Independent Loss of Nucleosomes over a Large Chromatin Domain at Hsp70 Loci
    • DOI 10.1016/j.cell.2008.05.029, PII S0092867408006892
    • Petesch SJ, Lis JT (2008) Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci. Cell 134:74-84 (Pubitemid 351905736)
    • (2008) Cell , vol.134 , Issue.1 , pp. 74-84
    • Petesch, S.J.1    Lis, J.T.2
  • 87
    • 33846006550 scopus 로고    scopus 로고
    • Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns
    • DOI 10.1101/gr.5767907
    • Roh TY, Wei G, Farrell CM, Zhao K (2007) Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns. Genome Res 17:74-81 (Pubitemid 46041668)
    • (2007) Genome Research , vol.17 , Issue.1 , pp. 74-81
    • Roh, T.-Y.1    Wei, G.2    Farrell, C.M.3    Zhao, K.4
  • 88
    • 37549010335 scopus 로고    scopus 로고
    • Launching the T-cell-lineage developmental programme
    • Rothenberg EV, Moore JE, Yui MA (2008) Launching the T-cell-lineage developmental programme. Nat Rev Immunol 8:9-21
    • (2008) Nat Rev Immunol , vol.8 , pp. 9-21
    • Rothenberg, E.V.1    Moore, J.E.2    Yui, M.A.3
  • 89
    • 0034665756 scopus 로고    scopus 로고
    • X inactivation in the mouse embryo deficient for Dnmt1: Distinct effect of hypomethylation on imprinted and random X inactivation
    • Sado T, Fenner MH, Tan SS, Tam P, Shioda T, Li E (2000) X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation. Dev Biol 225:294-303
    • (2000) Dev Biol , vol.225 , pp. 294-303
    • Sado, T.1    Fenner, M.H.2    Tan, S.S.3    Tam, P.4    Shioda, T.5    Li, E.6
  • 90
    • 77951284245 scopus 로고    scopus 로고
    • The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
    • Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier W (2010) The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol 11:442-448
    • (2010) Nat Immunol , vol.11 , pp. 442-448
    • Sakaguchi, S.1    Hombauer, M.2    Bilic, I.3    Naoe, Y.4    Schebesta, A.5    Taniuchi, I.6    Ellmeier, W.7
  • 91
    • 0026738567 scopus 로고
    • T cell-specific protein-DNA interactions occurring at the CD4 locus: Identification of possible transcriptional control elements of the murine CD4 gene
    • Sands JF, Nikolic-Zugic J (1992) T cell-specific protein-DNA interactions occurring at the CD4 locus: identification of possible transcriptional control elements of the murine CD4 gene. Int Immunol 4:1183-1194
    • (1992) Int Immunol , vol.4 , pp. 1183-1194
    • Sands, J.F.1    Nikolic-Zugic, J.2
  • 92
    • 22544471860 scopus 로고    scopus 로고
    • Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity
    • DOI 10.1016/j.immuni.2005.05.011, PII S1074761305002049
    • Sarafova SD, Erman B, Yu Q, Van Laethem F, Guinter T, Sharrow SO, Feigenbaum L, Wildt KF, Ellmeier W, Singer A (2005) Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23:75-87 (Pubitemid 41019659)
    • (2005) Immunity , vol.23 , Issue.1 , pp. 75-87
    • Sarafova, S.D.1    Erman, B.2    Yu, Q.3    Van Laethem, F.4    Guinter, T.5    Sharrow, S.O.6    Feigenbaum, L.7    Wildt, K.F.8    Ellmeier, W.9    Singer, A.10
  • 93
    • 15244342946 scopus 로고    scopus 로고
    • Dual functions of runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
    • DOI 10.1016/j.immuni.2005.01.012
    • Sato T, Ohno S, Hayashi T, Sato C, Kohu K, Satake M, Habu S (2005) Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity 22:317-328 (Pubitemid 40387474)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 317-328
    • Sato, T.1    Ohno, S.-I.2    Hayashi, T.3    Sato, C.4    Kohu, K.5    Satake, M.6    Habu, S.7
  • 94
    • 0025989268 scopus 로고
    • Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene
    • Sawada S, Littman DR (1991) Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol Cell Biol 11:5506-5515 (Pubitemid 21895316)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.11 , pp. 5506-5515
    • Sawada, S.1    Littman, D.R.2
  • 95
    • 0027237711 scopus 로고
    • A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
    • Sawada S, Littman DR (1993) A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol Cell Biol 13:5620-5628 (Pubitemid 23260664)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.9 , pp. 5620-5628
    • Sawada, S.1    Littman, D.R.2
  • 96
    • 0028242609 scopus 로고
    • A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
    • DOI 10.1016/0092-8674(94)90140-6
    • Sawada S, Scarborough JD, Killeen N, Littman DR (1994) A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917-929 (Pubitemid 24187689)
    • (1994) Cell , vol.77 , Issue.6 , pp. 917-929
    • Sawada, S.1    Scarborough, J.D.2    Killeen, N.3    Liftman, D.R.4
  • 97
    • 52949145604 scopus 로고    scopus 로고
    • Lineage fate and intense debate: Myths, models and mechanisms of CD4-versus CD8-lineage choice
    • Singer A, Adoro S, Park JH (2008) Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice. Nat Rev Immunol 8:788-801
    • (2008) Nat Rev Immunol , vol.8 , pp. 788-801
    • Singer, A.1    Adoro, S.2    Park, J.H.3
  • 98
    • 0028066834 scopus 로고
    • A transcriptional silencer controls the developmental expression of the CD4 gene
    • Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick SM (1994) A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J 13:3570-3579 (Pubitemid 24246194)
    • (1994) EMBO Journal , vol.13 , Issue.15 , pp. 3570-3579
    • Siu, G.1    Wurster, A.L.2    Duncan, D.D.3    Soliman, T.M.4    Hedrick, S.M.5
  • 99
    • 20444494936 scopus 로고    scopus 로고
    • Interchromosomal associations between alternatively expressed loci
    • DOI 10.1038/nature03574
    • Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA (2005) Interchromosomal associations between alternatively expressed loci. Nature 435:637-645 (Pubitemid 40825504)
    • (2005) Nature , vol.435 , Issue.7042 , pp. 637-645
    • Spilianakis, C.G.1    Lalioti, M.D.2    Town, T.3    Lee, G.R.4    Flavell, R.A.5
  • 100
    • 0042470456 scopus 로고    scopus 로고
    • Positive and negative selection of T cells
    • DOI 10.1146/annurev.immunol.21.120601.141107
    • Starr TK, Jameson SC, Hogquist KA (2003) Positive and negative selection of T cells. Annu Rev Immunol 21:139-176 (Pubitemid 37174529)
    • (2003) Annual Review of Immunology , vol.21 , pp. 139-176
    • Starr, T.K.1    Jameson, S.C.2    Hogquist, K.A.3
  • 101
    • 16844375768 scopus 로고    scopus 로고
    • The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
    • DOI 10.1038/ni1183
    • Sun G, Liu X, Mercado P, Jenkinson SR, Kypriotou M, Feigenbaum L, Galera P, Bosselut R (2005) The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 6:373-381 (Pubitemid 41716777)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 373-381
    • Sun, G.1    Liu, X.2    Mercado, P.3    Jenkinson, S.R.4    Kypriotou, M.5    Feigenbaum, L.6    Galera, P.7    Bosselut, R.8
  • 103
    • 2442688211 scopus 로고    scopus 로고
    • The CD4/CD8 lineage choice: New insights into epigenetic regulation during T cell development
    • DOI 10.1016/S0065-2776(04)83002-5
    • Taniuchi I, Ellmeier W, Littman DR (2004) The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol 83:55-89 (Pubitemid 38657637)
    • (2004) Advances in Immunology , vol.83 , pp. 55-89
    • Taniuchi, I.1    Ellmeier, W.2    Littman, D.R.3
  • 104
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • DOI 10.1016/S0092-8674(02)01111-X
    • Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR (2002a) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111:621-633 (Pubitemid 35441245)
    • (2002) Cell , vol.111 , Issue.5 , pp. 621-633
    • Taniuchi, I.1    Osato, M.2    Egawa, T.3    Sunshine, M.J.4    Bae, S.-C.5    Komori, T.6    Ito, Y.7    Littman, D.R.8
  • 105
    • 0036864610 scopus 로고    scopus 로고
    • Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    • DOI 10.1016/S1097-2765(02)00735-9
    • Taniuchi I, Sunshine MJ, Festenstein R, Littman DR (2002b) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell 10:1083-1096 (Pubitemid 35453826)
    • (2002) Molecular Cell , vol.10 , Issue.5 , pp. 1083-1096
    • Taniuchi, I.1    Sunshine, M.J.2    Festenstein, R.3    Littman, D.R.4
  • 106
    • 1642357581 scopus 로고    scopus 로고
    • Localization of the Domains in Runx Transcription Factors Required for the Repression of CD4 in Thymocytes
    • Telfer JC, Hedblom EE, Anderson MK, Laurent MN, Rothenberg EV (2004) Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J Immunol 172:4359-4370 (Pubitemid 38375251)
    • (2004) Journal of Immunology , vol.172 , Issue.7 , pp. 4359-4370
    • Telfer, J.C.1    Hedblom, E.E.2    Anderson, M.K.3    Laurent, M.N.4    Rothenberg, E.V.5
  • 108
    • 57449108862 scopus 로고    scopus 로고
    • The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    • Wang L, Wildt KF, Castro E, Xiong Y, Feigenbaum L, Tessarollo L, Bosselut R (2008a) The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 29:876-887
    • (2008) Immunity , vol.29 , pp. 876-887
    • Wang, L.1    Wildt, K.F.2    Castro, E.3    Xiong, Y.4    Feigenbaum, L.5    Tessarollo, L.6    Bosselut, R.7
  • 110
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • DOI 10.1038/ni1437, PII NI1437
    • Williams LM, Rudensky AY (2007) Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8:277-284 (Pubitemid 46745377)
    • (2007) Nature Immunology , vol.8 , Issue.3 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 112
    • 0018359588 scopus 로고
    • The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity
    • Wu C, Wong YC, Elgin SC (1979) The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity. Cell 16:807-814 (Pubitemid 9161331)
    • (1979) Cell , vol.16 , Issue.4 , pp. 807-814
    • Wu, C.1    Wong, Y.C.2    Elgin, S.C.R.3
  • 113
    • 77954842322 scopus 로고    scopus 로고
    • Dnmt3adependent nonpromoter DNA methylation facilitates transcription of neurogenic genes
    • Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, Li E, Zhang Y, Sun YE (2010) Dnmt3adependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329:444-448
    • (2010) Science , vol.329 , pp. 444-448
    • Wu, H.1    Coskun, V.2    Tao, J.3    Xie, W.4    Ge, W.5    Yoshikawa, K.6    Li, E.7    Zhang, Y.8    Sun, Y.E.9
  • 115
    • 0033637110 scopus 로고    scopus 로고
    • A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
    • Wutz A, Jaenisch R (2000) A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell 5:695-705
    • (2000) Mol Cell , vol.5 , pp. 695-705
    • Wutz, A.1    Jaenisch, R.2
  • 118
    • 0032169239 scopus 로고    scopus 로고
    • Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8α at double- and single-positive stages of thymic development
    • Zhang XL, Seong R, Piracha R, Larijani M, Heeney M, Parnes JR, Chamberlain JW (1998) Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double-and single-positive stages of thymic development. J Immunol 161:2254-2266 (Pubitemid 28397037)
    • (1998) Journal of Immunology , vol.161 , Issue.5 , pp. 2254-2266
    • Zhang, X.-L.1    Seong, R.2    Piracha, R.3    Larijani, M.4    Heeney, M.5    Parnes, J.R.6    Chamberlain, J.W.7
  • 119
    • 0035801606 scopus 로고    scopus 로고
    • low/intermediate stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes
    • DOI 10.1084/jem.194.5.685
    • Zhang XL, Zhao S, Borenstein SH, Liu Y, Jayabalasingham B, Chamberlain JW (2001) CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes. J Exp Med 194:685-693 (Pubitemid 32844778)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.5 , pp. 685-693
    • Zhang, X.-L.1    Zhao, S.2    Borenstein, S.H.3    Liu, Y.4    Jayabalasingham, B.5    Chamberlain, J.W.6
  • 120
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463:808-812
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 121


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.