Dual functions of runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

Immunity

Volumn 22, Issue 3, 2005, Pages 317-328

  Sato, Takehito ^a   Ohno, Shin Ichiro ^a   Hayashi, Takumi ^a   Sato, Chiharu ^a   Kohu, Kazuyoshi ^b   Satake, Masanobu ^b   Habu, Sonoko ^a  

^a TOKAI UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR RUNX3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; GENE SILENCING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; THYMOCYTE; THYMUS;

EID: 15244342946     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2005.01.012     Document Type: Article

References (46)

1. N. Avitahl, S. Winandy, C. Friedrich, B. Jones, Y. Ge, and K. Georgopoulos Ikaros sets thresholds for T cell activation and regulates chromosome propagation Immunity 10 1999 333 343
2. M. Banan, I.C. Rojas, W.-H. Lee, H.L. King, J.V. Harriss, R. Kobayashi, C.F. Webb, and P.D. Gottlieb Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8α gene J. Biol. Chem. 272 1997 18440 18452
3. K.E. Brown, S.S. Guest, S.T. Smale, K. Hahm, M. Merkenschlager, and A.G. Fisher Association of transcriptionally silent genes with Ikaros complexes at cetrometric heterochromatin Cell 91 1997 845 854
4. E. Brugnera, A. Bhandoola, R. Cibotti, Q. Yu, T.I. Guinter, Y. Yamashita, S.O. Sharrow, and A. Singer Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells Immunity 13 2000 59 71
5. S. Chakraborty, K.K. Sinha, V. Senyuk, and G. Nucifora SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo Oncogene 22 2003 5229 5237
6. T.H. Chi, M. Wan, K. Zhao, I. Taniuchi, L. Chen, D.R. Littman, and G.R. Crabtree Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes Nature 418 2002 195 199
7. J.R. Downing The core-binding factor leukemias: lessons learned from murine models Curr. Opin. Genet. Dev. 13 2003 48 54
8. M. Ehlers, K. Laule-Kilian, M. Petter, C.J. Aldrian, B. Grüter, A. Würch, N. Yoshida, T. Watanabe, M. Satake, and V. Steimle Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes J. Immunol. 171 2003 3594 3604
9. W. Ellmeier, M.J. Sunshine, K. Losos, F. Hatam, and D.R. Littman An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells Immunity 7 1997 537 547
10. W. Ellmeier, M.J. Sunshine, K. Losos, and D.R. Littman Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells Immunity 9 1998 485 496
11. W. Ellmeier, S. Sawada, and D.R. Littman The regulation of CD4 and CD8 coreceptor gene expression during T cell development Annu. Rev. Immunol. 17 1999 523 554
12. W. Ellmeier, M.J. Sunshine, R. Maschek, and D.R. Littman Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression Immunity 16 2002 623 634
13. A. Garefalaki, M. Coles, S. Hirschberg, G. Mavria, T. Norton, A. Hostert, and D. Kioussis Variegated expression of CD8α resulting from in situ deletion of regulatory sequences Immunity 16 2002 635 647
14. R.N. Germain T-cell development and the CD4-CD8 lineage decision Nat. Rev. Immunol. 2 2002 309 322
15. N. Harker, T. Naito, M. Cortes, A. Hostert, S. Hirschberg, M. Tolaini, K. Roderick, K. Georgopopulos, and D. Kioussis The CD8α gene locus is regulated by the Ikaros family of proteins Mol. Cell 10 2002 1403 1415
16. K. Hayashi, W. Natsume, T. Watanabe, N. Abe, N. Iwai, H. Okada, Y. Ito, M. Asano, Y. Iwakura, and S. Habu Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells J. Immunol. 165 2000 6816 6824
17. K. Hayashi, N. Abe, T. Watanabe, M. Obinata, M. Ito, T. Sato, S. Habu, and M. Satake Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage J. Immunol. 167 2001 4957 4965
18. S.M. Hedrick T cell development: bottoms-up Immunity 16 2002 619 622
19. G. Hernández-Hoyos, S.J. Sohn, E.V. Rothenberg, and J. AlberolaIla Lck activity controls CD4/CD8 T cell lineage commitment Immunity 12 2000 313 322
20. A. Hostert, M. Tolaini, R. Festenstein, L. McNeill, B. Malissen, O. Williams, R. Zamoyska, and D. Kioussis A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice J. Immunol. 158 1997 4270 4281
21. A. Hostert, M. Tolaini, K. Roderick, N. Harker, T. Norton, and D. Kioussis A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice Immunity 7 1997 525 536
22. A. Hostert, A. Garefalaki, G. Mavria, M. Tolaini, K. Roderick, T. Norton, P.J. Mee, V.L. Tybulewicz, M. Coles, and D. Kioussis Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells Immunity 9 1998 497 508
23. Y. Ito Oncogenic potential of the Runx gene family: 'overview' Oncogene 23 2004 4198 4208
24. D. Kioussis, and W. Ellmeier Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation Nat. Rev. Immunol. 2 2002 909 919
25. K. Kohu, T. Sato, S. Ohno, K. Hayashi, R. Uchino, N. Abe, M. Nakazato, N. Yoshida, T. Kikuchi, and Y. Iwakura Over-expression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single positive lineage J. Immunol. 174 2005 2627 2636
26. D.B. Landry, J.D. Engel, and R. Sen Functional GATA-3 binding sites within murine CD8α upstream regulatory sequences J. Exp. Med. 178 1993 941 949
27. R.K. Leung, K. Thomson, A. Gallimore, E. Jones, M. Van den Broek, S. Sierro, A.R. Alsheikhly, A. McMichael, and A. Rahemtulla Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment Nat. Immunol. 2 2001 1167 1173
28. K. Lundberg, W. Heath, F. Kontgen, F.R. Carbone, and K. Shortman Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes J. Exp. Med. 181 1995 1643 1651
29. Y. Ohoka, T. Kuwata, A. Asada, Y. Zhao, M. Mukai, and M. Iwata Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity J. Immunol. 158 1997 5707 5716
30. T. Sato, T. Sasahara, Y. Nakamura, T. Osaki, T. Hasegawa, T. Tadakuma, Y. Arata, Y. Kumagai, M. Katsuki, and S. Habu Naïve T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice Eur. J. Immunol. 24 1994 1512 1516
31. T. Sato, C. Sato, D. Suzuki, Y. Yoshida, S. Nunomura, T. Matsumura, K. Hozumi, and S. Habu Surface molecules essential for positive selection are retained but interfered in thymic epithelial cells after monolayer culture Cell. Immunol. 211 2001 71 79
32. T. Sato, R. Ito, S. Nunomura, S. Ohno, K. Hayashi, M. Satake, and S. Habu Requirement of transcription factor AML1 in proliferation of developing thymocytes Immunol. Lett. 89 2003 39 46
33. S. Sawada, J.D. Scarborough, N. Killeen, and D.R. Littman A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development Cell 77 1994 917 929
34. C. Schmedt, and A. Tarakhovsky Autonomous maturation of α/β T lineage cells in the absence of COOH-terminal Src kinase (CsK) J. Exp. Med. 193 2001 815 826
35. L.L. Sharp, D.A. Schwarz, C.M. Bott, C.J. Marshall, and S.M. Hedrick The influence of the MAPK pathway on T cell lineage commitment Immunity 7 1997 609 618
36. A. Singer New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision Curr. Opin. Immunol. 14 2002 207 215
37. G. Siu, A.L. Wurster, D.D. Duncan, T.M. Soliman, and S.M. Hedrick A transcriptional silencer controls the developmental expression of the CD4 gene EMBO J. 13 1994 3570 3579
38. H. Suzuki, J.A. Punt, L.G. Granger, and A. Singer Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection Immunity 1 1995 413 425
39. I. Taniuchi, M. Osato, T. Egawa, M.J. Sunshine, S.C. Bae, T. Komori, Y. Ito, and D.R. Littman Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development Cell 111 2002 621 633
40. I. Taniuchi, M.J. Sunshine, R. Festenstein, and D.R. Littman Evidence for distinct CD4 silencer functions at different stages of thymocytes differentiation Mol. Cell 10 2002 1083 1096
41. J.C. Telfer, E.E. Hedblom, M.K. Anderson, M.N. Laurent, and E.V. Rothenberg Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes J. Immunol. 172 2004 4359 4370
42. E. Woolf, C. Xiao, O. Fainaru, J. Lotem, D. Rosen, V. Negreanu, Y. Bernstein, D. Goldenberg, O. Brenner, and G. Berker Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis Proc. Natl. Acad. Sci. USA 100 2003 7731 7736
43. D. Wotton, J. Ghysdael, S. Wang, N.A. Speck, and M.J. Owen Cooperative binding of Ets-1 and Core binding factor to DNA Mol. Cell. Biol. 14 1994 840 850
44. K. Yasutomo, C. Doyle, L. Miele, C. Fuchs, and R.N. Germain The duration of antigen receptor signaling determines CD4+ versus CD8+ T-cell lineage fate Nature 404 2000 506 510
45. S.K. Zaidi, A.J. Sullivan, A.J. van Wijnen, J.L. Stein, G.S. Stein, and J.B. Lian Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites Proc. Natl. Acad. Sci. USA 99 2002 8048 8053
46. Y.R. Zou, M.J. Sunshine, I. Taniuchi, F. Hatam, N. Killeen, and D.R. Littman Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage Nat. Genet. 29 2001 332 336