Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 36, 2011, Pages 14873-14878

  Egawa, Takeshi ^a,b   Littman, Dan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bipotential precursors; Cell fate decision; T cell development; Transcriptional memory

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CD103 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR AP4; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; DOWN REGULATION; E BOX ELEMENT; EFFECTOR CELL; ENHANCER REGION; EPIGENETICS; GENE SILENCING; MEMORY T LYMPHOCYTE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SILENCER GENE; THYMOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, CD4; CD8-POSITIVE T-LYMPHOCYTES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; GENE SILENCING; MICE; MICE, KNOCKOUT; THYMUS GLAND; TRANSCRIPTION FACTORS;

MUS;

EID: 80052557419     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112293108     Document Type: Article

References (28)

1. Kioussis D, Ellmeier W (2002) Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol 2:909-919.
2. Taniuchi I, Sunshine MJ, Festenstein R, Littman DR (2002) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell 10: 1083-1096.
3. Zou YR, et al. (2001) Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet 29:332-336.
4. Taniuchi I, et al. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111:621-633.
5. Setoguchi R, Taniuchi I, Bevan MJ (2009) ThPOK derepression is required for robust CD8 T cell responses to viral infection. J Immunol 183:4467-4474.
6. Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR (2007) The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 204:1945-1957.
7. Sun G, et al. (2005) The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 6:373-381.
8. He X, et al. (2005) The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433:826-833.
9. Sawada S, Littman DR (1991) Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol Cell Biol 11:5506-5515.
10. Sawada S, Littman DR (1993) A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol Cell Biol 13: 5620-5628.
11. Zhuang Y, Cheng P, Weintraub H (1996) B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol 16:2898-2905.
12. Jones ME, Zhuang Y (2007) Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27: 860-870.
13. Naoe Y, et al. (2007) Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf βbinding to the Il4 silencer. J Exp Med 204:1749-1755.
14. Sawada S, Scarborough JD, Killeen N, Littman DR (1994) A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917-929.
15. Norment AM, Forbush KA, Nguyen N, Malissen M, Perlmutter RM (1997) Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor. J Exp Med 185: 121-130.
16. Yu M, et al. (2008) Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development. Proc Natl Acad Sci USA 105:3873-3878.
17. Engel I, Murre C (2004) E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 23:202-211.
18. Grueter B, et al. (2005) Runx3 regulates integrin á E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175:1694-1705.
19. McCaughtry TM, Wilken MS, Hogquist KA (2007) Thymic emigration revisited. J Exp Med 204:2513-2520.
20. Yu W, et al. (1999) Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400:682-687.
21. Imai K, Okamoto T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J Biol Chem 281:12495-12505.
22. Kim MY, et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci USA 103:13074-13079.
23. Hu YF, Lüscher B, Admon A, Mermod N, Tjian R (1990) Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev 4: 1741-1752.
24. Mermod N, Williams TJ, Tjian R (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332:557-561.
25. Morita S, Kojima T, Kitamura T (2000) Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 7:1063-1066.
26. Egawa T, Littman DR (2008) ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol 9:1131-1139.
27. Eberl G, et al. (2004) An essential function for the nuclear receptor RORγ(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 5:64-73.
28. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.