Dynamic repositioning of CD4 and CD8 genes during T cell development

Journal of Experimental Medicine

Volumn 200, Issue 11, 2004, Pages 1427-1435

  Delaire, Stephanie ^a   Huang, Yina Hsing ^a,b   Chan, Shaio Wei ^a   Robey, Ellen A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Gene repression; Heterochromatin; Lineage commitment; Nuclear position; Positive selection

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ALLELE; ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; GENE CONTROL; GENE LOCATION; GENE REPRESSION; GENETIC ASSOCIATION; HETEROCHROMATIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CELL LINEAGE; CHROMOSOME MAPPING; HETEROCHROMATIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 10644289346     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20041041     Document Type: Article

References (50)

1. Kioussis, D., and W. Ellmeier. 2002. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat. Rev. Immunol. 2:909-919.
2. Ellmeier, W., S. Sawada, and D.R. Littman. 1999. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu. Rev. Immunol. 17:523-554.
3. Siu, G. 2002. Controlling CD4 gene expression during T cell lineage commitment. Semin. Immunol. 14:441-451.
4. Sawada, S., J. Scarborough, N. Killeen, and D. Littman. 1994. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 77: 917-929.
5. Ehlers, M., K. Laule-Kilian, M. Petter, C.J. Aldrian, B. Grueter, A. Wurch, N. Yoshida, T. Watanabe, M. Satake, and V. Steimle. 2003. Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes. J. Immunol. 171:3594-3604.
6. Woolf, E., C. Xiao, O. Fainaru, J. Lotem, D. Rosen, V. Negreanu, Y. Bernstein, D. Goldenberg, O. Brenner, G. Berke, et al. 2003. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc. Natl. Acad. Sci. USA. 100:7731-7736.
7. Taniuchi, I., M. Osato, T. Egawa, M.J. Sunshine, S.C. Bae, T. Komori, Y. ko, and D.R. Littman. 2002. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 111:621-633.
8. Harker, N., T. Naito, M. Cortes, A. Hostert, S. Hirschberg, M. Tolaini, K. Roderick, K. Georgopoulos, and D. Kioussis. 2002. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol. Cell. 10:1403-1415.
9. Hernandez-Hoyos, G., M.K. Anderson, C. Wang, E.V. Rothenberg, and J. Alberola-Ila. 2003. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity. 19:83-94.
10. Pai, S.Y., M.L. Truitt, C.N. Ting, J.M. Leiden, L.H. Glimcher, and I.C. Ho. 2003. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 19:863-875.
11. Wilkinson, B., J.Y. Chen, P. Han, K.M. Rufner, O.D. Goularte, and J. Kaye. 2002. TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat. Immunol. 3:272-280.
12. Brown, K.E., S.S. Guest, S.T. Smale, K. Hahm, M. Merkenschlager, and A.G. Fisher. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 91:845-854.
13. Brown, K.E., J. Baxter, D. Graf, M. Merkenschlager, and A.G. Fisher. 1999. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell. 3:207-217.
14. Grogan, J.L., M. Mohrs, B. Harmon, D.A. Lacy, J.W. Sedat, and R.M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14:205-215.
15. Kosak, S.T., J.A. Skok, K.L. Medina, R. Riblet, M.M. Le Beau, A.G. Fisher, and H. Singh. 2002. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science. 296:158-162.
16. Kydd, R., K. Lundberg, D. Vremec, A.W. Harris, and K. Shortman. 1995. Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+ , CD4int8+ , and CD4+8int thymocytes with upregulated levels of TCR-CD3. J. Immunol. 155:3806-3814.
17. hi thymocytes. J. Exp. Med. 181:1643-1651.
18. Suzuki, H., J.A. Punt, L.G. Granger, and A. Singer. 1995. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity. 2:413-425.
19. Lucas, B., and R. Germain. 1996. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+ CD8+ thymocyte differentiation. Immunity. 5:461-477.
20. Correia-Neves, M., D. Mathis, and C. Benoist. 2001. A molecular chart of thymocyte positive selection. Eur. J. Immunol. 31:2583-2592.
21. Swat, W., L. Ignatowicz, H. von Boehmer, and P. Kisielow. 1991. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 351:150-153.
22. Page, D., L. Kane, J. Allison, and S. Hedrick. 1993. Two signals are required for negative selection of CD4+CD8+ thymocytes. J. Immunol. 151:1868-1880.
23. McGargill, M.A., and K.A. Hogquist. 1999. Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis. J. Immunol. 162:1237-1245.
24. Cibotti, R., A. Bhandoola, T.I. Guinter, S.O. Sharrow, and A. Singer. 2000. CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes. Mol. Cell. Biol. 20:3852-3859.
25. Barthlott, T., H. Kohler, and K. Eichmann. 1997. Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor. J. Exp. Med. 185:357-362.
26. Grusby, M., H.J. Auchincloss, R. Lee, R. Johnson, J. Spencer, M. Zijlstra, R. Jaenisch, V. Papaioannou, and L. Glimcher. 1993. Mice lacking major histocompatibility complex class I and class II molecules. Proc. Natl. Acad. Sci. USA. 90:3913-3917.
27. Mamalaki, C., J. Elliott, T. Norton, N. Yannoutsos, A.R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3:159-174.
28. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R.M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 342:559-561.
29. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
30. Kaye, J., M.L. Hsu, M.E. Sauron, S.C. Jameson, N.R. Gascoigne, and S.M. Hedrick. 1989. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:746-749.
31. Hogquist, K.A., S.C. Jameson, W.R. Heath, J.L. Howard, M.J. Bevan, and F.R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell. 76:17-27.
32. Kaye, J., and D.L. Ellenberger. 1992. Differentiation of an immature T cell line: a model of thymic positive selection. Cell. 71:423-435.
33. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetic and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 66:533-540.
34. Itano, A., and E. Robey. 2000. Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment. Immunity. 12:383-389.
35. Huang, Y.H., D.L. Li, A. Winoto, and E.A. Robey. 2004. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch., and positive selection signals. Proc. Natl. Acad. Sci. USA. 101:4936-4941.
36. Wilkinson, H., K. Fitzgerald, and I. Greenwald. 1994. Reciprocal changes in expression of the receptor lin-12 and its ligand prior to commitment in a C. elegans cell fate decision. Cell. 79:1187-1198.
37. Mikkola, I., B. Heavey, M. Horcher, and M. Busslinger. 2002. Reversion of B cell commitment upon loss of Pax5 expression. Science. 297:110-113.
38. Zou, Y.R., M.J. Sunshine, I. Taniuchi, F. Hatam, N. Killeen, and D.R. Littman. 2001. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29:332-336.
39. Kim, W.W., and G. Siu. 1999. Subclass-specific nuclear localization of a novel CD4 silencer binding factor. J. Exp. Med. 190:281-291.
40. Merkenschlager, M., S. Amoils, E. Roldan, A. Rahemtulla, E. O'Connor, A.G. Fisher, and K.E. Brown. 2004. Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice. J. Exp. Med. 200: 1437-1444.
41. Matechak, E., N. Killeen, S. Hedrick, and B. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:337-347.
42. Robey, E.A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R.A. Axel, and B.J. Fowlkes. 1992. The level of CD8 expression can determine the outcome of thymic selection. Cell. 69:1089-1096.
43. Davis, C.B., N. Killeen, M.E.C. Crooks, D. Raulet, and D.R. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 73:237-247.
44. Baron, A., K. Hafen, and H. von Boehmer. 1994. A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice. Eur. J. Immunol. 24:1933-1936.
45. Paterson, R., L. Burkly, D. Kurahara, A. Dunlap, R. Flavell, and T. Finkel. 1994. Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. J. Immunol. 153:3491-3503.
46. Leung, R.K., K. Thomson, A. Gallimore, E. Jones, M. Van den Broek, S. Sierro, A.R. Alsheikhly, A. McMichael, and A. Rahemtulla. 2001. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nat. Immunol. 2:1167-1173.
47. Robey, E.A., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
48. Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183:731-741.
49. Basson, M.A., and R. Zamoyska. 2000. The CD4/CD8 lineage decision: integration of signalling pathways. Immunol. Today. 21:509-514.
50. Germain, R.N. 2002. T-cell development and the CD4-CD8 lineage decision. Nat. Rev. Immunol. 2:309-322.