The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

Nature Immunology

Volumn 11, Issue 5, 2010, Pages 442-448

  Sakaguchi, Shinya ^a   Hombauer, Matthias ^a,d   Bilic, Ivan ^a,c   Naoe, Yoshinori ^b,d   Schebesta, Alexandra ^a   Taniuchi, Ichiro ^b   Ellmeier, Wilfried ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAZR; TRANSCRIPTION FACTOR TH POK; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FATE; CELL LINEAGE; CONTROLLED STUDY; GENE LOCUS; GENE REGULATORY NETWORK; GENE SILENCING; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; GENE REGULATORY NETWORKS; H-2 ANTIGENS; LYMPHOPOIESIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM PROTEINS; PROTEIN BINDING; RADIATION CHIMERA; RECEPTORS, ANTIGEN, T-CELL; REPRESSOR PROTEINS; SILENCER ELEMENTS, TRANSCRIPTIONAL; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 77951284245     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1860     Document Type: Article

References (36)

1. Bosselut, R. CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals. Nat. Rev. Immunol. 4, 529-540 (2004). (Pubitemid 38931768)
2. He, X. & Kappes, D.J. CD4/CD8 lineage commitment: light at the end of the tunnel? Curr. Opin. Immunol. 18, 135-142 (2006). (Pubitemid 43327294)
3. Singer, A., Adoro, S. & Park, J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice. Nat. Rev. Immunol. 8, 788-801 (2008).
4. Ellmeier, W., Sawada, S. & Littman, D.R. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu. Rev. Immunol. 17, 523-554 (1999). (Pubitemid 29241133)
5. Kioussis, D. & Ellmeier, W. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat. Rev. Immunol. 2, 909-919 (2002). (Pubitemid 37323212)
6. Ellmeier, W., Sunshine, M.J., Maschek, R. & Littman, D.R. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16, 623-634 (2002). (Pubitemid 34626684)
7. Garefalaki, A. et al. Variegated expression of CD8α resulting from in situ deletion of regulatory sequences. Immunity 16, 635-647 (2002). (Pubitemid 34626685)
8. Feik, N. et al. Functional and molecular analysis of the double-positive stage-specifc CD8 enhancer E8III during thymocyte development. J. Immunol. 174, 1513-1524 (2005).
9. Bilic, I. et al. Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc fnger protein MAZR. Nat. Immunol. 7, 392-400 (2006).
10. Taniuchi, I., Ellmeier, W. & Littman, D.R. The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv. Immunol. 83, 55-89 (2004). (Pubitemid 38657637)
11. Bilic, I. & Ellmeier, W. The role of BTB domain-containing zinc fnger proteins in T cell development and function. Immunol. Lett. 108, 1-9 (2007). (Pubitemid 44959055)
12. Kelly, K.F. & Daniel, J.M. POZ for effect-POZ-ZF transcription factors in cancer and development. Trends Cell Biol. 16, 578-587 (2006). (Pubitemid 44636217)
13. Kobayashi, A. et al. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol. Cell. Biol. 20, 1733-1746 (2000). (Pubitemid 30100192)
14. Fedele, M. et al. PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. J. Pathol. 215, 39-47 (2008). (Pubitemid 351619874)
15. He, X. et al. The zinc fnger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433, 826-833 (2005). (Pubitemid 40314886)
16. Sun, G. et al. The zinc fnger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol. 6, 373-381 (2005). (Pubitemid 41716777)
17. Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α-and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34-40 (1998). (Pubitemid 28194695)
18. Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994). (Pubitemid 24035278)
19. Taniuchi, I. et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633 (2002). (Pubitemid 35441245)
20. Setoguchi, R. et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319, 822-825 (2008). (Pubitemid 351225874)
21. Egawa, T. & Littman, D.R. ThPOK acts late in specifcation of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 9, 1131-1139 (2008).
22. + T cells. Nat. Immunol. 9, 1122-1130 (2008).
23. Aliahmad, P. & Kaye, J. Development of all CD4 T lineages requires nuclear factor TOX. J. Exp. Med. 205, 245-256 (2008). (Pubitemid 351185730)
24. Egawa, T., Tillman, R.E., Naoe, Y., Taniuchi, I. & Littman, D.R. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J. Exp. Med. 204, 1945-1957 (2007). (Pubitemid 47236329)
25. Muroi, S. et al. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat. Immunol. 9, 1113-1121 (2008).
26. He, X. et al. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28, 346-358 (2008). (Pubitemid 351335309)
27. Jepsen, K. & Rosenfeld, M.G. Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 115, 689-698 (2002). (Pubitemid 34196329)
28. Taniuchi, I. Transcriptional regulation in helper versus cytotoxic-lineage decision. Curr. Opin. Immunol. 21, 127-132 (2009).
29. Collins, A., Littman, D.R. & Taniuchi, I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat. Rev. Immunol. 9, 106-115 (2009).
30. Egawa, T. Runx and ThPOK: A balancing act to regulate thymocyte lineage commitment. J. Cell. Biochem. 107, 1037-1045 (2009).
31. + T cells. Immunity 29, 876-887 (2008).
32. Jenkinson, S.R. et al. Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. J. Exp. Med. 204, 267-272 (2007).
33. Zou, Y.R. et al. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29, 332-336 (2001).
34. Leung, R.K. et al. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nat. Immunol. 2, 1167-1173 (2001).
35. Liu, X. & Bosselut, R. Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat. Immunol. 5, 280-288 (2004). (Pubitemid 38332125)
36. Naoe, Y. et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer. J. Exp. Med. 204, 1749-1755 (2007). (Pubitemid 47236313)