Cellular fatty acid uptake: a pathway under construction

Trends in Endocrinology and Metabolism

Volumn 20, Issue 2, 2009, Pages 72-77

  Su, Xiong ^a   Abumrad, Nada A ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; LONG CHAIN FATTY ACID;

CARDIOMYOPATHY; CAVEOLA; CELL MEMBRANE; CHEMICAL MODIFICATION; DIABETES MELLITUS; DISEASE PREDISPOSITION; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GLUCOSE UTILIZATION; HEART FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; INSULIN RESISTANCE; METABOLIC SYNDROME X; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; UBIQUITINATION;

ANIMALS; ANTIGENS, CD36; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METABOLIC DISEASES; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RODENTIA; UBIQUITINATION;

EID: 63749108094     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2008.11.001     Document Type: Review

References (75)

1. Desvergne B., et al. Transcriptional regulation of metabolism. Physiol. Rev. 86 (2006) 465-514
2. Zaid H., et al. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem. J. 413 (2008) 201-215
3. Silveira L.R., et al. Updating the effects of fatty acids on skeletal muscle. J. Cell. Physiol. 217 (2008) 1-12
4. Prentki M., and Murthy Madiraju S.R. Glycerolipid metabolism and signaling in health and disease. Endocr. Rev. 29 (2008) 647-676
5. Schroeder F., et al. Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Lipids 43 (2008) 1-17
6. Nahle Z., et al. CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPARδ/β-mediated adaptation to metabolic stress. J. Biol. Chem. 283 (2008) 14317-14326
7. Yang J., et al. CD36 deficiency rescues lipotoxic cardiomyopathy. Circ. Res. 100 (2007) 1208-1217
8. Madrazo J.A., and Kelly D.P. The PPAR trio: regulators of myocardial energy metabolism in health and disease. J. Mol. Cell. Cardiol. 44 (2008) 968-975
9. Tontonoz P., and Spiegelman B.M. Fat and beyond: the diverse biology of PPARγ. Annu. Rev. Biochem. 77 (2008) 289-312
10. Buteau J., and Accili D. Regulation of pancreatic β-cell function by the forkhead protein FoxO1. Diabetes Obes. Metab. 9 Suppl. 2 (2007) 140-146
11. Gross D.N., et al. The role of FoxO in the regulation of metabolism. Oncogene 27 (2008) 2320-2336
12. Simard J.R., et al. Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase. Biochemistry 47 (2008) 9081-9089
13. Schwenk R.W., et al. Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease. Cardiovasc. Res. 79 (2008) 249-258
14. Abumrad, N. and Storch, J. 2006. Role of membrane and cytosolic fatty acid binding proteins in lipid processing by the small intestine. In Physiology of the Gastrointestinal Tract (4th edn) pp. 1693-1709, Burlington: Academic Press
15. Ehehalt R., et al. Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins. Mol. Cell. Biochem. 284 (2006) 135-140
16. Black P.N., and DiRusso C.C. Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim. Biophys. Acta 1771 (2007) 286-298
17. Stremmel W., et al. A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids. Lipids 36 (2001) 981-989
18. Covington D.K., et al. The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. Biochem. Soc. Trans. 34 (2006) 770-773
19. Hirasawa A., et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11 (2005) 90-94
20. Love-Gregory L., et al. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum. Mol. Genet. 17 (2008) 1695-1704
21. Zhou J., et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARγ in promoting steatosis. Gastroenterology 134 (2008) 556-567
22. Ma X., et al. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum. Mol. Genet. 13 (2004) 2197-2205
23. Hajri T., and Abumrad N.A. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu. Rev. Nutr. 22 (2002) 383-415
24. Febbraio M., and Silverstein R.L. CD36: implications in cardiovascular disease. Int. J. Biochem. Cell Biol. 39 (2007) 2012-2030
25. Hazen S.L. Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity. J. Biol. Chem. 283 (2008) 15527-15531
26. Stuart L.M., et al. CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J. Biol. Chem. 282 (2007) 27392-27401
27. Demers A., et al. Hexarelin signaling to PPARγ in metabolic diseases. PPAR Res. 2008 (2008) 364784
28. Hoebe K., et al. CD36 is a sensor of diacylglycerides. Nature 433 (2005) 523-527
29. Febbraio M. CD36 goes native. Arterioscler. Thromb. Vasc. Biol. 28 (2008) 1209-1210
30. El-Yassimi A., et al. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J. Biol. Chem. 283 (2008) 12949-12959
31. Susztak K., et al. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2 (2005) e45
32. Yamashita S., et al. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Mol. Cell. Biochem. 299 (2007) 19-22
33. Tanaka T., et al. Defect in human myocardial long-chain fatty acid uptake is caused by FAT/CD36 mutations. J. Lipid Res. 42 (2001) 751-759
34. Irie H., et al. Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6819-6824
35. Kuang M., et al. Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation 109 (2004) 1550-1557
36. Koonen D.P., et al. CD36 expression contributes to age-induced cardiomyopathy in mice. Circulation 116 (2007) 2139-2147
37. Drover V.A., et al. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J. Clin. Invest. 115 (2005) 1290-1297
38. Masuda, D. et al. Chylomicron remnants are increased in the postprandial state in CD36 deficiency. J. Lipid Res. (in press)
39. Nassir F., et al. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J. Biol. Chem. 282 (2007) 19493-19501
40. Drover V.A., et al. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J. Biol. Chem. 283 (2008) 13108-13115
41. Nauli A.M., et al. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology 131 (2006) 1197-1207
42. Sclafani A., et al. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R1823-R1832
43. Laugerette F., et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J. Clin. Invest. 115 (2005) 3177-3184
44. Goudriaan J.R., et al. CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J. Lipid Res. 46 (2005) 2175-2181
45. Cheung L., et al. Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver - a role for growth hormone in alternative exon usage. BMC Mol. Biol. 8 (2007) 60
46. Greco D., et al. Gene expression in human NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol. 294 (2008) G1281-G1287
47. Pravenec M., et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat. Genet. 40 (2008) 952-954
48. Zhu W., and Smart E.J. Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner. J. Biol. Chem. 280 (2005) 29543-29550
49. Bastie C.C., et al. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. J. Biol. Chem. 280 (2005) 14222-14229
50. Larsen T.S., and Aasum E. Metabolic (in)flexibility of the diabetic heart. Cardiovasc. Drugs Ther. 22 (2008) 91-95
51. Goudriaan J.R., et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J. Lipid Res. 44 (2003) 2270-2277
52. Pravenec M., et al. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Nat. Genet. 27 (2001) 156-158
53. An P., et al. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54 (2005) 909-914
54. Malhotra A., et al. Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes 56 (2007) 890-896
55. Ehehalt R., et al. Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/ sphingolipid enriched microdomains (lipid rafts). BMC Cell Biol. 9 (2008) 45
56. Ortegren U., et al. A new role for caveolae as metabolic platforms. Trends Endocrinol. Metab. 18 (2007) 344-349
57. Cohen A.W., et al. Role of caveolae and caveolins in health and disease. Physiol. Rev. 84 (2004) 1341-1379
58. Pilch P.F., et al. Cellular spelunking: exploring adipocyte caveolae. J. Lipid Res. 48 (2007) 2103-2111
59. Ring A., et al. Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Biochim. Biophys. Acta 1761 (2006) 416-423
60. Labrecque L., et al. Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase. J. Biol. Chem. 279 (2004) 52132-52140
61. Frank P.G., et al. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 98-105
62. Razani B., et al. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. 277 (2002) 8635-8647
63. Campbell S.E., et al. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J. Biol. Chem. 279 (2004) 36235-36241
64. Holloway G.P., et al. Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E1782-E1789
65. Benton C.R., et al. Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria. J. Physiol. 586 (2008) 1755-1766
66. Eyre N.S., et al. Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake. J. Lipid Res. 48 (2007) 528-542
67. Sun B., et al. Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI. J. Lipid Res. 48 (2007) 2560-2570
68. Miranda M., and Sorkin A. Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms. Mol. Interv. 7 (2007) 157-167
69. Pohl J., et al. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 (2005) 24-31
70. Smith J., et al. Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J. Biol. Chem. 283 (2008) 13578-13585
71. Liang C.P., et al. Increased CD36 protein as a response to defective insulin signaling in macrophages. J. Clin. Invest. 113 (2004) 764-773
72. Tao N., et al. CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails. J. Biol. Chem. 271 (1996) 22315-22320
73. Stahl A., et al. Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev. Cell 2 (2002) 477-488
74. Lobo S., et al. Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J. Lipid Res. 48 (2007) 609-620
75. Madden J., et al. Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men. Prostaglandins Leukot. Essent. Fatty Acids 78 (2008) 327-335