Amyloid precursor protein compartmentalization restricts β-amyloid production: Therapeutic targets based on BACE compartmentalization

Journal of Molecular Neuroscience

Volumn 24, Issue 1, 2004, Pages 137-143

  Gandhi, Swetal ^a   Refolo, Lorenzo M ^b   Sambamurti, Kumar ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Alzheimers Drug Discovery Foundation   (United States)

Author keywords

DIGs; Lipid rafts; Memapsin; TIMs

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; PHORBOL ESTER; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ADAM PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; DIPEPTIDE; ENZYME INHIBITOR; HYDROXAMIC ACID; METALLOPROTEINASE; N ((2 (HYDROXYAMINOCARBONYL)METHYL) 4 METHYLPENTANOYL) 3 (2' NAPHTHYL)ALANYLALANINE, 2 AMINOETHYLAMIDE; N-((2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL)-3-(2'-NAPHTHYL)ALANYLALANINE, 2-AMINOETHYLAMIDE; PEPTIDE FRAGMENT; PROTEINASE; SECRETASE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PROTEIN PROCESSING; SECRETORY VESICLE; STIMULATION; ALZHEIMER DISEASE; ARTICLE; BIOSYNTHESIS; CELL COMPARTMENTALIZATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL COMPARTMENTATION; CELL LINE, TUMOR; DIPEPTIDES; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; METALLOENDOPEPTIDASES; PEPTIDE FRAGMENTS; PHORBOL ESTERS; PROTEIN TRANSPORT; SECRETORY VESICLES;

EID: 16544373574     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:24:1:137     Document Type: Conference Paper

References (35)

1. Anderson J. P., Esch F. S., Keim P. S., Sambamurti K., Lieberburg I., and Robakis N. K. (1991) Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci. Lett. 128, 126-128.
2. Arribas J. and Massague J. (1995) Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. J. Cell Biol. 128, 433-441.
3. Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., et al. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
4. Buxbaum J. D., Gandy S. E., Cicchetti P., Ehrlich M. E., Czernik A. J., Fracasso R. P., et al. (1990) Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 87, 6003-6006.
5. Buxbaum J. D., Liu K. N., Luo Y., Slack J. L, Stocking K. L., Peschon J. J., et al. (1998) Evidence that tumo necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273, 27765-27767.
6. Checler F. (1995) Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65, 1431-1444.
7. Esch F. S., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., et al. (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248, 1122-1124.
8. Farzan M., Schnitzler C. E., Vasilieva N., Leung D., and Choe H. (2000) BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. U. S. A. 97, 9712-9717.
9. Fassbender K., Simons M., Bergmann C., Stroick M., Lutjohann D., Keller P., et al. (2001) Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861.
10. Gabuzda D., Busciglio J., and Yankner B. A. (1993) Inhibition of beta-amyloid production by activation of protein kinase C. J. Neurochem. 61, 2326-2329.
11. Hardy J. and Selkoe D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
12. Hartmann D., de Strooper B., Serneels L., Craessaerts K., Herreman A., Annaert W., et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11, 2615-2624.
13. Hartmann D., Tournoy J., Saftig P., Annaert W., and De Strooper B. (2001) Implication of APP secretases in notch signaling. J. Mol. Neurosci. 17, 171-181.
14. Hooper N. M. and Turner A. J. (2002) The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease. Curr. Med. Chem. 9, 1107-1119.
15. Koike H., Tomioka S., Sorimachi H., Saido T. C., Maruyama K., Okuyama A., et al. (1999) Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem. J. 343(Pt, 2), 371-375.
16. Lahiri D. K., Farlow M. R., and Sambamurti K. (1998) The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res. Mol. Brain Res. 62, 131-140.
17. Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., et al. (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927.
18. Marlow L., Cain M., and Sambamurti K. (2003) Regulation of beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J. Mol. Neurosci. 20, 233-239.
19. Mills J. and Reiner P. B. (1999) Regulation of amyloid precursor protein cleavage. J. Neurochem. 72, 443-460.
20. Nitsch R. M., Farber S. A., Growdon J. H., and Wurtman R. J. (1993) Release of amyloid beta-protein precursor derivatives stimulated by activation of muscarinic acetyl choline receptors. Science 258, 304-307.
21. Pinnix I., Musunuru U., Tun H., Sridharan A., Golde T., Eckman C., et al. (2001) A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J. Biol. Chem. 276, 481-487.
22. Refolo L. M., Malester B., LaFrancois J., Bryant-Thomas T., Wang R., Tint G. S., et al. (2000) Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321-331.
23. Refolo L. M., Pappolla M. A., LaFrancois J., Malester B., Schmidt S. D., Thomas-Bryant T, et al. (2001) A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8, 890-899.
24. Refolo L. M., Salton S. R., Anderson J. P., Mehta P., and Robakis N. K. (1989) Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochem. Biophys. Res. Commun. 164, 664-670.
25. Sambamurti K., Greig N. H., and Lahiri D. K. (2002a) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromol. Med. 1, 1-31.
26. Sambamurti K., Hardy J., Refolo L. M., and Lahiri D. K. (2002b) Targeting APP metabolism for the treatment of Alzheimer's disease. Drug Dev. Res. 56, 211-227.
27. Sambamurti K., Sevlever D., Koothan T., Refolo L. M., Pinnix I., Gandhi S., et al. (1999) Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. J. Biol. Chem. 274, 26810-26814.
28. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
29. Seubert P., Oltersdorf T., Lee M. G., Barbour R., Blomquist C., Davis D. L., et al. (1993) Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide. Nature 361, 260-263.
30. Simons M., Keller P., De Strooper B., Beyreuther K., Dotti C. G., and Simons K. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464.
31. Sinha S., Anderson J. P., Barbour R., Basi G. S., Caccavello R., Davis D., et al. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
32. Slack B. E., Ma L. K., and Seah C. C. (2001) Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme. Biochem. J. 357, 787-794.
33. Tun H., Marlow L., Pinnix I., Kinsey R., and Sambamurti K. (2002) Lipid rafts play an important role in A beta biogenesis by regulating beta-secretase pathway. J. Mol. Neurosci. 19, 31-35.
34. Wolozin B. (2003) Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease. Arch. Neurol. 60, 16-18.
35. Xu H., Greengard P., and Gandy S. (1995) Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J. Biol. Chem. 270, 23243-23245.