Transglutaminase 2: Biology, relevance to neurodegenerative diseases and therapeutic implications

Pharmacology and Therapeutics

Volumn 133, Issue 3, 2012, Pages 392-410

  Grosso, Hilary ^a   Mouradian, M Maral ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Huntington's disease; Neurodegenerative disease; Neuroprotection; Parkinson's disease; Protein aggregation; Transglutaminase 2

Indexed keywords

ACYLTRANSFERASE INHIBITOR; ALPHA SYNUCLEIN; BRAIN PROTEIN; CYSTAMINE; CYSTEINE; GLUTAMINE DERIVATIVE; GLUTEN; GUANOSINE TRIPHOSPHATASE; NEUROPROTECTIVE AGENT; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; AUTOPHAGY; BINDING SITE; CELL SURVIVAL; DEGENERATIVE DISEASE; DRUG EFFICACY; ENERGY YIELD; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUNTINGTON CHOREA; LEWY BODY; NEOPLASM; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNAPTIC EFFICACY; TRANSCRIPTION REGULATION;

ANIMALS; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; PROTEIN CONFORMATION; TRANSGLUTAMINASES;

EID: 84856442248     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.12.003     Document Type: Review

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