Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas

Journal of Neuro-Oncology

Volumn 103, Issue 2, 2011, Pages 207-219

  Yuan, Liya ^a   Holmes, Tracy C ^b   Watts, R Edward ^b   Khosla, Chaitan ^b   Broekelmann, Tom J ^a   Mecham, Robert ^a   Zheng, Hong ^a   Izaguirre, Enrique W ^a   Rich, Keith M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Cell death; Cellular motility; Drug resistance; ERW1227B; Focal adhesive complexes; Glioblastomas

Indexed keywords

ACTIN; ANTINEOPLASTIC AGENT; CARMUSTINE; ENZYME INHIBITOR; ERW 1041A; ERW 1095A; ERW 1095B; ERW 1227A; ERW 1227B; FOCAL ADHESION KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER RADIOTHERAPY; CELL DEATH; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; EXTRACELLULAR MATRIX; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PROTEIN BINDING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; FLUORESCENT ANTIBODY TECHNIQUE; GLIOBLASTOMA; HUMANS; IN SITU NICK-END LABELING; ISOXAZOLES; MICE; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION;

EID: 79959837759     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0379-2     Document Type: Article

References (35)

1. Castro MG, Cowen R, Williamson IK et al (2003) Current and future strategies for the treatment of malignant brain tumors. Pharmacol Ther 98:71-108 (Pubitemid 36349762)
2. Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997-1003 (Pubitemid 40349502)
3. Mariani L, Beaudry C, McDonough WS et al (2001) Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: a cDNA microarray analysis. J Neurooncol 53:161-176 (Pubitemid 33034689)
4. McCormick F (2004) Cancer: survival pathways meet their end. Nature 428:267-269
5. Haas-Kogan D, Shalev N, Wong M et al (1998) Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 8:1195-1198 (Pubitemid 28494720)
6. Sonoda Y, Ozawa T, Aldape KD et al (2001) Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res 61:6674-6678 (Pubitemid 32896484)
7. Li B, Chang CM, Yuan M et al (2003) Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas. Cancer Res 63:7443-7450 (Pubitemid 37413487)
8. Davies MA, Lu Y, Sano T et al (1998) Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 58:5285-5290 (Pubitemid 28551100)
9. Shingu T, Yamada K, Hara N et al (2003) Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res 63:4044-4047 (Pubitemid 36917925)
10. Yuan L, Siegel M, Choi K et al (2007) Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 26:2563-2573 (Pubitemid 46632005)
11. Choi K, Siegel M, Piper JL et al (2005) Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol 12:469-475 (Pubitemid 40588922)
12. Yuan L, Choi K, Khosla C et al (2005) Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Mol Cancer Ther 4:1293-1302
13. Watts RE, Siegel M, Khosla C (2006) Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. J Med Chem 49:7493-7501 (Pubitemid 44913408)
14. Czirók A, Rupp PA, Rongish BJ et al (2002) Multi-field 3D scanning light microscopy of early embryogenesis. J Microsc 206:209-217 (Pubitemid 34639418)
15. Kozel BA, Rongish BJ, Czirok A et al (2006) Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol 207:87-96
16. Rupp PA, András Czirók A, Little CD (2004) αvβ3 integrin-dependent endothelial cell dynamics in vivo. Development 131:2887-2897 (Pubitemid 38997277)
17. Stojadinovic S, Low DA, Hope AJ et al (2007) MicroRT-small animal conformal irradiator. Med Phys 34:4706-4716
18. Kiehl EL, Stojadinovic S, Malinowski KT et al (2008) Feasibility of small animal cranial irradiation with the microRT system. Med Phys 35:4735-4743
19. Jiang Z, Zheng X, Rich KM (2003) Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death. J Neurochem 84:273-281 (Pubitemid 36182269)
20. Lytle RA, Jiang Z, Zheng X et al (2004) BCNU down-regulates antiapoptotic proteins bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells. J Neurooncol 68:233-241 (Pubitemid 38878257)
21. Jiang Z, Zheng X, Lytle RA, Higashikubo R et al (2004) Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells. J Neurochem 89:168-178 (Pubitemid 38420686)
22. Joy AM, Beaudry CE, Tran NL et al (2003) Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. J Cell Sci 1:4409-4417 (Pubitemid 37369596)
23. Burridge K, Fath K, Kelly T, Nuckolls G, Turner C (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4:487-525 (Pubitemid 19139264)
24. Montgomery AM, Reisfeld RA, Cheresh DA (1994) Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 91:8856-8860 (Pubitemid 2148815)
25. Petitclerc E, Strömblad S, von Schalscha TL et al (1999) Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res 59:2724-2730 (Pubitemid 29269122)
26. Pupa SM, Ménard S, Forti S et al (2002) New insights into the role of extracellular matrix during tumor onset and progression. Cell Physiol 192:259-267 (Pubitemid 34827603)
27. Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626 (Pubitemid 24064472)
28. Danen EH, Yamada KM (2001) Fibronectin, integrins, and growth control. J Cell Physiol 189:1-13
29. Wierzbicka-Patynowski I, Schwarzbauer JE (2003) The ins and outs of fibronectin matrix assembly. J Cell Sci 15:3269-3276 (Pubitemid 37038975)
30. Taga T, Suzuki A, Gonzalez-Gomez I et al (2002) Alpha v-integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer 98:690-697 (Pubitemid 34228889)
31. Buckley CD, Pilling D, Henriquez NV et al (1999) RGD peptides induce apoptosis by direct caspase-3 activation. Nature 397:534-539
32. Deschesnes RG, Patenaude A, Rousseau JL et al (2007) Microtubule- destabilizing agents induce focal adhesion structure disorganization and anoikis in cancer cells. J Pharmacol Exp Ther 320:853-864 (Pubitemid 46147968)
33. Vachon PH, Harnois C, Grenier A et al (2002) Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis. Gastroenterology 123:1980-1991 (Pubitemid 35414331)
34. Harnois C, Demers MJ, Bouchard V et al (2004) Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol 198:209-222 (Pubitemid 38139312)
35. Ziegler WH, Liddington RC, Critchley DR (2006) The structure and regulation of vinculin. Trends Cell Biol 16:453-460 (Pubitemid 44293400)