Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy

Oncogene

Volumn 26, Issue 18, 2007, Pages 2563-2573

  Yuan, L ^a   Siegel, M ^b   Choi, K ^b   Khosla, C ^b   Miller, C R ^a   Jackson, E N ^a   Piwnica Worms, D ^a   Rich, K M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Apoptosis; BCNU; Brain tumor; Stroma; Tissue transglutaminase 2 inhibitors; U87MG

Indexed keywords

CARMUSTINE; FIBRONECTIN; KCC 009; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; TRANSFERASE INHIBITOR; TRANSGLUTAMINASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CANCER CELL; CANCER SURVIVAL; CELL SURFACE; CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EXTRACELLULAR MATRIX; GLIOBLASTOMA; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CARMUSTINE; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FEMALE; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; GLIOBLASTOMA; GTP-BINDING PROTEINS; HUMANS; ISOXAZOLES; MICE; MICE, INBRED BALB C; RNA, SMALL INTERFERING; SURVIVAL RATE; TRANSGLUTAMINASES; TUMOR CELLS, CULTURED;

MUS;

EID: 34247349128     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210048     Document Type: Article

References (30)

1. Aeschlimann D, Thomazy V. (2000). Protein cross-linking in assembly and remodeling of extracellular matrices: the role of transglutaminases. Connect Tissue Res 41: 1-27.
2. Akimov SS, Belkin AM. (2001). Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFbeta-dependent matrix deposition. J Cell Sci 114: 2989-3000.
3. Akimov SS, Krylov D, Fleischman LF, Belkin AM. (2000). Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Bio 148: 825-838.
4. Buckley CD, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D et al. (1999). RGD peptides induce apoptosis by direct caspase-3 activation. Nature 397: 534-539.
5. Castellani P, Borsi L, Carnemolla B, Biro A, Dorcaratto A, Viale GL et al. (2002). Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. Am J Pathol 161: 1695-1700.
6. Castro MG, Cowen R, Williamson IK, David A, Jimenez-Dalmaroni MJ, Yuan X et al. (2003). Current and future strategies for the treatment of malignant brain tumors. Pharmacol Ther 98: 71-108.
7. Chicoine MR, Won EK, Zahner M. (2001). Intra-tumoral injection of lipopolysaccharide causes regression of subcutaneously implanted mouse glioblastoma multiforme. Neurosurgery 48: 607-615.
8. Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P et al. (2005). Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol 12: 469-475.
9. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS. (1999). Cell adhesion mediated-drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93: 1658-1667.
10. De Laurenzi V, Melino G. (2001). Gene disruption of tissue transglutaminase. Mol Cell Biol 21: 148-155.
11. Fesus L, Piacentini M. (2002). Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci 27: 534-539.
12. Gross S, Piwnica-Worms D. (2005). Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters. Methods Enzymol 399: 512-530.
13. Hadden HL, Henke CA. (2000). Introduction of lung fibroblast apoptosis by soluble fibronectin peptides. Am J Respir Crit Care Med 162: 1553-1560.
14. Han JA, Park SC. (1999). Reduction of transglutaminase 2 expression is associated with an induction of drug sensitivity in the PC-14 human lung cancer cell line. J Cancer Res Clin Oncol 125: 89-95.
15. Jiang Z, Zheng X, Lytle RA, Higashikubo R, Rich KM. (2004). Lovastatin-induced up-regulation of the BH3-only protein, Bim and cell death in glioblastoma cells. J Neurochem 89: 168-178.
16. Jiang Z, Zheng X, Rich KM. (2003). Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment of glioblastoma cell lines induces cell death. J Neurochem 84: 273-281.
17. Kumanishi T. (1967). Brain tumors induced with Rous sarcoma virus, Schmidt-Ruppin strain. I. Induction of brain tumors in adult mice with Rous chicken sarcoma cells. Jpn J Exp Med 37: 461-474.
18. Martinez J, Chalupowicz DG, Roush RK, Sheth A, Barsigian C. (1994). Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers. Biochemistry 33: 2538-2545.
19. Mehta K. (1994). High levels of transglutaminase expression in doxorubicin-resistant human breast carcinoma cells. Int J Cancer 58: 400-406.
20. Midulla M, Verma R, Pignatelli M, Ritter MA, Courtenay-Luck NS. (2000). Source of oncofetal ED-B-containing fibronectin: implications of production by both tumor and endothelial cells. Cancer Res 60: 164-169.
21. h/tissue transglutaminase II. J Biol Chem 23: 20673-20678.
22. Nicolo G, Salvi S, Oliveri G, Borsi L, Castellani P, Zardi L et al. (1990). Expression of tenascin and of the ED-B containing oncofetal fibronectin isoform in human cancer. Cell Differ Dev 32: 401-408.
23. Ohnishi T, Hiraga S, Izumoto S, Matsumura H, Kanemura Y, Arita N et al. (1998). Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues. Clin Exp Metastasis 16: 729-741.
24. Pupa SM, Menard S, Forti S, Tagliabue E. (2002). New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 192: 259-267.
25. Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C et al. (1999). Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 5: 662-668.
26. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson EN. (2004). CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 64: 8604-8612.
27. Verderio EA, Telci D, Okoye A, Melino G, Griffin M. (2003). A novel RGD-independent cell adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J Biol Chem 278: 42604-42614.
28. Wernert N. (1997). The multiple roles of tumour stroma. Virchows Arch 430: 433-443.
29. Yuan L, Choi K, Khosla C, Zheng X, Higashikubo R, Chicoine MR et al. (2005). Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastoma. Mol Cancer Ther 4: 1293-1302.
30. Zemskov EA, Janiak A, Hang J, Waghray A, Belkin AM. (2006). The role of tissue transglutaminase in cell-matrix interactions. Frontiers Biosci 11: 1057-1076.